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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SPINK1
check button Gene summary
Basic gene informationGene symbolSPINK1
Gene nameserine peptidase inhibitor, Kazal type 1
SynonymsPCTT|PSTI|Spink3|TATI|TCP
CytomapUCSC genome browser: 5q32
Type of geneprotein-coding
RefGenesNM_003122.4,
Descriptionpancreatic secretory trypsin inhibitorserine protease inhibitor, Kazal type 1tumor-associated trypsin inhibitor
Modification date20141222
dbXrefs MIM : 167790
HGNC : HGNC
Ensembl : ENSG00000164266
HPRD : 01341
Vega : OTTHUMG00000129730
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SPINK1
BioGPS: 6690
PathwayNCI Pathway Interaction Database: SPINK1
KEGG: SPINK1
REACTOME: SPINK1
Pathway Commons: SPINK1
ContextiHOP: SPINK1
ligand binding site mutation search in PubMed: SPINK1
UCL Cancer Institute: SPINK1
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)PancreasStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAADSTAD
Reference showing the relevant tissue of SPINK1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SPINK1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD3.691348282-0.5265862014.2179344831.50E-108.74E-10
KIRP-1.6673602312.578852269-4.24621256.64E-095.22E-08
KIRC-0.0654605793.266496366-3.3319569441.10E-124.71E-12
HNSC-2.331464229-3.486910741.1554465128.02E-064.69E-05
LIHC5.1959361443.1372081442.0587280.01720.034138695
PRAD-0.041170087-1.5478797031.5067096150.003270.009002543


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TissGene-miRNA for SPINK1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SPINK1
TissGeneSNV for SPINK1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A13TUCEC1
p.F62LSTAD1
p.D50NSKCM1
p.P45SKIRP1
p.G38VSKCM1
p.D50NHNSC1
p.R65WSARC1
p.G38RSKCM1


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TissGeneCNV for SPINK1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SPINK1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAD82311SPINK1-SPINK1chr5:147210841chr5:147210564
Chimerdb3.0ChiTaRsNAAI571643SPINK1-NCOA3chr5:147207693chr20:46232662


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TissGeneNet for SPINK1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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COAD (tumor)COAD (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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HNSC (tumor)HNSC (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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KICH (tumor)KICH (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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KIRC (tumor)KIRC (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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KIRP (tumor)KIRP (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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LIHC (tumor)LIHC (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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LUAD (tumor)LUAD (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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LUSC (tumor)LUSC (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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PRAD (tumor)PRAD (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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STAD (tumor)STAD (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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THCA (tumor)THCA (normal)
SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (tumor)SPINK1, ONECUT1, CEBPB, ELN, TMPRSS15, CTRC, NRSN1 (normal)
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TissGeneProg for SPINK1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SPINK1
TissGeneDrug for SPINK1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SPINK1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0149521Pancreatitis, Chronic103BeFree,CTD_human,GAD,LHGDN
umls:C0030305Pancreatitis76BeFree,CTD_human,GAD,LHGDN
umls:C0238339Hereditary pancreatitis21BeFree,CLINVAR,UNIPROT
umls:C0001339Acute pancreatitis18BeFree,GAD
umls:C0341471Idiopathic chronic pancreatitis18BeFree,GAD
umls:C0376358Malignant neoplasm of prostate13BeFree
umls:C0600139Prostate carcinoma12BeFree
umls:C0010674Cystic Fibrosis11BeFree,GAD,LHGDN
umls:C0376670Pancreatitis, Alcoholic11BeFree,GAD,LHGDN
umls:C1842402TROPICAL CALCIFIC PANCREATITIS11BeFree,CLINVAR,CTD_human,GAD,ORPHANET,UNIPROT
umls:C0235974Pancreatic carcinoma10BeFree
umls:C0346647Malignant neoplasm of pancreas10BeFree,GAD
umls:C0747198pancreatitis idiopathic10BeFree
umls:C2239176Liver carcinoma6BeFree
umls:C0008354Cholera5BeFree
umls:C0011849Diabetes Mellitus5BeFree,LHGDN
umls:C0030286Pancreatic Diseases5BeFree,GAD
umls:C0267937Acute recurrent pancreatitis5BeFree
umls:C0011847Diabetes4BeFree
umls:C0271642Fibrocalculous pancreatic diabetes4BeFree
umls:C0001418Adenocarcinoma3BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0029925Ovarian Carcinoma3BeFree
umls:C0030297Pancreatic Neoplasm3CTD_human,GAD,LHGDN
umls:C0162565Acute intermittent porphyria3BeFree
umls:C0266270Pancreas divisum3BeFree,GAD
umls:C0281361Adenocarcinoma of pancreas3BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree
umls:C0006663Calcinosis2GAD
umls:C0007102Malignant tumor of colon2BeFree
umls:C0007570Celiac Disease2GAD
umls:C0009404Colorectal Neoplasms2BeFree,LHGDN
umls:C0015695Fatty Liver2BeFree,GAD
umls:C0023903Liver neoplasms2BeFree
umls:C0033578Prostatic Neoplasms2BeFree,LHGDN
umls:C0175683Citrullinemia2BeFree
umls:C0221002Hyperparathyroidism, Primary2BeFree,GAD
umls:C0267963Exocrine pancreatic insufficiency2BeFree,GAD
umls:C0400966Non-alcoholic Fatty Liver Disease2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0699885Carcinoma of bladder2BeFree
umls:C0810032Pancreatic disorders (not diabetes)2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C2609129Autoimmune pancreatitis2BeFree
umls:C0001430Adenoma1BeFree
umls:C0005699Blast Phase1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0009375Colonic Neoplasms1LHGDN
umls:C0009376Colonic Polyps1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0011881Diabetic Nephropathy1LHGDN
umls:C0017185Gastrointestinal Neoplasms1LHGDN
umls:C0019163Hepatitis B1BeFree
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0020437Hypercalcemia1BeFree
umls:C0020473Hyperlipidemia1GAD
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0021368Inflammation1RGD
umls:C0021655Insulin Resistance1GAD
umls:C0022661Kidney Failure, Chronic1GAD
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0028259Nodule1BeFree
umls:C0030293Pancreatic Insufficiency1BeFree
umls:C0030583Parotitis1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0035078Kidney Failure1BeFree
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0041234Chagas Disease1BeFree
umls:C0085694Chronic cholecystitis1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0162309Adrenoleukodystrophy1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0205645Adenocarcinoma, Tubular1BeFree
umls:C0272138Erythroblastosis1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0339985Idiopathic bronchiectasis1BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma1BeFree
umls:C0524620Metabolic Syndrome X1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C0878500Intraepithelial Neoplasia1BeFree
umls:C1168327High-Grade Prostatic Intraepithelial Neoplasia1BeFree
umls:C1290807Diarrheal disorder1BeFree
umls:C1290884Inflammatory disorder1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1527349Ductal Breast Carcinoma1BeFree
umls:C1565489Renal Insufficiency1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1863844Adult-onset citrullinemia type 21BeFree
umls:C1997910Citrin deficiency1BeFree
umls:C2931038Pancreatic carcinoma, familial1BeFree
umls:C1969419PANCREATITIS, CHRONIC, SUSCEPTIBILITY TO0CLINVAR