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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SPP1
check button Gene summary
Basic gene informationGene symbolSPP1
Gene namesecreted phosphoprotein 1
SynonymsBNSP|BSPI|ETA-1|OPN
CytomapUCSC genome browser: 4q22.1
Type of geneprotein-coding
RefGenesNM_000582.2,
NM_001040058.1,NM_001040060.1,NM_001251829.1,NM_001251830.1,
DescriptionSPP1/CALPHA1 fusionearly T-lymphocyte activation 1nephropontinosteopontinosteopontin/immunoglobulin alpha 1 heavy chain constant region fusion proteinsecreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)urinar
Modification date20141222
dbXrefs MIM : 166490
HGNC : HGNC
Ensembl : ENSG00000118785
HPRD : 01325
Vega : OTTHUMG00000130599
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SPP1
BioGPS: 6696
PathwayNCI Pathway Interaction Database: SPP1
KEGG: SPP1
REACTOME: SPP1
Pathway Commons: SPP1
ContextiHOP: SPP1
ligand binding site mutation search in PubMed: SPP1
UCL Cancer Institute: SPP1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of SPP1
Description by TissGene annotationsProtective TissGene in RFS
Cancer gene
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0033280response to vitamin D16720713
GO:0033280response to vitamin D16720713


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TissGeneExp for SPP1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
STAD-0.951432564-3.8745638142.923131254.72E-079.00E-06
COAD-0.322723429-3.4192349683.0965115381.63E-068.77E-06
LUAD1.5642836-3.2679026074.8321862072.96E-228.10E-21
HNSC0.047768163-3.5389899773.586758143.53E-106.35E-09
LUSC2.088072951-2.3412074414.4292803928.28E-221.25E-20
BRCA0.709858555-1.5502098672.2600684211.45E-201.09E-19
LIHC0.524595186-1.5905448142.115140.0009420.002602216
THCA-1.877086272-3.189220171.3121338980.0006150.001492993
KIRP5.6273143114.1910268111.43628750.0001050.000357223
BLCA0.215366449-3.8638335514.07922.04E-050.0003296


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TissGene-miRNA for SPP1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-181a-5pMIMAT00002560.013-0.2978
ACChsa-miR-181a-5pMIMAT00002560.013-0.2978


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TissGeneMut for SPP1
TissGeneSNV for SPP1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P37SLGG2
p.D107ABRCA1
p.I315VKIRC1
p.E277DSTAD1
p.G200SLUSC1
p.S81RSTAD1
p.Q229KOV1
p.V163ALUAD1
p.D99YESCA1
p.V149ALUAD1
p.A199VHNSC1
p.E28DSTAD1
p.P123SSKCM1
p.R145*SKCM1
p.P192SSKCM1
p.S304GTHYM1
p.D92YBLCA1
p.L306SCESC1
p.S237NDLBC1
p.R287CSKCM1
p.D86NUCEC1
p.S181ICOAD1
p.R234WBLCA1
p.P164HESCA1
p.A16SLUAD1
p.K282TCOAD1
p.R161CCOAD1
p.T42SLUAD1
p.K63TSTAD1
p.D95ALUAD1
p.E239KSKCM1
p.R145QSKCM1
p.K90TSTAD1
p.K249NUCEC1
p.E268*HNSC1
p.E282*HNSC1
p.D170GKIRC1
p.R145XSKCM1
p.M71ISKCM1
p.W203XSKCM1
p.V40ABRCA1
p.D78YBLCA1
p.W203*SKCM1
p.D94NCESC1
p.S94RSTAD1
p.K173TSTAD1


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TissGeneCNV for SPP1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SPP1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE815041CERS6-SPP1chr2:169630167chr4:88904333
Chimerdb3.0ChiTaRsNABF081314SPP1-SPP1chr4:88903727chr4:88903744
Chimerdb3.0ChiTaRsNABQ314733SPP1-ANXA2chr4:88904055chr15:60657754


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TissGeneNet for SPP1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SPP1, CSNK2A1, CD44, CSNK2A2, SP1, CASP8, ACP5, ITGB1, SGTA, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, CTNNBL1, ITGA9, ITGA5, PEPD, MMP3, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, SP1, PRKCA, ACP5, ITGAV, ITGB1, SGTA, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, ITGA5, PEPD, MMP3 (normal)
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COAD (tumor)COAD (normal)
SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, CASP8, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, IGFBP5, PRKG1, PDLIM7, CTNNBL1, ITGA9, ITGA5, MMP3, HNF1B, ABCF3 (tumor)SPP1, CD44, CSNK2A2, SP1, CASP8, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, IGFBP5, PRKG1, PDLIM7, MMP7, CTNNBL1, ITGA9, ITGA5, MMP3, HNF1B, ABCF3 (normal)
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HNSC (tumor)HNSC (normal)
SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, CASP8, PRKCA, ACP5, ITGAV, ITGB1, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, ITGA9, ITGA5, MMP3 (tumor)SPP1, CD44, CASP3, CSNK2A2, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, IGFBP5, PRKG1, MMP7, ING2, CTNNBL1, ITGA9, ITGA5, PEPD, MMP3, ABCF3 (normal)
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KICH (tumor)KICH (normal)
SPP1, CD44, CSNK2A2, SP1, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, PEPD, MMP3, HNF1B, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, SP1, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, APOA1, IGFBP5, PRKG1, MMP7, CTNNBL1, ITGA9, ITGA5, PEPD, HNF1B (normal)
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KIRC (tumor)KIRC (normal)
SPP1, CD44, CASP3, CSNK2A2, CASP8, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, APOA1, PRKG1, PDLIM7, MMP7, ING2, ITGA9, PEPD, MMP3, HNF1B, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, SP1, CASP8, PRKCA, ITGAV, UBQLN4, F2, PRKG1, PDLIM7, MMP7, ING2, CTNNBL1, ITGA9, ITGA5, PEPD, HNF1B, ABCF3 (normal)
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KIRP (tumor)KIRP (normal)
SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, APOA1, IGFBP5, PRKG1, MMP7, PEPD, MMP3, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, CASP8, PRKCA, ACP5, ITGAV, ITGB1, SGTA, F2, APOA1, PRKG1, PDLIM7, MMP7, ING2, CTNNBL1, ITGA9, HNF1B, ABCF3 (normal)
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LIHC (tumor)LIHC (normal)
SPP1, CSNK2A1, CD44, SP1, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, ITGA5, PEPD, MMP3, HNF1B, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CSNK2A2, CASP8, ACP5, ITGAV, ITGB1, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, CTNNBL1, ITGA5, PEPD, MMP3, HNF1B (normal)
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LUAD (tumor)LUAD (normal)
SPP1, CD44, CASP3, SP1, CASP8, PRKCA, ACP5, ITGAV, SGTA, UBQLN4, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, CTNNBL1, ITGA9, ITGA5, PEPD, HNF1B, ABCF3 (tumor)SPP1, CD44, CASP3, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, UBQLN4, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, ITGA9, ITGA5, PEPD, MMP3, HNF1B (normal)
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LUSC (tumor)LUSC (normal)
SPP1, CSNK2A1, CASP3, CSNK2A2, SP1, PRKCA, ACP5, ITGAV, ITGB1, UBQLN4, F2, APOA1, PDLIM7, MMP7, CTNNBL1, ITGA9, ITGA5, PEPD, MMP3, HNF1B, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, F2, APOA1, IGFBP5, PRKG1, MMP7, ING2, CTNNBL1, ITGA5, PEPD, MMP3 (normal)
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PRAD (tumor)PRAD (normal)
SPP1, CSNK2A1, CD44, CASP3, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, APOA1, IGFBP5, PRKG1, MMP7, ING2, CTNNBL1, ITGA9, MMP3, ABCF3 (tumor)SPP1, CSNK2A1, CD44, CASP3, SP1, CASP8, PRKCA, ITGAV, ITGB1, SGTA, UBQLN4, APOA1, IGFBP5, PRKG1, MMP7, CTNNBL1, ITGA9, PEPD, MMP3, HNF1B, ABCF3 (normal)
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STAD (tumor)STAD (normal)
SPP1, CSNK2A1, CASP3, CSNK2A2, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, F2, APOA1, IGFBP5, PRKG1, PDLIM7, ING2, CTNNBL1, ITGA9, ITGA5, HNF1B, ABCF3 (tumor)SPP1, CD44, CASP3, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, ING2, CTNNBL1, ITGA5, MMP3, HNF1B (normal)
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THCA (tumor)THCA (normal)
SPP1, CSNK2A1, CD44, CASP3, CSNK2A2, SP1, CASP8, PRKCA, ACP5, SGTA, UBQLN4, F2, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, CTNNBL1, ITGA9, ITGA5, ABCF3 (tumor)SPP1, CSNK2A1, CASP3, SP1, CASP8, PRKCA, ACP5, ITGAV, ITGB1, SGTA, UBQLN4, APOA1, IGFBP5, PRKG1, PDLIM7, MMP7, CTNNBL1, ITGA9, MMP3, HNF1B, ABCF3 (normal)
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TissGeneProg for SPP1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SPP1
TissGeneDrug for SPP1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SPP1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027627Neoplasm Metastasis147BeFree,CTD_human,LHGDN
umls:C0678222Breast Carcinoma57BeFree
umls:C0006142Malignant neoplasm of breast56BeFree
umls:C0178874Tumor Progression45BeFree
umls:C2239176Liver carcinoma44BeFree,LHGDN
umls:C0596263Carcinogenesis34BeFree
umls:C0699791Stomach Carcinoma21BeFree
umls:C0024623Malignant neoplasm of stomach20BeFree
umls:C0025202melanoma20BeFree,LHGDN
umls:C1458155Mammary Neoplasms18BeFree,CTD_human,LHGDN
umls:C0376358Malignant neoplasm of prostate17BeFree
umls:C0600139Prostate carcinoma16BeFree
umls:C0017638Glioma15BeFree,CTD_human,GAD,RGD
umls:C0242379Malignant neoplasm of lung15BeFree
umls:C0684249Carcinoma of lung15BeFree
umls:C0024141Lupus Erythematosus, Systemic14BeFree,GAD,LHGDN
umls:C0026769Multiple Sclerosis14BeFree,GAD,LHGDN
umls:C0003873Rheumatoid Arthritis13BeFree,GAD,LHGDN
umls:C0003850Arteriosclerosis12BeFree
umls:C0007131Non-Small Cell Lung Carcinoma12BeFree
umls:C0009402Colorectal Carcinoma12BeFree
umls:C0007137Squamous cell carcinoma11BeFree,GAD,LHGDN
umls:C1527249Colorectal Cancer11BeFree
umls:C0004153Atherosclerosis10BeFree,GAD,LHGDN
umls:C0004364Autoimmune Diseases10BeFree
umls:C0686619Secondary malignant neoplasm of lymph node10BeFree
umls:C0022650Kidney Calculi9BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0007102Malignant tumor of colon8BeFree
umls:C0011849Diabetes Mellitus8BeFree
umls:C0024121Lung Neoplasms8BeFree,CTD_human,LHGDN
umls:C0028754Obesity8BeFree
umls:C0494165Secondary malignant neoplasm of liver8BeFree
umls:C0699790Colon Carcinoma8BeFree
umls:C1140680Malignant neoplasm of ovary8BeFree,GAD
umls:C0001418Adenocarcinoma7BeFree,CTD_human,LHGDN
umls:C0007222Cardiovascular Diseases7BeFree,LHGDN
umls:C0011847Diabetes7BeFree
umls:C0013264Muscular Dystrophy, Duchenne7BeFree,GAD
umls:C0017636Glioblastoma7BeFree
umls:C0025500Mesothelioma7BeFree,CTD_human,LHGDN
umls:C0029408Degenerative polyarthritis7BeFree
umls:C0029925Ovarian Carcinoma7BeFree
umls:C0345904Malignant neoplasm of liver7BeFree
umls:C2931822Nasopharyngeal carcinoma7BeFree
umls:C0023895Liver diseases6BeFree
umls:C0026764Multiple Myeloma6BeFree,LHGDN
umls:C0033578Prostatic Neoplasms6BeFree,LHGDN
umls:C1335302Pancreatic Ductal Adenocarcinoma6BeFree
umls:C0006118Brain Neoplasms5BeFree,CTD_human
umls:C0009324Ulcerative Colitis5BeFree,LHGDN
umls:C0009375Colonic Neoplasms5BeFree,LHGDN
umls:C0014072Experimental Autoimmune Encephalomyelitis5BeFree
umls:C0019158Hepatitis5BeFree,LHGDN
umls:C0020538Hypertensive disease5BeFree,GAD
umls:C0029463Osteosarcoma5BeFree,LHGDN
umls:C0041296Tuberculosis5BeFree,GAD,LHGDN
umls:C0153676Secondary malignant neoplasm of lung5BeFree
umls:C0153690Secondary malignant neoplasm of bone5BeFree
umls:C0238463Papillary thyroid carcinoma5BeFree
umls:C0278883Metastatic melanoma5BeFree
umls:C0451641Urolithiasis5BeFree,GAD
umls:C0521158Recurrent tumor5BeFree
umls:C0524910Hepatitis C, Chronic5BeFree,GAD,LHGDN
umls:C0585442Osteosarcoma of bone5BeFree
umls:C0812413Malignant Pleural Mesothelioma5BeFree
umls:C0919267ovarian neoplasm5BeFree,LHGDN
umls:C0003486Aortic Aneurysm4BeFree
umls:C0007103Malignant neoplasm of endometrium4BeFree
umls:C0007847Malignant tumor of cervix4BeFree
umls:C0010346Crohn Disease4BeFree,LHGDN
umls:C0019159Hepatitis A4BeFree
umls:C0019163Hepatitis B4BeFree
umls:C0019196Hepatitis C4BeFree
umls:C0019693HIV Infections4BeFree,GAD
umls:C0036202Sarcoidosis4BeFree,GAD
umls:C0038356Stomach Neoplasms4BeFree,LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)4BeFree
umls:C0235974Pancreatic carcinoma4BeFree
umls:C0239946Fibrosis, Liver4BeFree
umls:C0280100Solid tumour4BeFree
umls:C0302592Cervix carcinoma4BeFree
umls:C0346647Malignant neoplasm of pancreas4BeFree
umls:C0346957Disseminated Malignant Neoplasm4BeFree
umls:C0392525Nephrolithiasis4BeFree,GAD
umls:C0409974Lupus Erythematosus4BeFree,GAD
umls:C0476089Endometrial Carcinoma4BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis4BeFree
umls:C1883486Uterine Corpus Cancer4BeFree
umls:C0001430Adenoma3BeFree
umls:C0004096Asthma3BeFree
umls:C0005940Bone Diseases3BeFree,LHGDN
umls:C0006663Calcinosis3CTD_human,RGD
umls:C0011854Diabetes Mellitus, Insulin-Dependent3BeFree,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0014175Endometriosis3BeFree
umls:C0021368Inflammation3LHGDN
umls:C0023467Leukemia, Myelocytic, Acute3BeFree
umls:C0023896Alcoholic Liver Diseases3BeFree,CTD_human
umls:C0023903Liver neoplasms3BeFree
umls:C0024131Lupus Vulgaris3BeFree
umls:C0024138Lupus Erythematosus, Discoid3BeFree
umls:C0026850Muscular Dystrophy3BeFree
umls:C0027051Myocardial Infarction3BeFree,LHGDN
umls:C0029456Osteoporosis3BeFree
umls:C0039103Synovitis3BeFree
umls:C0085580Essential Hypertension3BeFree
umls:C0149721Left Ventricular Hypertrophy3BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma3BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma3BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0555198Malignant Glioma3BeFree
umls:C0740457Malignant neoplasm of kidney3BeFree
umls:C0850666Helicobacter pylori infection3BeFree
umls:C1378703Renal carcinoma3BeFree
umls:C1519670Tumor Angiogenesis3BeFree
umls:C2711227Steatohepatitis3BeFree
umls:C0001883Airway Obstruction2BeFree
umls:C0003507Aortic Valve Stenosis2BeFree
umls:C0004114Astrocytoma2BeFree
umls:C0009319Colitis2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010278Craniosynostosis2BeFree
umls:C0011436Dentinogenesis Imperfecta2BeFree
umls:C0011881Diabetic Nephropathy2BeFree,RGD
umls:C0015302External exotoses2BeFree
umls:C0015695Fatty Liver2BeFree
umls:C0016059Fibrosis2LHGDN
umls:C0017152Gastritis2BeFree
umls:C0017658Glomerulonephritis2BeFree,RGD
umls:C0018801Heart failure2BeFree
umls:C0018802Congestive heart failure2BeFree
umls:C0020217Hydatidiform Mole2BeFree
umls:C0021390Inflammatory Bowel Diseases2BeFree
umls:C0022116Ischemia2BeFree
umls:C0023890Liver Cirrhosis2BeFree,CTD_human
umls:C0024117Chronic Obstructive Airway Disease2BeFree
umls:C0025286Meningioma2BeFree
umls:C0027059Myocarditis2BeFree,RGD
umls:C0027430Nasal Polyps2BeFree
umls:C0027659Neoplasms, Experimental2BeFree,CTD_human
umls:C0027831Neurofibromatosis 12BeFree
umls:C0028259Nodule2BeFree
umls:C0032927Precancerous Conditions2BeFree
umls:C0033860Psoriasis2BeFree,LHGDN
umls:C0036421Systemic Scleroderma2BeFree
umls:C0041948Uremia2BeFree,CTD_human
umls:C0085096Peripheral Vascular Diseases2BeFree,LHGDN
umls:C0149516Chronic sinusitis2BeFree
umls:C0149521Pancreatitis, Chronic2BeFree,LHGDN
umls:C0149925Small cell carcinoma of lung2BeFree
umls:C0149939Obstructive nephropathy2BeFree
umls:C0162309Adrenoleukodystrophy2BeFree
umls:C0162871Aortic Aneurysm, Abdominal2BeFree,GAD
umls:C0206139Lichen Planus, Oral2BeFree,LHGDN
umls:C0206638Giant Cell Tumor of Bone2BeFree
umls:C0206681Adenocarcinoma, Clear Cell2BeFree
umls:C0238198Gastrointestinal Stromal Tumors2BeFree
umls:C0240035Interstitial fibrosis2BeFree
umls:C0268731Renal glomerular disease2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0279702Conventional (Clear Cell) Renal Cell Carcinoma2BeFree
umls:C0338106Adenocarcinoma of colon2BeFree
umls:C0340629Aortic aneurysm without mention of rupture NOS2BeFree
umls:C0345967Malignant mesothelioma2BeFree
umls:C0497406Overweight2BeFree
umls:C0598766Leukemogenesis2BeFree
umls:C0752347Lewy Body Disease2BeFree,GAD
umls:C0853897Diabetic Cardiomyopathies2BeFree,CTD_human
umls:C0948008Ischemic stroke2BeFree
umls:C1261473Sarcoma2BeFree
umls:C1318544M5b Acute differentiated monocytic leukemia2BeFree
umls:C1328840Autoimmune Lymphoproliferative Syndrome2BeFree
umls:C1511291Breast Cancer Model2BeFree
umls:C1520166Xenograft Model2BeFree
umls:C1621958Glioblastoma Multiforme2BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C1708565Invasive Skin Melanoma2BeFree
umls:C1833683NEPHROLITHIASIS, CALCIUM OXALATE2BeFree
umls:C1851585MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA2BeFree
umls:C1956089Osteophyte2BeFree
umls:C2607914Allergic rhinitis (disorder)2BeFree
umls:C2609414Acute kidney injury2CTD_human
umls:C2931071Dianzani autoimmune lymphoproliferative syndrome2BeFree
umls:C3272363Ischemic Cerebrovascular Accident2BeFree
umls:C3463897HYDATIDIFORM MOLE, RECURRENT, 12BeFree
umls:C3495559Juvenile arthritis2BeFree
umls:C3542024AORTIC VALVE DISEASE 22BeFree
umls:C3714757Juvenile rheumatoid arthritis2BeFree
umls:C0001925Albuminuria1RGD
umls:C0002171Alopecia Areata1BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0002690Amputation Stumps1BeFree
umls:C0002726Amyloidosis1BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1GAD
umls:C0003130Anoxia1GAD
umls:C0003864Arthritis1BeFree
umls:C0004623Bacterial Infections1BeFree
umls:C0005411Biliary Atresia1BeFree,LHGDN
umls:C0005956Bone Marrow Diseases1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0007273Carotid Artery Diseases1GAD
umls:C0007282Carotid Stenosis1LHGDN
umls:C0007682CNS disorder1BeFree
umls:C0007786Brain Ischemia1BeFree
umls:C0008479Chondrosarcoma1BeFree
umls:C0009241Cognition Disorders1BeFree
umls:C0011265Presenile dementia1BeFree
umls:C0011303Demyelinating Diseases1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0011633Dermatomyositis1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0014038Encephalitis1BeFree
umls:C0014070Encephalomyelitis1RGD
umls:C0014170Endometrial Neoplasms1LHGDN
umls:C0014457Eosinophilia1BeFree
umls:C0014859Esophageal Neoplasms1BeFree
umls:C0015625Fanconi Anemia1BeFree
umls:C0017154Gastritis, Atrophic1BeFree
umls:C0017205Gaucher Disease1BeFree
umls:C0017661IGA Glomerulonephritis1BeFree
umls:C0017668Focal glomerulosclerosis1CTD_human
umls:C0018133Graft-vs-Host Disease1BeFree
umls:C0018188Granuloma1LHGDN
umls:C0018213Graves Disease1BeFree
umls:C0018378Guillain-Barre Syndrome1BeFree
umls:C0018671Head and Neck Neoplasms1GAD
umls:C0018799Heart Diseases1CTD_human
umls:C0018824Heart valve disease1CTD_human
umls:C0019187Hepatitis, Alcoholic1BeFree
umls:C0019562Von Hippel-Lindau Syndrome1BeFree
umls:C0019621Histiocytosis, Langerhans-Cell1BeFree
umls:C0020456Hyperglycemia1BeFree
umls:C0020517Hypersensitivity1CTD_human
umls:C0020541Hypertension, Portal1BeFree
umls:C0020545Hypertension, Renovascular1RGD
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0022602Actinic keratosis1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0022661Kidney Failure, Chronic1LHGDN
umls:C0023448Lymphoid leukemia1BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0023465Acute monocytic leukemia1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0023893Liver Cirrhosis, Experimental1RGD
umls:C0023904Liver Neoplasms, Experimental1CTD_human
umls:C0024115Lung diseases1LHGDN
umls:C0024143Lupus Nephritis1GAD
umls:C0024198Lyme Disease1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024314Lymphoproliferative Disorders1BeFree
umls:C0024668Mammary Neoplasms, Experimental1CTD_human
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0026640Mouth Neoplasms1GAD
umls:C0026918Mycobacterium Infections1BeFree
umls:C0027613Neonatal hepatitis1BeFree
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0027809Neurilemmoma1BeFree
umls:C0027814Neuritis, Autoimmune, Experimental1RGD
umls:C0027859Acoustic Neuroma1BeFree
umls:C0027873Neuromyelitis Optica1LHGDN
umls:C0028432Nose Diseases1BeFree
umls:C0028756Obesity, Morbid1BeFree
umls:C0029410Osteoarthritis of hip1BeFree
umls:C0029423Cartilaginous exostosis1BeFree
umls:C0029458Osteoporosis, Postmenopausal1BeFree
umls:C0029928Ovarian Diseases1BeFree
umls:C0030286Pancreatic Diseases1CTD_human
umls:C0030297Pancreatic Neoplasm1BeFree,LHGDN
umls:C0030305Pancreatitis1BeFree
umls:C0032227Pleural effusion disorder1BeFree
umls:C0032285Pneumonia1CTD_human
umls:C0032460Polycystic Ovary Syndrome1BeFree
umls:C0032584polyps1BeFree
umls:C0033687Proteinuria1CTD_human
umls:C0033847Pseudoxanthoma Elasticum1BeFree,GAD
umls:C0034069Pulmonary Fibrosis1CTD_human
umls:C0035235Respiratory Syncytial Virus Infections1BeFree
umls:C0035412Rhabdomyosarcoma1BeFree
umls:C0035851Root Resorption1BeFree
umls:C0035869Rotavirus Infections1LHGDN
umls:C0036330Schistosomiasis mansoni1BeFree
umls:C0036572Seizures1RGD
umls:C0037019Shy-Drager Syndrome1BeFree
umls:C0037579Soft Tissue Neoplasms1BeFree
umls:C0037928Spinal Cord Diseases1BeFree
umls:C0038354Stomach Diseases1BeFree
umls:C0038454Cerebrovascular accident1BeFree
umls:C0038868Progressive supranuclear palsy1BeFree
umls:C0039106Pigmented villonodular synovitis1BeFree
umls:C0040136Thyroid Neoplasm1LHGDN
umls:C0041755Adverse reaction to drug1CTD_human
umls:C0042170Uveomeningoencephalitic Syndrome1BeFree
umls:C0042345Varicosity1BeFree
umls:C0042373Vascular Diseases1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0079588Ichthyosis, X-Linked1BeFree
umls:C0079744Diffuse Large B-Cell Lymphoma1BeFree
umls:C0085110Severe Combined Immunodeficiency1BeFree
umls:C0085167Granular cell tumor1BeFree,LHGDN
umls:C0085183Neoplasms, Second Primary1GAD
umls:C0085413Polycystic Kidney, Autosomal Dominant1RGD
umls:C0085786Hamman-Rich syndrome1BeFree
umls:C0086445Idiopathic Membranous Glomerulonephritis1BeFree
umls:C0086543Cataract1BeFree
umls:C0086692Benign Neoplasm1BeFree
umls:C0151744Myocardial Ischemia1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0152025Polyneuropathy1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0155686Acute myocarditis1BeFree
umls:C0158266Intervertebral Disc Degeneration1BeFree
umls:C0162820Dermatitis, Allergic Contact1CTD_human
umls:C0162872Aortic Aneurysm, Thoracic1BeFree
umls:C0206019HIV Encephalopathy1BeFree
umls:C0206062Lung Diseases, Interstitial1BeFree
umls:C0206687Carcinoma, Endometrioid1BeFree
umls:C0206695Carcinoma, Neuroendocrine1LHGDN
umls:C0206698Cholangiocarcinoma1LHGDN
umls:C0206701Cystadenocarcinoma, Serous1BeFree
umls:C0206711Pilomatrixoma1BeFree
umls:C0206728Plexiform Neurofibroma1BeFree
umls:C0206743Rhabdoid Tumor1LHGDN
umls:C0220633Uveal melanoma1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0221056Adult type dermatomyositis1BeFree
umls:C0221204Lytic lesion1CTD_human
umls:C0238378Desquamative interstitial pneumonia1BeFree
umls:C0238790bone destruction1BeFree
umls:C0242422Parkinsonian Disorders1BeFree
umls:C0242596Neoplasm, Residual1BeFree
umls:C0242966Systemic Inflammatory Response Syndrome1LHGDN
umls:C0243026Sepsis1LHGDN
umls:C0259779Fibrous Dysplasia1BeFree
umls:C0262401Carcinoma of ampulla of Vater1BeFree
umls:C0263666Dermatomyositis, Childhood Type1BeFree
umls:C0267159Superficial gastritis1BeFree
umls:C0268381Primary amyloidosis1BeFree
umls:C0268407Senile cardiac amyloidosis1BeFree
umls:C0270612Leukoencephalopathies1CTD_human
umls:C0276548HIV encephalitis1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0278504Non-small cell lung cancer stage I1BeFree
umls:C0278689Ovarian epithelial cancer recurrent1BeFree
umls:C0278987Non-small cell lung cancer metastatic1BeFree
umls:C0280803Primary central nervous system lymphoma1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0311213Dermatitis verrucosa1BeFree
umls:C0334424Nodular melanoma1BeFree
umls:C0334579Anaplastic astrocytoma1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0339573Glaucoma, Primary Open Angle1BeFree
umls:C0346153Breast Cancer, Familial1BeFree
umls:C0346156Benign neoplasm of breast1BeFree
umls:C0348374Malignant neoplasm of central nervous system1BeFree
umls:C0393571Multiple System Atrophy1BeFree
umls:C0395887Tympanosclerosis1BeFree
umls:C0403396Steroid-sensitive nephrotic syndrome1BeFree
umls:C0403416Idiopathic crescentic glomerulonephritis1BeFree
umls:C0410158Muscle damage1BeFree
umls:C0428796Senile sclerosis of aortic cusp1BeFree
umls:C0473583Nevus elasticus1BeFree
umls:C0497327Dementia1BeFree
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0543800Idiopathic hypercalciuria1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0595921Intraocular pressure disorder1BeFree
umls:C0595936Aqueous Humor Disorders1BeFree
umls:C0598894Monocytic leukemia1BeFree
umls:C0677607Hashimoto Disease1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0679225multiple pathologies1BeFree
umls:C0700594Radiculopathy1RGD
umls:C0740903allergic symptom1BeFree
umls:C0741923cardiac event1BeFree
umls:C0751606Adult Acute Lymphocytic Leukemia1BeFree
umls:C0751674Lymphangioleiomyomatosis1BeFree
umls:C0751690Malignant Peripheral Nerve Sheath Tumor1BeFree
umls:C0751792Trauma, Nervous System1RGD
umls:C0751967Multiple Sclerosis, Relapsing-Remitting1BeFree
umls:C0856747Aneurysm of ascending aorta1BeFree
umls:C0860207Drug-Induced Liver Injury1CTD_human
umls:C0862506Borderline ovarian tumour1BeFree
umls:C0865681Myocarditis, chronic1BeFree
umls:C0948089Acute Coronary Syndrome1BeFree
umls:C0971858Arthritis, Collagen-Induced1BeFree
umls:C1134719Invasive Ductal Breast Carcinoma1BeFree
umls:C1168327High-Grade Prostatic Intraepithelial Neoplasia1BeFree
umls:C1168328Low Grade Prostatic Intraepithelial Neoplasia1BeFree
umls:C1260873Aortic valve disorder1BeFree
umls:C1266002Non-small cell carcinoma1BeFree
umls:C1266184Atypical teratoid/rhabdoid tumor1BeFree
umls:C1274648Segmental vitiligo1BeFree
umls:C1306759Eosinophilic disorder1BeFree
umls:C1314694Astrocytoma, low grade1BeFree
umls:C1368683Epithelioma1BeFree
umls:C1455780Aortic valve sclerosis1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1562010Langerhans cell histiocytosis of lung1BeFree
umls:C1636667Disorder characterized by eosinophilia1BeFree
umls:C1704321Nephrotic Syndrome, Minimal Change1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype1BeFree
umls:C1840392HYPERPIGMENTATION, FAMILIAL PROGRESSIVE1BeFree
umls:C1840451MULTICYSTIC RENAL DYSPLASIA, BILATERAL1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C2931785Juvenile dermatomyositis1BeFree
umls:C2937358Cerebral Hemorrhage1CTD_human
umls:C2945695Limb ischemia1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)1BeFree
umls:C3536984Vitamin D-Resistant Rickets, X-Linked1BeFree
umls:C3539909Allergic disposition1BeFree
umls:C3665444Neutrophilia (disorder)1BeFree
umls:C3714514Infection1LHGDN
umls:C3805083Portal fibrosis1BeFree