 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for AURKC |
 Gene summary |
| Basic gene information | Gene symbol | AURKC |
| Gene name | aurora kinase C | |
| Synonyms | AIE2|AIK3|ARK3|AurC|SPGF5|STK13|aurora-C | |
| Cytomap | UCSC genome browser: 19q13.43 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001015878.1, NM_001015879.1,NM_003160.2, | |
| Description | ARK-3aurora 3aurora-related kinase 3aurora/IPL1-related kinase 3aurora/IPL1/EG2 protein 2serine/threonine kinase 13 (aurora/IPL1-like)serine/threonine-protein kinase 13serine/threonine-protein kinase aurora-C | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603495 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105146 | ||
| HPRD : 04605 | ||
| Vega : OTTHUMG00000183106 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AURKC | |
| BioGPS: 6795 | ||
| Pathway | NCI Pathway Interaction Database: AURKC | |
| KEGG: AURKC | ||
| REACTOME: AURKC | ||
| Pathway Commons: AURKC | ||
| Context | iHOP: AURKC | |
| ligand binding site mutation search in PubMed: AURKC | ||
| UCL Cancer Institute: AURKC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of AURKC | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 15670791 | GO:0006468 | protein phosphorylation | 15670791 |
| Top |
| TissGeneExp for AURKC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for AURKC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for AURKC |
| TissGeneSNV for AURKC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L288M | UCEC | 1 |
| p.R298* | HNSC | 1 |
| p.R47H | UCEC | 1 |
| p.R125K | SKCM | 1 |
| p.P263S | PRAD | 1 |
| p.G50V | KIRC | 1 |
| p.E170Q | OV | 1 |
| p.E240D | HNSC | 1 |
| p.L194Q | BLCA | 1 |
| p.S77L | UCEC | 1 |
| p.Y276* | STAD | 1 |
| p.E131K | LUAD | 1 |
| p.G83* | LUAD | 1 |
| p.L206S | UCEC | 1 |
| p.E21K | CESC | 1 |
| p.R142C | LAML | 1 |
| p.M191I | READ | 1 |
| p.Q133H | HNSC | 1 |
| p.T111M | COAD | 1 |
| p.E93Q | BLCA | 1 |
| p.R298* | LUAD | 1 |
| p.R55H | READ | 1 |
| p.T198A | LUSC | 1 |
| p.Q133E | HNSC | 1 |
| p.R298Q | STAD | 1 |
| p.H290L | STAD | 1 |
| p.T26A | STAD | 1 |
| p.Q141H | LUAD | 1 |
| p.R142L | CHOL | 1 |
| p.H86R | LUAD | 1 |
| p.R91K | SKCM | 1 |
| p.R275* | LUAD | 1 |
| p.R61L | STAD | 1 |
| p.S188F | SKCM | 1 |
| p.M210I | PRAD | 1 |
| p.A285V | SKCM | 1 |
| p.S261A | OV | 1 |
| p.F76V | READ | 1 |
| p.E240Q | BLCA | 1 |
| p.N171T | ESCA | 1 |
| p.R250L | HNSC | 1 |
| p.P303S | SKCM | 1 |
| p.D42G | STAD | 1 |
| p.V69M | HNSC | 1 |
| p.V162L | BLCA | 1 |
| p.R281I | BLCA | 1 |
| p.S43L | READ | 1 |
| p.S154F | SKCM | 1 |
| p.P259L | SKCM | 1 |
| p.P67H | COAD | 1 |
| p.P225L | SKCM | 1 |
| p.G83V | HNSC | 1 |
| p.R115W | SKCM | 1 |
| p.E148* | LUAD | 1 |
| p.R47C | STAD | 1 |
| p.Y236F | STAD | 1 |
| Top |
| TissGeneCNV for AURKC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for AURKC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A03V-01A | PPP6R1-AURKC | 5'UTR-CDS | chr19:55769802 | chr19:57743400 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A03V-01A | PPP6R1-AURKC | 5UTR-CDS | Chr19:55769803 | Chr19:57743401 |
| Top |
| TissGeneNet for AURKC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (tumor) | AURKC, NEDD4, CENPA, NEDD4L, LNX1, INCENP, BIRC5, HDAC8, TACC2 (normal) |
 |  |
| Top |
| TissGeneProg for AURKC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for AURKC |
| TissGeneDrug for AURKC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for AURKC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0021364 | Male infertility | 3 | BeFree,CTD_human,GAD |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree,GAD |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0346429 | Multiple malignancy | 1 | BeFree |
| umls:C0553573 | Primary infertility | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1527349 | Ductal Breast Carcinoma | 1 | BeFree |
| umls:C0403812 | Male Infertility with Large-Headed, Multiflagellar, Polyploid Spermatozoa | 0 | CLINVAR,CTD_human,ORPHANET |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |