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TissGeneSummary for TF |
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Basic gene information | Gene symbol | TF |
Gene name | transferrin | |
Synonyms | PRO1557|PRO2086|TFQTL1 | |
Cytomap | UCSC genome browser: 3q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001063.3, | |
Description | beta-1 metal-binding globulinserotransferrinsiderophilin | |
Modification date | 20141207 | |
dbXrefs | MIM : 190000 | |
HGNC : HGNC | ||
Ensembl : ENSG00000091513 | ||
HPRD : 01811 | ||
Vega : OTTHUMG00000150356 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TF | |
BioGPS: 7018 | ||
Pathway | NCI Pathway Interaction Database: TF | |
KEGG: TF | ||
REACTOME: TF | ||
Pathway Commons: TF | ||
Context | iHOP: TF | |
ligand binding site mutation search in PubMed: TF | ||
UCL Cancer Institute: TF | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCUVM | |
Reference showing the relevant tissue of TF | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for TF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -3.052395701 | -0.828553394 | -2.223842308 | 1.28E-06 | 7.08E-06 |
HNSC | -0.053180943 | 4.59747022 | -4.650651163 | 9.19E-15 | 6.15E-13 |
BRCA | 0.881255716 | 5.386408347 | -4.505152632 | 3.43E-34 | 5.99E-33 |
LIHC | 11.68953845 | 13.32902645 | -1.639488 | 1.46E-05 | 5.94E-05 |
KICH | -3.169607547 | -1.573483547 | -1.596124 | 1.27E-05 | 3.93E-05 |
THCA | -2.735069039 | -1.50213853 | -1.232930508 | 1.21E-05 | 3.88E-05 |
STAD | -1.762002672 | 0.254628578 | -2.01663125 | 0.00181 | 0.008445415 |
KIRP | -2.769477672 | -1.260346422 | -1.50913125 | 0.000332 | 0.001019649 |
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TissGene-miRNA for TF |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TF |
TissGeneSNV for TF |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R132* | SKCM | 2 |
p.K618N | BLCA | 1 |
p.P50L | SKCM | 1 |
p.S687L | SKCM | 1 |
p.L681P | COAD | 1 |
p.G547E | SKCM | 1 |
p.R42C | KIRC | 1 |
p.D633Y | LUAD | 1 |
p.A62S | COAD | 1 |
p.E394K | SKCM | 1 |
p.R273X | COAD | 1 |
p.D435N | SKCM | 1 |
p.V324A | LIHC | 1 |
p.M45I | SKCM | 1 |
p.A539T | UCEC | 1 |
p.Q555K | PRAD | 1 |
p.V13I | PRAD | 1 |
p.D109_splice | UCEC | 1 |
p.G383R | LUAD | 1 |
p.E337X | ESCA | 1 |
p.G294V | BLCA | 1 |
p.P164H | LUAD | 1 |
p.P266S | SKCM | 1 |
p.A605D | STAD | 1 |
p.S317C | HNSC | 1 |
p.K489N | LUAD | 1 |
p.P568L | STAD | 1 |
p.Q623K | LUAD | 1 |
p.R663K | LUSC | 1 |
p.R132X | COAD | 1 |
p.R103* | UCEC | 1 |
p.R273* | STAD | 1 |
p.E279K | SKCM | 1 |
p.P98L | SKCM | 1 |
p.A455S | LUSC | 1 |
p.G146V | LUAD | 1 |
p.C517S | LUAD | 1 |
p.F186L | SKCM | 1 |
p.E501D | STAD | 1 |
p.E672K | HNSC | 1 |
p.A594V | COAD | 1 |
p.K453X | READ | 1 |
p.F321Y | LUSC | 1 |
p.V5M | STAD | 1 |
p.K37M | LUAD | 1 |
p.C437F | OV | 1 |
p.P505H | LGG | 1 |
p.D77N | LUSC | 1 |
p.R273Q | BLCA | 1 |
p.L131I | HNSC | 1 |
p.E394K | COAD | 1 |
p.A72V | COAD | 1 |
p.S40N | LGG | 1 |
p.T269I | SKCM | 1 |
p.E352K | ESCA | 1 |
p.P482T | STAD | 1 |
p.E394K | UCEC | 1 |
p.C246Y | UCEC | 1 |
p.E370K | SKCM | 1 |
p.A145T | PAAD | 1 |
p.R475T | LUAD | 1 |
p.L573M | UCEC | 1 |
p.V451A | UCS | 1 |
p.L463M | LUAD | 1 |
p.D296Y | UCEC | 1 |
p.N235S | SKCM | 1 |
p.T586S | SKCM | 1 |
p.C656Y | HNSC | 1 |
p.D88A | HNSC | 1 |
p.P482L | SKCM | 1 |
p.R273X | STAD | 1 |
p.P307L | SKCM | 1 |
p.E32K | SKCM | 1 |
p.A594V | STAD | 1 |
p.G562E | SKCM | 1 |
p.R69G | STAD | 1 |
p.A263S | LUAD | 1 |
p.D395E | COAD | 1 |
p.R132X | SKCM | 1 |
p.E231D | READ | 1 |
p.D584Y | THYM | 1 |
p.K452N | UCEC | 1 |
p.E337Q | BRCA | 1 |
p.K399N | BLCA | 1 |
p.R162H | UVM | 1 |
p.T440I | UCEC | 1 |
p.P589S | COAD | 1 |
p.R609Q | SARC | 1 |
p.P150L | SKCM | 1 |
p.F498I | STAD | 1 |
p.A398S | LUSC | 1 |
p.E438K | THCA | 1 |
p.L165F | SKCM | 1 |
p.G309E | SKCM | 1 |
p.R273Q | UCEC | 1 |
p.K37E | UCEC | 1 |
p.P482S | SKCM | 1 |
p.L131F | STAD | 1 |
p.L165V | BRCA | 1 |
p.R132* | UCEC | 1 |
p.F113L | UCEC | 1 |
p.G562V | LUAD | 1 |
p.R42C | STAD | 1 |
p.N129K | BRCA | 1 |
p.K452T | ESCA | 1 |
p.C542F | ESCA | 1 |
p.P307S | SKCM | 1 |
p.S687L | LUSC | 1 |
p.A218V | THYM | 1 |
p.E75K | SKCM | 1 |
p.W363C | OV | 1 |
p.K61E | STAD | 1 |
p.T654R | SKCM | 1 |
p.R273Q | SKCM | 1 |
p.R26T | LUAD | 1 |
p.K331N | UCEC | 1 |
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TissGeneCNV for TF |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TF |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE766500 | TF-TTL | chr3:133485171 | chr2:113280709 | |
Chimerdb3.0 | ChiTaRs | NA | AF116645 | TF-ALB | chr3:133490909 | chr4:74279289 | |
Chimerdb3.0 | ChiTaRs | NA | AI110837 | TF-CLDN4 | chr3:133497623 | chr7:73247009 | |
Chimerdb3.0 | ChiTaRs | NA | AI064867 | TF-MATR3 | chr3:133474221 | chr5:138641490 | |
Chimerdb3.0 | ChiTaRs | NA | W27988 | TF-TF | chr3:133483752 | chr3:133475763 | |
Chimerdb3.0 | ChiTaRs | NA | BF948784 | TF-NEAT1 | chr3:133462945 | chr11:65191227 | |
Chimerdb3.0 | ChiTaRs | NA | BF948793 | TF-NEAT1 | chr3:133462934 | chr11:65191227 | |
Chimerdb3.0 | ChiTaRs | NA | DA338823 | ZNFX1-AS1-TF | chr20:47896939 | chr3:133465239 | |
Chimerdb3.0 | ChiTaRs | NA | AI114794 | PICALM-TF | chr11:85700516 | chr3:133472515 | |
Chimerdb3.0 | ChiTaRs | NA | BG769694 | LGALS1-TF | chr22:38074620 | chr3:133473543 | |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-69-8255-01A | TF-ALB | Out-of-Frame | chr3:133485222 | chr4:74279261 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-69-8255-01A | TF-ALB | Out-of-Frame | chr3:133478016 | chr4:74280751 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2U-11A | TF-ALB | Out-of-Frame | chr3:133495926 | chr4:74280769 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA34-11A | TF-ALB | In-Frame | chr3:133474300 | chr4:74283329 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA30-11A | TF-ALB | In-Frame | chr3:133478117 | chr4:74283976 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA34-11A | TF-ALB | Out-of-Frame | chr3:133495892 | chr4:74280797 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA30-11A | TF-ALB | In-Frame | chr3:133486980 | chr4:74285331 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2I-11A | TF-ALB | Out-of-Frame | chr3:133495892 | chr4:74280797 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2R-11A | TF-ALB | Out-of-Frame | chr3:133476733 | chr4:74283999 |
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TissGeneNet for TF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TF |
TissGeneDrug for TF |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01370 | Aluminium | Small molecule | Approved |
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TissGeneDisease for TF |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 15 | CTD_human,GAD,LHGDN |
umls:C0018995 | Hemochromatosis | 5 | BeFree,GAD |
umls:C0036341 | Schizophrenia | 4 | BeFree,GAD,LHGDN |
umls:C0521802 | Congenital atransferrinemia | 4 | BeFree,CTD_human,MGD,ORPHANET,UNIPROT |
umls:C0242383 | Age related macular degeneration | 3 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | CTD_human |
umls:C0002871 | Anemia | 2 | BeFree,RGD |
umls:C0003873 | Rheumatoid Arthritis | 2 | GAD,LHGDN |
umls:C0006118 | Brain Neoplasms | 2 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 2 | GAD |
umls:C0007786 | Brain Ischemia | 2 | GAD,LHGDN |
umls:C0015695 | Fatty Liver | 2 | CTD_human |
umls:C0019158 | Hepatitis | 2 | CTD_human,RGD |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_mouse,RGD |
umls:C0023903 | Liver neoplasms | 2 | BeFree |
umls:C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
umls:C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
umls:C0028754 | Obesity | 2 | CTD_human,RGD |
umls:C0030567 | Parkinson Disease | 2 | GAD,LHGDN |
umls:C0038454 | Cerebrovascular accident | 2 | GAD |
umls:C0041296 | Tuberculosis | 2 | GAD,LHGDN |
umls:C0162316 | Iron deficiency anemia | 2 | GAD |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0392514 | Hereditary hemochromatosis | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0000786 | Spontaneous abortion | 1 | GAD |
umls:C0001349 | Acute-Phase Reaction | 1 | RGD |
umls:C0003130 | Anoxia | 1 | GAD |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0004352 | Autistic Disorder | 1 | CTD_human |
umls:C0004623 | Bacterial Infections | 1 | LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
umls:C0010674 | Cystic Fibrosis | 1 | GAD,LHGDN |
umls:C0011570 | Mental Depression | 1 | GAD |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | LHGDN |
umls:C0011881 | Diabetic Nephropathy | 1 | RGD |
umls:C0013502 | Echinococcosis | 1 | CTD_human |
umls:C0015814 | Femur Head Necrosis | 1 | GAD |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | CTD_human,GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
umls:C0021655 | Insulin Resistance | 1 | RGD |
umls:C0022116 | Ischemia | 1 | GAD |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | GAD |
umls:C0023976 | Long QT Syndrome | 1 | GAD |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | GAD |
umls:C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
umls:C0027627 | Neoplasm Metastasis | 1 | LHGDN |
umls:C0027726 | Nephrotic Syndrome | 1 | CTD_human |
umls:C0029445 | Bone necrosis | 1 | GAD |
umls:C0030305 | Pancreatitis | 1 | LHGDN |
umls:C0030524 | Paratuberculosis | 1 | CTD_human |
umls:C0035258 | Restless Legs Syndrome | 1 | CTD_human |
umls:C0040136 | Thyroid Neoplasm | 1 | LHGDN |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0151699 | Intracranial Hemorrhages | 1 | RGD |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0271901 | Microcytic hypochromic anemia (disorder) | 1 | CTD_human |
umls:C0282193 | Iron Overload | 1 | CTD_human |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0483368 | Human anaplasmosis due to Anaplasma phagocytophilum | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
umls:C0867389 | Chronic graft-versus-host disease | 1 | BeFree |
umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |