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| TissGeneSummary for STX1A |
 Gene summary |
| Basic gene information | Gene symbol | STX1A |
| Gene name | syntaxin 1A (brain) | |
| Synonyms | HPC-1|P35-1|STX1|SYN1A | |
| Cytomap | UCSC genome browser: 7q11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001165903.1, NM_004603.3, | |
| Description | neuron-specific antigen HPC-1syntaxin-1A | |
| Modification date | 20141214 | |
| dbXrefs | MIM : 186590 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106089 | ||
| HPRD : 01721 | ||
| Vega : OTTHUMG00000137422 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STX1A | |
| BioGPS: 6804 | ||
| Pathway | NCI Pathway Interaction Database: STX1A | |
| KEGG: STX1A | ||
| REACTOME: STX1A | ||
| Pathway Commons: STX1A | ||
| Context | iHOP: STX1A | |
| ligand binding site mutation search in PubMed: STX1A | ||
| UCL Cancer Institute: STX1A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGOV | |
| Reference showing the relevant tissue of STX1A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0032940 | secretion by cell | 12130530 | GO:0032940 | secretion by cell | 12130530 |
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| TissGeneExp for STX1A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.04748138 | -1.494953914 | 1.542435294 | 1.39E-14 | 8.09E-14 |
| COAD | 0.655787036 | -0.947920656 | 1.603707692 | 5.83E-10 | 6.79E-09 |
| BRCA | -0.279683274 | -1.318784152 | 1.039100877 | 6.36E-20 | 4.49E-19 |
| HNSC | 0.227366195 | -1.669617526 | 1.896983721 | 1.16E-17 | 3.26E-15 |
| KIRP | -0.619040128 | -1.702724503 | 1.083684375 | 4.54E-06 | 2.02E-05 |
| LUAD | 1.04405136 | -1.817652089 | 2.861703448 | 3.25E-25 | 1.39E-23 |
| LIHC | -1.669654503 | -2.966218503 | 1.296564 | 4.98E-13 | 1.07E-11 |
| ESCA | 1.199330043 | -0.483942684 | 1.683272727 | 0.000689 | 0.011267176 |
| BLCA | 0.823133392 | -0.296929766 | 1.120063158 | 0.000739 | 0.005485867 |
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| TissGene-miRNA for STX1A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for STX1A |
| TissGeneSNV for STX1A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A280T | ESCA | 1 |
| p.M131I | ESCA | 1 |
| p.M229L | HNSC | 1 |
| p.A220T | COAD | 1 |
| p.R148P | STAD | 1 |
| p.D25H | KIRC | 1 |
| p.R41G | SKCM | 1 |
| p.R28C | HNSC | 1 |
| p.S240* | LUAD | 1 |
| p.S250L | HNSC | 1 |
| p.D214N | UCEC | 1 |
| p.A247D | THYM | 1 |
| p.E224D | SARC | 1 |
| p.T71A | LIHC | 1 |
| p.D31N | PRAD | 1 |
| p.D112Y | HNSC | 1 |
| p.E170D | HNSC | 1 |
| p.N66H | STAD | 1 |
| p.R108H | READ | 1 |
| p.I203M | BLCA | 1 |
| p.S185F | SKCM | 1 |
| p.E194K | HNSC | 1 |
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| TissGeneCNV for STX1A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for STX1A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for STX1A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| STX1A, ABCC9, RNF40, STXBP1, CDK5, SEPT5, VAMP8, SCNN1A, VIM, SDCBP, UNC13B, SYT7, KCNB1, CPLX1, VAMP7, ATP6V1B1, SCNN1G, STXBP2, SEPT2, CACNA1D, STXBP6 (tumor) | STX1A, PPP1CA, MDM2, ABCC9, STXBP1, CDK5, SEPT5, SYT4, SNAP25, NSF, SDCBP, RAB27A, SNAP23, CPLX1, NAPA, VAMP7, STXBP5, STXBP2, SEPT2, SYP, CPLX2 (normal) |
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| COAD (tumor) | COAD (normal) |
| STX1A, PPP1CA, ABCC9, STXBP1, SEPT5, SYT4, SCNN1A, SNAP25, VAMP2, NSF, VIM, DAPK1, VAMP1, SYT1, KCNB1, STXBP2, SYP, SLC6A9, CPLX2, TXLNB, SNPH (tumor) | STX1A, CFTR, MDM2, SNAP29, RNF40, CDK5, SYT4, APBA1, SNAP25, NSF, RAB27A, VAMP1, SNAP23, CPLX1, SLC6A3, VAMP7, ATP6V1B1, STXBP2, SYP, STXBP6, CPLX2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| STX1A, CSNK2A1, STXBP1, SEPT5, SCNN1B, SNAP25, VAMP2, NSF, SLC6A4, TRDMT1, VAPB, SDCBP, RIMS1, SYT7, SLC6A1, CPLX1, VAMP7, STXBP5, VPS18, CPLX2, SNPH (tumor) | STX1A, VPS11, CSNK2A2, PPP1CA, MDM2, SCNN1B, SCNN1A, NSF, SLC6A4, TXLNA, SDCBP, UNC13B, DAPK1, SNAP23, SYT7, VAMP7, STXBP5, ATP6V1B1, STX8, SLC6A9, CACNA1D (normal) |
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| KICH (tumor) | KICH (normal) |
| STX1A, ABCC9, SNAP29, SYTL4, SLC6A4, VAPB, TXLNA, SDCBP, RAB27A, DAPK1, VAMP1, SNAP23, SYT1, SLC6A1, CPLX1, VAMP7, STXBP5, ATP6V1B1, SCNN1G, SLC6A9, STXBP6 (tumor) | STX1A, CSNK2A1, VPS11, PPP1CA, RNF40, SLC6A2, CDK5, SEPT5, APBA1, SCNN1A, VAMP2, SLC6A4, VIM, RAB27A, UNC13B, VAMP1, VAMP7, CACNA1D, CPLX2, TXLNB, SNPH (normal) |
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| KIRC (tumor) | KIRC (normal) |
| STX1A, RNF40, STXBP1, APBA1, SYTL4, SCNN1A, VAPB, TXLNA, VIM, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SNAP23, SYT7, KCNB1, CPLX1, VAMP7, SLC6A9, SNPH (tumor) | STX1A, PPP1CA, SNAP29, RNF40, CDK5, SEPT5, VAMP8, NSF, TRDMT1, VAPB, TXLNA, VAMP1, SNAP23, SYT1, SLC6A1, CPLX1, NAPA, VAMP7, SYP, SLC6A9, SNPH (normal) |
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| KIRP (tumor) | KIRP (normal) |
| STX1A, CSNK2A1, CSNK2A2, SCNN1B, SYTL4, SCNN1A, VAMP2, VAPB, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SLC6A1, CPLX1, NAPA, SLC6A3, VAMP7, SCNN1G, SYP, STXBP6 (tumor) | STX1A, CSNK2A1, VPS11, PPP1CA, SNAP29, STXBP1, CDK5, SEPT5, SYTL4, SCNN1A, NSF, VAPB, TXLNA, SDCBP, RAB27A, UNC13B, DAPK1, VAMP1, SNAP23, VAMP7, VPS18 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| STX1A, CSNK2A1, PPP1CA, ABCC9, SLC6A2, SEPT5, VAMP8, SCNN1A, SNAP25, NSF, TRDMT1, VAPB, VIM, SDCBP, UNC13B, SYT7, SLC6A1, VAMP7, STXBP2, SEPT2, STXBP6 (tumor) | STX1A, PPP1CA, CFTR, ABCC9, SNAP29, CDK5, SEPT5, VAMP8, APBA1, SNAP25, TRDMT1, SYT1, SLC6A1, KCNB1, SLC6A3, VAMP7, STXBP5, STXBP2, SEPT2, VPS18, SLC6A9 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| STX1A, VPS11, PPP1CA, MDM2, SNAP29, RNF40, STXBP1, VAMP8, APBA1, TXLNA, UNC13B, DAPK1, VAMP1, SNAP23, VAMP7, STXBP5, STX8, SEPT2, CACNA1D, STXBP6, CPLX2 (tumor) | STX1A, PPP1CA, MDM2, ABCC9, RNF40, STXBP1, CDK5, SCNN1B, SYTL4, VAMP2, SLC6A4, TRDMT1, UNC13B, DAPK1, CPLX1, ATP6V1B1, SCNN1G, STXBP2, VPS18, CACNA1D, ATP4B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| STX1A, CSNK2A1, VPS11, CSNK2A2, SNAP29, RNF40, SEPT5, SNAP25, VAMP2, NSF, VAPB, TXLNA, SDCBP, DAPK1, VAMP1, SYT1, SLC6A1, CPLX1, VAMP7, STXBP2, SEPT2 (tumor) | STX1A, PPP1CA, MDM2, RNF40, SLC6A2, SYT4, APBA1, SNAP25, NSF, SLC6A4, RIMS1, DAPK1, VAMP1, SNAP23, SYT7, CPLX1, VAMP7, ATP6V1B1, SYP, STXBP6, TXLNB (normal) |
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| PRAD (tumor) | PRAD (normal) |
| STX1A, CSNK2A2, CFTR, RNF40, SLC6A2, SEPT5, SCNN1B, SCNN1A, TRDMT1, VAPB, UNC13B, VAMP1, KCNB1, SLC6A3, VAMP7, STXBP5, ATP6V1B1, STX8, SCNN1G, SEPT2, STXBP6 (tumor) | STX1A, CSNK2A1, PPP1CA, MDM2, CDK5, SEPT5, SYT4, SCNN1B, NSF, TRDMT1, VAPB, RAB27A, RIMS1, VAMP1, SNAP23, KCNB1, CPLX1, VAMP7, STXBP5, ATP6V1B1, CPLX2 (normal) |
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| STAD (tumor) | STAD (normal) |
| STX1A, CSNK2A1, MDM2, SYT4, SCNN1B, SNAP25, VAMP2, NSF, VIM, SDCBP, UNC13B, DAPK1, SYT1, SLC6A1, CPLX1, STXBP5, SYP, SLC6A9, STXBP6, CPLX2, SNPH (tumor) | STX1A, CSNK2A1, MDM2, ABCC9, SNAP29, STXBP1, SCNN1A, SNAP25, SLC6A4, VAPB, VIM, RAB27A, SYT7, SYT1, CPLX1, SLC6A3, ATP6V1B1, SYP, CACNA1D, CPLX2, TXLNB (normal) |
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| THCA (tumor) | THCA (normal) |
| STX1A, CSNK2A1, PPP1CA, MDM2, ABCC9, SNAP29, CDK5, SEPT5, VAMP8, APBA1, NSF, TRDMT1, VAPB, SNAP23, CPLX1, NAPA, VAMP7, STXBP5, STXBP2, SEPT2, SLC6A9 (tumor) | STX1A, CSNK2A1, VPS11, PPP1CA, SNAP29, STXBP1, CDK5, NSF, TRDMT1, VAPB, VIM, RAB27A, UNC13B, CPLX1, VAMP7, STXBP5, ATP6V1B1, STXBP2, SEPT2, CACNA1D, STXBP6 (normal) |
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| TissGeneProg for STX1A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for STX1A |
| TissGeneDrug for STX1A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for STX1A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0175702 | Williams Syndrome | 8 | BeFree |
| umls:C0302810 | Uremia syndrome | 8 | BeFree |
| umls:C0019061 | Hemolytic-Uremic Syndrome | 6 | BeFree |
| umls:C0011991 | Diarrhea | 5 | BeFree |
| umls:C0013371 | Shigella Infections | 4 | BeFree |
| umls:C0151594 | Hemorrhagic diarrhea | 4 | BeFree |
| umls:C0004352 | Autistic Disorder | 3 | BeFree,CTD_human,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,GAD |
| umls:C0149931 | Migraine Disorders | 3 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 2 | BeFree,LHGDN |
| umls:C0302358 | Disease caused by Shigella dysenteriae | 2 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | LHGDN |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0014544 | Epilepsy | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0025362 | Mental Retardation | 1 | GAD |
| umls:C0028754 | Obesity | 1 | BeFree,GAD |
| umls:C0030521 | Parathyroid Neoplasms | 1 | LHGDN |
| umls:C0152517 | Enteritis due to specified virus | 1 | BeFree |
| umls:C0220669 | Familial benign neonatal epilepsy | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0270851 | Benign neonatal epilepsy | 1 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 1 | GAD,LHGDN |
| umls:C0275522 | Asymptomatic Infections | 1 | BeFree |
| umls:C0333516 | Tumor necrosis | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree,GAD |
| umls:C0600427 | Cocaine Dependence | 1 | BeFree |
| umls:C1268936 | Diarrhea-associated hemolytic uremic syndrome | 1 | BeFree |
| umls:C3840214 | High-functioning autism | 1 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 0 | ORPHANET |
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