TissGeneSummary for BRDT |
Gene summary |
Basic gene information | Gene symbol | BRDT |
Gene name | bromodomain, testis-specific | |
Synonyms | BRD6|CT9 | |
Cytomap | UCSC genome browser: 1p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001242805.2, NM_001242806.2,NM_001242807.2,NM_001242808.2,NM_001242810.2, NM_001726.4,NM_207189.3, | |
Description | RING3-like proteinbromodomain testis-specific proteincancer/testis antigen 9 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602144 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137948 | ||
HPRD : 03684 | ||
Vega : OTTHUMG00000010113 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BRDT | |
BioGPS: 676 | ||
Pathway | NCI Pathway Interaction Database: BRDT | |
KEGG: BRDT | ||
REACTOME: BRDT | ||
Pathway Commons: BRDT | ||
Context | iHOP: BRDT | |
ligand binding site mutation search in PubMed: BRDT | ||
UCL Cancer Institute: BRDT | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of BRDT | The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target. Bourova-Flin E, Chuffart F, Rousseaux S, Khochbin S. Cell J. 2017 Spring;19(Suppl 1):1-8. doi: 10.22074/cellj.2017.5060. Epub 2017 May 17. Review. (pmid:28580303) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for BRDT |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 2.448521707 | -0.439436914 | 2.887958621 | 3.76E-07 | 1.33E-06 |
HNSC | 0.587546245 | -0.784300266 | 1.371846512 | 0.00222 | 0.006759134 |
Top |
TissGene-miRNA for BRDT |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for BRDT |
TissGeneSNV for BRDT |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S748F | SKCM | 2 |
p.S821F | SKCM | 2 |
p.E282* | UCEC | 2 |
p.E462* | UCEC | 2 |
p.E335K | SKCM | 2 |
p.P109S | SKCM | 2 |
p.S823* | BLCA | 1 |
p.L534R | BLCA | 1 |
p.M346I | UCEC | 1 |
p.D931N | UCEC | 1 |
p.E370K | SKCM | 1 |
p.S708I | UCS | 1 |
p.R543K | SKCM | 1 |
p.K183R | LUAD | 1 |
p.K192N | LUAD | 1 |
p.P105S | SKCM | 1 |
p.Q363H | SARC | 1 |
p.D731N | LUAD | 1 |
p.P453S | SKCM | 1 |
p.S342F | SKCM | 1 |
p.A18T | HNSC | 1 |
p.K129N | STAD | 1 |
p.E345K | SKCM | 1 |
p.Q650H | LUAD | 1 |
p.S196L | CESC | 1 |
p.E103K | SKCM | 1 |
p.A432V | UCEC | 1 |
p.P178T | BLCA | 1 |
p.E431K | BLCA | 1 |
p.K71T | READ | 1 |
p.E429D | BLCA | 1 |
p.P542R | BRCA | 1 |
p.K56N | STAD | 1 |
p.E848X | KIRC | 1 |
p.V656I | HNSC | 1 |
p.V116F | LIHC | 1 |
p.E453A | UCEC | 1 |
p.L130S | STAD | 1 |
p.I279V | STAD | 1 |
p.S816L | CESC | 1 |
p.S58C | LUAD | 1 |
p.P688L | SKCM | 1 |
p.V347G | HNSC | 1 |
p.T940I | UCEC | 1 |
p.E504K | BLCA | 1 |
p.I322N | SKCM | 1 |
p.E64Q | BLCA | 1 |
p.L32I | SKCM | 1 |
p.D113V | STAD | 1 |
p.S455Y | PAAD | 1 |
p.K500T | COAD | 1 |
p.G626E | SKCM | 1 |
p.P182S | SKCM | 1 |
p.M388I | DLBC | 1 |
p.E23Q | THCA | 1 |
p.G320V | UCEC | 1 |
p.D227E | LUAD | 1 |
p.E176K | SKCM | 1 |
p.E592Q | UCEC | 1 |
p.T940K | GBM | 1 |
p.A366T | THYM | 1 |
p.D300E | LUAD | 1 |
p.K852M | ESCA | 1 |
p.A205T | UCEC | 1 |
p.A230S | SARC | 1 |
p.A89V | LUAD | 1 |
p.E771* | KIRC | 1 |
p.S200I | LUAD | 1 |
p.D712G | HNSC | 1 |
p.K246Q | UCEC | 1 |
p.K290N | STAD | 1 |
p.K195R | SKCM | 1 |
p.P653T | LUAD | 1 |
p.K835N | LUAD | 1 |
p.E743* | UCEC | 1 |
p.V192L | LUSC | 1 |
p.H734Y | BLCA | 1 |
p.D639G | HNSC | 1 |
p.A16V | LUAD | 1 |
p.E322K | SKCM | 1 |
p.R54C | BLCA | 1 |
p.E458K | SKCM | 1 |
p.K286N | STAD | 1 |
p.E592* | UCEC | 1 |
p.P609S | SKCM | 1 |
p.I283V | STAD | 1 |
p.G797R | SKCM | 1 |
p.F373L | OV | 1 |
p.R774Q | SKCM | 1 |
p.L491I | LUAD | 1 |
p.L491Q | KIRC | 1 |
p.K246N | READ | 1 |
p.E123D | UCEC | 1 |
p.S382Y | PAAD | 1 |
p.F289S | LUSC | 1 |
p.S415F | SKCM | 1 |
p.P678L | SKCM | 1 |
p.L607R | BLCA | 1 |
p.S428F | SKCM | 1 |
p.L564I | LUAD | 1 |
p.A665S | STAD | 1 |
p.I249N | SKCM | 1 |
p.S575* | HNSC | 1 |
p.V239I | ESCA | 1 |
p.V312I | GBM | 1 |
p.S459Y | PAAD | 1 |
p.V316I | ESCA | 1 |
p.R27* | STAD | 1 |
p.K483T | UCEC | 1 |
p.G813E | BLCA | 1 |
p.E385K | SKCM | 1 |
p.A142E | THCA | 1 |
p.D355N | BRCA | 1 |
p.D607Y | BLCA | 1 |
p.P509H | UCEC | 1 |
p.E818K | SKCM | 1 |
p.R419G | LUAD | 1 |
p.C501* | ACC | 1 |
p.E20* | KIRC | 1 |
p.E888* | UCEC | 1 |
p.K375N | COAD | 1 |
p.N410K | COAD | 1 |
p.Q862* | BLCA | 1 |
p.G398D | BRCA | 1 |
p.E370K | UCEC | 1 |
p.D97Y | THYM | 1 |
p.K110R | LUAD | 1 |
p.N679T | LUAD | 1 |
p.Y439H | SKCM | 1 |
p.Y512H | SKCM | 1 |
p.E418K | SKCM | 1 |
p.R922K | UCEC | 1 |
p.T371M | GBM | 1 |
p.P244H | STAD | 1 |
p.S545R | HNSC | 1 |
p.P225S | SKCM | 1 |
p.I449R | BLCA | 1 |
p.Q675H | LUAD | 1 |
p.G699E | SKCM | 1 |
p.P605L | SKCM | 1 |
p.V192L | UCEC | 1 |
p.T321A | LUSC | 1 |
p.V38L | CHOL | 1 |
p.R349H | HNSC | 1 |
p.K408M | LUAD | 1 |
p.E209* | BLCA | 1 |
p.S127I | LUAD | 1 |
p.C574X | ACC | 1 |
p.K213N | LUAD | 1 |
p.A204V | CESC | 1 |
p.P105T | BLCA | 1 |
p.Q7* | UCEC | 1 |
p.S472R | HNSC | 1 |
p.E297K | SKCM | 1 |
p.K908N | LUAD | 1 |
p.A742S | STAD | 1 |
p.C578X | ACC | 1 |
p.F172V | OV | 1 |
p.A219T | LGG | 1 |
p.K71N | UCEC | 1 |
p.V312I | COAD | 1 |
p.C636Y | LGG | 1 |
p.K268R | SKCM | 1 |
p.R543I | LUAD | 1 |
p.P248H | STAD | 1 |
p.H661Y | BLCA | 1 |
p.G872V | THYM | 1 |
p.V43F | LIHC | 1 |
p.N774D | DLBC | 1 |
p.E136X | READ | 1 |
p.S642T | LUAD | 1 |
p.R27Q | STAD | 1 |
p.A171T | CHOL | 1 |
p.S572L | UCEC | 1 |
p.Q826K | LUAD | 1 |
p.K515E | UCEC | 1 |
p.R6Q | SKCM | 1 |
p.Q185* | STAD | 1 |
p.S93R | LUAD | 1 |
p.E71K | SKCM | 1 |
p.Q935H | UCEC | 1 |
Top |
TissGeneCNV for BRDT |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for BRDT |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI520125 | BRDT-LANCL2 | chr1:92433748 | chr7:55459489 | |
Chimerdb3.0 | ChiTaRs | NA | AW367786 | PICALM-BRDT | chr11:85701967 | chr1:92444130 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A7-A26G-01A | MTF2-BRDT | Out-of-frame | Chr1:93545088 | Chr1:92469971 |
Top |
TissGeneNet for BRDT |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for BRDT |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for BRDT |
TissGeneDrug for BRDT |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for BRDT |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004509 | Azoospermia | 2 | BeFree,GAD |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0729353 | Subfertility | 1 | BeFree |