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| TissGeneSummary for FOXL2 |
 Gene summary |
| Basic gene information | Gene symbol | FOXL2 |
| Gene name | forkhead box L2 | |
| Synonyms | BPES|BPES1|PFRK|PINTO|POF3 | |
| Cytomap | UCSC genome browser: 3q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_023067.3, | |
| Description | forkhead box protein L2forkhead transcription factor FOXL2 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 605597 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183770 | ||
| HPRD : 05723 | ||
| Vega : OTTHUMG00000159889 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOXL2 | |
| BioGPS: 668 | ||
| Pathway | NCI Pathway Interaction Database: FOXL2 | |
| KEGG: FOXL2 | ||
| REACTOME: FOXL2 | ||
| Pathway Commons: FOXL2 | ||
| Context | iHOP: FOXL2 | |
| ligand binding site mutation search in PubMed: FOXL2 | ||
| UCL Cancer Institute: FOXL2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVUCEC,UCS | |
| Reference showing the relevant tissue of FOXL2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 19744555 | GO:0045892 | negative regulation of transcription, DNA-templated | 19744555 |
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| TissGeneExp for FOXL2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.463784911 | -3.009020971 | 3.472805882 | 1.14E-10 | 4.26E-10 |
| HNSC | 1.84121633 | -1.535576694 | 3.376793023 | 2.95E-15 | 2.55E-13 |
| BLCA | 1.152958802 | -1.851772777 | 3.004731579 | 0.000103 | 0.001117424 |
| PRAD | 0.694067 | -0.763554153 | 1.457621154 | 4.21E-05 | 0.00019493 |
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| TissGene-miRNA for FOXL2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOXL2 |
| TissGeneSNV for FOXL2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E118K | BLCA | 2 |
| p.E69D | BLCA | 2 |
| p.R349L | LUAD | 1 |
| p.P212A | LIHC | 1 |
| p.P116Q | STAD | 1 |
| p.A336E | CESC | 1 |
| p.R145C | COAD | 1 |
| p.T76M | COAD | 1 |
| p.S339T | LUAD | 1 |
| p.G38S | STAD | 1 |
| p.E118Q | LUAD | 1 |
| p.N109S | STAD | 1 |
| p.R68C | COAD | 1 |
| p.A66T | SKCM | 1 |
| p.G43V | LUAD | 1 |
| p.A308G | KIRP | 1 |
| p.A71V | COAD | 1 |
| p.E352K | STAD | 1 |
| p.G43R | STAD | 1 |
| p.E139K | STAD | 1 |
| p.Y143* | LUAD | 1 |
| p.R103S | LUAD | 1 |
| p.R147H | SKCM | 1 |
| p.E69K | CESC | 1 |
| p.E118K | CESC | 1 |
| p.A340V | STAD | 1 |
| p.A369T | COAD | 1 |
| p.P157A | STAD | 1 |
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| TissGeneCNV for FOXL2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOXL2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for FOXL2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| COAD (tumor) | COAD (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| KICH (tumor) | KICH (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| STAD (tumor) | STAD (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (tumor) | FOXL2, PAK1, SMAD3, ELAVL1, SUMO1, UBE2I (normal) |
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| TissGeneProg for FOXL2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOXL2 |
| TissGeneDrug for FOXL2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOXL2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005744 | Blepharophimosis | 62 | BeFree,GAD,LHGDN |
| umls:C0085215 | Ovarian Failure, Premature | 35 | BeFree,GAD,LHGDN |
| umls:C0018206 | granulosa cell tumor | 31 | BeFree,GAD |
| umls:C0220663 | BLEPHAROPHIMOSIS, PTOSIS, AND EPICANTHUS INVERSUS (disorder) | 27 | BeFree,CLINVAR,CTD_human,GAD,MGD,UNIPROT |
| umls:C0025322 | Premature Menopause | 20 | BeFree |
| umls:C0005745 | Blepharoptosis | 14 | BeFree,GAD |
| umls:C0678230 | Congenital Epicanthus | 14 | BeFree |
| umls:C0033377 | Ptosis | 13 | BeFree |
| umls:C0000768 | Congenital Abnormality | 9 | BeFree |
| umls:C1862261 | BPES, TYPE II | 9 | BeFree |
| umls:C0154208 | Disorder of endocrine ovary | 7 | BeFree |
| umls:C1862260 | BPES, TYPE I | 7 | BeFree |
| umls:C2239120 | eyelids (symptom) | 7 | BeFree |
| umls:C0206724 | Sex Cord-Stromal Tumor | 5 | BeFree |
| umls:C1370419 | Granulosa cell tumor of the ovary | 5 | BeFree |
| umls:C0032002 | Pituitary Diseases | 4 | BeFree |
| umls:C0039747 | Thecoma | 4 | BeFree,GAD |
| umls:C0206661 | Gonadoblastoma | 4 | BeFree |
| umls:C0423113 | Telecanthus | 4 | BeFree |
| umls:C0751606 | Adult Acute Lymphocytic Leukemia | 4 | BeFree |
| umls:C1879643 | Adult Type Granulosa Cell Tumor | 4 | BeFree |
| umls:C0206723 | Sertoli-Leydig Cell Tumor | 3 | BeFree |
| umls:C0747102 | Ovarian failure | 3 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,GAD |
| umls:C2931135 | Blepharophimosis syndrome type 1 | 3 | CLINVAR,CTD_human |
| umls:C0008073 | Developmental Disabilities | 2 | BeFree |
| umls:C0008626 | Congenital chromosomal disease | 2 | BeFree |
| umls:C0016045 | fibroma | 2 | BeFree |
| umls:C0025362 | Mental Retardation | 2 | BeFree |
| umls:C0025958 | Microcephaly | 2 | BeFree |
| umls:C0041408 | Turner Syndrome | 2 | BeFree |
| umls:C0879615 | Stromal Neoplasm | 2 | BeFree |
| umls:C1368683 | Epithelioma | 2 | BeFree |
| umls:C1837008 | PREMATURE OVARIAN FAILURE 3 (disorder) | 2 | CLINVAR,CTD_human,UNIPROT |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| umls:C0010093 | Corpus Luteum Cyst | 1 | BeFree |
| umls:C0013261 | Duane Retraction Syndrome | 1 | BeFree,LHGDN |
| umls:C0015423 | Eyelid Diseases | 1 | BeFree |
| umls:C0018051 | Gonadal Dysgenesis | 1 | BeFree |
| umls:C0019086 | Hemorrhagic ascites | 1 | BeFree |
| umls:C0022548 | Keloid | 1 | CTD_human,GAD |
| umls:C0029182 | orbit (eye disorders) | 1 | BeFree |
| umls:C0029927 | Ovarian Cysts | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0036974 | Shock | 1 | LHGDN |
| umls:C0042138 | Uterine Neoplasms | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0221060 | Mobius Syndrome | 1 | BeFree |
| umls:C0266316 | Congenital hydronephrosis | 1 | BeFree |
| umls:C0266572 | Congenital anomaly of eyelid | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0334342 | Skin appendage adenoma | 1 | BeFree |
| umls:C0342549 | Familial Testotoxicosis | 1 | BeFree |
| umls:C0346178 | Ovarian gynandroblastoma | 1 | BeFree |
| umls:C0346304 | Gonadotroph adenoma | 1 | BeFree |
| umls:C0432475 | XX males | 1 | BeFree |
| umls:C0600113 | Stromal tumor of ovary | 1 | BeFree |
| umls:C0740404 | Limb defects | 1 | BeFree |
| umls:C0948896 | Primary hypogonadism | 1 | BeFree |
| umls:C0994516 | Type 1 Duane Retraction Syndrome | 1 | BeFree |
| umls:C1266118 | Cellular fibroma | 1 | BeFree |
| umls:C1318541 | Sertoli-Leydig cell tumor of intermediate differentiation | 1 | BeFree |
| umls:C1401084 | Ovarian Insufficiency | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1834582 | MYELOPROLIFERATIVE SYNDROME, TRANSIENT | 1 | BeFree |
| umls:C1862264 | Bpes With Duane Retraction Syndrome | 1 | CTD_human |
| umls:C1882229 | Ovarian Thecoma | 1 | BeFree |
| umls:C3825567 | Tumors in children | 1 | BeFree |
| umls:C2931136 | Blepharophimosis syndrome type 2 | 0 | CLINVAR |
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