TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for BRCA2

Gene summary

Basic gene information	Gene symbol	BRCA2
	Gene name	breast cancer 2, early onset
	Synonyms	BRCC2\|BROVCA2\|FACD\|FAD\|FAD1\|FANCD\|FANCD1\|GLM3\|PNCA2\|XRCC11
	Cytomap	UCSC genome browser: 13q12.3
	Type of gene	protein-coding
	RefGenes	NM_000059.3,
	Description	BRCA1/BRCA2-containing complex, subunit 2Fanconi anemia group D1 proteinbreast and ovarian cancer susceptibility gene, early onsetbreast cancer 2 tumor suppressorbreast cancer type 2 susceptibility protein
	Modification date	20141222
dbXrefs	MIM : 600185
	HGNC : HGNC
	Ensembl : ENSG00000139618
	HPRD : 02554
	Vega : OTTHUMG00000017411
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_BRCA2
	BioGPS: 675
Pathway	NCI Pathway Interaction Database: BRCA2
	KEGG: BRCA2
	REACTOME: BRCA2
	Pathway Commons: BRCA2
Context	iHOP: BRCA2
	ligand binding site mutation search in PubMed: BRCA2
	UCL Cancer Institute: BRCA2
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	TGCT
Reference showing the relevant tissue of BRCA2
Description by TissGene annotations	Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0000724	double-strand break repair via homologous recombination	20729832
GO:0000910	cytokinesis	17286961
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	15930293
GO:0043966	histone H3 acetylation	9619837
GO:0043967	histone H4 acetylation	9619837
GO:0045893	positive regulation of transcription, DNA-templated	9126734
GO:0000724	double-strand break repair via homologous recombination	20729832
GO:0000910	cytokinesis	17286961
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	15930293
GO:0043966	histone H3 acetylation	9619837
GO:0043967	histone H4 acetylation	9619837
GO:0045893	positive regulation of transcription, DNA-templated	9126734

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TissGeneExp for BRCA2

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRP	-0.774721924	-2.384500049	1.609778125	9.85E-09	7.53E-08
LUSC	1.437698113	-0.169731299	1.607429412	6.03E-17	4.76E-16
BLCA	1.377437122	-0.909389194	2.286826316	1.18E-06	3.70E-05
STAD	1.999728076	-0.065940674	2.06566875	7.35E-09	3.67E-07
BRCA	1.328230981	-0.261595334	1.589826316	3.65E-23	3.24E-22
COAD	1.75159947	-0.147812068	1.899411538	8.56E-14	2.98E-12
KIRC	0.197788145	-1.726677133	1.924465278	9.21E-29	1.56E-27
HNSC	1.596050096	0.124838468	1.471211628	1.07E-07	1.04E-06
ESCA	2.975368701	0.292250519	2.683118182	2.77E-06	0.000684498
LIHC	-0.936929299	-2.023815299	1.086886	0.000166	0.000544588

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TissGene-miRNA for BRCA2

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for BRCA2

TissGeneSNV for BRCA2

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R2842C	UCEC	2
p.R2888H	UCEC	2
p.H334Y	SKCM	2
p.E2020K	UCEC	2
p.N1642T	PAAD	1
p.L2155H	READ	1
p.D189H	KIRC	1
p.S3375G	STAD	1
p.F1192C	UCEC	1
p.S1685L	LUAD	1
p.T2542M	UCEC	1
p.E2650Q	BRCA	1
p.E1245G	LIHC	1
p.E2343Q	BLCA	1
p.E2903K	HNSC	1
p.R2336C	THYM	1
p.S1259R	ESCA	1
p.E1158Q	BRCA	1
p.D1911N	BLCA	1
p.L482I	UCEC	1
p.Q2731*	BLCA	1
p.E49X	READ	1
p.S1597Y	READ	1
p.R2336C	BRCA	1
p.G500V	HNSC	1
p.E1646Q	LUAD	1
p.S445Y	COAD	1
p.D1352Y	COAD	1
p.Q609H	BLCA	1
p.L1598F	SKCM	1
p.Q3262P	STAD	1
p.M124V	ESCA	1
p.P2352S	STAD	1
p.L139V	COAD	1
p.A1996G	LIHC	1
p.I2149V	LUAD	1
p.S3332Y	UCEC	1
p.G1529R	UCEC	1
p.Q2655*	BLCA	1
p.L2926*	BRCA	1
p.Y1569C	UCEC	1
p.R1512C	UCEC	1
p.R1570I	ESCA	1
p.C711*	OV	1
p.N2781D	UCEC	1
p.K3015*	LUAD	1
p.E97X	COAD	1
p.E2635G	COAD	1
p.N556S	KIRP	1
p.R2488T	UCEC	1
p.A3297T	KIRC	1
p.P1702L	SKCM	1
p.Q3299R	HNSC	1
p.S3218F	HNSC	1
p.T2097M	BLCA	1
p.E826*	BLCA	1
p.Q2870*	BLCA	1
p.A2698T	GBM	1
p.W993C	LUSC	1
p.Q2159*	CESC	1
p.K2316Q	UCEC	1
p.V1605D	HNSC	1
p.I3418S	STAD	1
p.G1761V	UCEC	1
p.I580L	KIRP	1
p.K3313T	KIRP	1
p.R2861T	HNSC	1
p.S3123G	HNSC	1
p.A1981S	UCEC	1
p.L759I	UCEC	1
p.S1961T	LUAD	1
p.N1747S	UCEC	1
p.Q3247H	UCEC	1
p.S2887T	KIRC	1
p.Q2539H	STAD	1
p.S2887L	LIHC	1
p.K604*	UCEC	1
p.D1386Y	BLCA	1
p.A1439T	STAD	1
p.T868I	BLCA	1
p.T2880I	UCEC	1
p.S1882*	BLCA	1
p.Q3026*	SKCM	1
p.S708Y	BLCA	1
p.K1264R	KIRP	1
p.D1386N	HNSC	1
p.A1725S	UCEC	1
p.S1882*	UCEC	1
p.S2695L	SKCM	1
p.E732Q	BLCA	1
p.C1265Y	LGG	1
p.S278N	PAAD	1
p.S1172L	STAD	1
p.I332F	STAD	1
p.T1354M	OV	1
p.M1090L	UCS	1
p.E510X	COAD	1
p.C1399R	LUAD	1
p.A2738S	THCA	1
p.Y2884*	HNSC	1
p.E832K	BLCA	1
p.E1382D	UCEC	1
p.V2820I	LUSC	1
p.H2074D	LIHC	1
p.V494A	STAD	1
p.C1159S	STAD	1
p.F3298C	LIHC	1
p.E2258K	BLCA	1
p.V3290F	SARC	1
p.E1046K	BLCA	1
p.E897*	UCEC	1
p.E3403Q	LUAD	1
p.T1087I	SKCM	1
p.K2741N	UCEC	1
p.V348A	STAD	1
p.K3238N	ESCA	1
p.Y3308*	BRCA	1
p.S1064*	UCEC	1
p.H1752Y	SKCM	1
p.I1017F	PAAD	1
p.G1771C	LUAD	1
p.R316K	SKCM	1
p.A1393V	STAD	1
p.E2599X	COAD	1
p.S2216F	UCEC	1
p.E2903D	THYM	1
p.P2827L	SKCM	1
p.E2391K	LUAD	1
p.S2378A	READ	1
p.C3304S	BRCA	1
p.G1338D	STAD	1
p.E1493X	COAD	1
p.G1963V	THYM	1
p.R2268I	UCEC	1
p.S313Y	KIRC	1
p.P606S	SKCM	1
p.I1772S	UCEC	1
p.E1726K	BLCA	1
p.K2570*	UCEC	1
p.Q1562*	SKCM	1
p.R2494Q	UCEC	1
p.P740S	SKCM	1
p.H3117N	LUAD	1
p.L3180F	UCS	1
p.Y1749H	LUAD	1
p.E3393Q	HNSC	1
p.K1139N	UCEC	1
p.T1915M	COAD	1
p.E1571K	HNSC	1
p.R3052Q	UCEC	1
p.A2711T	UCEC	1
p.S2695L	LIHC	1
p.E187*	LUSC	1
p.S3376*	LUAD	1
p.S3231X	READ	1
p.S3239Y	UCEC	1
p.T868I	UCEC	1
p.H1332D	BLCA	1
p.K3315N	HNSC	1
p.E1876K	SKCM	1
p.P288S	UCEC	1
p.D1096N	READ	1
p.G2063R	LUAD	1
p.V1810I	STAD	1
p.I2718V	LUAD	1
p.S1743R	COAD	1
p.E1895K	BLCA	1
p.F2568C	COAD	1
p.D1096E	READ	1
p.I2105V	HNSC	1
p.I1607S	UCEC	1
p.E3342K	STAD	1
p.D878N	COAD	1
p.Q619*	SKCM	1
p.R3052W	COAD	1
p.Q2157*	BLCA	1
p.D913E	ESCA	1
p.S196I	UCEC	1
p.E2275D	PRAD	1
p.C279Y	LGG	1
p.P606L	SKCM	1
p.F892L	LIHC	1
p.Q2870*	SKCM	1
p.L3180R	READ	1
p.S1172L	UCEC	1
p.I2105L	LUAD	1
p.R2034H	LUSC	1
p.K1541E	LUAD	1
p.N372H	COAD	1
p.S1341*	BLCA	1
p.E1514Q	CHOL	1
p.S3252F	SKCM	1
p.R2336C	UCEC	1
p.N1619D	STAD	1
p.R18H	LIHC	1
p.Q3398H	SKCM	1
p.E1120*	LUAD	1
p.A843V	UCEC	1
p.D281H	PRAD	1
p.K1536E	KIRP	1
p.R2502H	STAD	1
p.C2473R	UCEC	1
p.V1663I	CHOL	1
p.A2951V	STAD	1
p.R2494Q	READ	1
p.P3067S	LUAD	1
p.E2953A	COAD	1
p.C1159Y	UCEC	1
p.N1935D	STAD	1
p.P2800R	KIRC	1
p.R2625*	HNSC	1
p.R2991C	COAD	1
p.F1273L	CESC	1
p.P3324L	SKCM	1
p.V1078I	UCEC	1
p.R2418I	UCEC	1
p.H2932Y	THCA	1
p.C3097R	PCPG	1
p.D3260H	BLCA	1
p.E764K	LUAD	1
p.S1468F	UCEC	1
p.V290I	LUAD	1
p.S206C	ESCA	1
p.F2349C	READ	1
p.N2706S	CESC	1
p.S2067F	SKCM	1
p.I1136M	BLCA	1
p.S76*	BLCA	1
p.V2079M	PAAD	1
p.D1355Y	BRCA	1
p.E532K	LGG	1
p.I1047M	READ	1
p.E3405Q	BLCA	1
p.W2970*	LGG	1
p.T1346N	PAAD	1
p.F2841I	KIRC	1
p.N2452T	STAD	1
p.C554F	LUAD	1
p.V1306F	LUAD	1
p.K1649E	LUAD	1
p.T3401M	READ	1
p.K2206N	UCEC	1
p.I2177V	KIRC	1
p.D427G	BLCA	1
p.N978S	LUAD	1
p.G2529D	SKCM	1
p.G2529S	SKCM	1
p.M2262T	LUAD	1
p.N1435T	PRAD	1
p.S205R	COAD	1
p.Y2660C	LUSC	1
p.S1961G	COAD	1
p.P555L	SKCM	1
p.N633K	SARC	1
p.K1638E	OV	1
p.E832K	KIRC	1
p.F312C	HNSC	1
p.C2422*	UCEC	1
p.L613R	COAD	1
p.G2755A	BLCA	1
p.T1785I	UCEC	1
p.A2711T	ESCA	1
p.S2201F	LUSC	1
p.P493L	SKCM	1
p.S2670L	READ	1
p.T1067A	UCEC	1
p.F851L	UCEC	1
p.E294X	ESCA	1
p.E2129*	BLCA	1
p.H1752N	GBM	1
p.S3231L	HNSC	1
p.E3342K	HNSC	1
p.E3177Q	BRCA	1
p.D1547E	SKCM	1
p.N1435H	COAD	1
p.G1963W	CHOL	1
p.V1804I	SARC	1
p.S3014L	BLCA	1
p.E1441*	UCEC	1
p.E626K	SKCM	1
p.L901I	COAD	1
p.R468I	STAD	1
p.G2584C	UCEC	1
p.S158P	COAD	1
p.S3241C	LUAD	1
p.E1812G	LGG	1
p.Q499*	LUSC	1
p.Q2943E	BLCA	1
p.R1570T	BLCA	1
p.L2654F	BLCA	1
p.L1908V	BLCA	1
p.V2545I	STAD	1
p.R155I	UCEC	1
p.Y2726C	LIHC	1
p.H223Y	SKCM	1
p.E2906*	OV	1
p.R858T	BLCA	1
p.M192T	BLCA	1
p.H1332Y	LIHC	1
p.Q3047H	STAD	1
p.S1680Y	UCEC	1
p.K2316R	LUSC	1
p.A766T	COAD	1
p.K3313Q	STAD	1
p.S1115F	STAD	1
p.D526N	BLCA	1
p.H1350N	UCEC	1
p.Q649H	BLCA	1
p.F1092L	SKCM	1
p.Q1089E	BLCA	1
p.S2695X	STAD	1
p.E2081Q	BLCA	1
p.D224V	GBM	1
p.S1121T	STAD	1
p.R2273K	BLCA	1
p.L35F	SKCM	1
p.N852K	STAD	1
p.K2111E	LIHC	1
p.D2218Y	READ	1
p.P2107S	SKCM	1
p.R1512H	LUAD	1
p.A2351T	STAD	1
p.E2175Q	HNSC	1
p.E897K	BLCA	1
p.L2917F	SKCM	1
p.A1393V	LGG	1
p.L2753F	BLCA	1
p.E816G	KIRP	1
p.K1191N	BRCA	1
p.R1190W	CESC	1
p.S2243C	LUAD	1
p.E2476*	UCEC	1
p.Q3398R	UCS	1
p.D988N	UCEC	1
p.E510*	UCEC	1
p.S2053P	LGG	1
p.N1878K	DLBC	1
p.E3043A	BLCA	1
p.N517S	LGG	1
p.S1597Y	UCEC	1
p.V2503F	LUAD	1
p.S3396R	UCEC	1
p.V1542A	STAD	1
p.P2734H	STAD	1
p.S3231*	CESC	1
p.D1420N	UCEC	1
p.P606L	HNSC	1
p.M3118V	THYM	1
p.Y232C	COAD	1
p.V2190I	PRAD	1
p.S2243Y	READ	1
p.K1264E	SKCM	1
p.S2098T	LUSC	1
p.E1318K	BLCA	1
p.V3091I	DLBC	1
p.L833R	LUAD	1
p.S1882*	OV	1
p.T3401M	PCPG	1
p.F439C	STAD	1
p.N1910S	OV	1
p.E826*	CESC	1
p.E1036K	LUSC	1
p.P3063S	ESCA	1
p.K722Q	READ	1
p.Y2624N	LIHC	1
p.D381G	BLCA	1
p.Q2354E	BLCA	1
p.P143S	UCEC	1
p.Y3049S	BRCA	1
p.N1805D	UCS	1
p.D125G	KIRC	1
p.E1126K	BLCA	1
p.S2695*	LUAD	1
p.S2307L	SKCM	1
p.P2187L	SKCM	1
p.L1091F	LGG	1
p.S641Y	COAD	1
p.D281Y	COAD	1
p.E294*	ESCA	1
p.H1966R	GBM	1
p.P2608S	LUAD	1
p.A577S	LUAD	1
p.V1486I	LGG	1
p.Q2749*	HNSC	1
p.S1792F	SKCM	1
p.R2520Q	COAD	1
p.S44C	LUAD	1
p.P3054S	ESCA	1
p.E1518Q	BLCA	1
p.I2822T	LUSC	1
p.E1879D	READ	1
p.S2022L	STAD	1
p.E2004X	ESCA	1
p.S2695*	STAD	1
p.T1887M	UCEC	1
p.D1469Y	KIRP	1
p.S2704F	SKCM	1
p.E456D	READ	1
p.L2838F	UVM	1
p.E1126Q	BLCA	1

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TissGeneCNV for BRCA2

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for BRCA2

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for BRCA2

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
BRCA2, BRCA1, UBC, BRCC3, ATR, BUB1B, CCNA2, MCPH1, SHFM1, ATM, SIRT2, ELF1, BARD1, PMS1, FANCD2, PALB2, RAD23A, RBBP8, C11orf30, KIF4A, BACH1 (tumor)	BRCA2, SIRT3, PLK1, RAD51, CDK1, CDK2, BRCC3, MGMT, SKP2, ATR, BUB1B, USF2, CCNA2, ATM, BARD1, FANCD2, PALB2, C11orf30, KIF4A, BACH1, HMG20B (normal)

COAD (tumor)	COAD (normal)
BRCA2, BRCA1, PLK1, RAD51, CDK1, CDK2, CCNE1, BRCC3, SKP2, ATR, CHEK2, BUB1B, CCNA2, SIRT2, MTA2, AURKB, FANCG, H2AFX, FANCD2, KIF4A, XRCC3 (tumor)	BRCA2, BRCA1, PLK1, RAD51, CDK1, CDK2, BRCC3, SKP2, ATR, CHEK2, BUB1B, USF1, CCNA2, ELF1, AURKB, BARD1, PMS1, FANCD2, PALB2, KIF4A, UQCC (normal)

HNSC (tumor)	HNSC (normal)
BRCA2, TP53, BRCA1, SP1, SIRT3, PLK1, CDK1, CDK2, BRCC3, MGMT, SKP2, ATR, BUB1B, USF2, CCNA2, ELF1, BARD1, PALB2, C11orf30, KIF4A, BACH1 (tumor)	BRCA2, BRCA1, SP1, SIRT3, CDK2, BRCC3, SKP2, ABL1, ATR, SIRT1, BUB1B, CCNA2, SHFM1, ATM, ELF1, BARD1, FANCD2, PALB2, RBBP8, C11orf30, KIF4A (normal)

KICH (tumor)	KICH (normal)
BRCA2, BRCA1, PLK1, RAD51, SMAD2, CCNE1, TCF4, ATR, CHEK2, BUB1B, CCNA2, MCPH1, ATM, ELF1, AURKB, BARD1, FANCG, FANCD2, FANCE, KIF4A, XRCC3 (tumor)	BRCA2, BRCA1, PLK1, RAD51, CDK1, CDK2, SKP2, BUB1B, USF2, CCNA2, RPA1, ATM, SIRT2, AURKB, BARD1, PMS1, FANCD2, DMC1, C11orf30, KIF4A, HMG20B (normal)

KIRC (tumor)	KIRC (normal)
BRCA2, BRCA1, PLK1, RAD51, CDK1, CDK2, CCNE1, TCF4, SKP2, ATR, CHEK2, BUB1B, CCNA2, ATM, ELF1, AURKB, BARD1, PMS1, FANCD2, KIF4A, UQCC (tumor)	BRCA2, BRCA1, SP1, SIRT3, RAD51, CDK2, MGMT, SKP2, SIRT1, BUB1B, SHFM1, ATM, ELF1, BARD1, FANCD2, PALB2, RAD23A, C11orf30, KIF4A, BACH1, HMG20B (normal)

KIRP (tumor)	KIRP (normal)
BRCA2, TP53, BRCA1, SP1, PLK1, TCF4, SKP2, ATR, CHEK2, BUB1B, CCNA2, RPA1, ATM, ELF1, AURKB, BARD1, SERPINH1, FANCD2, RAD23A, KIF4A, UQCC (tumor)	BRCA2, BRCA1, SIRT3, RAD51, CDK1, CDK2, BRCC3, MGMT, SKP2, ATR, SIRT1, BUB1B, ATM, ELF1, BARD1, FANCD2, PALB2, C11orf30, KIF4A, BACH1, HMG20B (normal)

LIHC (tumor)	LIHC (normal)
BRCA2, BRCA1, PLK1, CDK1, BRCC3, SKP2, ATR, BUB1B, USF2, CCNA2, MCPH1, ATM, AURKB, BARD1, FANCG, PMS1, FANCD2, PALB2, RAD23A, C11orf30, KIF4A (tumor)	BRCA2, BRCA1, SP1, SIRT3, CDK1, CDK2, MGMT, SKP2, ABL1, ATR, BUB1B, CCNA2, SHFM1, ATM, ELF1, BARD1, FANCD2, PALB2, RBBP8, C11orf30, KIF4A (normal)

LUAD (tumor)	LUAD (normal)
BRCA2, GRB2, PLK1, CDK1, CCNE1, BRCC3, ATR, CHEK2, BUB1B, CCNA2, ATM, SIRT2, AURKB, BARD1, RPA2, PMS1, FANCD2, RAD23A, KIF4A, MORF4L1, HMG20B (tumor)	BRCA2, BRCA1, SIRT3, PLK1, RAD51, CDK1, CDK2, CCNE1, SKP2, ATR, CHEK2, BUB1B, CCNA2, AURKB, BARD1, FANCG, FANCD2, PALB2, DMC1, C11orf30, KIF4A (normal)

LUSC (tumor)	LUSC (normal)
BRCA2, BRCA1, PLK1, RAD51, CDK1, CCNE1, BRCC3, SKP2, ATR, CHEK2, BUB1B, CCNA2, ATM, AURKB, BARD1, FANCG, PMS1, FANCD2, RAD23A, C11orf30, KIF4A (tumor)	BRCA2, BRCA1, SP1, PLK1, RAD51, CDK1, CDK2, SKP2, ATR, CHEK2, BUB1B, CCNA2, RPA1, ATM, AURKB, BARD1, FANCG, PMS1, FANCD2, C11orf30, KIF4A (normal)

PRAD (tumor)	PRAD (normal)
BRCA2, BRCA1, SP1, SIRT3, RAD51, MGMT, SKP2, ATR, BUB1B, USF1, USF2, CCNA2, SHFM1, ELF1, BARD1, FANCD2, RAD23A, C11orf30, KIF4A, BACH1, UQCC (tumor)	BRCA2, BRCA1, SP1, SIRT3, CDK2, MGMT, SKP2, ATR, SIRT1, BUB1B, USF2, CCNA2, ATM, ELF1, BARD1, FANCD2, PALB2, RAD23A, RBBP8, C11orf30, HMG20B (normal)

STAD (tumor)	STAD (normal)
BRCA2, TP53, PLK1, HDAC1, FLNA, RAD51, CDK1, SKP2, ABL1, SIRT1, CHEK2, BUB1B, CCNA2, ELF1, AURKB, FANCG, H2AFX, FANCD2, KIF4A, MORF4L1, XRCC3 (tumor)	BRCA2, BRCA1, PLK1, FLNA, RAD51, CDK1, CDK2, CCNE1, BRCC3, SKP2, ATR, CHEK2, BUB1B, CCNA2, ELF1, AURKB, BARD1, FANCD2, PALB2, KIF4A, XRCC3 (normal)

THCA (tumor)	THCA (normal)
BRCA2, SIRT3, PLK1, FLNA, RAD51, CDK1, CDK2, TCF4, FYN, BUB1B, CCNA2, ATM, SIRT2, ELF1, AURKB, BARD1, STAT5A, FANCD2, DMC1, KIF4A, BACH1 (tumor)	BRCA2, SP1, SIRT3, FLNA, RAD51, CDK2, BRCC3, MGMT, SIRT1, BUB1B, SHFM1, ATM, ELF1, BARD1, FANCD2, PALB2, RBBP8, C11orf30, KIF4A, BACH1, HMG20B (normal)

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TissGeneProg for BRCA2

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for BRCA2

TissGeneDrug for BRCA2

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for BRCA2

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0006142	Malignant neoplasm of breast	1358	BeFree,GAD,GWASCAT,MGD,UNIPROT
umls:C0678222	Breast Carcinoma	1211	BeFree
umls:C1140680	Malignant neoplasm of ovary	818	BeFree,CLINVAR,GAD
umls:C0029925	Ovarian Carcinoma	808	BeFree
umls:C1458155	Mammary Neoplasms	226	BeFree,CTD_human,GAD,LHGDN
umls:C0346153	Breast Cancer, Familial	192	BeFree,CLINVAR,GAD
umls:C0919267	ovarian neoplasm	118	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0677776	Hereditary Breast and Ovarian Cancer Syndrome	115	BeFree,CLINVAR,CTD_human,ORPHANET
umls:C0376358	Malignant neoplasm of prostate	87	BeFree,CLINVAR,GAD
umls:C0600139	Prostate carcinoma	78	BeFree
umls:C0015625	Fanconi Anemia	74	BeFree,CTD_human,GAD,LHGDN,ORPHANET
umls:C0242787	Malignant neoplasm of male breast	73	BeFree
umls:C0235974	Pancreatic carcinoma	70	BeFree
umls:C0346647	Malignant neoplasm of pancreas	70	BeFree,GAD
umls:C0024667	Animal Mammary Neoplasms	62	GAD
umls:C3469521	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	59	BeFree
umls:C0238033	Carcinoma of Male Breast	56	BeFree,GAD
umls:C0596263	Carcinogenesis	55	BeFree
umls:C1336076	Sporadic Breast Carcinoma	52	BeFree
umls:C0677886	Epithelial ovarian cancer	48	BeFree,GAD
umls:C1096616	Contralateral breast cancer	30	BeFree
umls:C1333990	Hereditary Nonpolyposis Colorectal Cancer	26	BeFree
umls:C0025202	melanoma	24	BeFree,GAD
umls:C0007104	Female Breast Carcinoma	22	BeFree
umls:C0235653	Malignant neoplasm of female breast	22	BeFree
umls:C0027627	Neoplasm Metastasis	20	BeFree
umls:C0007124	Noninfiltrating Intraductal Carcinoma	19	BeFree,GAD,LHGDN
umls:C3539878	Triple Negative Breast Neoplasms	18	BeFree
umls:C0009402	Colorectal Carcinoma	17	BeFree
umls:C1527249	Colorectal Cancer	17	BeFree,GAD
umls:C1333600	Hereditary Malignant Neoplasm	16	BeFree
umls:C2931038	Pancreatic carcinoma, familial	16	BeFree,ORPHANET
umls:C0238122	Fallopian Tube Carcinoma	15	BeFree
umls:C0242788	Breast Neoplasms, Male	14	BeFree,GAD,LHGDN
umls:C0281267	bilateral breast cancer	14	BeFree
umls:C0853879	Invasive breast carcinoma	14	BeFree
umls:C0008626	Congenital chromosomal disease	12	BeFree
umls:C0030297	Pancreatic Neoplasm	12	BeFree,CTD_human,GAD,LHGDN
umls:C0153467	Malignant tumor of peritoneum	11	BeFree
umls:C0153579	Malignant neoplasm of fallopian tube	11	BeFree
umls:C1710547	Unilateral Breast Carcinoma	11	BeFree
umls:C0033578	Prostatic Neoplasms	10	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0281361	Adenocarcinoma of pancreas	10	BeFree
umls:C0015558	Fallopian Tube Neoplasms	9	GAD,LHGDN
umls:C0023418	leukemia	9	BeFree,LHGDN
umls:C0035335	Retinoblastoma	9	BeFree
umls:C0242379	Malignant neoplasm of lung	9	BeFree,GAD,GWASCAT
umls:C0476089	Endometrial Carcinoma	9	BeFree
umls:C1854365	BREAST CANCER 3	9	BeFree
umls:C0001418	Adenocarcinoma	7	BeFree,GAD,LHGDN
umls:C0004135	Ataxia Telangiectasia	7	BeFree
umls:C0024623	Malignant neoplasm of stomach	7	BeFree,GAD
umls:C0085390	Li-Fraumeni Syndrome	7	BeFree,LHGDN
umls:C2931456	Prostate cancer, familial	7	BeFree,ORPHANET
umls:C0007103	Malignant neoplasm of endometrium	6	BeFree
umls:C0007137	Squamous cell carcinoma	6	BeFree,GAD,LHGDN
umls:C0024299	Lymphoma	6	BeFree,GAD
umls:C0178874	Tumor Progression	6	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	6	BeFree
umls:C0699791	Stomach Carcinoma	6	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	6	BeFree
umls:C1883486	Uterine Corpus Cancer	6	BeFree
umls:C3839280	High grade serous carcinoma	6	BeFree
umls:C0007102	Malignant tumor of colon	5	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	5	BeFree,GAD
umls:C0027672	Neoplastic Syndromes, Hereditary	5	BeFree,CLINVAR,GAD
umls:C0031149	Peritoneal Neoplasms	5	BeFree,GAD
umls:C0206701	Cystadenocarcinoma, Serous	5	BeFree,GAD
umls:C0699790	Colon Carcinoma	5	BeFree
umls:C0014859	Esophageal Neoplasms	4	BeFree,GAD
umls:C0018553	Hamartoma Syndrome, Multiple	4	BeFree
umls:C0024301	Lymphoma, Follicular	4	BeFree,GAD
umls:C0278704	Malignant Childhood Neoplasm	4	BeFree
umls:C0280100	Solid tumour	4	BeFree
umls:C0546837	Malignant neoplasm of esophagus	4	BeFree,GAD
umls:C0684249	Carcinoma of lung	4	BeFree
umls:C0699889	Malignant Female Reproductive System Neoplasm	4	BeFree
umls:C0003469	Anxiety Disorders	3	BeFree
umls:C0009375	Colonic Neoplasms	3	BeFree,GAD
umls:C0012860	DNA Damage	3	GAD
umls:C0023467	Leukemia, Myelocytic, Acute	3	BeFree
umls:C0025149	Medulloblastoma	3	BeFree,CLINVAR,CTD_human
umls:C0027626	Neoplasm Invasiveness	3	GAD
umls:C0032927	Precancerous Conditions	3	GAD
umls:C0037286	Skin Neoplasms	3	GAD
umls:C0151779	Cutaneous Melanoma	3	BeFree
umls:C0152018	Esophageal carcinoma	3	BeFree
umls:C0220633	Uveal melanoma	3	BeFree,GAD
umls:C0278488	Carcinoma breast stage IV	3	BeFree
umls:C0278689	Ovarian epithelial cancer recurrent	3	BeFree
umls:C0278996	Cancer of Head and Neck	3	BeFree,GAD
umls:C0497327	Dementia	3	BeFree
umls:C0558356	Malignant melanoma of eye	3	BeFree
umls:C0948303	Carcinoma of peritoneum	3	BeFree
umls:C1168401	Squamous cell carcinoma of the head and neck	3	BeFree
umls:C1512981	Mammary Tumorigenesis	3	BeFree
umls:C1838457	FANCONI ANEMIA, COMPLEMENTATION GROUP D1	3	BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C1861906	Breast Cancer, Familial Male	3	BeFree
umls:C2239176	Liver carcinoma	3	BeFree
umls:C0004509	Azoospermia	2	BeFree,GAD,LHGDN
umls:C0005684	Malignant neoplasm of urinary bladder	2	GAD
umls:C0006118	Brain Neoplasms	2	BeFree,GAD
umls:C0007222	Cardiovascular Diseases	2	BeFree
umls:C0007621	Neoplastic Cell Transformation	2	GAD
umls:C0009404	Colorectal Neoplasms	2	GAD
umls:C0011265	Presenile dementia	2	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	2	BeFree
umls:C0014170	Endometrial Neoplasms	2	GAD,LHGDN
umls:C0018923	Hemangiosarcoma	2	BeFree
umls:C0023903	Liver neoplasms	2	BeFree
umls:C0025500	Mesothelioma	2	BeFree
umls:C0027643	Neoplasm Recurrence, Local	2	GAD
umls:C0027663	Neoplasms, Multiple Primary	2	GAD
umls:C0027708	Nephroblastoma	2	BeFree,CTD_human,GAD
umls:C0028960	Oligospermia	2	BeFree,GAD
umls:C0029463	Osteosarcoma	2	BeFree,RGD
umls:C0031269	Peutz-Jeghers Syndrome	2	BeFree
umls:C0032580	Adenomatous Polyposis Coli	2	BeFree
umls:C0042162	Uveal Neoplasms	2	GAD
umls:C0079744	Diffuse Large B-Cell Lymphoma	2	BeFree,GAD
umls:C0154084	Stage 0 Breast Carcinoma	2	BeFree
umls:C0205747	Familial Atypical Multiple Mole-Melanoma	2	BeFree
umls:C0206692	Carcinoma, Lobular	2	BeFree,GAD
umls:C0238339	Hereditary pancreatitis	2	BeFree
umls:C0276496	Familial Alzheimer Disease (FAD)	2	BeFree
umls:C0424605	Developmental delay (disorder)	2	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	2	BeFree
umls:C0677898	invasive cancer	2	BeFree
umls:C0685938	Malignant neoplasm of gastrointestinal tract	2	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	2	BeFree
umls:C0861727	Pancreatic adenocarcinoma metastatic	2	BeFree
umls:C0862506	Borderline ovarian tumour	2	BeFree
umls:C0878500	Intraepithelial Neoplasia	2	BeFree
umls:C1134719	Invasive Ductal Breast Carcinoma	2	BeFree,GAD
umls:C1168327	High-Grade Prostatic Intraepithelial Neoplasia	2	BeFree
umls:C1176475	Ductal Carcinoma	2	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	2	BeFree
umls:C1333992	Hereditary Ovarian Carcinoma	2	BeFree
umls:C1516170	Cancer Cell Growth	2	BeFree
umls:C1520166	Xenograft Model	2	BeFree
umls:C1559271	Non-Malignant Ascites Adverse Event	2	BeFree
umls:C1856689	FRIEDREICH ATAXIA 1	2	BeFree
umls:C2675080	Li-Fraumeni-Like Syndrome	2	BeFree
umls:C2931822	Nasopharyngeal carcinoma	2	BeFree
umls:C2936791	Antley-Bixler Syndrome, Autosomal Dominant	2	BeFree
umls:C2986665	Early-Stage Breast Carcinoma	2	BeFree
umls:C3549742	Breast cancer, lobular	2	BeFree
umls:C0000786	Spontaneous abortion	1	GAD
umls:C0001815	Primary Myelofibrosis	1	BeFree
umls:C0002453	Amenorrhea	1	BeFree
umls:C0005586	Bipolar Disorder	1	BeFree
umls:C0005859	Bloom Syndrome	1	BeFree
umls:C0007095	Carcinoid Tumor	1	BeFree
umls:C0007107	Malignant neoplasm of larynx	1	BeFree
umls:C0007115	Malignant neoplasm of thyroid	1	BeFree
umls:C0007117	Basal cell carcinoma	1	GAD
umls:C0007133	Carcinoma, Papillary	1	BeFree
umls:C0011847	Diabetes	1	BeFree
umls:C0011849	Diabetes Mellitus	1	BeFree
umls:C0013336	Dwarfism	1	BeFree
umls:C0014175	Endometriosis	1	LHGDN
umls:C0015414	Eye Neoplasms	1	GAD
umls:C0016412	Folic Acid Deficiency	1	BeFree
umls:C0016667	Fragile X Syndrome	1	BeFree
umls:C0017185	Gastrointestinal Neoplasms	1	GAD
umls:C0017638	Glioma	1	CTD_human,GAD
umls:C0018206	granulosa cell tumor	1	BeFree
umls:C0018418	Gynecomastia	1	BeFree
umls:C0019829	Hodgkin Disease	1	GAD
umls:C0021364	Male infertility	1	BeFree,GAD
umls:C0022116	Ischemia	1	BeFree
umls:C0023530	Leukopenia	1	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	1	GAD
umls:C0024121	Lung Neoplasms	1	CTD_human
umls:C0024236	Lymphedema	1	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	1	GAD
umls:C0025267	Multiple Endocrine Neoplasia Type 1	1	BeFree
umls:C0025286	Meningioma	1	BeFree
umls:C0025517	Metabolic Diseases	1	BeFree
umls:C0026640	Mouth Neoplasms	1	GAD
umls:C0026769	Multiple Sclerosis	1	GAD
umls:C0026946	Mycoses	1	BeFree
umls:C0027066	Myoclonus	1	BeFree
umls:C0027404	Narcolepsy	1	GAD
umls:C0027654	Embryonal Neoplasm	1	BeFree
umls:C0027831	Neurofibromatosis 1	1	BeFree
umls:C0027947	Neutropenia	1	BeFree
umls:C0029928	Ovarian Diseases	1	GAD
umls:C0031117	Peripheral Neuropathy	1	CTD_human
umls:C0032002	Pituitary Diseases	1	BeFree
umls:C0032285	Pneumonia	1	BeFree
umls:C0033027	Preleukemia	1	BeFree
umls:C0036341	Schizophrenia	1	BeFree
umls:C0038644	Sudden infant death syndrome	1	BeFree
umls:C0041296	Tuberculosis	1	BeFree
umls:C0079731	B-Cell Lymphomas	1	LHGDN
umls:C0085136	Central Nervous System Neoplasms	1	BeFree
umls:C0085159	Seasonal Affective Disorder	1	BeFree
umls:C0085183	Neoplasms, Second Primary	1	GAD
umls:C0086132	Depressive Symptoms	1	BeFree
umls:C0086543	Cataract	1	RGD
umls:C0149782	Squamous cell carcinoma of lung	1	BeFree
umls:C0152013	Adenocarcinoma of lung (disorder)	1	BeFree
umls:C0153567	Uterine Cancer	1	BeFree
umls:C0153653	Malignant tumor of parathyroid gland	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0153690	Secondary malignant neoplasm of bone	1	BeFree
umls:C0162872	Aortic Aneurysm, Thoracic	1	BeFree
umls:C0206663	Neuroectodermal Tumor, Primitive	1	BeFree
umls:C0206681	Adenocarcinoma, Clear Cell	1	BeFree
umls:C0206684	Sebaceous Adenocarcinoma	1	BeFree
umls:C0206685	Acinar Cell Carcinoma	1	BeFree
umls:C0206720	Squamous Cell Neoplasms	1	CTD_human
umls:C0260037	Multiple tumors	1	BeFree
umls:C0270814	Spastic syndrome	1	BeFree
umls:C0279628	Adenocarcinoma Of Esophagus	1	BeFree
umls:C0279661	Acinar cell carcinoma of pancreas	1	BeFree
umls:C0279980	Extraosseous Ewings sarcoma-primitive neuroepithelial tumor	1	BeFree
umls:C0280220	stage, ovarian epithelial cancer	1	BeFree
umls:C0280324	Laryngeal Squamous Cell Carcinoma	1	BeFree
umls:C0302592	Cervix carcinoma	1	BeFree
umls:C0333463	Senile Plaques	1	BeFree
umls:C0334359	Papillary serous cystadenocarcinoma	1	BeFree
umls:C0334371	Secretory breast carcinoma	1	BeFree
umls:C0338457	Aphasia, Progressive	1	BeFree
umls:C0342276	Maturity onset diabetes mellitus in young	1	BeFree
umls:C0342573	PITUITARY DWARFISM I	1	BeFree,CLINVAR
umls:C0346156	Benign neoplasm of breast	1	BeFree
umls:C0346648	Malignant tumor of exocrine pancreas	1	BeFree
umls:C0347176	Carcinoma in situ of fallopian tube	1	BeFree
umls:C0376545	Hematologic Neoplasms	1	LHGDN
umls:C0376628	Chromosome Breakage	1	GAD
umls:C0392998	Carcinosarcoma of ovary	1	BeFree
umls:C0398623	Thrombophilia	1	BeFree
umls:C0424091	Loss of interest	1	BeFree
umls:C0521158	Recurrent tumor	1	BeFree
umls:C0524851	Neurodegenerative Disorders	1	BeFree
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0684337	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	1	BeFree
umls:C0687150	Parathyroid Gland Adenocarcinoma	1	BeFree
umls:C0740380	Varicella zoster	1	BeFree
umls:C0750901	Alzheimer Disease, Early Onset	1	BeFree
umls:C0751416	Pelvic Cancer	1	BeFree
umls:C0751690	Malignant Peripheral Nerve Sheath Tumor	1	BeFree
umls:C0751887	Medullary Neoplasms	1	BeFree
umls:C0752347	Lewy Body Disease	1	BeFree
umls:C0815107	psychological distress	1	BeFree
umls:C0854917	Rhabdoid Tumor of the Kidney	1	BeFree
umls:C0887833	Carcinoma, Pancreatic Ductal	1	BeFree
umls:C1112474	Small cell carcinoma of esophagus	1	BeFree
umls:C1261473	Sarcoma	1	BeFree
umls:C1266082	Atypical medullary carcinoma	1	BeFree
umls:C1301034	Pancreatic intraepithelial neoplasia	1	BeFree
umls:C1318485	Liver regeneration disorder	1	BeFree
umls:C1332442	BRCA1 Syndrome	1	BeFree
umls:C1333991	Hereditary Non-Polyposis Colon Cancer Type 2	1	BeFree
umls:C1334274	Invasive Carcinoma	1	BeFree
umls:C1334411	Locally Metastatic Malignant Neoplasm	1	BeFree
umls:C1335177	Ovarian Serous Adenocarcinoma	1	BeFree
umls:C1336048	Spinal Cord Primitive Neuroectodermal Tumor	1	BeFree
umls:C1336735	Treatment related acute myeloid leukaemia	1	BeFree
umls:C1514428	Primary Peritoneal Carcinoma	1	BeFree
umls:C1762616	Meningioma, benign, no ICD-O subtype	1	BeFree
umls:C1839780	FRAGILE X TREMOR/ATAXIA SYNDROME	1	BeFree
umls:C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	BeFree
umls:C2216702	malignant neoplasm of breast staging	1	BeFree
umls:C2314896	Familial Atypical Mole Melanoma Syndrome	1	BeFree
umls:C2936349	Plaque, Amyloid	1	BeFree
umls:C2986662	Multifocal Breast Carcinoma	1	BeFree
umls:C3274709	Contralateral Breast Carcinoma	1	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	BeFree
umls:C3536893	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	1	BeFree
umls:C3839507	Diminished ovarian reserve	1	BeFree
umls:C2675520	BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2	0	CLINVAR,CTD_human
umls:C2751641	GLIOMA SUSCEPTIBILITY 3	0	CLINVAR
umls:C3150546	PANCREATIC CANCER, SUSCEPTIBILITY TO, 2	0	CLINVAR