TissGeneSummary for WNK3 |
Gene summary |
Basic gene information | Gene symbol | WNK3 |
Gene name | WNK lysine deficient protein kinase 3 | |
Synonyms | PRKWNK3 | |
Cytomap | UCSC genome browser: Xp11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_001002838.3, NM_020922.4, | |
Description | protein kinase with no lysine 3serine/threonine-protein kinase WNK3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300358 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196632 | ||
HPRD : 02289 | ||
Vega : OTTHUMG00000021626 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WNK3 | |
BioGPS: 65267 | ||
Pathway | NCI Pathway Interaction Database: WNK3 | |
KEGG: WNK3 | ||
REACTOME: WNK3 | ||
Pathway Commons: WNK3 | ||
Context | iHOP: WNK3 | |
ligand binding site mutation search in PubMed: WNK3 | ||
UCL Cancer Institute: WNK3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of WNK3 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0010765 | positive regulation of sodium ion transport | 16275913 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16275913 | GO:0032414 | positive regulation of ion transmembrane transporter activity | 16275913 | GO:0046777 | protein autophosphorylation | 16275913 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane | 16275913 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 16275913 | GO:2000682 | positive regulation of rubidium ion transport | 16275913 | GO:2000688 | positive regulation of rubidium ion transmembrane transporter activity | 16275913 | GO:0010765 | positive regulation of sodium ion transport | 16275913 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16275913 | GO:0032414 | positive regulation of ion transmembrane transporter activity | 16275913 | GO:0046777 | protein autophosphorylation | 16275913 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane | 16275913 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 16275913 | GO:2000682 | positive regulation of rubidium ion transport | 16275913 | GO:2000688 | positive regulation of rubidium ion transmembrane transporter activity | 16275913 |
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TissGeneExp for WNK3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.146125662 | 2.529613227 | -2.675738889 | 3.48E-27 | 5.10E-26 |
KIRP | -0.260311773 | 2.127835102 | -2.388146875 | 3.30E-10 | 3.39E-09 |
THCA | 0.051701362 | 1.270009837 | -1.218308475 | 7.65E-07 | 2.94E-06 |
STAD | -1.303627398 | -0.016449273 | -1.287178125 | 0.00146 | 0.007169301 |
KICH | 3.399913227 | 1.974161227 | 1.425752 | 0.000124 | 0.000317417 |
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TissGene-miRNA for WNK3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-17-5p | MIMAT0000070 | 0.022 | -0.26 | 78 |
ACC | hsa-miR-17-5p | MIMAT0000070 | 0.022 | -0.26 | 78 |
LUAD | hsa-let-7a-5p | MIMAT0000062 | 0.023 | -0.3 | 60 |
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TissGeneMut for WNK3 |
TissGeneSNV for WNK3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S1393L | SKCM | 3 |
p.S1346L | SKCM | 2 |
p.S1771F | BRCA | 2 |
p.R181Q | SKCM | 2 |
p.S832Y | UCEC | 2 |
p.E380* | UCEC | 2 |
p.N925S | PRAD | 2 |
p.S344L | READ | 1 |
p.F1287L | THYM | 1 |
p.S1331L | SKCM | 1 |
p.R1590I | STAD | 1 |
p.A37T | LGG | 1 |
p.E107K | CESC | 1 |
p.P1101S | SKCM | 1 |
p.R1587H | PRAD | 1 |
p.P1076L | LUSC | 1 |
p.R387H | THYM | 1 |
p.G1239S | TGCT | 1 |
p.R208* | UCEC | 1 |
p.Q256H | UCEC | 1 |
p.R487W | COAD | 1 |
p.S483Y | LUAD | 1 |
p.P1730S | UCEC | 1 |
p.S1147F | SKCM | 1 |
p.E688Q | LUAD | 1 |
p.E1098* | UCEC | 1 |
p.E446D | CESC | 1 |
p.S513T | LIHC | 1 |
p.P204T | LUAD | 1 |
p.D940N | SKCM | 1 |
p.I914T | KIRC | 1 |
p.R737Q | COAD | 1 |
p.S232F | UCEC | 1 |
p.L1032V | BLCA | 1 |
p.P585H | LUAD | 1 |
p.G1330V | LUSC | 1 |
p.Q1088E | HNSC | 1 |
p.R1109X | COAD | 1 |
p.E383K | STAD | 1 |
p.S1212I | SARC | 1 |
p.N851I | SKCM | 1 |
p.E73* | BLCA | 1 |
p.E461K | CESC | 1 |
p.P1176S | SKCM | 1 |
p.R80G | HNSC | 1 |
p.F263L | UCEC | 1 |
p.T534I | LGG | 1 |
p.I396M | HNSC | 1 |
p.P1582R | BRCA | 1 |
p.G1716R | READ | 1 |
p.G647C | LUAD | 1 |
p.S1473N | SKCM | 1 |
p.D1599Y | ACC | 1 |
p.Q1575* | OV | 1 |
p.G993V | LUSC | 1 |
p.E1159X | COAD | 1 |
p.W1269* | BLCA | 1 |
p.S983A | COAD | 1 |
p.H623P | SKCM | 1 |
p.A1014V | SKCM | 1 |
p.E130K | LUSC | 1 |
p.P1730T | LUAD | 1 |
p.E806* | UCEC | 1 |
p.Q1619K | HNSC | 1 |
p.P1728S | SKCM | 1 |
p.K439I | SKCM | 1 |
p.K439N | SKCM | 1 |
p.Q1676K | HNSC | 1 |
p.Q673* | SKCM | 1 |
p.R57I | UCEC | 1 |
p.L295I | UCEC | 1 |
p.L620V | UCEC | 1 |
p.E103* | UCEC | 1 |
p.R507S | BLCA | 1 |
p.P367R | HNSC | 1 |
p.R1301G | LUAD | 1 |
p.G572A | HNSC | 1 |
p.E1501K | BLCA | 1 |
p.T1604K | LUAD | 1 |
p.P1071L | BRCA | 1 |
p.H1217_splice | LUSC | 1 |
p.E537G | KIRC | 1 |
p.W1646R | COAD | 1 |
p.R1550* | BLCA | 1 |
p.H1008D | BLCA | 1 |
p.A1235V | BLCA | 1 |
p.R241L | LIHC | 1 |
p.Q1088P | LUAD | 1 |
p.E1691K | CESC | 1 |
p.S44G | LUAD | 1 |
p.T45I | UCEC | 1 |
p.S1521N | STAD | 1 |
p.S1665Y | UCEC | 1 |
p.Q1333* | CESC | 1 |
p.F209C | COAD | 1 |
p.E739Q | LUAD | 1 |
p.M1328I | BLCA | 1 |
p.E323* | UCEC | 1 |
p.E739Q | BLCA | 1 |
p.L526S | SKCM | 1 |
p.Q745* | UCEC | 1 |
p.P1516S | UCEC | 1 |
p.K372E | UCEC | 1 |
p.S1474N | STAD | 1 |
p.S308I | LGG | 1 |
p.R700X | READ | 1 |
p.P1156S | SKCM | 1 |
p.S865X | KIRC | 1 |
p.V1412A | STAD | 1 |
p.V587I | COAD | 1 |
p.D419H | HNSC | 1 |
p.D180N | COAD | 1 |
p.S852P | COAD | 1 |
p.R1550Q | SKCM | 1 |
p.E1115X | LIHC | 1 |
p.R495S | BLCA | 1 |
p.P1673I | LUAD | 1 |
p.L526S | LIHC | 1 |
p.V26A | SKCM | 1 |
p.E923X | COAD | 1 |
p.P906T | LUSC | 1 |
p.M1051I | STAD | 1 |
p.E417Q | STAD | 1 |
p.G260E | BRCA | 1 |
p.D330Y | SARC | 1 |
p.S980Y | UCEC | 1 |
p.Q625E | OV | 1 |
p.V1365A | STAD | 1 |
p.A298D | THYM | 1 |
p.P1785L | SKCM | 1 |
p.S1464X | COAD | 1 |
p.T1557K | LUAD | 1 |
p.K800T | UCEC | 1 |
p.V651F | LUAD | 1 |
p.Q1042E | BLCA | 1 |
p.E1564K | BLCA | 1 |
p.K555* | HNSC | 1 |
p.G219E | SKCM | 1 |
p.V161L | UCEC | 1 |
p.H819Y | CESC | 1 |
p.S1474R | STAD | 1 |
p.T1700I | BLCA | 1 |
p.P669T | LUAD | 1 |
p.P1728L | SKCM | 1 |
p.D166Y | SKCM | 1 |
p.G1756R | SKCM | 1 |
p.S1665F | UCEC | 1 |
p.T1063R | LUAD | 1 |
p.R872* | GBM | 1 |
p.R1565H | UCEC | 1 |
p.V941E | LUAD | 1 |
p.P1084Q | LGG | 1 |
p.R1597Q | LGG | 1 |
p.A1746V | UCEC | 1 |
p.S1367Y | ACC | 1 |
p.K1291E | LIHC | 1 |
p.Q1088K | READ | 1 |
p.R208* | SKCM | 1 |
p.P1730L | LUAD | 1 |
p.P204H | UCEC | 1 |
p.E1427K | BRCA | 1 |
p.E1357D | READ | 1 |
p.L919F | STAD | 1 |
p.S1670R | STAD | 1 |
p.G1692E | STAD | 1 |
p.S832Y | UCS | 1 |
p.H655Q | KIRP | 1 |
p.R181P | HNSC | 1 |
p.S1421C | BRCA | 1 |
p.E455K | BLCA | 1 |
p.Q1601L | HNSC | 1 |
p.Q1528K | HNSC | 1 |
p.N1323H | UCEC | 1 |
p.S451G | SKCM | 1 |
p.T237M | BRCA | 1 |
p.V173F | HNSC | 1 |
p.R1597Q | SKCM | 1 |
p.C254* | LUAD | 1 |
p.S1284L | SKCM | 1 |
p.P665S | UCEC | 1 |
p.E1023K | COAD | 1 |
p.P1176L | SKCM | 1 |
p.G1239S | DLBC | 1 |
p.H1243N | UCEC | 1 |
p.S1146F | LUAD | 1 |
p.Y615H | UCEC | 1 |
p.R916Q | BLCA | 1 |
p.S75F | STAD | 1 |
p.V1004L | LUAD | 1 |
p.R1597* | BLCA | 1 |
p.L235S | LUAD | 1 |
p.S1393L | UCEC | 1 |
p.D1038V | SKCM | 1 |
p.V543F | LGG | 1 |
p.C1155F | GBM | 1 |
p.D330N | LUAD | 1 |
p.I641N | SARC | 1 |
p.M1645I | LUAD | 1 |
p.M245I | HNSC | 1 |
p.F121S | COAD | 1 |
p.S1613R | STAD | 1 |
p.I386V | LUAD | 1 |
p.Q1333K | SARC | 1 |
p.Q1575K | HNSC | 1 |
p.Y1278C | UCEC | 1 |
p.Q619K | UCEC | 1 |
p.R1099I | LUAD | 1 |
p.R1334W | UCEC | 1 |
p.T1062A | SKCM | 1 |
p.R1543I | STAD | 1 |
p.W213L | UCEC | 1 |
p.E1357Q | ACC | 1 |
p.R190I | LUAD | 1 |
p.H819R | STAD | 1 |
p.S1453F | SARC | 1 |
p.R38K | PRAD | 1 |
p.P1006T | STAD | 1 |
p.L528V | HNSC | 1 |
p.S617F | LGG | 1 |
p.E327K | LUSC | 1 |
p.R1254G | LUAD | 1 |
p.R882H | HNSC | 1 |
p.R870L | HNSC | 1 |
p.L178V | STAD | 1 |
p.Q189* | CESC | 1 |
p.L1581X | KIRP | 1 |
p.N1608T | STAD | 1 |
p.C1496Y | UCEC | 1 |
p.V488A | LUSC | 1 |
p.E1531K | SKCM | 1 |
p.K1570N | ESCA | 1 |
p.R359Q | LAML | 1 |
p.S1521R | STAD | 1 |
p.T878M | KICH | 1 |
p.P1263L | SKCM | 1 |
p.E196G | LUSC | 1 |
p.T284M | COAD | 1 |
p.D1656Y | ACC | 1 |
p.S1320Y | ACC | 1 |
p.E1404Q | ACC | 1 |
p.S663L | BRCA | 1 |
p.E1484K | SKCM | 1 |
p.S212Y | UCEC | 1 |
p.E1440K | CESC | 1 |
p.E1682D | UCEC | 1 |
p.I1127T | BRCA | 1 |
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TissGeneCNV for WNK3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WNK3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for WNK3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WNK3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WNK3 |
TissGeneDrug for WNK3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WNK3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1136249 | Mental Retardation, X-Linked | 2 | BeFree,LHGDN |
umls:C0004352 | Autistic Disorder | 1 | BeFree,GAD,LHGDN |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C1846055 | Siderius X-linked mental retardation syndrome | 1 | BeFree |