 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SLC22A1 |
 Gene summary |
| Basic gene information | Gene symbol | SLC22A1 |
| Gene name | solute carrier family 22 (organic cation transporter), member 1 | |
| Synonyms | HOCT1|OCT1|oct1_cds | |
| Cytomap | UCSC genome browser: 6q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003057.2, NM_153187.1, | |
| Description | organic cation transporter 1solute carrier family 22 member 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602607 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000175003 | ||
| HPRD : 04007 | ||
| Vega : OTTHUMG00000015947 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC22A1 | |
| BioGPS: 6580 | ||
| Pathway | NCI Pathway Interaction Database: SLC22A1 | |
| KEGG: SLC22A1 | ||
| REACTOME: SLC22A1 | ||
| Pathway Commons: SLC22A1 | ||
| Context | iHOP: SLC22A1 | |
| ligand binding site mutation search in PubMed: SLC22A1 | ||
| UCL Cancer Institute: SLC22A1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTExHPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SLC22A1 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SLC22A1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.535232456 | -0.548612456 | -1.98662 | 2.15E-07 | 9.20E-07 |
| KIRC | -1.730080845 | -0.274422511 | -1.455658333 | 1.34E-07 | 3.70E-07 |
| LIHC | 5.853753544 | 10.87143354 | -5.01768 | 5.48E-13 | 1.17E-11 |
| HNSC | -0.249371898 | -1.88742306 | 1.638051163 | 3.77E-05 | 0.000186839 |
| KIRP | -1.108985706 | 0.625004919 | -1.733990625 | 4.33E-05 | 0.000160993 |
| Top |
| TissGene-miRNA for SLC22A1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SLC22A1 |
| TissGeneSNV for SLC22A1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I421F | PAAD | 7 |
| p.I421F | THYM | 3 |
| p.Y127C | LUAD | 2 |
| p.I421F | KIRC | 2 |
| p.E68D | UCEC | 1 |
| p.Y199* | LUSC | 1 |
| p.T245M | UCEC | 1 |
| p.A80S | HNSC | 1 |
| p.V419F | LUSC | 1 |
| p.W146* | SKCM | 1 |
| p.R90H | UCEC | 1 |
| p.A250T | COAD | 1 |
| p.L511V | SKCM | 1 |
| p.R339C | SKCM | 1 |
| p.S196* | LUSC | 1 |
| p.P388L | STAD | 1 |
| p.R439Q | SKCM | 1 |
| p.Y352N | CESC | 1 |
| p.R402C | BRCA | 1 |
| p.R342H | UCEC | 1 |
| p.G215A | LUAD | 1 |
| p.L511P | SKCM | 1 |
| p.G465R | COAD | 1 |
| p.S470F | SKCM | 1 |
| p.A80T | ESCA | 1 |
| p.R342H | HNSC | 1 |
| p.R482C | SKCM | 1 |
| p.K308N | UCEC | 1 |
| p.C88R | LGG | 1 |
| p.P2S | UCEC | 1 |
| p.P46S | COAD | 1 |
| p.M420I | PAAD | 1 |
| p.A99T | BRCA | 1 |
| p.M420I | COAD | 1 |
| p.W64C | LUSC | 1 |
| p.G253R | UCEC | 1 |
| p.P388L | KIRC | 1 |
| p.I299M | STAD | 1 |
| p.K329N | LUAD | 1 |
| p.V191M | UCEC | 1 |
| p.R402S | SKCM | 1 |
| p.G310R | STAD | 1 |
| p.A500P | ESCA | 1 |
| p.A80T | UCEC | 1 |
| p.E323K | BLCA | 1 |
| p.R90H | STAD | 1 |
| p.R399H | UCEC | 1 |
| p.W146X | SKCM | 1 |
| p.M420I | THCA | 1 |
| p.I421F | PCPG | 1 |
| p.I421F | KIRP | 1 |
| p.M406I | STAD | 1 |
| p.R172_splice | LUSC | 1 |
| p.P506S | SKCM | 1 |
| p.A520T | COAD | 1 |
| p.V484A | LUAD | 1 |
| p.E324D | UCEC | 1 |
| p.L513F | MESO | 1 |
| p.R262H | STAD | 1 |
| p.I421F | THCA | 1 |
| Top |
| TissGeneCNV for SLC22A1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SLC22A1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for SLC22A1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SLC22A1, HNF4A, POU2AF1 (tumor) | SLC22A1, HNF4A, POU2AF1 (normal) |
 |  |
| Top |
| TissGeneProg for SLC22A1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SLC22A1 |
| TissGeneDrug for SLC22A1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SLC22A1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023473 | Myeloid Leukemia, Chronic | 18 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 8 | BeFree,GAD |
| umls:C0023474 | Leukemia, Myeloid, Chronic-Phase | 5 | BeFree,GAD |
| umls:C1857231 | LACTASE PERSISTENCE | 4 | BeFree |
| umls:C2239176 | Liver carcinoma | 4 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree,GAD |
| umls:C0178874 | Tumor Progression | 3 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 2 | BeFree |
| umls:C0008370 | Cholestasis | 2 | BeFree,GAD |
| umls:C0023418 | leukemia | 2 | BeFree,GAD |
| umls:C0028754 | Obesity | 2 | BeFree,CTD_human |
| umls:C0033578 | Prostatic Neoplasms | 2 | GAD |
| umls:C0206698 | Cholangiocarcinoma | 2 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | RGD |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005398 | Cholestasis, Extrahepatic | 1 | RGD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0008372 | Intrahepatic Cholestasis | 1 | RGD |
| umls:C0009375 | Colonic Neoplasms | 1 | CTD_human |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0013221 | Drug toxicity | 1 | GAD |
| umls:C0013295 | Duodenal Ulcer | 1 | BeFree |
| umls:C0014132 | Endocrine Gland Neoplasms | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0024534 | Malaria, Cerebral | 1 | BeFree |
| umls:C0027686 | Pathologic Neovascularization | 1 | GAD |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0085695 | Chronic gastritis | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0206659 | Embryonal Carcinoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0334279 | Adenocarcinoma, intestinal type | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0555278 | Cerebral metastasis | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C2609414 | Acute kidney injury | 1 | RGD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |