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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SST
check button Gene summary
Basic gene informationGene symbolSST
Gene namesomatostatin
SynonymsSMST
CytomapUCSC genome browser: 3q28
Type of geneprotein-coding
RefGenesNM_001048.3,
Descriptiongrowth hormone release-inhibiting factorprepro-somatostatinsomatostatin-14somatostatin-28
Modification date20141207
dbXrefs MIM : 182450
HGNC : HGNC
Ensembl : ENSG00000157005
HPRD : 08920
Vega : OTTHUMG00000156462
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SST
BioGPS: 6750
PathwayNCI Pathway Interaction Database: SST
KEGG: SST
REACTOME: SST
Pathway Commons: SST
ContextiHOP: SST
ligand binding site mutation search in PubMed: SST
UCL Cancer Institute: SST
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)PancreasStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAADSTAD
Reference showing the relevant tissue of SST
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SST

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD-1.811345783.930019604-5.7413653852.34E-184.66E-16
ESCA-2.099656273.517689185-5.6173454550.001210.016611358
STAD-0.0009599633.257796287-3.258756250.001510.007334752
PRAD-2.790093857-1.516932319-1.2731615380.002540.007223528


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TissGene-miRNA for SST

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SST
TissGeneSNV for SST

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R99QSKCM1
p.E64KPAAD1
p.E85APAAD1
p.D66NSKCM1
p.T63MGBM1
p.A9TSTAD1
p.R5CESCA1
p.R5HCESC1
p.P94LCOAD1
p.M82ILUSC1
p.A95PLUAD1
p.R101STHYM1
p.V16IBRCA1
p.A95HLUAD1
p.P94QPRAD1
p.T63MLUAD1
p.R101HCOAD1
p.A95DLUAD1
p.E100*UCEC1
p.E64KSKCM1


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TissGeneCNV for SST

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SST

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACA946867SST-NASPchr3:187386794chr1:46049819
Chimerdb3.0ChiTaRsNADB303581SST-ANKRD52chr3:187386808chr12:56636333
Chimerdb3.0ChiTaRsNAAK126893ANKRD52-SSTchr12:56648006chr3:187386705


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TissGeneNet for SST

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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COAD (tumor)COAD (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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HNSC (tumor)HNSC (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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KICH (tumor)KICH (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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KIRC (tumor)KIRC (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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KIRP (tumor)KIRP (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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LIHC (tumor)LIHC (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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LUAD (tumor)LUAD (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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LUSC (tumor)LUSC (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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PRAD (tumor)PRAD (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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STAD (tumor)STAD (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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THCA (tumor)THCA (normal)
SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (tumor)SST, SSTR3, ATF1, SSTR5, SSTR2, SSTR1, SSTR4 (normal)
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TissGeneProg for SST

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SST
TissGeneDrug for SST

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00847CysteamineBinderSmall moleculeApproved|Investigational


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TissGeneDisease for SST

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0206754Neuroendocrine Tumors32BeFree,LHGDN
umls:C0001206Acromegaly30BeFree
umls:C0032000Pituitary Adenoma30BeFree
umls:C0001430Adenoma25BeFree
umls:C0235974Pancreatic carcinoma21BeFree
umls:C0346647Malignant neoplasm of pancreas20BeFree
umls:C0032019Pituitary Neoplasms18BeFree
umls:C0006142Malignant neoplasm of breast17BeFree,GAD
umls:C0032002Pituitary Diseases16BeFree
umls:C0346302Growth Hormone-Secreting Pituitary Adenoma16BeFree
umls:C0678222Breast Carcinoma15BeFree
umls:C0007095Carcinoid Tumor14BeFree
umls:C0376358Malignant neoplasm of prostate14BeFree,GAD
umls:C0600139Prostate carcinoma14BeFree
umls:C0027819Neuroblastoma13BeFree
umls:C0700095Central neuroblastoma12BeFree
umls:C0238462Medullary carcinoma of thyroid11BeFree
umls:C0009402Colorectal Carcinoma9BeFree
umls:C0017638Glioma9BeFree
umls:C0596263Carcinogenesis9BeFree
umls:C0036341Schizophrenia8BeFree
umls:C1527249Colorectal Cancer8BeFree
umls:C2239176Liver carcinoma8BeFree
umls:C0001418Adenocarcinoma7BeFree,LHGDN
umls:C0007102Malignant tumor of colon7BeFree
umls:C0029925Ovarian Carcinoma7BeFree
umls:C0334299Carcinoid tumor no ICD-O subtype7BeFree
umls:C0699791Stomach Carcinoma7BeFree
umls:C0031511Pheochromocytoma6BeFree
umls:C1140680Malignant neoplasm of ovary6BeFree
umls:C0002395Alzheimer's Disease5BeFree,GAD,LHGDN
umls:C0021670insulinoma5BeFree
umls:C0024623Malignant neoplasm of stomach5BeFree
umls:C0025149Medulloblastoma5BeFree
umls:C0027627Neoplasm Metastasis5BeFree,LHGDN
umls:C0033375Prolactinoma5BeFree
umls:C0036572Seizures5BeFree,CTD_human
umls:C0919267ovarian neoplasm5BeFree,LHGDN
umls:C0006118Brain Neoplasms4BeFree
umls:C0030297Pancreatic Neoplasm4BeFree,CTD_human
umls:C0030421Paraganglioma4BeFree,LHGDN
umls:C0040136Thyroid Neoplasm4BeFree
umls:C0041696Unipolar Depression4BeFree
umls:C0149925Small cell carcinoma of lung4BeFree
umls:C0699790Colon Carcinoma4BeFree
umls:C1269683Major Depressive Disorder4BeFree
umls:C0001624Adrenal Gland Neoplasms3BeFree
umls:C0005586Bipolar Disorder3BeFree,GAD
umls:C0014175Endometriosis3BeFree,CTD_human
umls:C0024586Malignant Carcinoid Syndrome3BeFree
umls:C0025286Meningioma3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0279735TSH secreting adenoma3BeFree
umls:C0338656Impaired cognition3BeFree
umls:C0339143Thyroid associated opthalmopathies3BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0549473Thyroid carcinoma3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C1306214ACTH-Secreting Pituitary Adenoma3BeFree
umls:C1458155Mammary Neoplasms3BeFree
umls:C0004114Astrocytoma2BeFree
umls:C0007115Malignant neoplasm of thyroid2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0011884Diabetic Retinopathy2BeFree,LHGDN
umls:C0014556Epilepsy, Temporal Lobe2BeFree
umls:C0017150Gastrinoma2BeFree
umls:C0019693HIV Infections2BeFree
umls:C0020456Hyperglycemia2BeFree
umls:C0020538Hypertensive disease2BeFree,RGD
umls:C0023903Liver neoplasms2BeFree
umls:C0024121Lung Neoplasms2BeFree
umls:C0025202melanoma2BeFree
umls:C0025267Multiple Endocrine Neoplasia Type 12BeFree
umls:C0030193Pain2BeFree
umls:C0035309Retinal Diseases2BeFree
umls:C0036337Schizoaffective Disorder2BeFree
umls:C0036631Seminoma2BeFree
umls:C0040100Thymoma2BeFree
umls:C0085400Neurofibrillary degeneration (morphologic abnormality)2BeFree
umls:C0206663Neuroectodermal Tumor, Primitive2BeFree
umls:C0235782Gallbladder Carcinoma2BeFree
umls:C0278864Growth Hormone-Producing Pituitary Gland Neoplasm2BeFree
umls:C0338078Non-Functioning Pituitary Gland Neoplasm2BeFree
umls:C0494165Secondary malignant neoplasm of liver2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C0850666Helicobacter pylori infection2BeFree
umls:C1168401Squamous cell carcinoma of the head and neck2BeFree
umls:C1261473Sarcoma2BeFree
umls:C1319315Adenocarcinoma of large intestine2BeFree
umls:C1337013Differentiated Thyroid Gland Carcinoma2BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype2BeFree
umls:C0000786Spontaneous abortion1CTD_human
umls:C0001622Adrenal Gland Hyperfunction1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004352Autistic Disorder1BeFree
umls:C0004763Barrett Esophagus1BeFree,CTD_human
umls:C0006012Borderline Personality Disorder1BeFree
umls:C0006111Brain Diseases1BeFree
umls:C0006287Bronchopulmonary Dysplasia1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007129Merkel cell carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0007682CNS disorder1BeFree
umls:C0008489Chorea1BeFree
umls:C0009324Ulcerative Colitis1BeFree
umls:C0010678Cysticercosis1BeFree
umls:C0010709Cyst1BeFree
umls:C0011269Dementia, Vascular1RGD
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011993Vipoma1CTD_human
umls:C0012546Diphtheria1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0014038Encephalitis1BeFree
umls:C0014130Endocrine System Diseases1BeFree
umls:C0014132Endocrine Gland Neoplasms1BeFree
umls:C0014474Ependymoma1BeFree
umls:C0014849Esophageal and Gastric Varices1CTD_human
umls:C0014859Esophageal Neoplasms1CTD_human
umls:C0017075Ganglioneuroma1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0018021Goiter1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0018671Head and Neck Neoplasms1GAD
umls:C0019196Hepatitis C1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0020459Hyperinsulinism1BeFree
umls:C0020621Hypokalemia1CTD_human
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0022602Actinic keratosis1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024305Lymphoma, Non-Hodgkin1BeFree
umls:C0024899Mastocytosis1BeFree
umls:C0025284Meningeal Neoplasms1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0026766Multiple Organ Failure1CTD_human
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0027773Nesidioblastosis1BeFree
umls:C0027809Neurilemmoma1BeFree
umls:C0027830neurofibroma1BeFree
umls:C0027858Neuroma1BeFree
umls:C0028945oligodendroglioma1BeFree
umls:C0030305Pancreatitis1CTD_human
umls:C0031118Peripheral Nervous System Neoplasms1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0036323Schistosomiasis1BeFree
umls:C0036690Septicemia1BeFree
umls:C0037661Somatostatinoma1BeFree
umls:C0038220Status Epilepticus1BeFree
umls:C0038358Gastric ulcer1RGD
umls:C0042109Urticaria1BeFree
umls:C0042111Urticaria Pigmentosa1BeFree
umls:C0042133Uterine Fibroids1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085136Central Nervous System Neoplasms1BeFree
umls:C0085183Neoplasms, Second Primary1GAD
umls:C0085584Encephalopathies1BeFree
umls:C0086768Pancreatic Cholera1BeFree
umls:C0087169Withdrawal Symptoms1BeFree
umls:C0149782Squamous cell carcinoma of lung1BeFree
umls:C0153382Malignant neoplasm of oropharynx1BeFree
umls:C0154830Proliferative diabetic retinopathy1BeFree
umls:C0155789Bleeding esophageal varices1BeFree
umls:C0206019HIV Encephalopathy1BeFree
umls:C0206629Pulmonary Blastoma1BeFree
umls:C0206718Ganglioneuroblastoma1BeFree
umls:C0221232Welts1BeFree
umls:C0221406Pituitary-dependent Cushing's disease1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1BeFree
umls:C0238461Anaplastic thyroid carcinoma1BeFree
umls:C0242383Age related macular degeneration1BeFree
umls:C0243026Sepsis1BeFree,LHGDN
umls:C0262405brain dysfunction1BeFree
umls:C0267834Liver cyst1BeFree
umls:C0271051Macular retinal edema1LHGDN
umls:C0276548HIV encephalitis1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0334590Anaplastic Oligodendroglioma1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0432306Ichthyosis Bullosa of Siemens1BeFree
umls:C0442874Neuropathy1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0525045Mood Disorders1BeFree
umls:C0729233Dissecting aneurysm of the thoracic aorta1BeFree
umls:C0751396Well Differentiated Oligodendroglioma1BeFree
umls:C0751398Familial Olivopontocerebellar Atrophy1BeFree
umls:C0751689Peripheral Nerve Sheath Neoplasm1BeFree
umls:C0751690Malignant Peripheral Nerve Sheath Tumor1BeFree
umls:C0812413Malignant Pleural Mesothelioma1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1336538Supratentorial Primitive Neuroectodermal Tumor1BeFree
umls:C1368041Pancreatic Somatostatinoma1BeFree
umls:C1368066pancreatic gastrinoma1BeFree
umls:C1504404Hippocampal sclerosis1BeFree
umls:C1514422Primary Glioblastoma1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2063389Retroperitoneal liposarcoma1BeFree
umls:C2349952Oropharyngeal Carcinoma1BeFree
umls:C2931833Hyperinsulinemic hypoglycemia, familial, 21BeFree
umls:C2945759aggressive cancer1BeFree
umls:C3272528Small Intestinal Neuroendocrine Tumor1BeFree
umls:C3662483Allergic sensitization1BeFree
umls:C3714644Thymus Neoplasms1BeFree