TissGDB

Home

	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for BMPR1B

Gene summary

Basic gene information	Gene symbol	BMPR1B
	Gene name	bone morphogenetic protein receptor, type IB
	Synonyms	ALK-6\|ALK6\|CDw293
	Cytomap	UCSC genome browser: 4q22-q24
	Type of gene	protein-coding
	RefGenes	NM_001203.2, NM_001256792.1,NM_001256793.1,NM_001256794.1,
	Description	BMP type-1B receptorBMPR-1Bactivin receptor-like kinase 6bone morphogenetic protein receptor type-1Bserine/threonine receptor kinase
	Modification date	20141207
dbXrefs	MIM : 603248
	HGNC : HGNC
	Ensembl : ENSG00000138696
	HPRD : 04457
	Vega : OTTHUMG00000130991
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_BMPR1B
	BioGPS: 658
Pathway	NCI Pathway Interaction Database: BMPR1B
	KEGG: BMPR1B
	REACTOME: BMPR1B
	Pathway Commons: BMPR1B
Context	iHOP: BMPR1B
	ligand binding site mutation search in PubMed: BMPR1B
	UCL Cancer Institute: BMPR1B
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	PRAD
Reference showing the relevant tissue of BMPR1B
Description by TissGene annotations	Protective TissGene in RFS Cancer gene Fused withTSGene Fused withOncogene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006468	protein phosphorylation	12065756
GO:0030509	BMP signaling pathway	18436533
GO:0006468	protein phosphorylation	12065756
GO:0030509	BMP signaling pathway	18436533

Top

TissGeneExp for BMPR1B

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
HNSC	-0.033033394	-1.634468278	1.601434884	1.18E-06	8.88E-06
BRCA	2.489476888	-0.21493013	2.704407018	1.49E-12	6.61E-12
LIHC	-4.768355533	-2.055551533	-2.712804	3.53E-11	4.96E-10
THCA	-4.84015933	-2.850932211	-1.989227119	4.25E-14	4.61E-13
KIRP	-2.371247783	2.236558467	-4.60780625	2.71E-10	2.88E-09
KIRC	-3.0703707	2.628047356	-5.698418056	5.82E-35	1.53E-33
KICH	4.061592467	2.530476467	1.531116	0.0108	0.019336474
LUSC	-1.044940553	-0.035144475	-1.009796078	0.0013	0.002374371
LUAD	-0.924767395	0.218992949	-1.143760345	8.90E-05	0.000227366

Top

TissGene-miRNA for BMPR1B

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
ACC	hsa-miR-506-3p	MIMAT0002878	0.021	-0.28	78
ACC	hsa-miR-506-3p	MIMAT0002878	0.021	-0.28	78

Top

TissGeneMut for BMPR1B

TissGeneSNV for BMPR1B

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.K498N	STAD	1
p.A411T	SKCM	1
p.P326L	STAD	1
p.A328T	LIHC	1
p.S402G	UCEC	1
p.W474C	ACC	1
p.L94F	ESCA	1
p.E167Q	HNSC	1
p.T309A	LIHC	1
p.A411D	SKCM	1
p.S497F	SKCM	1
p.P356L	STAD	1
p.S446*	CESC	1
p.R376C	STAD	1
p.R243*	LUAD	1
p.L351M	UCEC	1
p.Y395D	ESCA	1
p.S416*	CESC	1
p.A359V	STAD	1
p.A484T	LUSC	1
p.S293P	BRCA	1
p.R82P	COAD	1
p.Q249*	BLCA	1
p.S321R	PRAD	1
p.C81F	KIRC	1
p.G100V	THYM	1
p.Y245S	ESCA	1
p.S62C	LUAD	1
p.K488R	STAD	1
p.R284G	ESCA	1
p.G70V	THYM	1
p.G268E	SKCM	1
p.A329V	STAD	1
p.P87S	SKCM	1
p.R224C	COAD	1
p.W504C	ACC	1
p.K501E	COAD	1
p.T279I	UCEC	1
p.D47Y	THYM	1
p.G106C	STAD	1
p.I142L	SKCM	1
p.K468N	STAD	1
p.G211E	BLCA	1
p.I419M	UCEC	1
p.R406C	STAD	1
p.G76C	STAD	1
p.T279A	LIHC	1
p.L469I	LUAD	1
p.S62C	HNSC	1
p.P65S	BRCA	1
p.T102M	BLCA	1
p.Y425D	ESCA	1
p.V59I	KIRP	1
p.Q184*	BLCA	1
p.A522S	ESCA	1
p.Y215S	ESCA	1
p.P171T	LUAD	1
p.C111F	KIRC	1
p.E226*	UCEC	1
p.S466C	CESC	1
p.S131F	BLCA	1
p.R331Q	LUAD	1
p.K342I	UCEC	1
p.K518R	STAD	1
p.W219C	LUAD	1
p.Y437H	SKCM	1
p.R82W	LUAD	1
p.V29I	KIRP	1

Top

TissGeneCNV for BMPR1B

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

Top

TissGeneFusions for BMPR1B

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BG990101	BMPR1B-MRPL39		chr4:95958790	chr21:26960826
Chimerdb3.0	ChiTaRs	NA	DQ207770	RUNX1-BMPR1B		chr21:36286088	chr4:95732914
Chimerdb3.0	FusionScan	PRAD	TCGA-SU-A7E7-01A	BMPR1B-ETV1	5'UTR-5'UTR	chr4:95679219	chr7:14028764
Chimerdb3.0	FusionScan	BRCA	TCGA-A2-A0ET-01A	BMPR1B-MCC	5'UTR-CDS	chr4:95917285	chr5:112406931
TCGAfusionPortal	PRADA	BRCA	TCGA-A2-A0ET-01A	BMPR1B-MCC	5UTR-CDS	Chr4:95917285	Chr5:112406931
TCGAfusionPortal	PRADA	KIRC	TCGA-B0-4698-01A	BMPR1B-DDAH1	Out-of-frame	Chr4:96025718	Chr1:85824530
TCGAfusionPortal	PRADA	PRAD	TCGA-SU-A7E7-01A	BMPR1B-ETV1	5UTR-5UTR	Chr4:95679219	Chr7:14028764

Top

TissGeneNet for BMPR1B

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
BMPR1B, SQSTM1, SH3KBP1, PAK1, TGFBR1, PPP2CA, STUB1, RAB25, XIAP, DCAF7, FANCL, PLEKHB1, SOCS6, RASD2, RAB38, GDF5, VEPH1, IGSF1, DCAF12, SRGAP1, TTC17 (tumor)	BMPR1B, SH3KBP1, RAP2A, PPP2CA, EZH2, RHEBL1, RAN, XIAP, CDK4, DNMT1, RPS27A, BMP7, SOCS6, RASD2, RAB6B, GDF5, RRAS2, CHN1, SRGAP1, NKIRAS1, TTC17 (normal)

COAD (tumor)	COAD (normal)
BMPR1B, SH3KBP1, PAK1, TGFBR1, RAB25, BMPR2, BMP7, PLEKHB1, SASH3, CDK14, RAB6B, GDF5, BMPR1A, IGSF1, DCAF12, CHN1, RHOJ, RASL12, NKIRAS1, GDF6, KLHL1 (tumor)	BMPR1B, PAK1, TGFBR1, EZH2, RAN, CDK4, BMPR2, BMP6, SASH3, RASD2, CDK14, ARHGEF6, RAB6B, GDF5, VEPH1, CHN1, RHOJ, RASL12, SRGAP1, GDF6, SGK196 (normal)

HNSC (tumor)	HNSC (normal)
BMPR1B, SQSTM1, SH3KBP1, PAK1, RHOD, RAP2A, PPP2CA, RAB25, RHEBL1, RAN, CDK4, DCAF7, RPS27A, PLEKHB1, STAMBP, RASD2, CDK14, PPP3CC, RRAS2, TTC27, BMP15 (tumor)	BMPR1B, SQSTM1, RHOD, TGFBR1, BMP2, GDF9, EZH2, RHEBL1, SNX6, TNNT1, FANCL, BMP7, SOCS6, SMAD7, CDK14, RAB38, RAB6B, RRAS2, RHOJ, SRGAP1, GDF6 (normal)

KICH (tumor)	KICH (normal)
BMPR1B, SQSTM1, SH3KBP1, RHOD, RAP2A, BMP2, GDF9, RAB25, FANCL, PLEKHB1, BMP6, SASH3, RASD2, CDK14, RAB6B, VEPH1, BMPR1A, RRAS2, DCAF6, IGSF1, RHOJ (tumor)	BMPR1B, SH3KBP1, RHOD, TGFBR1, GDF9, STUB1, SMAD6, SMURF1, OXSR1, XIAP, BMP7, STAMBP, BMP6, ARHGEF6, BMPR1A, RRAS2, DCAF6, DCAF12, AMHR2, STK35, BMP4 (normal)

KIRC (tumor)	KIRC (normal)
BMPR1B, SQSTM1, SH3KBP1, RHOD, RAP2A, BMP2, TSC22D1, GDF9, RAB25, TNNT1, PLEKHB1, BMP6, SASH3, RASD2, CDK14, ARHGEF6, VEPH1, BMPR1A, RRAS2, IGSF1, GDF6 (tumor)	BMPR1B, TGFBR1, RAP2A, BMP2, TSC22D1, SMURF1, RAB25, RAN, SNX6, CDK4, TNNT1, BMP7, PLEKHB1, SASH3, RAB6B, GDF5, VEPH1, RRAS2, TTC27, SRGAP1, GDF6 (normal)

KIRP (tumor)	KIRP (normal)
BMPR1B, SH3KBP1, PAK1, RHOD, RAP2A, BMP2, TSC22D1, GDF9, RAB25, DCAF7, FANCL, PLEKHB1, SMAD7, BMP6, CDK14, RAB6B, VEPH1, RRAS2, IGSF1, RHOJ, GDF6 (tumor)	BMPR1B, SH3KBP1, TGFBR1, RAN, XIAP, SNX6, CDK4, TNNT1, DNMT1, RPS27A, PLEKHB1, RASD2, RAB38, ARHGEF6, PPP3CC, BMPR1A, RHOJ, SRGAP1, GDF6, TTC17, SGK196 (normal)

LIHC (tumor)	LIHC (normal)
BMPR1B, SQSTM1, PAK1, RHOD, TGFBR1, BMP2, EZH2, RAN, SNX6, CDK4, UBE2Z, DNMT1, SASH3, ARHGEF6, BMPR1A, TTC27, CHN1, RHOJ, RASL12, SRGAP1, BMP4 (tumor)	BMPR1B, TGFBR1, GDF9, SMAD6, RAB25, BMPR2, TNNT1, BMP7, PLEKHB1, SMAD7, SASH3, RASD2, RAB38, ARHGEF6, RAB6B, VEPH1, CHN1, RHOJ, RASL12, SRGAP1, GDF6 (normal)

LUAD (tumor)	LUAD (normal)
BMPR1B, SQSTM1, SH3KBP1, TRAF6, BMP2, GDF9, RHEBL1, CDK4, PLEKHB1, SOCS6, SASH3, CDK14, RAB6B, PPP3CC, BMPR1A, TTC27, DCAF6, IGSF1, BMP15, SRGAP1, BMP4 (tumor)	BMPR1B, SQSTM1, PAK1, BMP2, RAB25, RHEBL1, UBE2Z, DNMT1, PLEKHB1, SASH3, RASD2, CDK14, RAB6B, RRAS2, IGSF1, DCAF12, CHN1, BMP15, STK35, SRGAP1, NKIRAS1 (normal)

LUSC (tumor)	LUSC (normal)
BMPR1B, SQSTM1, TGFBR1, GDF9, SMURF1, RHEBL1, RAN, CDK4, BMPR2, UBE2Z, RPS27A, PLEKHB1, SOCS6, SMAD7, SASH3, RAB6B, BMPR1A, DCAF6, DCAF12, BMP15, GDF6 (tumor)	BMPR1B, SH3KBP1, PAK1, TSC22D1, SMAD6, EZH2, BMPR2, PLEKHB1, SOCS6, SMAD7, CDK14, RAB6B, GDF5, VEPH1, DCAF12, CHN1, BMP15, RHOJ, RASL12, SRGAP1, BMP4 (normal)

PRAD (tumor)	PRAD (normal)
BMPR1B, SH3KBP1, RAP2A, BMP2, SMAD6, RAB25, XIAP, DCAF7, TNNT1, DNMT1, SMAD7, STAMBP, SASH3, ARHGEF6, GDF5, DCAF12, CHN1, RHOJ, RASL12, BMP4, TTC17 (tumor)	BMPR1B, SH3KBP1, RHEBL1, XIAP, BMPR2, DCAF7, TNNT1, SOCS6, SASH3, RASD2, RAB38, GDF5, PPP3CC, DCAF6, DCAF12, CHN1, RHOJ, RASL12, STK35, BMP4, SGK196 (normal)

STAD (tumor)	STAD (normal)
BMPR1B, RHOD, TGFBR1, TSC22D1, PPP2CA, RAB25, EZH2, TNNT1, PLEKHB1, STAMBP, RASD2, CDK14, ARHGEF6, RAB6B, GDF5, BMPR1A, IGSF1, DCAF12, CHN1, RHOJ, NKIRAS1 (tumor)	BMPR1B, TGFBR1, RAB25, EZH2, RAN, BMPR2, DNMT1, BMP6, RASD2, CDK14, RAB38, RAB6B, GDF5, BMPR1A, IGSF1, CHN1, RHOJ, RASL12, SRGAP1, NKIRAS1, GDF6 (normal)

THCA (tumor)	THCA (normal)
BMPR1B, SH3KBP1, EZH2, RHEBL1, RAN, BMPR2, DNMT1, PLEKHB1, SOCS6, SASH3, RAB6B, PPP3CC, VEPH1, BMPR1A, CHN1, BMP15, RHOJ, SRGAP1, NKIRAS1, GDF6, BMP4 (tumor)	BMPR1B, SH3KBP1, RHOD, RAP2A, BMP2, STUB1, SMURF1, SNX6, BMPR2, TNNT1, DNMT1, FANCL, SASH3, CDK14, ARHGEF6, GDF5, DCAF6, DCAF12, CHN1, GDF6, SGK196 (normal)

Top

TissGeneProg for BMPR1B

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Top

TissGeneClin for BMPR1B

TissGeneDrug for BMPR1B

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

TissGeneDisease for BMPR1B

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C1832702	BRACHYDACTYLY, TYPE A2	6	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0033578	Prostatic Neoplasms	2	CTD_human,LHGDN
umls:C0039075	Syndactyly	2	BeFree
umls:C0152171	Idiopathic pulmonary hypertension	2	BeFree
umls:C0343284	Chondrodysplasia	2	BeFree
umls:C3203102	Idiopathic pulmonary arterial hypertension	2	BeFree
umls:C0001973	Alcoholic Intoxication, Chronic	1	GAD
umls:C0004096	Asthma	1	LHGDN
umls:C0005941	Bone Diseases, Developmental	1	CTD_human
umls:C0006142	Malignant neoplasm of breast	1	BeFree
umls:C0007113	Rectal Carcinoma	1	BeFree
umls:C0015393	Eye Abnormalities	1	CTD_human
umls:C0017636	Glioblastoma	1	BeFree
umls:C0018206	granulosa cell tumor	1	BeFree
umls:C0020538	Hypertensive disease	1	GAD
umls:C0020542	Pulmonary Hypertension	1	LHGDN
umls:C0029456	Osteoporosis	1	BeFree
umls:C0031117	Peripheral Neuropathy	1	CTD_human
umls:C0206762	Limb Deformities, Congenital	1	BeFree
umls:C0345893	Juvenile polyposis syndrome	1	GAD
umls:C0376634	Craniofacial Abnormalities	1	CTD_human
umls:C0678222	Breast Carcinoma	1	BeFree
umls:C1263846	Attention deficit hyperactivity disorder	1	GAD
umls:C1266044	Collecting Duct Carcinoma of the Kidney	1	BeFree
umls:C1836182	Chondrodysplasia, acromesomelic, with genital anomalies	1	CLINVAR,CTD_human
umls:C1861385	SYMPHALANGISM, PROXIMAL	1	BeFree
umls:C1862103	Brachydactyly type C	1	BeFree,ORPHANET
umls:C0265260	Chondrodysplasia, Grebe type	0	ORPHANET
umls:C1300268	Brachydactyly syndrome type C	0	ORPHANET
umls:C1856738	Fibular hypoplasia and complex brachydactyly	0	ORPHANET