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| TissGeneSummary for SYN1 |
 Gene summary |
| Basic gene information | Gene symbol | SYN1 |
| Gene name | synapsin I | |
| Synonyms | SYN1a|SYN1b|SYNI | |
| Cytomap | UCSC genome browser: Xp11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006950.3, NM_133499.2, | |
| Description | brain protein 4.1synapsin-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 313440 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000008056 | ||
| HPRD : 02433 | ||
| Vega : OTTHUMG00000021454 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SYN1 | |
| BioGPS: 6853 | ||
| Pathway | NCI Pathway Interaction Database: SYN1 | |
| KEGG: SYN1 | ||
| REACTOME: SYN1 | ||
| Pathway Commons: SYN1 | ||
| Context | iHOP: SYN1 | |
| ligand binding site mutation search in PubMed: SYN1 | ||
| UCL Cancer Institute: SYN1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of SYN1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SYN1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.12975478 | -3.458110712 | 2.328355932 | 1.61E-13 | 1.65E-12 |
| LIHC | -1.997654305 | -0.790786305 | -1.206868 | 0.000573 | 0.001648488 |
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| TissGene-miRNA for SYN1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SYN1 |
| TissGeneSNV for SYN1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G396D | SKCM | 2 |
| p.F148L | UCEC | 2 |
| p.G132R | SKCM | 1 |
| p.I363V | OV | 1 |
| p.Q450X | LIHC | 1 |
| p.R234* | UCEC | 1 |
| p.A230T | LIHC | 1 |
| p.T359M | UCEC | 1 |
| p.H188Y | STAD | 1 |
| p.M327I | LUAD | 1 |
| p.E243K | UCEC | 1 |
| p.T448A | STAD | 1 |
| p.H136N | LUAD | 1 |
| p.I247T | READ | 1 |
| p.F288L | SKCM | 1 |
| p.K378Q | CESC | 1 |
| p.P393L | LIHC | 1 |
| p.G396S | SKCM | 1 |
| p.P63A | BLCA | 1 |
| p.F161L | COAD | 1 |
| p.R693P | SKCM | 1 |
| p.R420W | STAD | 1 |
| p.K133N | LUAD | 1 |
| p.H433L | LUAD | 1 |
| p.F130L | UCEC | 1 |
| p.W335* | CESC | 1 |
| p.T298A | UCEC | 1 |
| p.T329A | UCEC | 1 |
| p.A155D | BLCA | 1 |
| p.A371T | UCEC | 1 |
| p.A112P | GBM | 1 |
| p.A155D | UCEC | 1 |
| p.P680A | LUAD | 1 |
| p.E242K | LUSC | 1 |
| p.F13L | UCEC | 1 |
| p.R234Q | READ | 1 |
| p.Y326C | COAD | 1 |
| p.G380R | UCEC | 1 |
| p.D140G | LIHC | 1 |
| p.A700G | LUAD | 1 |
| p.R693H | UCEC | 1 |
| p.Y252H | UCEC | 1 |
| p.R446H | COAD | 1 |
| p.N221K | LUAD | 1 |
| p.A208D | BRCA | 1 |
| p.P645L | OV | 1 |
| p.F182C | STAD | 1 |
| p.K311R | STAD | 1 |
| p.P33Q | LUAD | 1 |
| p.D313N | SKCM | 1 |
| p.T48I | TGCT | 1 |
| p.S177Y | UCEC | 1 |
| p.H274R | LUAD | 1 |
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| TissGeneCNV for SYN1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SYN1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BU620269 | SYN1-GM2A | chrX:47446188 | chr5:150647002 | |
| Chimerdb3.0 | ChiTaRs | NA | CD743038 | SYN1-DUSP3 | chrX:47446188 | chr17:41846479 | |
| Chimerdb3.0 | ChiTaRs | NA | DB258055 | SYN1-ADAMTS2 | chrX:47442862 | chr5:178581638 | |
| Chimerdb3.0 | ChiTaRs | NA | AI193580 | SYN1-ALDOC | chrX:47446190 | chr17:26900382 | |
| Chimerdb3.0 | ChiTaRs | NA | DB289761 | FAM120B-SYN1 | chr6:170654093 | chrX:47445377 | |
| Chimerdb3.0 | ChiTaRs | NA | BF948432 | SYN1-SYN1 | chrX:47466395 | chrX:47435924 | |
| Chimerdb3.0 | ChiTaRs | NA | AW897752 | SYN1-GAB1 | chrX:47431866 | chr4:144285231 | |
| Chimerdb3.0 | ChiTaRs | NA | AW965197 | SYN1-RDH14 | chrX:47446186 | chr2:18736702 | |
| Chimerdb3.0 | ChiTaRs | NA | BF824769 | SYN1-PDGFRB | chrX:47442882 | chr5:149505801 | |
| Chimerdb3.0 | ChiTaRs | NA | AI910121 | FARP1-SYN1 | chr13:99059419 | chrX:47445920 | |
| TCGAfusionPortal | PRADA | LGG | TCGA-CS-6669-01A | SYN1-ATAD1 | 3UTR-CDS | ChrX:47431303 | Chr10:89552512 |
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| TissGeneNet for SYN1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SYN1, PAK1, PLCG1, PRKACA, CAMK1, ITSN2, PFN2, CAMK2G, EGFR, NOS1AP, SYN2, MAPK3, CDK5, SPTAN1, BIN1, CRK, RASA1, VIM, REST, NOS1, SYN3 (tumor) | SYN1, PAK1, KAT5, SRC, PRKACA, CAMK1, SH3GL2, NCF1, PIK3R1, ITSN2, PARK2, PAK2, PFN2, SYN2, MAPK3, CDK5, SPTAN1, BLM, RASA1, REST, SYN3 (normal) |
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| COAD (tumor) | COAD (normal) |
| SYN1, PAK1, PLCG1, PRKACA, CAMK1, NCF1, PIK3R1, PAK3, PARK2, CAMK2G, SYN2, MAPK3, CDK5, SPTAN1, BIN1, CRK, BLM, S100A1, VIM, AMPH, NOS1 (tumor) | SYN1, PAK1, KAT5, PLCG1, GRB2, SRC, PRKACA, CAMK1, SH3GL2, PAK3, PFN2, CAMK2G, SYN2, CDK5, SPTAN1, CRK, S100A1, VIM, AMPH, NOS1, SYN3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SYN1, KAT5, PRKACA, CAMK1, PIK3R1, ITSN2, PAK3, PARK2, PFN2, CAMK2G, EGFR, SYN2, MAPK3, CDK5, BIN1, CRK, BLM, S100A1, VIM, AMPH, NOS1 (tumor) | SYN1, PLCG1, GRB2, SRC, PRKACA, CAMK1, SH3GL2, PIK3R1, ITSN2, PAK3, PARK2, PFN2, SYN2, MAPK3, BIN1, CRK, RASA1, S100A1, VIM, AMPH, SYN3 (normal) |
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| KICH (tumor) | KICH (normal) |
| SYN1, PAK1, GRB2, SRC, PRKACA, NCF1, PIK3R1, PAK3, PARK2, PFN2, CAMK2G, SYN2, CDK5, SPTAN1, BIN1, CRK, BLM, VIM, REST, AMPH, SYN3 (tumor) | SYN1, PAK1, PLCG1, SRC, PRKACA, CAMK1, ITSN2, PAK3, PARK2, PAK2, PFN2, EGFR, NOS1AP, SYN2, CDK5, BIN1, CRK, BLM, RASA1, REST, SYN3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SYN1, KAT5, PLCG1, PRKACA, SH3GL2, NCF1, PIK3R1, ITSN2, PAK3, PARK2, PAK2, PFN2, CAMK2G, SYN2, CDK5, SPTAN1, BLM, RASA1, VIM, AMPH, SYN3 (tumor) | SYN1, PAK1, KAT5, PLCG1, GRB2, SRC, PRKACA, CAMK1, ITSN2, PAK3, PARK2, PFN2, CAMK2G, SYN2, CDK5, BLM, RASA1, S100A1, VIM, AMPH, SYN3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SYN1, KAT5, PLCG1, SRC, PRKACA, SH3GL2, NCF1, PIK3R1, PAK3, PARK2, PAK2, PFN2, CAMK2G, MAPK3, CDK5, CRK, BLM, VIM, REST, AMPH, NOS1 (tumor) | SYN1, PAK1, KAT5, PLCG1, SRC, SH3GL2, PARK2, PAK2, PFN2, CAMK2G, EGFR, NOS1AP, SYN2, MAPK3, CDK5, BIN1, BLM, RASA1, VIM, REST, AMPH (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SYN1, KAT5, PLCG1, GRB2, SRC, PRKACA, SH3GL2, PIK3R1, PAK2, PFN2, CAMK2G, EGFR, SYN2, CDK5, SPTAN1, BIN1, CRK, RASA1, VIM, REST, AMPH (tumor) | SYN1, PAK1, KAT5, SRC, PRKACA, SH3GL2, NCF1, PIK3R1, PAK3, PARK2, PAK2, PFN2, NOS1AP, MAPK3, CDK5, BIN1, BLM, RASA1, S100A1, VIM, AMPH (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SYN1, PAK1, KAT5, PLCG1, GRB2, SRC, PRKACA, ITSN2, PAK3, PARK2, PAK2, CAMK2G, EGFR, NOS1AP, SYN2, CDK5, SPTAN1, CRK, VIM, REST, AMPH (tumor) | SYN1, PAK1, PLCG1, GRB2, SRC, PRKACA, SH3GL2, NCF1, PIK3R1, ITSN2, PAK3, PARK2, PFN2, CAMK2G, EGFR, NOS1AP, SYN2, CDK5, SPTAN1, VIM, AMPH (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SYN1, PAK1, KAT5, GRB2, SRC, PRKACA, SH3GL2, ITSN2, PAK3, PARK2, PAK2, CAMK2G, NOS1AP, SPTAN1, BIN1, BLM, RASA1, S100A1, VIM, AMPH, SYN3 (tumor) | SYN1, KAT5, PLCG1, PRKACA, SH3GL2, PAK3, PARK2, PAK2, PFN2, CAMK2G, EGFR, SYN2, MAPK3, CDK5, SPTAN1, BIN1, BLM, S100A1, VIM, AMPH, SYN3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SYN1, PAK1, PLCG1, GRB2, PRKACA, SH3GL2, NCF1, PARK2, PFN2, CAMK2G, EGFR, SYN2, MAPK3, SPTAN1, BIN1, CRK, RASA1, VIM, REST, AMPH, SYN3 (tumor) | SYN1, KAT5, PRKACA, NCF1, ITSN2, PAK3, PARK2, PAK2, CAMK2G, EGFR, NOS1AP, SYN2, MAPK3, SPTAN1, BIN1, RASA1, S100A1, VIM, REST, AMPH, SYN3 (normal) |
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| STAD (tumor) | STAD (normal) |
| SYN1, KAT5, PLCG1, PRKACA, CAMK1, SH3GL2, PIK3R1, PAK3, PARK2, PFN2, CAMK2G, SYN2, MAPK3, CDK5, SPTAN1, BIN1, BLM, VIM, AMPH, NOS1, SYN3 (tumor) | SYN1, PAK1, PLCG1, PRKACA, CAMK1, SH3GL2, PAK3, PARK2, PFN2, CAMK2G, SYN2, CDK5, BIN1, BLM, RASA1, S100A1, VIM, REST, AMPH, NOS1, SYN3 (normal) |
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| THCA (tumor) | THCA (normal) |
| SYN1, PAK1, KAT5, GRB2, CAMK1, NCF1, ITSN2, PARK2, PAK2, PFN2, EGFR, CDK5, BIN1, CRK, BLM, RASA1, S100A1, VIM, REST, NOS1, SYN3 (tumor) | SYN1, SRC, CAMK1, SH3GL2, NCF1, PARK2, PAK2, PFN2, CAMK2G, EGFR, NOS1AP, CDK5, SPTAN1, BIN1, BLM, RASA1, S100A1, VIM, AMPH, NOS1, SYN3 (normal) |
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| TissGeneProg for SYN1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SYN1 |
| TissGeneDrug for SYN1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SYN1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014544 | Epilepsy | 5 | BeFree |
| umls:C0004352 | Autistic Disorder | 3 | BeFree,MGD |
| umls:C0035372 | Rett Syndrome | 3 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 3 | BeFree |
| umls:C0014547 | Epilepsies, Partial | 2 | BeFree |
| umls:C0027819 | Neuroblastoma | 2 | BeFree |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C0700095 | Central neuroblastoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027126 | Myotonic Dystrophy | 1 | BeFree |
| umls:C0028945 | oligodendroglioma | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0236642 | Pick Disease of the Brain | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0338451 | Frontotemporal dementia | 1 | BeFree |
| umls:C0391957 | idiopathic epilepsy | 1 | BeFree |
| umls:C0410226 | Congenital Myotonic Dystrophy | 1 | BeFree |
| umls:C0454651 | Specific language impairment | 1 | BeFree |
| umls:C0524528 | Pervasive Development Disorder | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1845343 | Epilepsy, X-Linked, with Variable Learning Disabilities and Behavior Disorders | 0 | CLINVAR,CTD_human,MGD,ORPHANET |
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