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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for WNK4
check button Gene summary
Basic gene informationGene symbolWNK4
Gene nameWNK lysine deficient protein kinase 4
SynonymsPHA2B|PRKWNK4
CytomapUCSC genome browser: 17q21-q22
Type of geneprotein-coding
RefGenesNM_032387.4,
Descriptionprotein kinase lysine-deficient 4protein kinase with no lysine 4serine/threonine-protein kinase WNK4
Modification date20141219
dbXrefs MIM : 601844
HGNC : HGNC
Ensembl : ENSG00000126562
HPRD : 03505
Vega : OTTHUMG00000180650
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_WNK4
BioGPS: 65266
PathwayNCI Pathway Interaction Database: WNK4
KEGG: WNK4
REACTOME: WNK4
Pathway Commons: WNK4
ContextiHOP: WNK4
ligand binding site mutation search in PubMed: WNK4
UCL Cancer Institute: WNK4
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonKidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADKIRC,KIRP,KICH
Reference showing the relevant tissue of WNK4
Description by TissGene annotationsProtective TissGene in OS
Cancer gene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for WNK4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC-2.855577797-0.057191751-2.7983860473.60E-118.27E-10
KIRC0.1573628045.115700304-4.95833758.57E-362.43E-34
KICH-1.315396035.38466397-6.700064.91E-171.83E-15
KIRP0.4642763455.520920095-5.056643753.43E-181.60E-16
LIHC-0.94647203-3.015374032.0689024.22E-050.000158054


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TissGene-miRNA for WNK4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for WNK4
TissGeneSNV for WNK4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S621THNSC1
p.S818FSKCM1
p.A80DCOAD1
p.R433CSTAD1
p.S728LSTAD1
p.S376FSKCM1
p.A542GLUAD1
p.R669WLAML1
p.G607WSKCM1
p.L650FSKCM1
p.A716VUCEC1
p.R687THNSC1
p.E372QHNSC1
p.R521CUCEC1
p.M1181ITHCA1
p.Q1048*HNSC1
p.P992ACESC1
p.A344PSTAD1
p.P856SBLCA1
p.V188MPRAD1
p.V11ALIHC1
p.E346KUCEC1
p.G452DUCEC1
p.A717DHNSC1
p.P605HGBM1
p.L996ILGG1
p.S1231ROV1
p.P115LSKCM1
p.D586NBLCA1
p.H794DLIHC1
p.A574GLUAD1
p.R482WCOAD1
p.P889SSARC1
p.A1003VSTAD1
p.S1165RLUSC1
p.S852*HNSC1
p.E1126DKIRC1
p.R1142QCOAD1
p.E759KSKCM1
p.R1166QSTAD1
p.D238NSARC1
p.P340LSKCM1
p.P663SUCEC1
p.D706ALUAD1
p.E767KSKCM1
p.E529KLGG1
p.1222_1222insTLUAD1
p.L617IUCEC1
p.E690QHNSC1
p.M459VSTAD1
p.R1166WACC1
p.F872LUCS1
p.E1052KHNSC1
p.M1111IBLCA1
p.S621LSTAD1
p.W240*SKCM1
p.L455PPRAD1
p.G437SREAD1
p.P712QLUSC1
p.P545SESCA1
p.F1236SUCEC1
p.S805CCESC1
p.R738WKIRC1
p.S1107ISARC1
p.E8QHNSC1
p.S637FSKCM1
p.R508HSTAD1
p.R1188HSTAD1
p.G191RSKCM1
p.P1011SPAAD1
p.D1089YUCEC1
p.P403TLIHC1
p.S1127NBRCA1
p.A601TUCEC1
p.V234IPRAD1
p.P1208QLUAD1
p.M160VHNSC1
p.L1182VTHCA1
p.R994QSKCM1
p.E714KSARC1
p.E723KUCEC1
p.L668IPAAD1
p.A601SBRCA1
p.G108SSKCM1
p.R1016HUCEC1
p.R392KBLCA1
p.I1212NHNSC1
p.P620TSTAD1
p.E444DLUSC1
p.G133DLUAD1
p.V510LLUAD1
p.R736QSTAD1
p.R35HTHYM1
p.P105HLIHC1
p.E155KSKCM1
p.S888FCESC1
p.R1075HSTAD1
p.P340SSKCM1
p.R670CPAAD1
p.F1134LCESC1
p.P537SCOAD1
p.R23QSKCM1
p.T415KLUAD1
p.M1243IHNSC1
p.R572SPRAD1
p.R736QHNSC1
p.A1003TSTAD1
p.E199DCOAD1
p.E1072QHNSC1
p.1212_1212insNHNSC1
p.S925FSKCM1
p.R669QSTAD1
p.P296SSKCM1
p.1242_1242insRSKCM1
p.S804LSTAD1
p.R386CSTAD1
p.R1142WCESC1
p.P825LDLBC1
p.E1093KSKCM1
p.V1109LHNSC1
p.G607RSKCM1
p.S101GLUAD1
p.P862LBLCA1
p.S1039COV1
p.1234_1234insVLUAD1
p.N697TBLCA1
p.S242WLUAD1
p.E529GLGG1
p.I408FESCA1
p.E1024KSKCM1
p.T1056ASTAD1


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TissGeneCNV for WNK4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for WNK4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAH91370WNK4-MT1Gchr17:40939455chr16:56701878
TCGAfusionPortalPRADALUADTCGA-55-6978-01APPARD-WNK45UTR-CDSChr6:35314927Chr17:40945610


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TissGeneNet for WNK4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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COAD (tumor)COAD (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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HNSC (tumor)HNSC (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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KICH (tumor)KICH (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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KIRC (tumor)KIRC (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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KIRP (tumor)KIRP (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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LIHC (tumor)LIHC (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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LUAD (tumor)LUAD (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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LUSC (tumor)LUSC (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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PRAD (tumor)PRAD (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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STAD (tumor)STAD (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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THCA (tumor)THCA (normal)
WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (tumor)WNK4, YWHAZ, BCL6, YWHAQ, NEDD4L, OXSR1, SIRT1, SGK1, CLDN2, CLDN1, STK39, SLC12A3, CLDN4, CLDN3 (normal)
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TissGeneProg for WNK4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for WNK4
TissGeneDrug for WNK4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for WNK4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease36BeFree,CTD_human,GAD,LHGDN
umls:C1449844Pseudohypoaldosteronism, Type II27BeFree
umls:C0085580Essential Hypertension8BeFree
umls:C3469605PSEUDOHYPOALDOSTERONISM, TYPE IID6BeFree
umls:C0020438Hypercalciuria5BeFree,LHGDN
umls:C0598428genetic hypertension3BeFree
umls:C1840390Pseudohypoaldosteronism, Type IIb3CLINVAR,MGD,ORPHANET,UNIPROT
umls:C0033805Pseudohypoaldosteronism2BeFree,CTD_human
umls:C0220666ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA2BeFree
umls:C0013336Dwarfism1BeFree
umls:C0020461Hyperkalemia1LHGDN
umls:C0020488Hypernatremia1BeFree
umls:C0025149Medulloblastoma1BeFree
umls:C0029456Osteoporosis1BeFree
umls:C0035078Kidney Failure1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0242510Drug usage1BeFree
umls:C2936861Cortisol 11-beta-ketoreductase deficiency1BeFree
umls:C0268450Gitelman Syndrome0MGD
umls:C1840389Pseudohypoaldosteronism, Type IIa0MGD