TissGeneSummary for SULT1C2 |
Gene summary |
Basic gene information | Gene symbol | SULT1C2 |
Gene name | sulfotransferase family, cytosolic, 1C, member 2 | |
Synonyms | ST1C1|ST1C2|SULT1C1|humSULTC2 | |
Cytomap | UCSC genome browser: 2q12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001056.3, NM_176825.2, | |
Description | SULT1C#1sulfotransferase 1C1sulfotransferase 1C2sulfotransferase family, cytosolic, 1C, member 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602385 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198203 | ||
HPRD : 03858 | ||
Vega : OTTHUMG00000153215 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SULT1C2 | |
BioGPS: 6819 | ||
Pathway | NCI Pathway Interaction Database: SULT1C2 | |
KEGG: SULT1C2 | ||
REACTOME: SULT1C2 | ||
Pathway Commons: SULT1C2 | ||
Context | iHOP: SULT1C2 | |
ligand binding site mutation search in PubMed: SULT1C2 | ||
UCL Cancer Institute: SULT1C2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSTAD | |
Reference showing the relevant tissue of SULT1C2 | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051923 | sulfation | 20056724 | GO:0051923 | sulfation | 20056724 |
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TissGeneExp for SULT1C2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 3.817909882 | 5.327804327 | -1.509894444 | 1.89E-14 | 9.15E-14 |
LUSC | -0.754652944 | 1.357641173 | -2.112294118 | 1.21E-10 | 4.51E-10 |
COAD | 1.063049092 | -0.453054754 | 1.516103846 | 0.00322 | 0.00811855 |
KICH | 6.414112938 | 5.267308938 | 1.146804 | 0.00394 | 0.007610657 |
LIHC | 0.593976938 | -1.153911062 | 1.747888 | 0.00159 | 0.004149694 |
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TissGene-miRNA for SULT1C2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SULT1C2 |
TissGeneSNV for SULT1C2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E63Q | BLCA | 3 |
p.E36K | LUSC | 1 |
p.R156K | SKCM | 1 |
p.R241C | COAD | 1 |
p.R131Q | STAD | 1 |
p.M194I | ESCA | 1 |
p.D261G | UCEC | 1 |
p.W120X | SKCM | 1 |
p.E279K | HNSC | 1 |
p.R252C | SARC | 1 |
p.R217L | KIRP | 1 |
p.R131Q | SKCM | 1 |
p.E290K | HNSC | 1 |
p.D60G | UCEC | 1 |
p.R206W | COAD | 1 |
p.E57K | SKCM | 1 |
p.I175T | UCEC | 1 |
p.H198Y | LGG | 1 |
p.D6E | LUAD | 1 |
p.R252C | SKCM | 1 |
p.S265F | SKCM | 1 |
p.V180G | LGG | 1 |
p.S92T | LIHC | 1 |
p.P153T | LUSC | 1 |
p.D233H | BLCA | 1 |
p.I164T | UCEC | 1 |
p.E95K | HNSC | 1 |
p.E169G | OV | 1 |
p.V16E | HNSC | 1 |
p.T108S | DLBC | 1 |
p.K214N | LUSC | 1 |
p.V236I | LUAD | 1 |
p.E95K | SKCM | 1 |
p.R142Q | SKCM | 1 |
p.N28H | SKCM | 1 |
p.P91H | COAD | 1 |
p.D186N | BLCA | 1 |
p.A144S | ESCA | 1 |
p.G8E | SKCM | 1 |
p.E63X | ESCA | 1 |
p.R206L | KIRP | 1 |
p.P101S | STAD | 1 |
p.P128L | LAML | 1 |
p.D261V | LUAD | 1 |
p.R142Q | STAD | 1 |
p.S129Y | UCEC | 1 |
p.W131* | SKCM | 1 |
p.K107N | READ | 1 |
p.S102F | SKCM | 1 |
p.G166E | LUSC | 1 |
p.K232N | READ | 1 |
p.P81L | SKCM | 1 |
p.V168L | LGG | 1 |
p.E215D | SKCM | 1 |
p.P81S | SKCM | 1 |
p.D196N | BRCA | 1 |
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TissGeneCNV for SULT1C2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SULT1C2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SULT1C2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SULT1C2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SULT1C2 |
TissGeneDrug for SULT1C2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SULT1C2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002793 | Anaplasia | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | GAD |
umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C3887873 | Hearing Loss | 1 | GAD |