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| TissGeneSummary for SPRR2A |
 Gene summary |
| Basic gene information | Gene symbol | SPRR2A |
| Gene name | small proline-rich protein 2A | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q21-q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005988.2, | |
| Description | 2-1SPR-2A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 182267 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000241794 | ||
| HPRD : 01649 | ||
| Vega : OTTHUMG00000014395 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPRR2A | |
| BioGPS: 6700 | ||
| Pathway | NCI Pathway Interaction Database: SPRR2A | |
| KEGG: SPRR2A | ||
| REACTOME: SPRR2A | ||
| Pathway Commons: SPRR2A | ||
| Context | iHOP: SPRR2A | |
| ligand binding site mutation search in PubMed: SPRR2A | ||
| UCL Cancer Institute: SPRR2A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
| Reference showing the relevant tissue of SPRR2A | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SPRR2A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 5.080191901 | -1.102002217 | 6.182194118 | 1.81E-13 | 9.10E-13 |
| KIRC | -3.385746498 | -1.959983998 | -1.4257625 | 6.34E-13 | 2.76E-12 |
| KICH | -3.529879942 | -1.682703942 | -1.847176 | 3.08E-09 | 1.77E-08 |
| KIRP | -2.368856567 | -1.276725317 | -1.09213125 | 0.00982 | 0.021627151 |
| COAD | -1.841504404 | -3.413292865 | 1.571788462 | 0.000994 | 0.002835747 |
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| TissGene-miRNA for SPRR2A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SPRR2A |
| TissGeneSNV for SPRR2A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P55L | SKCM | 1 |
| p.P21Q | UCEC | 1 |
| p.P55S | SKCM | 1 |
| p.Q52H | UCEC | 1 |
| p.Q64L | LIHC | 1 |
| p.K31N | PAAD | 1 |
| p.P30Q | ACC | 1 |
| p.S71R | OV | 1 |
| p.K72N | UCEC | 1 |
| p.P35H | LIHC | 1 |
| p.S60P | STAD | 1 |
| p.P69S | SKCM | 1 |
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| TissGeneCNV for SPRR2A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SPRR2A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE714440 | SPRR2A-PCYOX1 | chr1:153066051 | chr2:70508168 | |
| Chimerdb3.0 | ChiTaRs | NA | BE181532 | ANXA2-SPRR2A | chr15:60657832 | chr1:153028861 | |
| Chimerdb3.0 | ChiTaRs | NA | BE181563 | RHBDF1-SPRR2A | chr16:108595 | chr1:153028802 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A6L4-01A | SPRR2A-SERINC2 | 5'UTR-CDS | chr1:153029946 | chr1:31905813 |
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| TissGeneNet for SPRR2A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| COAD (tumor) | COAD (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| KICH (tumor) | KICH (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| STAD (tumor) | STAD (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| THCA (tumor) | THCA (normal) |
| SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (tumor) | SPRR2A, SRC, HCK, DLG4, YES1, CTTN, ABL1, EVPL, AKT2, CRK, ITK (normal) |
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| TissGeneProg for SPRR2A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SPRR2A |
| TissGeneDrug for SPRR2A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SPRR2A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 2 | BeFree |
| umls:C0005818 | Blood Platelet Disorders | 1 | BeFree |
| umls:C0008533 | Hemophilia B | 1 | BeFree |
| umls:C0019069 | Hemophilia A | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0030552 | Paresis | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0085580 | Essential Hypertension | 1 | BeFree |
| umls:C0151786 | Muscle Weakness | 1 | BeFree |
| umls:C0153446 | Malignant neoplasm of anus | 1 | BeFree |
| umls:C0175702 | Williams Syndrome | 1 | BeFree |
| umls:C0206659 | Embryonal Carcinoma | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0279637 | Anal carcinoma | 1 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
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