TissGeneSummary for SNAP25 |
Gene summary |
Basic gene information | Gene symbol | SNAP25 |
Gene name | synaptosomal-associated protein, 25kDa | |
Synonyms | RIC-4|RIC4|SEC9|SNAP|SNAP-25|bA416N4.2|dJ1068F16.2 | |
Cytomap | UCSC genome browser: 20p12-p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_003081.3, NM_130811.2, | |
Description | SUPresistance to inhibitors of cholinesterase 4 homologsuper proteinsynaptosomal-associated protein 25synaptosomal-associated protein, 25kD | |
Modification date | 20141214 | |
dbXrefs | MIM : 600322 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132639 | ||
HPRD : 02637 | ||
Vega : OTTHUMG00000031863 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SNAP25 | |
BioGPS: 6616 | ||
Pathway | NCI Pathway Interaction Database: SNAP25 | |
KEGG: SNAP25 | ||
REACTOME: SNAP25 | ||
Pathway Commons: SNAP25 | ||
Context | iHOP: SNAP25 | |
ligand binding site mutation search in PubMed: SNAP25 | ||
UCL Cancer Institute: SNAP25 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of SNAP25 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SNAP25 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.456562177 | 0.564184399 | 1.892377778 | 1.24E-12 | 5.26E-12 |
KIRP | 2.700331274 | 0.328328149 | 2.372003125 | 7.77E-07 | 4.02E-06 |
COAD | -1.450698293 | 1.664324784 | -3.115023077 | 2.37E-10 | 3.07E-09 |
PRAD | 0.747563245 | 2.754836322 | -2.007273077 | 1.49E-09 | 2.23E-08 |
THCA | 1.362933975 | -0.029681279 | 1.392615254 | 3.33E-06 | 1.17E-05 |
STAD | -0.337574976 | 1.759200024 | -2.096775 | 0.00317 | 0.01332585 |
KICH | -1.168532601 | 0.526055399 | -1.694588 | 0.000358 | 0.000842983 |
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TissGene-miRNA for SNAP25 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-181a-5p | MIMAT0000256 | 0.045 | -0.26 | 60 |
ACC | hsa-miR-613 | MIMAT0003281 | 0.019 | -0.27 | 78 |
ACC | hsa-miR-449b-5p | MIMAT0003327 | 0.036 | -0.27 | 78 |
ACC | hsa-miR-613 | MIMAT0003281 | 0.019 | -0.27 | 78 |
ACC | hsa-miR-449b-5p | MIMAT0003327 | 0.036 | -0.27 | 78 |
ACC | hsa-miR-425-5p | MIMAT0003393 | 0.0067 | -0.31 | 78 |
ACC | hsa-miR-425-5p | MIMAT0003393 | 0.0067 | -0.31 | 78 |
ACC | hsa-miR-543 | MIMAT0004954 | 0.0051 | -0.32 | 78 |
ACC | hsa-miR-543 | MIMAT0004954 | 0.0051 | -0.32 | 78 |
ACC | hsa-miR-1298-5p | MIMAT0005800 | 0.0025 | -0.34 | 78 |
ACC | hsa-miR-1298-5p | MIMAT0005800 | 0.0025 | -0.34 | 78 |
ACC | hsa-miR-181d-5p | MIMAT0002821 | 0.0011 | -0.37 | 78 |
ACC | hsa-miR-181d-5p | MIMAT0002821 | 0.0011 | -0.37 | 78 |
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TissGeneMut for SNAP25 |
TissGeneSNV for SNAP25 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G82E | SKCM | 2 |
p.E61K | SKCM | 2 |
p.G158E | SKCM | 2 |
p.R161S | LUAD | 1 |
p.K201N | LUSC | 1 |
p.D58N | SKCM | 1 |
p.L78F | BLCA | 1 |
p.H66D | PRAD | 1 |
p.K40T | UCEC | 1 |
p.R161C | UCEC | 1 |
p.G82R | SKCM | 1 |
p.S187F | SKCM | 1 |
p.S25L | UCEC | 1 |
p.E125G | LIHC | 1 |
p.F84L | UCEC | 1 |
p.E183D | HNSC | 1 |
p.E183K | SKCM | 1 |
p.E194D | LUAD | 1 |
p.A104S | READ | 1 |
p.I67M | LIHC | 1 |
p.E123K | SKCM | 1 |
p.P91A | LIHC | 1 |
p.E75D | STAD | 1 |
p.S187T | LUAD | 1 |
p.R59C | UCEC | 1 |
p.L160F | SKCM | 1 |
p.D58N | UCEC | 1 |
p.T79M | BLCA | 1 |
p.G204E | SKCM | 1 |
p.G206D | SKCM | 1 |
p.R8H | UCEC | 1 |
p.R119S | ESCA | 1 |
p.R176C | STAD | 1 |
p.R59C | PAAD | 1 |
p.F133L | LIHC | 1 |
p.R176C | UCEC | 1 |
p.R59C | COAD | 1 |
p.R8H | BRCA | 1 |
p.E151Q | BLCA | 1 |
p.E143K | SKCM | 1 |
p.R8H | HNSC | 1 |
p.D179Y | LUAD | 1 |
p.R198H | HNSC | 1 |
p.I44T | UCEC | 1 |
p.G111A | BRCA | 1 |
p.E73A | SKCM | 1 |
p.R119H | PRAD | 1 |
p.M71K | LUAD | 1 |
p.R191T | BLCA | 1 |
p.R124Q | STAD | 1 |
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TissGeneCNV for SNAP25 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SNAP25 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA524284 | RASA4-SNAP25 | chr7:102257204 | chr20:10287139 | |
Chimerdb3.0 | ChiTaRs | NA | AW899942 | ROR1-SNAP25 | chr1:64286029 | chr20:10287562 | |
Chimerdb3.0 | ChiTaRs | NA | AV726363 | LAMA3-SNAP25 | chr18:21489176 | chr20:10286843 | |
Chimerdb3.0 | ChiTaRs | NA | AW898620 | SNAP25-SNAP25 | chr20:10287360 | chr20:10287483 | |
Chimerdb3.0 | ChiTaRs | NA | BQ340310 | SNAP25-IGSF9B | chr20:10287819 | chr11:133802427 | |
Chimerdb3.0 | ChiTaRs | NA | BI033650 | SNAP25-CREBBP | chr20:10287974 | chr16:3784039 | |
Chimerdb3.0 | ChiTaRs | NA | AW900408 | SNAP25-EHMT1 | chr20:10288007 | chr9:140514186 | |
Chimerdb3.0 | ChiTaRs | NA | BG715348 | SNRPN-SNAP25 | chr15:25220210 | chr20:10286958 | |
Chimerdb3.0 | ChiTaRs | NA | CD250904 | SNAP25-SNAP25 | chr20:10287786 | chr20:10279945 |
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TissGeneNet for SNAP25 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SNAP25 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SNAP25 |
TissGeneDrug for SNAP25 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00083 | Botulinum Toxin Type A | Inhibitor | Biotech | Approved|Investigational |
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TissGeneDisease for SNAP25 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1263846 | Attention deficit hyperactivity disorder | 40 | BeFree,GAD |
umls:C0036341 | Schizophrenia | 15 | BeFree,GAD,LHGDN,MGD |
umls:C0009363 | Congenital ocular coloboma (disorder) | 7 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 6 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 5 | BeFree |
umls:C0004936 | Mental disorders | 4 | BeFree |
umls:C0024299 | Lymphoma | 4 | BeFree |
umls:C0699885 | Carcinoma of bladder | 4 | BeFree |
umls:C1960397 | Philadelphia chromosome-positive acute lymphoblastic leukemia | 4 | BeFree |
umls:C0005586 | Bipolar Disorder | 3 | BeFree,CTD_human,GAD |
umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | BeFree |
umls:C0033975 | Psychotic Disorders | 3 | BeFree,CTD_human |
umls:C0001430 | Adenoma | 2 | BeFree,LHGDN |
umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
umls:C0004352 | Autistic Disorder | 2 | BeFree |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 2 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 2 | GAD |
umls:C0041696 | Unipolar Depression | 2 | BeFree |
umls:C0043094 | Weight Gain | 2 | GAD |
umls:C0079772 | T-Cell Lymphoma | 2 | BeFree |
umls:C0338656 | Impaired cognition | 2 | BeFree |
umls:C0424101 | Inattention | 2 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 2 | BeFree,GAD |
umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
umls:C1510586 | Autism Spectrum Disorders | 2 | BeFree |
umls:C2911647 | Weight Gain Adverse Event | 2 | GAD |
umls:C0001339 | Acute pancreatitis | 1 | BeFree |
umls:C0001969 | Alcoholic Intoxication | 1 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0003944 | As If Personality | 1 | GAD |
umls:C0004134 | Ataxia | 1 | BeFree |
umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
umls:C0004138 | Ataxias, Hereditary | 1 | BeFree |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | CTD_human |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
umls:C0013080 | Down Syndrome | 1 | BeFree,LHGDN |
umls:C0014544 | Epilepsy | 1 | GAD |
umls:C0016053 | Fibromyalgia | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020175 | Hunger | 1 | BeFree |
umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
umls:C0025362 | Mental Retardation | 1 | BeFree,GAD |
umls:C0027404 | Narcolepsy | 1 | GAD |
umls:C0027765 | nervous system disorder | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028968 | Olivopontocerebellar Atrophies | 1 | BeFree |
umls:C0029121 | Oppositional Defiant Disorder | 1 | BeFree |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0030521 | Parathyroid Neoplasms | 1 | LHGDN |
umls:C0031511 | Pheochromocytoma | 1 | BeFree |
umls:C0033375 | Prolactinoma | 1 | LHGDN |
umls:C0036337 | Schizoaffective Disorder | 1 | GAD |
umls:C0085280 | Alagille Syndrome | 1 | BeFree |
umls:C0162830 | Dermatitis, Phototoxic | 1 | BeFree |
umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | BeFree |
umls:C0206743 | Rhabdoid Tumor | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0236642 | Pick Disease of the Brain | 1 | BeFree |
umls:C0278076 | Behavioral tic | 1 | CTD_human |
umls:C0338451 | Frontotemporal dementia | 1 | BeFree |
umls:C0342257 | Complications of Diabetes Mellitus | 1 | GAD |
umls:C0394996 | Acute alcoholic intoxication | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0751072 | Frontotemporal Lobar Degeneration | 1 | BeFree |
umls:C0752252 | Neuromuscular Manifestations | 1 | CTD_human |
umls:C1520166 | Xenograft Model | 1 | BeFree |
umls:C1527358 | Phototoxicity | 1 | BeFree |
umls:C1842981 | NEUROTICISM | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | BeFree |