 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for WNK4 |
 Gene summary |
| Basic gene information | Gene symbol | WNK4 |
| Gene name | WNK lysine deficient protein kinase 4 | |
| Synonyms | PHA2B|PRKWNK4 | |
| Cytomap | UCSC genome browser: 17q21-q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032387.4, | |
| Description | protein kinase lysine-deficient 4protein kinase with no lysine 4serine/threonine-protein kinase WNK4 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 601844 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126562 | ||
| HPRD : 03505 | ||
| Vega : OTTHUMG00000180650 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WNK4 | |
| BioGPS: 65266 | ||
| Pathway | NCI Pathway Interaction Database: WNK4 | |
| KEGG: WNK4 | ||
| REACTOME: WNK4 | ||
| Pathway Commons: WNK4 | ||
| Context | iHOP: WNK4 | |
| ligand binding site mutation search in PubMed: WNK4 | ||
| UCL Cancer Institute: WNK4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
| Reference showing the relevant tissue of WNK4 | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for WNK4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -2.855577797 | -0.057191751 | -2.798386047 | 3.60E-11 | 8.27E-10 |
| KIRC | 0.157362804 | 5.115700304 | -4.9583375 | 8.57E-36 | 2.43E-34 |
| KICH | -1.31539603 | 5.38466397 | -6.70006 | 4.91E-17 | 1.83E-15 |
| KIRP | 0.464276345 | 5.520920095 | -5.05664375 | 3.43E-18 | 1.60E-16 |
| LIHC | -0.94647203 | -3.01537403 | 2.068902 | 4.22E-05 | 0.000158054 |
| Top |
| TissGene-miRNA for WNK4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for WNK4 |
| TissGeneSNV for WNK4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S621T | HNSC | 1 |
| p.S818F | SKCM | 1 |
| p.A80D | COAD | 1 |
| p.R433C | STAD | 1 |
| p.S728L | STAD | 1 |
| p.S376F | SKCM | 1 |
| p.A542G | LUAD | 1 |
| p.R669W | LAML | 1 |
| p.G607W | SKCM | 1 |
| p.L650F | SKCM | 1 |
| p.A716V | UCEC | 1 |
| p.R687T | HNSC | 1 |
| p.E372Q | HNSC | 1 |
| p.R521C | UCEC | 1 |
| p.M1181I | THCA | 1 |
| p.Q1048* | HNSC | 1 |
| p.P992A | CESC | 1 |
| p.A344P | STAD | 1 |
| p.P856S | BLCA | 1 |
| p.V188M | PRAD | 1 |
| p.V11A | LIHC | 1 |
| p.E346K | UCEC | 1 |
| p.G452D | UCEC | 1 |
| p.A717D | HNSC | 1 |
| p.P605H | GBM | 1 |
| p.L996I | LGG | 1 |
| p.S1231R | OV | 1 |
| p.P115L | SKCM | 1 |
| p.D586N | BLCA | 1 |
| p.H794D | LIHC | 1 |
| p.A574G | LUAD | 1 |
| p.R482W | COAD | 1 |
| p.P889S | SARC | 1 |
| p.A1003V | STAD | 1 |
| p.S1165R | LUSC | 1 |
| p.S852* | HNSC | 1 |
| p.E1126D | KIRC | 1 |
| p.R1142Q | COAD | 1 |
| p.E759K | SKCM | 1 |
| p.R1166Q | STAD | 1 |
| p.D238N | SARC | 1 |
| p.P340L | SKCM | 1 |
| p.P663S | UCEC | 1 |
| p.D706A | LUAD | 1 |
| p.E767K | SKCM | 1 |
| p.E529K | LGG | 1 |
| p.1222_1222insT | LUAD | 1 |
| p.L617I | UCEC | 1 |
| p.E690Q | HNSC | 1 |
| p.M459V | STAD | 1 |
| p.R1166W | ACC | 1 |
| p.F872L | UCS | 1 |
| p.E1052K | HNSC | 1 |
| p.M1111I | BLCA | 1 |
| p.S621L | STAD | 1 |
| p.W240* | SKCM | 1 |
| p.L455P | PRAD | 1 |
| p.G437S | READ | 1 |
| p.P712Q | LUSC | 1 |
| p.P545S | ESCA | 1 |
| p.F1236S | UCEC | 1 |
| p.S805C | CESC | 1 |
| p.R738W | KIRC | 1 |
| p.S1107I | SARC | 1 |
| p.E8Q | HNSC | 1 |
| p.S637F | SKCM | 1 |
| p.R508H | STAD | 1 |
| p.R1188H | STAD | 1 |
| p.G191R | SKCM | 1 |
| p.P1011S | PAAD | 1 |
| p.D1089Y | UCEC | 1 |
| p.P403T | LIHC | 1 |
| p.S1127N | BRCA | 1 |
| p.A601T | UCEC | 1 |
| p.V234I | PRAD | 1 |
| p.P1208Q | LUAD | 1 |
| p.M160V | HNSC | 1 |
| p.L1182V | THCA | 1 |
| p.R994Q | SKCM | 1 |
| p.E714K | SARC | 1 |
| p.E723K | UCEC | 1 |
| p.L668I | PAAD | 1 |
| p.A601S | BRCA | 1 |
| p.G108S | SKCM | 1 |
| p.R1016H | UCEC | 1 |
| p.R392K | BLCA | 1 |
| p.I1212N | HNSC | 1 |
| p.P620T | STAD | 1 |
| p.E444D | LUSC | 1 |
| p.G133D | LUAD | 1 |
| p.V510L | LUAD | 1 |
| p.R736Q | STAD | 1 |
| p.R35H | THYM | 1 |
| p.P105H | LIHC | 1 |
| p.E155K | SKCM | 1 |
| p.S888F | CESC | 1 |
| p.R1075H | STAD | 1 |
| p.P340S | SKCM | 1 |
| p.R670C | PAAD | 1 |
| p.F1134L | CESC | 1 |
| p.P537S | COAD | 1 |
| p.R23Q | SKCM | 1 |
| p.T415K | LUAD | 1 |
| p.M1243I | HNSC | 1 |
| p.R572S | PRAD | 1 |
| p.R736Q | HNSC | 1 |
| p.A1003T | STAD | 1 |
| p.E199D | COAD | 1 |
| p.E1072Q | HNSC | 1 |
| p.1212_1212insN | HNSC | 1 |
| p.S925F | SKCM | 1 |
| p.R669Q | STAD | 1 |
| p.P296S | SKCM | 1 |
| p.1242_1242insR | SKCM | 1 |
| p.S804L | STAD | 1 |
| p.R386C | STAD | 1 |
| p.R1142W | CESC | 1 |
| p.P825L | DLBC | 1 |
| p.E1093K | SKCM | 1 |
| p.V1109L | HNSC | 1 |
| p.G607R | SKCM | 1 |
| p.S101G | LUAD | 1 |
| p.P862L | BLCA | 1 |
| p.S1039C | OV | 1 |
| p.1234_1234insV | LUAD | 1 |
| p.N697T | BLCA | 1 |
| p.S242W | LUAD | 1 |
| p.E529G | LGG | 1 |
| p.I408F | ESCA | 1 |
| p.E1024K | SKCM | 1 |
| p.T1056A | STAD | 1 |
| Top |
| TissGeneCNV for WNK4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for WNK4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | H91370 | WNK4-MT1G | chr17:40939455 | chr16:56701878 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-6978-01A | PPARD-WNK4 | 5UTR-CDS | Chr6:35314927 | Chr17:40945610 |
| Top |
| TissGeneNet for WNK4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor) | WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal) |
 |  |
| Top |
| TissGeneProg for WNK4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for WNK4 |
| TissGeneDrug for WNK4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for WNK4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020538 | Hypertensive disease | 36 | BeFree,CTD_human,GAD,LHGDN |
| umls:C1449844 | Pseudohypoaldosteronism, Type II | 27 | BeFree |
| umls:C0085580 | Essential Hypertension | 8 | BeFree |
| umls:C3469605 | PSEUDOHYPOALDOSTERONISM, TYPE IID | 6 | BeFree |
| umls:C0020438 | Hypercalciuria | 5 | BeFree,LHGDN |
| umls:C0598428 | genetic hypertension | 3 | BeFree |
| umls:C1840390 | Pseudohypoaldosteronism, Type IIb | 3 | CLINVAR,MGD,ORPHANET,UNIPROT |
| umls:C0033805 | Pseudohypoaldosteronism | 2 | BeFree,CTD_human |
| umls:C0220666 | ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA | 2 | BeFree |
| umls:C0013336 | Dwarfism | 1 | BeFree |
| umls:C0020461 | Hyperkalemia | 1 | LHGDN |
| umls:C0020488 | Hypernatremia | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0242510 | Drug usage | 1 | BeFree |
| umls:C2936861 | Cortisol 11-beta-ketoreductase deficiency | 1 | BeFree |
| umls:C0268450 | Gitelman Syndrome | 0 | MGD |
| umls:C1840389 | Pseudohypoaldosteronism, Type IIa | 0 | MGD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |