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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TAT
check button Gene summary
Basic gene informationGene symbolTAT
Gene nametyrosine aminotransferase
Synonyms-
CytomapUCSC genome browser: 16q22.1
Type of geneprotein-coding
RefGenesNM_000353.2,
DescriptionL-tyrosine:2-oxoglutarate aminotransferasetyrosine aminotransferase, cytosolic
Modification date20141207
dbXrefs MIM : 613018
HGNC : HGNC
HPRD : 11776
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TAT
BioGPS: 6898
PathwayNCI Pathway Interaction Database: TAT
KEGG: TAT
REACTOME: TAT
Pathway Commons: TAT
ContextiHOP: TAT
ligand binding site mutation search in PubMed: TAT
UCL Cancer Institute: TAT
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of TATTwo liver-enriched trans-acting factors support the tissue-specific basal transcription from the rat tyrosine aminotransferase promoter. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):747-52. (pmid:1348627)
go to article
Description by TissGene annotationsSignificant down-regulated DEG
TissgsKTS
CNV lost TissGeneKTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:00061032-oxoglutarate metabolic process7999802
GO:0006536glutamate metabolic process7999802
GO:0006572tyrosine catabolic process7999802
GO:00061032-oxoglutarate metabolic process7999802
GO:0006536glutamate metabolic process7999802
GO:0006572tyrosine catabolic process7999802


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TissGeneExp for TAT

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD-2.6062754370.656128409-3.2624038464.86E-117.55E-10
BRCA1.370618225.752488396-4.3818701758.27E-164.55E-15
KICH-2.971137745-1.654869745-1.3162686.42E-072.49E-06
LIHC9.06693825511.90820826-2.841271.59E-071.06E-06


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TissGene-miRNA for TAT

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TAT
TissGeneSNV for TAT

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R367HGBM2
p.A430VCOAD2
p.E207KSKCM2
p.S193CBLCA1
p.E385KREAD1
p.H229YBLCA1
p.G290CLUAD1
p.V20MBRCA1
p.W194LCESC1
p.A58PCESC1
p.R37KSKCM1
p.W194*SKCM1
p.E182GUCEC1
p.G180RSKCM1
p.N54SSKCM1
p.E92KSKCM1
p.S103LSKCM1
p.R333CSKCM1
p.P67QLUAD1
p.E248DCESC1
p.A359DESCA1
p.E92DUCEC1
p.L346ROV1
p.R27KLUAD1
p.V419IUCEC1
p.A430VSTAD1
p.G325RSKCM1
p.R333HUCEC1
p.L343VSKCM1
p.S77FSKCM1
p.P423LSKCM1
p.M5ISKCM1
p.G32RSKCM1
p.A407TKICH1
p.P158RLUAD1
p.Y4HSTAD1
p.R333LLUAD1
p.S29FSKCM1
p.A39DSTAD1
p.M97IHNSC1
p.S369PTHYM1
p.C409FLIHC1
p.S112YLUSC1
p.D269NUCEC1
p.G325ESKCM1
p.R315SLUAD1
p.R119QKIRP1
p.R281CLUAD1
p.R281CUCEC1
p.R281LLUAD1
p.E424*ESCA1
p.T393MDLBC1
p.A100VSTAD1
p.E424XESCA1
p.E337QBLCA1
p.R306QUCEC1
p.P15SCOAD1
p.W291*SKCM1
p.E304KSKCM1
p.Y260CLIHC1
p.I244MHNSC1
p.E304KPAAD1
p.G180ESKCM1
p.D80NREAD1
p.R306*BLCA1
p.S256LSKCM1
p.N13KLUAD1
p.T321ISKCM1
p.A49TCOAD1
p.D61NSKCM1
p.K208TSTAD1
p.S16LSKCM1
p.M97ISKCM1
p.E191DUCEC1
p.D453NSKCM1
p.Q449LSKCM1
p.R57QKIRC1
p.E195KSTAD1
p.P3SOV1
p.R433QSKCM1
p.E411GLGG1


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TissGeneCNV for TAT

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TAT

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABG562569TAT-PPP2R1Bchr16:71601625chr11:111610550
TCGAfusionPortalPRADALGGTCGA-HT-7857-01AMAP9-TATCDS-5UTRChr4:156281320Chr16:71610330


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TissGeneNet for TAT

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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COAD (tumor)COAD (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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HNSC (tumor)HNSC (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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KICH (tumor)KICH (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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KIRC (tumor)KIRC (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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KIRP (tumor)KIRP (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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LIHC (tumor)LIHC (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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LUAD (tumor)LUAD (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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LUSC (tumor)LUSC (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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PRAD (tumor)PRAD (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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STAD (tumor)STAD (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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THCA (tumor)THCA (normal)
TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (tumor)TAT, HNF4A, ONECUT1, SETDB1, CDK9, SMARCA2, SUV39H1, SETDB2, EHMT2, NCOA2, SMARCB1, EP300, SMARCC2, CCNT1, SETMAR, GRN, SMARCC1, MDFIC (normal)
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TissGeneProg for TAT

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TAT
TissGeneDrug for TAT

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00135L-TyrosineSmall moleculeApproved|Nutraceutical


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TissGeneDisease for TAT

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019693HIV Infections209BeFree
umls:C0268487Tyrosine Transaminase Deficiency Disease11BeFree,CLINVAR,ORPHANET,UNIPROT
umls:C1518296Neuropathogenesis7BeFree
umls:C0162872Aortic Aneurysm, Thoracic6BeFree
umls:C0001175Acquired Immunodeficiency Syndrome5BeFree
umls:C0023418leukemia5BeFree
umls:C0019348Herpes Simplex Infections4BeFree
umls:C0268483Tyrosinemias4BeFree,CTD_human
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0023524Leukoencephalopathy, Progressive Multifocal3BeFree
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0079731B-Cell Lymphomas3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C1519680Tumor Immunity3BeFree
umls:C2239176Liver carcinoma3BeFree
umls:C0002736Amyotrophic Lateral Sclerosis2BeFree
umls:C0004114Astrocytoma2BeFree
umls:C0011570Mental Depression2BeFree
umls:C0011581Depressive disorder2BeFree
umls:C0013146Drug abuse2BeFree
umls:C0020429Hyperalgesia2BeFree
umls:C0023449Acute lymphocytic leukemia2BeFree
umls:C0025286Meningioma2BeFree
umls:C0025362Mental Retardation2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0280100Solid tumour2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0870082Hyperkeratosis2BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype2BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2BeFree
umls:C0003864Arthritis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0007785Cerebral Infarction1BeFree
umls:C0010692Cystitis1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0012739Disseminated Intravascular Coagulation1BeFree
umls:C0014057Japanese Encephalitis1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0017638Glioma1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0021367Mammary Ductal Carcinoma1BeFree
umls:C0022116Ischemia1BeFree
umls:C0022568Keratitis1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023976Long QT Syndrome1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024312Lymphopenia1BeFree
umls:C0025268Multiple Endocrine Neoplasia Type 2a1BeFree
umls:C0027796Neuralgia1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0030193Pain1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0036220Kaposi Sarcoma1BeFree
umls:C0036690Septicemia1BeFree
umls:C0039614Tetanus1BeFree
umls:C0078911AIDS-Associated Nephropathy1BeFree
umls:C0206754Neuroendocrine Tumors1BeFree
umls:C0235782Gallbladder Carcinoma1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0243026Sepsis1BeFree
umls:C0263641Epithelial hyperplasia of skin1BeFree
umls:C0266929Chronic Periodontitis1BeFree
umls:C0268125Purine-nucleoside phosphorylase deficiency1BeFree
umls:C0271650Impaired glucose tolerance1BeFree
umls:C0272375Antithrombin III Deficiency1BeFree
umls:C0275522Asymptomatic Infections1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0282607Vascular Neoplasms1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0344307Absence of pain sensation1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0525041Neurobehavioral Manifestations1BeFree
umls:C0553681Hypofibrinogenemia1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0751214Hyperalgesia, Thermal1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1516170Cancer Cell Growth1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1527349Ductal Breast Carcinoma1BeFree
umls:C1842981NEUROTICISM1BeFree
umls:C1879362Hypertyrosinemia1BeFree
umls:C2717961Thrombotic Microangiopathies1BeFree
umls:C2745900Promyelocytic leukemia1BeFree