TissGeneSummary for SUPV3L1 |
Gene summary |
Basic gene information | Gene symbol | SUPV3L1 |
Gene name | suppressor of var1, 3-like 1 (S. cerevisiae) | |
Synonyms | SUV3 | |
Cytomap | UCSC genome browser: 10q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001301683.1, NM_003171.4, | |
Description | ATP-dependent RNA helicase SUPV3L1, mitochondrialSUV3-like protein 1suppressor of var1, 3-like 1(SUV3) | |
Modification date | 20141207 | |
dbXrefs | MIM : 605122 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156502 | ||
HPRD : 05493 | ||
Vega : OTTHUMG00000018375 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SUPV3L1 | |
BioGPS: 6832 | ||
Pathway | NCI Pathway Interaction Database: SUPV3L1 | |
KEGG: SUPV3L1 | ||
REACTOME: SUPV3L1 | ||
Pathway Commons: SUPV3L1 | ||
Context | iHOP: SUPV3L1 | |
ligand binding site mutation search in PubMed: SUPV3L1 | ||
UCL Cancer Institute: SUPV3L1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisUterus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUCEC,UCS | |
Reference showing the relevant tissue of SUPV3L1 | ||
Description by TissGene annotations | Cancer gene TissgsLTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000962 | positive regulation of mitochondrial RNA catabolic process | 19509288 | GO:0006200 | ATP catabolic process | 19509288 | GO:0000962 | positive regulation of mitochondrial RNA catabolic process | 19509288 | GO:0006200 | ATP catabolic process | 19509288 |
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TissGeneExp for SUPV3L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SUPV3L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SUPV3L1 |
TissGeneSNV for SUPV3L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R383W | SKCM | 1 |
p.A300V | SKCM | 1 |
p.P34S | UCEC | 1 |
p.R610Q | ACC | 1 |
p.E457K | HNSC | 1 |
p.R656Q | UCEC | 1 |
p.P745S | SKCM | 1 |
p.L163V | UCEC | 1 |
p.A471S | LGG | 1 |
p.Y221* | UCEC | 1 |
p.E768K | CESC | 1 |
p.N600K | UCEC | 1 |
p.R29C | CESC | 1 |
p.E752Q | CESC | 1 |
p.S136F | SKCM | 1 |
p.L524V | HNSC | 1 |
p.R388Q | HNSC | 1 |
p.F100L | UCEC | 1 |
p.Q596R | LIHC | 1 |
p.S2F | DLBC | 1 |
p.I427F | LUAD | 1 |
p.L532F | READ | 1 |
p.F585C | COAD | 1 |
p.K749R | COAD | 1 |
p.G248_splice | OV | 1 |
p.D77N | BLCA | 1 |
p.S476L | BRCA | 1 |
p.D633H | LUSC | 1 |
p.Q706R | LIHC | 1 |
p.L405F | SKCM | 1 |
p.P250S | UCEC | 1 |
p.L319V | UCEC | 1 |
p.M747I | LUAD | 1 |
p.A23V | SKCM | 1 |
p.Q72* | HNSC | 1 |
p.A195V | STAD | 1 |
p.R777* | LIHC | 1 |
p.G509D | HNSC | 1 |
p.S732F | SKCM | 1 |
p.P87H | UCEC | 1 |
p.R259L | HNSC | 1 |
p.I187M | UCEC | 1 |
p.R777X | LIHC | 1 |
p.L625F | CESC | 1 |
p.M295I | KIRC | 1 |
p.P13S | LGG | 1 |
p.S51Y | THYM | 1 |
p.W607C | BLCA | 1 |
p.H205Y | SKCM | 1 |
p.D503N | BLCA | 1 |
p.L119I | PAAD | 1 |
p.E681G | SKCM | 1 |
p.S50F | SKCM | 1 |
p.R307S | LIHC | 1 |
p.A6T | PAAD | 1 |
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TissGeneCNV for SUPV3L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SUPV3L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI063294 | ACTB-SUPV3L1 | chr7:5567775 | chr10:70967584 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A03P-01A | UBR1-SUPV3L1 | In-frame | Chr15:43258351 | Chr10:70945743 |
TCGAfusionPortal | PRADA | OV | TCGA-36-1578-01A | SUPV3L1-VPS26A | In-frame | Chr10:70962799 | Chr10:70915568 |
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TissGeneNet for SUPV3L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SUPV3L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SUPV3L1 |
TissGeneDrug for SUPV3L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SUPV3L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002170 | Alopecia | 1 | CTD_human |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0020757 | Ichthyoses | 1 | BeFree,CTD_human |
umls:C0020758 | Congenital ichthyosis | 1 | BeFree |
umls:C0037268 | Skin Abnormalities | 1 | CTD_human |
umls:C0151514 | Atrophic condition of skin | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0872084 | Sarcopenia | 1 | CTD_human |
umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |