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| TissGeneSummary for SYCP1 |
 Gene summary |
| Basic gene information | Gene symbol | SYCP1 |
| Gene name | synaptonemal complex protein 1 | |
| Synonyms | CT8|HOM-TES-14|SCP-1|SCP1 | |
| Cytomap | UCSC genome browser: 1p13-p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001282541.1, NM_001282542.1,NM_003176.3,NR_104211.1, | |
| Description | cancer/testis antigen 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602162 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198765 | ||
| HPRD : 03698 | ||
| Vega : OTTHUMG00000012057 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SYCP1 | |
| BioGPS: 6847 | ||
| Pathway | NCI Pathway Interaction Database: SYCP1 | |
| KEGG: SYCP1 | ||
| REACTOME: SYCP1 | ||
| Pathway Commons: SYCP1 | ||
| Context | iHOP: SYCP1 | |
| ligand binding site mutation search in PubMed: SYCP1 | ||
| UCL Cancer Institute: SYCP1 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SYCP1 | A promoter fragment of the sycp1 gene is sufficient to drive transgene expression in male and female meiotic germ cells in zebrafish. Biol Reprod. 2013 Oct 17;89(4):89. doi: 10.1095/biolreprod.113.107706. Print 2013 Oct. (pmid:23966324) go to article | |
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SYCP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for SYCP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SYCP1 |
| TissGeneSNV for SYCP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R882K | SKCM | 5 |
| p.S374L | SKCM | 2 |
| p.W119X | SKCM | 2 |
| p.W808* | SKCM | 2 |
| p.E515K | SKCM | 2 |
| p.E509K | SKCM | 2 |
| p.E60K | SKCM | 2 |
| p.W119* | SKCM | 2 |
| p.P850L | SKCM | 1 |
| p.T337N | UCEC | 1 |
| p.L594V | UCS | 1 |
| p.G462E | SKCM | 1 |
| p.E435* | UCEC | 1 |
| p.R955H | SKCM | 1 |
| p.E442K | SKCM | 1 |
| p.I673M | LGG | 1 |
| p.E411X | COAD | 1 |
| p.L467R | COAD | 1 |
| p.D700N | SKCM | 1 |
| p.E775K | SKCM | 1 |
| p.D403A | UCEC | 1 |
| p.Q413* | SKCM | 1 |
| p.T423S | LIHC | 1 |
| p.R587I | UCEC | 1 |
| p.L228V | LUAD | 1 |
| p.E279K | UCEC | 1 |
| p.R236S | STAD | 1 |
| p.D284Y | UCEC | 1 |
| p.Q26E | CESC | 1 |
| p.N612K | LUAD | 1 |
| p.E507G | READ | 1 |
| p.N297K | LUSC | 1 |
| p.L511P | SKCM | 1 |
| p.L502I | READ | 1 |
| p.Y110C | LIHC | 1 |
| p.S743L | COAD | 1 |
| p.R822X | SKCM | 1 |
| p.E435D | COAD | 1 |
| p.T445I | BRCA | 1 |
| p.S941F | SKCM | 1 |
| p.E759X | KIRC | 1 |
| p.I327N | SKCM | 1 |
| p.N918H | COAD | 1 |
| p.R702X | READ | 1 |
| p.E290D | BLCA | 1 |
| p.K642_splice | UCEC | 1 |
| p.V687L | UCS | 1 |
| p.V384L | STAD | 1 |
| p.E256* | UCEC | 1 |
| p.A147P | HNSC | 1 |
| p.K220N | STAD | 1 |
| p.R771I | READ | 1 |
| p.K497N | SKCM | 1 |
| p.S366F | STAD | 1 |
| p.P49S | SKCM | 1 |
| p.I222V | KICH | 1 |
| p.I707R | DLBC | 1 |
| p.R392I | COAD | 1 |
| p.E411K | HNSC | 1 |
| p.P804H | LUAD | 1 |
| p.E315K | SKCM | 1 |
| p.Q585H | SKCM | 1 |
| p.Q655H | READ | 1 |
| p.Q26H | ESCA | 1 |
| p.K880* | HNSC | 1 |
| p.E759* | KIRC | 1 |
| p.A689S | SARC | 1 |
| p.E972K | BLCA | 1 |
| p.E482K | SKCM | 1 |
| p.R964K | ESCA | 1 |
| p.K92N | COAD | 1 |
| p.R952P | LUSC | 1 |
| p.E379K | SKCM | 1 |
| p.E731K | SKCM | 1 |
| p.E323X | READ | 1 |
| p.R474K | LUAD | 1 |
| p.L523V | LUAD | 1 |
| p.R145L | LUSC | 1 |
| p.R229C | SKCM | 1 |
| p.Q79_splice | LUSC | 1 |
| p.R822* | SKCM | 1 |
| p.L713F | LIHC | 1 |
| p.R702Q | GBM | 1 |
| p.S374* | UCEC | 1 |
| p.S832F | BLCA | 1 |
| p.E970G | LUAD | 1 |
| p.M962I | UCEC | 1 |
| p.E248* | SARC | 1 |
| p.P939S | SKCM | 1 |
| p.Q766K | PRAD | 1 |
| p.G101R | SKCM | 1 |
| p.E131K | SKCM | 1 |
| p.L936V | STAD | 1 |
| p.P25L | HNSC | 1 |
| p.K350T | UCEC | 1 |
| p.S744L | STAD | 1 |
| p.A67V | SKCM | 1 |
| p.R702Q | SKCM | 1 |
| p.R955H | COAD | 1 |
| p.E563* | UCEC | 1 |
| p.S417R | OV | 1 |
| p.S535R | COAD | 1 |
| p.R771K | HNSC | 1 |
| p.A371T | LGG | 1 |
| p.Y914N | HNSC | 1 |
| p.E498Q | BLCA | 1 |
| p.E454G | LGG | 1 |
| p.E399K | ESCA | 1 |
| p.G830D | LGG | 1 |
| p.R229S | LUAD | 1 |
| p.H829Q | LUSC | 1 |
| p.E168X | READ | 1 |
| p.L974X | ESCA | 1 |
| p.L756F | SKCM | 1 |
| p.E364Q | KIRP | 1 |
| p.T207I | STAD | 1 |
| p.M962I | SKCM | 1 |
| p.K400N | READ | 1 |
| p.L974* | ESCA | 1 |
| p.Q566E | LUAD | 1 |
| p.R204W | PAAD | 1 |
| p.E617* | UCEC | 1 |
| p.R952W | UCEC | 1 |
| p.L871F | BLCA | 1 |
| p.S496L | BRCA | 1 |
| p.D213N | SKCM | 1 |
| p.K642N | UCEC | 1 |
| p.S842F | BLCA | 1 |
| p.R229H | STAD | 1 |
| p.R952G | LUAD | 1 |
| p.H373D | CESC | 1 |
| p.S812Y | COAD | 1 |
| p.N401H | COAD | 1 |
| p.W808X | SKCM | 1 |
| p.K242T | STAD | 1 |
| p.S826L | LIHC | 1 |
| p.S754F | SKCM | 1 |
| p.S524L | SKCM | 1 |
| p.P75L | COAD | 1 |
| p.E290Q | BRCA | 1 |
| p.L810S | SKCM | 1 |
| p.R702* | SARC | 1 |
| p.P816S | SKCM | 1 |
| p.E343X | ESCA | 1 |
| p.K451E | BLCA | 1 |
| p.E449* | UCEC | 1 |
| p.A631T | UCEC | 1 |
| p.E459* | UCEC | 1 |
| p.E581K | BLCA | 1 |
| p.H318N | LUAD | 1 |
| p.F888L | SKCM | 1 |
| p.T517A | HNSC | 1 |
| p.F886I | LIHC | 1 |
| p.E2D | HNSC | 1 |
| p.R587K | SKCM | 1 |
| p.R474K | SKCM | 1 |
| p.L270Q | OV | 1 |
| p.E556K | HNSC | 1 |
| p.E556K | SKCM | 1 |
| p.K757N | LUAD | 1 |
| p.K339N | LUAD | 1 |
| p.E680* | LUAD | 1 |
| p.L900R | STAD | 1 |
| p.E675K | SKCM | 1 |
| p.E444K | SKCM | 1 |
| p.D793N | SKCM | 1 |
| p.D31N | HNSC | 1 |
| p.D722N | SKCM | 1 |
| p.Q867K | LUAD | 1 |
| p.R952Q | LUSC | 1 |
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| TissGeneCNV for SYCP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SYCP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW393520 | DYNC1LI2-SYCP1 | chr16:66756246 | chr1:115520197 |
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| TissGeneNet for SYCP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| COAD (tumor) | COAD (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| KICH (tumor) | KICH (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| STAD (tumor) | STAD (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| THCA (tumor) | THCA (normal) |
| SYCP1, UBC (tumor) | SYCP1, UBC (normal) |
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| TissGeneProg for SYCP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SYCP1 |
| TissGeneDrug for SYCP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SYCP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0153594 | Malignant neoplasm of testis | 4 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | CTD_human |
| umls:C0004509 | Azoospermia | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0028960 | Oligospermia | 1 | GAD |
| umls:C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| umls:C0030491 | Parapsoriasis | 1 | BeFree |
| umls:C0039101 | synovial sarcoma | 1 | BeFree |
| umls:C0043346 | Xeroderma Pigmentosum | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
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