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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SNAP25
check button Gene summary
Basic gene informationGene symbolSNAP25
Gene namesynaptosomal-associated protein, 25kDa
SynonymsRIC-4|RIC4|SEC9|SNAP|SNAP-25|bA416N4.2|dJ1068F16.2
CytomapUCSC genome browser: 20p12-p11.2
Type of geneprotein-coding
RefGenesNM_003081.3,
NM_130811.2,
DescriptionSUPresistance to inhibitors of cholinesterase 4 homologsuper proteinsynaptosomal-associated protein 25synaptosomal-associated protein, 25kD
Modification date20141214
dbXrefs MIM : 600322
HGNC : HGNC
Ensembl : ENSG00000132639
HPRD : 02637
Vega : OTTHUMG00000031863
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SNAP25
BioGPS: 6616
PathwayNCI Pathway Interaction Database: SNAP25
KEGG: SNAP25
REACTOME: SNAP25
Pathway Commons: SNAP25
ContextiHOP: SNAP25
ligand binding site mutation search in PubMed: SNAP25
UCL Cancer Institute: SNAP25
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Brain
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGG
Reference showing the relevant tissue of SNAP25
Description by TissGene annotationsHave significant anti-correlated miRNA
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SNAP25

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC2.4565621770.5641843991.8923777781.24E-125.26E-12
KIRP2.7003312740.3283281492.3720031257.77E-074.02E-06
COAD-1.4506982931.664324784-3.1150230772.37E-103.07E-09
PRAD0.7475632452.754836322-2.0072730771.49E-092.23E-08
THCA1.362933975-0.0296812791.3926152543.33E-061.17E-05
STAD-0.3375749761.759200024-2.0967750.003170.01332585
KICH-1.1685326010.526055399-1.6945880.0003580.000842983


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TissGene-miRNA for SNAP25

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-181a-5pMIMAT00002560.045-0.2660
ACChsa-miR-613MIMAT00032810.019-0.2778
ACChsa-miR-449b-5pMIMAT00033270.036-0.2778
ACChsa-miR-613MIMAT00032810.019-0.2778
ACChsa-miR-449b-5pMIMAT00033270.036-0.2778
ACChsa-miR-425-5pMIMAT00033930.0067-0.3178
ACChsa-miR-425-5pMIMAT00033930.0067-0.3178
ACChsa-miR-543MIMAT00049540.0051-0.3278
ACChsa-miR-543MIMAT00049540.0051-0.3278
ACChsa-miR-1298-5pMIMAT00058000.0025-0.3478
ACChsa-miR-1298-5pMIMAT00058000.0025-0.3478
ACChsa-miR-181d-5pMIMAT00028210.0011-0.3778
ACChsa-miR-181d-5pMIMAT00028210.0011-0.3778


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TissGeneMut for SNAP25
TissGeneSNV for SNAP25

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G82ESKCM2
p.E61KSKCM2
p.G158ESKCM2
p.R161SLUAD1
p.K201NLUSC1
p.D58NSKCM1
p.L78FBLCA1
p.H66DPRAD1
p.K40TUCEC1
p.R161CUCEC1
p.G82RSKCM1
p.S187FSKCM1
p.S25LUCEC1
p.E125GLIHC1
p.F84LUCEC1
p.E183DHNSC1
p.E183KSKCM1
p.E194DLUAD1
p.A104SREAD1
p.I67MLIHC1
p.E123KSKCM1
p.P91ALIHC1
p.E75DSTAD1
p.S187TLUAD1
p.R59CUCEC1
p.L160FSKCM1
p.D58NUCEC1
p.T79MBLCA1
p.G204ESKCM1
p.G206DSKCM1
p.R8HUCEC1
p.R119SESCA1
p.R176CSTAD1
p.R59CPAAD1
p.F133LLIHC1
p.R176CUCEC1
p.R59CCOAD1
p.R8HBRCA1
p.E151QBLCA1
p.E143KSKCM1
p.R8HHNSC1
p.D179YLUAD1
p.R198HHNSC1
p.I44TUCEC1
p.G111ABRCA1
p.E73ASKCM1
p.R119HPRAD1
p.M71KLUAD1
p.R191TBLCA1
p.R124QSTAD1


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TissGeneCNV for SNAP25

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SNAP25

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADA524284RASA4-SNAP25chr7:102257204chr20:10287139
Chimerdb3.0ChiTaRsNAAW899942ROR1-SNAP25chr1:64286029chr20:10287562
Chimerdb3.0ChiTaRsNAAV726363LAMA3-SNAP25chr18:21489176chr20:10286843
Chimerdb3.0ChiTaRsNAAW898620SNAP25-SNAP25chr20:10287360chr20:10287483
Chimerdb3.0ChiTaRsNABQ340310SNAP25-IGSF9Bchr20:10287819chr11:133802427
Chimerdb3.0ChiTaRsNABI033650SNAP25-CREBBPchr20:10287974chr16:3784039
Chimerdb3.0ChiTaRsNAAW900408SNAP25-EHMT1chr20:10288007chr9:140514186
Chimerdb3.0ChiTaRsNABG715348SNRPN-SNAP25chr15:25220210chr20:10286958
Chimerdb3.0ChiTaRsNACD250904SNAP25-SNAP25chr20:10287786chr20:10279945


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TissGeneNet for SNAP25

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SNAP25, PRKACA, SRCIN1, TRIM9, VAMP8, STX2, STX11, ITSN1, STX1A, SNAPIN, GOSR1, UNC13B, CENPF, KCNB1, CPLX1, STX3, STX12, SCAMP1, SYT9, STXBP6, CCDC53 (tumor)SNAP25, STX5, TRIM9, VAMP8, STX2, DNM1, STX1A, SNAPIN, VAMP2, RIMS1, CENPF, STX4, SYT1, KCNB1, CPLX1, NAPA, STX12, SCAMP1, ZDHHC17, PRRT2, CCDC53 (normal)
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COAD (tumor)COAD (normal)
SNAP25, PRKCA, KIF5B, HGS, SRCIN1, TRIM9, STX2, STX1A, SNAPIN, VAMP2, UNC13B, RIMS1, CENPF, SYT1, KCNB1, STX3, SCAMP1, SYT9, ZDHHC17, CCDC53, SYT3 (tumor)SNAP25, PRKACA, HGS, EGFR, TRIM9, VAMP8, STX2, STX11, DNM1, ITSN1, STX1A, VAMP2, RIMS1, SYT1, KCNB1, CPLX1, STX3, SYT9, ZDHHC17, PRRT2, SYT3 (normal)
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HNSC (tumor)HNSC (normal)
SNAP25, PRKCA, HGS, TRIM9, VAMP8, STX2, DNM1, ITSN1, STX1A, GOSR1, VAMP2, UNC13B, RIMS1, CENPF, SYT1, KCNB1, CPLX1, VAMP7, STX12, ZDHHC17, PRRT2 (tumor)SNAP25, PRKCA, HGS, TRIM9, VAMP8, STX2, DNM1, ITSN1, STX1A, VAMP2, RIMS1, SYT1, KCNB1, CPLX1, NAPA, VAMP7, SYT9, ZDHHC17, STXBP6, PRRT2, SYT3 (normal)
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KICH (tumor)KICH (normal)
SNAP25, PRKCA, TRIM9, STX2, STX11, DNM1, ITSN1, GOSR1, VAMP2, UNC13B, RIMS1, CENPF, STX4, SYT1, KCNB1, STX3, NAPA, VAMP7, STXBP6, PRRT2, SYT3 (tumor)SNAP25, KIF5B, EGFR, STX5, TRIM9, VAMP8, DNM1, STX1A, SNAPIN, VAMP2, RIMS1, CENPF, KCNB1, STX3, STX12, SCAMP1, SYT9, ZDHHC17, STXBP6, PRRT2, SYT3 (normal)
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KIRC (tumor)KIRC (normal)
SNAP25, PRKCA, HGS, TRIM9, STX11, DNM1, ITSN1, SNAPIN, GOSR1, VAMP2, UNC13B, CENPF, STX4, SYT1, KCNB1, STX3, NAPA, VAMP7, SYT9, PRRT2, CCDC53 (tumor)SNAP25, PRKCA, KIF5B, PRKACA, SRCIN1, EGFR, TRIM9, STX2, STX11, DNM1, STX1A, VAMP2, RIMS1, STX4, SYT1, KCNB1, CPLX1, NAPA, VAMP7, ZDHHC17, PRRT2 (normal)
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KIRP (tumor)KIRP (normal)
SNAP25, PRKCA, TRIM9, VAMP8, STX11, DNM1, ITSN1, SNAPIN, GOSR1, VAMP2, UNC13B, CENPF, SYT1, KCNB1, CPLX1, STX3, VAMP7, SYT9, ZDHHC17, STXBP6, SYT3 (tumor)SNAP25, PRKCA, HGS, SRCIN1, TRIM9, STX2, DNM1, STX1A, UNC13B, CENPF, STX4, SYT1, CPLX1, STX3, VAMP7, STX12, ZDHHC17, STXBP6, PRRT2, CCDC53, SYT3 (normal)
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LIHC (tumor)LIHC (normal)
SNAP25, KIF5B, SRCIN1, STX5, TRIM9, VAMP8, STX2, STX11, STX1A, SNAPIN, CENPF, STX4, SYT1, CPLX1, STX3, STX12, SCAMP1, SYT9, ZDHHC17, PRRT2, SYT3 (tumor)SNAP25, KIF5B, EGFR, STX5, STX2, DNM1, STX1A, GOSR1, UNC13B, CENPF, STX4, KCNB1, CPLX1, STX3, NAPA, VAMP7, STX12, SYT9, ZDHHC17, PRRT2, CCDC53 (normal)
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LUAD (tumor)LUAD (normal)
SNAP25, PRKCA, KIF5B, HGS, EGFR, STX5, STX2, STX11, DNM1, ITSN1, STX1A, VAMP2, UNC13B, RIMS1, CENPF, KCNB1, CPLX1, STX12, SCAMP1, STXBP6, PRRT2 (tumor)SNAP25, PRKCA, KIF5B, HGS, EGFR, TRIM9, VAMP8, STX2, DNM1, ITSN1, STX1A, VAMP2, CENPF, STX4, SYT1, KCNB1, CPLX1, VAMP7, STX12, ZDHHC17, STXBP6 (normal)
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LUSC (tumor)LUSC (normal)
SNAP25, PRKCA, KIF5B, PRKACA, EGFR, STX2, STX11, DNM1, ITSN1, STX1A, GOSR1, VAMP2, UNC13B, CENPF, STX4, CPLX1, STX3, STX12, SCAMP1, STXBP6, PRRT2 (tumor)SNAP25, PRKCA, HGS, STX5, VAMP8, STX2, STX11, ITSN1, STX1A, SNAPIN, VAMP2, RIMS1, KCNB1, CPLX1, NAPA, STX12, SCAMP1, ZDHHC17, STXBP6, PRRT2, SYT3 (normal)
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PRAD (tumor)PRAD (normal)
SNAP25, PRKCA, KIF5B, PRKACA, SRCIN1, TRIM9, STX2, DNM1, ITSN1, GOSR1, UNC13B, RIMS1, CENPF, KCNB1, CPLX1, STX3, STX12, SYT9, ZDHHC17, STXBP6, SYT3 (tumor)SNAP25, PRKCA, PRKACA, SRCIN1, TRIM9, STX2, STX11, DNM1, ITSN1, GOSR1, UNC13B, CENPF, STX4, SYT1, KCNB1, CPLX1, STX3, STX12, SYT9, STXBP6, PRRT2 (normal)
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STAD (tumor)STAD (normal)
SNAP25, PRKCA, PRKACA, HGS, TRIM9, VAMP8, STX2, DNM1, ITSN1, STX1A, VAMP2, UNC13B, RIMS1, CENPF, SYT1, KCNB1, NAPA, SYT9, ZDHHC17, STXBP6, PRRT2 (tumor)SNAP25, PRKCA, PRKACA, HGS, TRIM9, VAMP8, STX2, STX11, DNM1, ITSN1, SNAPIN, VAMP2, RIMS1, CENPF, SYT1, KCNB1, STX3, SYT9, ZDHHC17, PRRT2, SYT3 (normal)
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THCA (tumor)THCA (normal)
SNAP25, PRKCA, PRKACA, HGS, SRCIN1, EGFR, STX5, TRIM9, STX2, SNAPIN, RIMS1, CENPF, STX3, NAPA, VAMP7, STX12, SCAMP1, ZDHHC17, STXBP6, PRRT2, CCDC53 (tumor)SNAP25, PRKCA, HGS, SRCIN1, EGFR, VAMP8, DNM1, GOSR1, UNC13B, RIMS1, CENPF, SYT1, KCNB1, CPLX1, STX3, NAPA, SYT9, STXBP6, PRRT2, CCDC53, SYT3 (normal)
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TissGeneProg for SNAP25

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SNAP25
TissGeneDrug for SNAP25

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00083Botulinum Toxin Type AInhibitorBiotechApproved|Investigational


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TissGeneDisease for SNAP25

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C1263846Attention deficit hyperactivity disorder40BeFree,GAD
umls:C0036341Schizophrenia15BeFree,GAD,LHGDN,MGD
umls:C0009363Congenital ocular coloboma (disorder)7BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma6BeFree
umls:C0023449Acute lymphocytic leukemia5BeFree
umls:C0004936Mental disorders4BeFree
umls:C0024299Lymphoma4BeFree
umls:C0699885Carcinoma of bladder4BeFree
umls:C1960397Philadelphia chromosome-positive acute lymphoblastic leukemia4BeFree
umls:C0005586Bipolar Disorder3BeFree,CTD_human,GAD
umls:C0005684Malignant neoplasm of urinary bladder3BeFree
umls:C0033975Psychotic Disorders3BeFree,CTD_human
umls:C0001430Adenoma2BeFree,LHGDN
umls:C0002395Alzheimer's Disease2BeFree
umls:C0004352Autistic Disorder2BeFree
umls:C0023418leukemia2BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia2BeFree
umls:C0040336Tobacco Use Disorder2GAD
umls:C0041696Unipolar Depression2BeFree
umls:C0043094Weight Gain2GAD
umls:C0079772T-Cell Lymphoma2BeFree
umls:C0338656Impaired cognition2BeFree
umls:C0424101Inattention2BeFree
umls:C0524620Metabolic Syndrome X2BeFree,GAD
umls:C1269683Major Depressive Disorder2BeFree
umls:C1510586Autism Spectrum Disorders2BeFree
umls:C2911647Weight Gain Adverse Event2GAD
umls:C0001339Acute pancreatitis1BeFree
umls:C0001969Alcoholic Intoxication1BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0003944As If Personality1GAD
umls:C0004134Ataxia1BeFree
umls:C0004135Ataxia Telangiectasia1BeFree
umls:C0004138Ataxias, Hereditary1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0007222Cardiovascular Diseases1GAD
umls:C0008626Congenital chromosomal disease1BeFree
umls:C0011581Depressive disorder1CTD_human
umls:C0011853Diabetes Mellitus, Experimental1CTD_human
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
umls:C0013080Down Syndrome1BeFree,LHGDN
umls:C0014544Epilepsy1GAD
umls:C0016053Fibromyalgia1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0018817Atrial Septal Defects1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0020175Hunger1BeFree
umls:C0023492Leukemia, T-Cell1BeFree
umls:C0025362Mental Retardation1BeFree,GAD
umls:C0027404Narcolepsy1GAD
umls:C0027765nervous system disorder1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0028968Olivopontocerebellar Atrophies1BeFree
umls:C0029121Oppositional Defiant Disorder1BeFree
umls:C0029456Osteoporosis1GAD
umls:C0030521Parathyroid Neoplasms1LHGDN
umls:C0031511Pheochromocytoma1BeFree
umls:C0033375Prolactinoma1LHGDN
umls:C0036337Schizoaffective Disorder1GAD
umls:C0085280Alagille Syndrome1BeFree
umls:C0162830Dermatitis, Phototoxic1BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma1BeFree
umls:C0206743Rhabdoid Tumor1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0236642Pick Disease of the Brain1BeFree
umls:C0278076Behavioral tic1CTD_human
umls:C0338451Frontotemporal dementia1BeFree
umls:C0342257Complications of Diabetes Mellitus1GAD
umls:C0394996Acute alcoholic intoxication1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0751072Frontotemporal Lobar Degeneration1BeFree
umls:C0752252Neuromuscular Manifestations1CTD_human
umls:C1520166Xenograft Model1BeFree
umls:C1527358Phototoxicity1BeFree
umls:C1842981NEUROTICISM1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C3714756Intellectual Disability1BeFree