TissGeneSummary for SULT2A1 |
Gene summary |
Basic gene information | Gene symbol | SULT2A1 |
Gene name | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | |
Synonyms | DHEA-ST|DHEAS|HST|ST2|ST2A1|ST2A3|STD|hSTa | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_003167.3, | |
Description | alcohol/hydroxysteroid sulfotransferasebile salt sulfotransferasebile-salt sulfotranasferase 2A1 | |
Modification date | 20141211 | |
dbXrefs | MIM : 125263 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105398 | ||
HPRD : 00502 | ||
Vega : OTTHUMG00000162469 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SULT2A1 | |
BioGPS: 6822 | ||
Pathway | NCI Pathway Interaction Database: SULT2A1 | |
KEGG: SULT2A1 | ||
REACTOME: SULT2A1 | ||
Pathway Commons: SULT2A1 | ||
Context | iHOP: SULT2A1 | |
ligand binding site mutation search in PubMed: SULT2A1 | ||
UCL Cancer Institute: SULT2A1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of SULT2A1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051923 | sulfation | 20056724 | GO:0051923 | sulfation | 20056724 |
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TissGeneExp for SULT2A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 9.934238561 | 12.24007856 | -2.30584 | 1.98E-06 | 9.88E-06 |
STAD | -0.390138564 | 2.138220811 | -2.528359375 | 0.00669 | 0.024746398 |
PRAD | -2.4871489 | -0.96927967 | -1.517869231 | 0.000628 | 0.00212912 |
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TissGene-miRNA for SULT2A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SULT2A1 |
TissGeneSNV for SULT2A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R74Q | SKCM | 2 |
p.T90M | UCEC | 2 |
p.G46E | SKCM | 1 |
p.K141N | READ | 1 |
p.V239E | LUAD | 1 |
p.M228I | LUAD | 1 |
p.G17S | UCEC | 1 |
p.L54I | UCEC | 1 |
p.K255T | HNSC | 1 |
p.G169D | LUAD | 1 |
p.P278S | BLCA | 1 |
p.F18L | LUSC | 1 |
p.P172S | THYM | 1 |
p.R193K | BLCA | 1 |
p.L119F | SKCM | 1 |
p.W254C | COAD | 1 |
p.L50M | LUSC | 1 |
p.S129Y | LUAD | 1 |
p.R27C | UCEC | 1 |
p.L277F | STAD | 1 |
p.T15I | HNSC | 1 |
p.L181F | UCS | 1 |
p.E209K | SKCM | 1 |
p.W254X | SKCM | 1 |
p.G156E | SKCM | 1 |
p.G46V | LUAD | 1 |
p.S68F | SKCM | 1 |
p.S108Y | UCEC | 1 |
p.W254* | SKCM | 1 |
p.S75* | LUSC | 1 |
p.T85A | OV | 1 |
p.T259I | SKCM | 1 |
p.N212K | SKCM | 1 |
p.L269F | LUAD | 1 |
p.W7C | UCEC | 1 |
p.R193K | SKCM | 1 |
p.N217S | UCS | 1 |
p.V37I | LGG | 1 |
p.W134* | STAD | 1 |
p.E285K | SKCM | 1 |
p.W134X | STAD | 1 |
p.R124G | UCS | 1 |
p.P70S | STAD | 1 |
p.K224E | BLCA | 1 |
p.W284R | BLCA | 1 |
p.R24K | SKCM | 1 |
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TissGeneCNV for SULT2A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SULT2A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF130100 | SULT2A1-SERPINC1 | chr19:48374252 | chr1:173872947 | |
Chimerdb3.0 | ChiTaRs | NA | AI110855 | SULT2A1-SERPINC1 | chr19:48374252 | chr1:173883739 |
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TissGeneNet for SULT2A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SULT2A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SULT2A1 |
TissGeneDrug for SULT2A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01708 | Prasterone | Small molecule | Approved|Nutraceutical |
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TissGeneDisease for SULT2A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 6 | BeFree |
umls:C0018081 | Gonorrhea | 5 | BeFree |
umls:C0029928 | Ovarian Diseases | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C2239176 | Liver carcinoma | 4 | BeFree,LHGDN |
umls:C0004096 | Asthma | 3 | BeFree |
umls:C0017638 | Glioma | 3 | BeFree |
umls:C0032460 | Polycystic Ovary Syndrome | 3 | BeFree,GAD,LHGDN |
umls:C0151281 | Genital ulceration | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree,GAD |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree,GAD |
umls:C0009324 | Ulcerative Colitis | 2 | BeFree |
umls:C0009663 | Condylomata Acuminata | 2 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 2 | BeFree |
umls:C0013595 | Eczema | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0026764 | Multiple Myeloma | 2 | BeFree |
umls:C0039128 | Syphilis | 2 | BeFree |
umls:C0311389 | Nonspecific urethritis | 2 | BeFree |
umls:C0343641 | Human papilloma virus infection | 2 | BeFree |
umls:C0001627 | Congenital adrenal hyperplasia | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0004352 | Autistic Disorder | 1 | GAD |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0011991 | Diarrhea | 1 | BeFree |
umls:C0023290 | Leishmaniasis, Visceral | 1 | BeFree |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0027662 | Multiple Endocrine Neoplasia | 1 | BeFree |
umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
umls:C0033375 | Prolactinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0038015 | Spondyloepiphyseal Dysplasia | 1 | BeFree |
umls:C0080032 | Pleural Effusion, Malignant | 1 | BeFree |
umls:C0206081 | Hyperandrogenism | 1 | BeFree |
umls:C0206667 | Adrenal Cortical Adenoma | 1 | LHGDN |
umls:C0241934 | Hypomania | 1 | BeFree |
umls:C0265279 | Kniest dysplasia | 1 | BeFree |
umls:C0276093 | edema disease | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0338831 | Manic | 1 | BeFree |
umls:C0342492 | Adrenal hypertrophy or hyperplasia | 1 | BeFree |
umls:C0343752 | Acute HIV infection | 1 | BeFree |
umls:C0700345 | Candidiasis, Vulvovaginal | 1 | BeFree |
umls:C0729353 | Subfertility | 1 | BeFree |
umls:C0747249 | Paranoid ideation | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1621895 | Adrenal hyperplasia | 1 | BeFree |
umls:C2745959 | Spondyloepiphyseal dysplasia, congenita | 1 | BeFree |