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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for STX1A
check button Gene summary
Basic gene informationGene symbolSTX1A
Gene namesyntaxin 1A (brain)
SynonymsHPC-1|P35-1|STX1|SYN1A
CytomapUCSC genome browser: 7q11.23
Type of geneprotein-coding
RefGenesNM_001165903.1,
NM_004603.3,
Descriptionneuron-specific antigen HPC-1syntaxin-1A
Modification date20141214
dbXrefs MIM : 186590
HGNC : HGNC
Ensembl : ENSG00000106089
HPRD : 01721
Vega : OTTHUMG00000137422
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STX1A
BioGPS: 6804
PathwayNCI Pathway Interaction Database: STX1A
KEGG: STX1A
REACTOME: STX1A
Pathway Commons: STX1A
ContextiHOP: STX1A
ligand binding site mutation search in PubMed: STX1A
UCL Cancer Institute: STX1A
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BrainOvary
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGGOV
Reference showing the relevant tissue of STX1A
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0032940secretion by cell12130530
GO:0032940secretion by cell12130530


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TissGeneExp for STX1A

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC0.04748138-1.4949539141.5424352941.39E-148.09E-14
COAD0.655787036-0.9479206561.6037076925.83E-106.79E-09
BRCA-0.279683274-1.3187841521.0391008776.36E-204.49E-19
HNSC0.227366195-1.6696175261.8969837211.16E-173.26E-15
KIRP-0.619040128-1.7027245031.0836843754.54E-062.02E-05
LUAD1.04405136-1.8176520892.8617034483.25E-251.39E-23
LIHC-1.669654503-2.9662185031.2965644.98E-131.07E-11
ESCA1.199330043-0.4839426841.6832727270.0006890.011267176
BLCA0.823133392-0.2969297661.1200631580.0007390.005485867


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TissGene-miRNA for STX1A

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for STX1A
TissGeneSNV for STX1A

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A280TESCA1
p.M131IESCA1
p.M229LHNSC1
p.A220TCOAD1
p.R148PSTAD1
p.D25HKIRC1
p.R41GSKCM1
p.R28CHNSC1
p.S240*LUAD1
p.S250LHNSC1
p.D214NUCEC1
p.A247DTHYM1
p.E224DSARC1
p.T71ALIHC1
p.D31NPRAD1
p.D112YHNSC1
p.E170DHNSC1
p.N66HSTAD1
p.R108HREAD1
p.I203MBLCA1
p.S185FSKCM1
p.E194KHNSC1


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TissGeneCNV for STX1A

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for STX1A

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for STX1A

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
STX1A, ABCC9, RNF40, STXBP1, CDK5, SEPT5, VAMP8, SCNN1A, VIM, SDCBP, UNC13B, SYT7, KCNB1, CPLX1, VAMP7, ATP6V1B1, SCNN1G, STXBP2, SEPT2, CACNA1D, STXBP6 (tumor)STX1A, PPP1CA, MDM2, ABCC9, STXBP1, CDK5, SEPT5, SYT4, SNAP25, NSF, SDCBP, RAB27A, SNAP23, CPLX1, NAPA, VAMP7, STXBP5, STXBP2, SEPT2, SYP, CPLX2 (normal)
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COAD (tumor)COAD (normal)
STX1A, PPP1CA, ABCC9, STXBP1, SEPT5, SYT4, SCNN1A, SNAP25, VAMP2, NSF, VIM, DAPK1, VAMP1, SYT1, KCNB1, STXBP2, SYP, SLC6A9, CPLX2, TXLNB, SNPH (tumor)STX1A, CFTR, MDM2, SNAP29, RNF40, CDK5, SYT4, APBA1, SNAP25, NSF, RAB27A, VAMP1, SNAP23, CPLX1, SLC6A3, VAMP7, ATP6V1B1, STXBP2, SYP, STXBP6, CPLX2 (normal)
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HNSC (tumor)HNSC (normal)
STX1A, CSNK2A1, STXBP1, SEPT5, SCNN1B, SNAP25, VAMP2, NSF, SLC6A4, TRDMT1, VAPB, SDCBP, RIMS1, SYT7, SLC6A1, CPLX1, VAMP7, STXBP5, VPS18, CPLX2, SNPH (tumor)STX1A, VPS11, CSNK2A2, PPP1CA, MDM2, SCNN1B, SCNN1A, NSF, SLC6A4, TXLNA, SDCBP, UNC13B, DAPK1, SNAP23, SYT7, VAMP7, STXBP5, ATP6V1B1, STX8, SLC6A9, CACNA1D (normal)
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KICH (tumor)KICH (normal)
STX1A, ABCC9, SNAP29, SYTL4, SLC6A4, VAPB, TXLNA, SDCBP, RAB27A, DAPK1, VAMP1, SNAP23, SYT1, SLC6A1, CPLX1, VAMP7, STXBP5, ATP6V1B1, SCNN1G, SLC6A9, STXBP6 (tumor)STX1A, CSNK2A1, VPS11, PPP1CA, RNF40, SLC6A2, CDK5, SEPT5, APBA1, SCNN1A, VAMP2, SLC6A4, VIM, RAB27A, UNC13B, VAMP1, VAMP7, CACNA1D, CPLX2, TXLNB, SNPH (normal)
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KIRC (tumor)KIRC (normal)
STX1A, RNF40, STXBP1, APBA1, SYTL4, SCNN1A, VAPB, TXLNA, VIM, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SNAP23, SYT7, KCNB1, CPLX1, VAMP7, SLC6A9, SNPH (tumor)STX1A, PPP1CA, SNAP29, RNF40, CDK5, SEPT5, VAMP8, NSF, TRDMT1, VAPB, TXLNA, VAMP1, SNAP23, SYT1, SLC6A1, CPLX1, NAPA, VAMP7, SYP, SLC6A9, SNPH (normal)
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KIRP (tumor)KIRP (normal)
STX1A, CSNK2A1, CSNK2A2, SCNN1B, SYTL4, SCNN1A, VAMP2, VAPB, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SLC6A1, CPLX1, NAPA, SLC6A3, VAMP7, SCNN1G, SYP, STXBP6 (tumor)STX1A, CSNK2A1, VPS11, PPP1CA, SNAP29, STXBP1, CDK5, SEPT5, SYTL4, SCNN1A, NSF, VAPB, TXLNA, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SNAP23, VAMP7, VPS18 (normal)
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LIHC (tumor)LIHC (normal)
STX1A, CSNK2A1, PPP1CA, ABCC9, SLC6A2, SEPT5, VAMP8, SCNN1A, SNAP25, NSF, TRDMT1, VAPB, VIM, SDCBP, UNC13B, SYT7, SLC6A1, VAMP7, STXBP2, SEPT2, STXBP6 (tumor)STX1A, PPP1CA, CFTR, ABCC9, SNAP29, CDK5, SEPT5, VAMP8, APBA1, SNAP25, TRDMT1, SYT1, SLC6A1, KCNB1, SLC6A3, VAMP7, STXBP5, STXBP2, SEPT2, VPS18, SLC6A9 (normal)
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LUAD (tumor)LUAD (normal)
STX1A, VPS11, PPP1CA, MDM2, SNAP29, RNF40, STXBP1, VAMP8, APBA1, TXLNA, UNC13B, DAPK1, VAMP1, SNAP23, VAMP7, STXBP5, STX8, SEPT2, CACNA1D, STXBP6, CPLX2 (tumor)STX1A, PPP1CA, MDM2, ABCC9, RNF40, STXBP1, CDK5, SCNN1B, SYTL4, VAMP2, SLC6A4, TRDMT1, UNC13B, DAPK1, CPLX1, ATP6V1B1, SCNN1G, STXBP2, VPS18, CACNA1D, ATP4B (normal)
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LUSC (tumor)LUSC (normal)
STX1A, CSNK2A1, VPS11, CSNK2A2, SNAP29, RNF40, SEPT5, SNAP25, VAMP2, NSF, VAPB, TXLNA, SDCBP, DAPK1, VAMP1, SYT1, SLC6A1, CPLX1, VAMP7, STXBP2, SEPT2 (tumor)STX1A, PPP1CA, MDM2, RNF40, SLC6A2, SYT4, APBA1, SNAP25, NSF, SLC6A4, RIMS1, DAPK1, VAMP1, SNAP23, SYT7, CPLX1, VAMP7, ATP6V1B1, SYP, STXBP6, TXLNB (normal)
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PRAD (tumor)PRAD (normal)
STX1A, CSNK2A2, CFTR, RNF40, SLC6A2, SEPT5, SCNN1B, SCNN1A, TRDMT1, VAPB, UNC13B, VAMP1, KCNB1, SLC6A3, VAMP7, STXBP5, ATP6V1B1, STX8, SCNN1G, SEPT2, STXBP6 (tumor)STX1A, CSNK2A1, PPP1CA, MDM2, CDK5, SEPT5, SYT4, SCNN1B, NSF, TRDMT1, VAPB, RAB27A, RIMS1, VAMP1, SNAP23, KCNB1, CPLX1, VAMP7, STXBP5, ATP6V1B1, CPLX2 (normal)
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STAD (tumor)STAD (normal)
STX1A, CSNK2A1, MDM2, SYT4, SCNN1B, SNAP25, VAMP2, NSF, VIM, SDCBP, UNC13B, DAPK1, SYT1, SLC6A1, CPLX1, STXBP5, SYP, SLC6A9, STXBP6, CPLX2, SNPH (tumor)STX1A, CSNK2A1, MDM2, ABCC9, SNAP29, STXBP1, SCNN1A, SNAP25, SLC6A4, VAPB, VIM, RAB27A, SYT7, SYT1, CPLX1, SLC6A3, ATP6V1B1, SYP, CACNA1D, CPLX2, TXLNB (normal)
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THCA (tumor)THCA (normal)
STX1A, CSNK2A1, PPP1CA, MDM2, ABCC9, SNAP29, CDK5, SEPT5, VAMP8, APBA1, NSF, TRDMT1, VAPB, SNAP23, CPLX1, NAPA, VAMP7, STXBP5, STXBP2, SEPT2, SLC6A9 (tumor)STX1A, CSNK2A1, VPS11, PPP1CA, SNAP29, STXBP1, CDK5, NSF, TRDMT1, VAPB, VIM, RAB27A, UNC13B, CPLX1, VAMP7, STXBP5, ATP6V1B1, STXBP2, SEPT2, CACNA1D, STXBP6 (normal)
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TissGeneProg for STX1A

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for STX1A
TissGeneDrug for STX1A

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for STX1A

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0175702Williams Syndrome8BeFree
umls:C0302810Uremia syndrome8BeFree
umls:C0019061Hemolytic-Uremic Syndrome6BeFree
umls:C0011991Diarrhea5BeFree
umls:C0013371Shigella Infections4BeFree
umls:C0151594Hemorrhagic diarrhea4BeFree
umls:C0004352Autistic Disorder3BeFree,CTD_human,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0149931Migraine Disorders3BeFree,GAD
umls:C0036341Schizophrenia2BeFree,LHGDN
umls:C0302358Disease caused by Shigella dysenteriae2BeFree
umls:C1263846Attention deficit hyperactivity disorder2BeFree
umls:C0001430Adenoma1LHGDN
umls:C0002395Alzheimer's Disease1GAD
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0014544Epilepsy1GAD
umls:C0022661Kidney Failure, Chronic1GAD
umls:C0025362Mental Retardation1GAD
umls:C0028754Obesity1BeFree,GAD
umls:C0030521Parathyroid Neoplasms1LHGDN
umls:C0152517Enteritis due to specified virus1BeFree
umls:C0220669Familial benign neonatal epilepsy1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0238339Hereditary pancreatitis1BeFree
umls:C0270851Benign neonatal epilepsy1BeFree
umls:C0271650Impaired glucose tolerance1GAD,LHGDN
umls:C0275522Asymptomatic Infections1BeFree
umls:C0333516Tumor necrosis1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0497406Overweight1BeFree,GAD
umls:C0600427Cocaine Dependence1BeFree
umls:C1268936Diarrhea-associated hemolytic uremic syndrome1BeFree
umls:C3840214High-functioning autism1BeFree
umls:C0010674Cystic Fibrosis0ORPHANET