TissGeneSummary for TDO2 |
Gene summary |
Basic gene information | Gene symbol | TDO2 |
Gene name | tryptophan 2,3-dioxygenase | |
Synonyms | TDO|TO|TPH2|TRPO | |
Cytomap | UCSC genome browser: 4q31-q32 | |
Type of gene | protein-coding | |
RefGenes | NM_005651.3, | |
Description | TDOTOTRPOtryptamin 2,3-dioxygenasetryptophan oxygenasetryptophan pyrrolasetryptophanase | |
Modification date | 20141211 | |
dbXrefs | MIM : 191070 | |
HGNC : HGNC | ||
Ensembl : ENSG00000151790 | ||
HPRD : 01847 | ||
Vega : OTTHUMG00000161838 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TDO2 | |
BioGPS: 6999 | ||
Pathway | NCI Pathway Interaction Database: TDO2 | |
KEGG: TDO2 | ||
REACTOME: TDO2 | ||
Pathway Commons: TDO2 | ||
Context | iHOP: TDO2 | |
ligand binding site mutation search in PubMed: TDO2 | ||
UCL Cancer Institute: TDO2 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of TDO2 | Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage. Eur Rev Med Pharmacol Sci. 2009 Mar;13 Suppl 1:71-8. (pmid:19530515) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TDO2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.277452004 | -1.798434203 | 2.075886207 | 1.27E-11 | 8.66E-11 |
BRCA | -0.803412183 | -4.333314814 | 3.529902632 | 1.83E-44 | 7.78E-43 |
THCA | -2.628017342 | -4.209371579 | 1.581354237 | 1.36E-05 | 4.32E-05 |
HNSC | -0.182374259 | -2.704948678 | 2.522574419 | 3.99E-08 | 4.23E-07 |
LIHC | 4.728298624 | 8.027482624 | -3.299184 | 1.25E-10 | 1.61E-09 |
STAD | -0.936126876 | -2.595683126 | 1.65955625 | 0.00121 | 0.006156765 |
ESCA | 0.367124261 | -4.248248467 | 4.615372727 | 2.51E-05 | 0.001388764 |
BLCA | -0.375402534 | -3.146270955 | 2.770868421 | 0.000123 | 0.001296455 |
LUSC | 0.585703762 | -0.548523689 | 1.134227451 | 0.000654 | 0.001243926 |
COAD | -0.08053553 | -1.522908606 | 1.442373077 | 0.000337 | 0.00108265 |
KIRC | -2.097844931 | -3.291124098 | 1.193279167 | 0.000102 | 0.000214229 |
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TissGene-miRNA for TDO2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TDO2 |
TissGeneSNV for TDO2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q197H | LUAD | 2 |
p.E69G | UCEC | 1 |
p.K16X | STAD | 1 |
p.T384S | LUAD | 1 |
p.L90M | LGG | 1 |
p.L204* | LUAD | 1 |
p.D139H | ACC | 1 |
p.R178I | STAD | 1 |
p.M331R | COAD | 1 |
p.H179L | LGG | 1 |
p.R334K | HNSC | 1 |
p.S345F | SKCM | 1 |
p.Y359C | PAAD | 1 |
p.K164N | READ | 1 |
p.T30A | BRCA | 1 |
p.V167A | COAD | 1 |
p.R272G | LUAD | 1 |
p.G337V | ESCA | 1 |
p.G219R | SKCM | 1 |
p.K16T | STAD | 1 |
p.K27N | COAD | 1 |
p.E404* | LUAD | 1 |
p.E89D | LUAD | 1 |
p.G38R | SKCM | 1 |
p.N382K | STAD | 1 |
p.Y399* | LUAD | 1 |
p.E236K | SKCM | 1 |
p.R117Q | DLBC | 1 |
p.G31A | HNSC | 1 |
p.G22C | THCA | 1 |
p.G337D | UCEC | 1 |
p.L202M | READ | 1 |
p.E270K | SKCM | 1 |
p.M294L | BLCA | 1 |
p.G337D | STAD | 1 |
p.R172T | LUSC | 1 |
p.L71I | COAD | 1 |
p.G43E | SKCM | 1 |
p.S319L | SKCM | 1 |
p.L365V | COAD | 1 |
p.D142Y | UCEC | 1 |
p.M171I | COAD | 1 |
p.H386Q | SKCM | 1 |
p.A35T | READ | 1 |
p.R211I | READ | 1 |
p.E187D | STAD | 1 |
p.Q197K | HNSC | 1 |
p.T134M | THYM | 1 |
p.R272C | PRAD | 1 |
p.L202M | ESCA | 1 |
p.L192V | KIRP | 1 |
p.I317T | BLCA | 1 |
p.K16* | STAD | 1 |
p.G8E | LUSC | 1 |
p.R181C | SKCM | 1 |
p.R181L | BLCA | 1 |
p.S401G | STAD | 1 |
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TissGeneCNV for TDO2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TDO2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG314637 | TDO2-GZMB | chr4:156830093 | chr14:25101153 |
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TissGeneNet for TDO2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TDO2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TDO2 |
TissGeneDrug for TDO2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TDO2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0041696 | Unipolar Depression | 13 | BeFree |
umls:C1269683 | Major Depressive Disorder | 13 | BeFree |
umls:C0003469 | Anxiety Disorders | 9 | BeFree |
umls:C0011570 | Mental Depression | 9 | BeFree |
umls:C0011581 | Depressive disorder | 9 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 9 | BeFree |
umls:C0036341 | Schizophrenia | 8 | BeFree,GAD |
umls:C0001973 | Alcoholic Intoxication, Chronic | 7 | BeFree |
umls:C0005586 | Bipolar Disorder | 7 | BeFree,GAD |
umls:C0004352 | Autistic Disorder | 5 | BeFree,CTD_human,LHGDN |
umls:C0852733 | Completed Suicide | 5 | BeFree |
umls:C0004930 | Behavior Disorders | 4 | BeFree |
umls:C0004936 | Mental disorders | 4 | BeFree |
umls:C0086132 | Depressive Symptoms | 4 | BeFree |
umls:C0028768 | Obsessive-Compulsive Disorder | 3 | BeFree |
umls:C0033975 | Psychotic Disorders | 3 | BeFree |
umls:C0040517 | Gilles de la Tourette syndrome | 3 | BeFree,GAD |
umls:C0006012 | Borderline Personality Disorder | 2 | BeFree |
umls:C0013473 | Eating Disorders | 2 | BeFree |
umls:C0018817 | Atrial Septal Defects | 2 | BeFree |
umls:C0036349 | Paranoid Schizophrenia | 2 | BeFree |
umls:C0038436 | Post-Traumatic Stress Disorder | 2 | BeFree |
umls:C0232600 | Self-induced vomiting | 2 | BeFree |
umls:C0525045 | Mood Disorders | 2 | BeFree |
umls:C1510586 | Autism Spectrum Disorders | 2 | BeFree |
umls:C0001956 | alcohol use disorder | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0003125 | Anorexia Nervosa | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
umls:C0011351 | Dental Enamel Hypoplasia | 1 | BeFree |
umls:C0011991 | Diarrhea | 1 | BeFree |
umls:C0015672 | Fatigue | 1 | BeFree |
umls:C0019337 | Heroin Dependence | 1 | BeFree |
umls:C0020505 | Hyperphagia | 1 | BeFree |
umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree |
umls:C0024523 | Malabsorption Syndrome | 1 | BeFree |
umls:C0026850 | Muscular Dystrophy | 1 | BeFree |
umls:C0031212 | Personality Disorders | 1 | BeFree |
umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
umls:C0032914 | Pre-Eclampsia | 1 | LHGDN |
umls:C0038187 | Starvation | 1 | CTD_human |
umls:C0038441 | Stress Disorders, Traumatic | 1 | BeFree |
umls:C0038443 | Stress, Psychological | 1 | BeFree |
umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
umls:C0149931 | Migraine Disorders | 1 | BeFree |
umls:C0220702 | SCHIZOPHRENIA 1 (disorder) | 1 | BeFree |
umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0338480 | Common Migraine | 1 | BeFree |
umls:C0338908 | Mixed anxiety and depressive disorder | 1 | BeFree |
umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
umls:C0432306 | Ichthyosis Bullosa of Siemens | 1 | BeFree |
umls:C0525041 | Neurobehavioral Manifestations | 1 | BeFree |
umls:C0600104 | Obsessive compulsive behavior | 1 | BeFree |
umls:C0865424 | Adult attention deficit hyperactivity disorder | 1 | BeFree |
umls:C1519680 | Tumor Immunity | 1 | BeFree |
umls:C1848140 | COGNITIVE FUNCTION 1, SOCIAL | 1 | BeFree |
umls:C2129214 | Loose stool | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |