TissGeneSummary for SPRR3 |
Gene summary |
Basic gene information | Gene symbol | SPRR3 |
Gene name | small proline-rich protein 3 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q21-q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001097589.1, NM_005416.2, | |
Description | 22 kDa pancornulincornifin betaesophagin | |
Modification date | 20141207 | |
dbXrefs | MIM : 182271 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163209 | ||
HPRD : 01652 | ||
Vega : OTTHUMG00000013872 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPRR3 | |
BioGPS: 6707 | ||
Pathway | NCI Pathway Interaction Database: SPRR3 | |
KEGG: SPRR3 | ||
REACTOME: SPRR3 | ||
Pathway Commons: SPRR3 | ||
Context | iHOP: SPRR3 | |
ligand binding site mutation search in PubMed: SPRR3 | ||
UCL Cancer Institute: SPRR3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of SPRR3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPRR3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 4.183036097 | -2.078697236 | 6.261733333 | 6.67E-13 | 3.15E-12 |
LUAD | -1.957856026 | -3.652971543 | 1.695115517 | 8.61E-06 | 2.54E-05 |
HNSC | 6.784887078 | 11.20501731 | -4.420130233 | 3.03E-06 | 2.01E-05 |
COAD | -2.728562922 | -4.002297538 | 1.273734615 | 0.00352 | 0.008804018 |
PRAD | -3.687001384 | -2.675974461 | -1.011026923 | 0.000929 | 0.00303809 |
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TissGene-miRNA for SPRR3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPRR3 |
TissGeneSNV for SPRR3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H42R | HNSC | 1 |
p.G57C | COAD | 1 |
p.P134S | SKCM | 1 |
p.P142S | SKCM | 1 |
p.I131L | LUAD | 1 |
p.I53S | COAD | 1 |
p.G49V | BLCA | 1 |
p.G137E | SKCM | 1 |
p.P126S | SKCM | 1 |
p.G105D | DLBC | 1 |
p.P64S | UCEC | 1 |
p.T83I | SKCM | 1 |
p.P86S | SKCM | 1 |
p.Q26H | SARC | 1 |
p.Q120K | LUAD | 1 |
p.P48H | LUAD | 1 |
p.P118S | SKCM | 1 |
p.G49E | SKCM | 1 |
p.C90F | PRAD | 1 |
p.Q23H | CESC | 1 |
p.G57S | SKCM | 1 |
p.P86L | SKCM | 1 |
p.T166I | STAD | 1 |
p.K148M | LUAD | 1 |
p.L149V | COAD | 1 |
p.T139A | KIRC | 1 |
p.Q15H | LUAD | 1 |
p.K84T | STAD | 1 |
p.E103A | STAD | 1 |
p.T91A | STAD | 1 |
p.Y146C | UCEC | 1 |
p.F33C | LIHC | 1 |
p.V141A | SKCM | 1 |
p.P142L | SKCM | 1 |
p.V157I | LUAD | 1 |
p.Y106C | KIRC | 1 |
p.P72S | UCEC | 1 |
p.E95G | UCEC | 1 |
p.P28L | HNSC | 1 |
p.E31K | SKCM | 1 |
p.F33L | COAD | 1 |
p.P94S | SKCM | 1 |
p.G57D | THYM | 1 |
p.E103K | SKCM | 1 |
p.V45F | LUAD | 1 |
p.E39D | LUAD | 1 |
p.E71K | SKCM | 1 |
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TissGeneCNV for SPRR3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPRR3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE716419 | SPRR3-RPS15A | chr1:152976131 | chr16:18800992 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A6Y0-01B | SPRR3-SERINC2 | 5'UTR-CDS | chr1:152974269 | chr1:31905813 |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-7103-11A | SPRR3-KRT4 | 3'UTR-CDS | chr1:152976095 | chr12:53202201 |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-7103-11A | SPRR3-KRT16 | 3'UTR-CDS | chr1:152976018 | chr17:39768644 |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-7103-11A | SPRR3-KRT13 | Out-of-Frame | chr1:152975574 | chr17:39661634 |
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TissGeneNet for SPRR3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPRR3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPRR3 |
TissGeneDrug for SPRR3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPRR3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,LHGDN |
umls:C0011615 | Dermatitis, Atopic | 2 | BeFree |
umls:C0013595 | Eczema | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0037274 | Dermatologic disorders | 1 | BeFree |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0206706 | Verrucous carcinoma | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C1258085 | Barrett Epithelium | 1 | BeFree |
umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 1 | BeFree |