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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TFAP2B
check button Gene summary
Basic gene informationGene symbolTFAP2B
Gene nametranscription factor AP-2 beta (activating enhancer binding protein 2 beta)
SynonymsAP-2B|AP2-B
CytomapUCSC genome browser: 6p12
Type of geneprotein-coding
RefGenesNM_003221.3,
DescriptionAP2-betaactivating enhancer binding protein 2 betaactivating enhancer-binding protein 2-betatranscription factor AP-2-beta
Modification date20141219
dbXrefs MIM : 601601
HGNC : HGNC
Ensembl : ENSG00000008196
HPRD : 03360
Vega : OTTHUMG00000014836
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TFAP2B
BioGPS: 7021
PathwayNCI Pathway Interaction Database: TFAP2B
KEGG: TFAP2B
REACTOME: TFAP2B
Pathway Commons: TFAP2B
ContextiHOP: TFAP2B
ligand binding site mutation search in PubMed: TFAP2B
UCL Cancer Institute: TFAP2B
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BreastKidneyEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BRCAKIRC,KIRP,KICHUVM
Reference showing the relevant tissue of TFAP2B
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter7559606
GO:0006355regulation of transcription, DNA-templated12169688
GO:0008284positive regulation of cell proliferation17525748
GO:0008285negative regulation of cell proliferation20607706
GO:0043066negative regulation of apoptotic process17525748
GO:0043525positive regulation of neuron apoptotic process20607706
GO:0045595regulation of cell differentiation20607706
GO:0045892negative regulation of transcription, DNA-templated20607706
GO:0045893positive regulation of transcription, DNA-templated11505339
GO:0045944positive regulation of transcription from RNA polymerase II promoter12169688
GO:0000122negative regulation of transcription from RNA polymerase II promoter7559606
GO:0006355regulation of transcription, DNA-templated12169688
GO:0008284positive regulation of cell proliferation17525748
GO:0008285negative regulation of cell proliferation20607706
GO:0043066negative regulation of apoptotic process17525748
GO:0043525positive regulation of neuron apoptotic process20607706
GO:0045595regulation of cell differentiation20607706
GO:0045892negative regulation of transcription, DNA-templated20607706
GO:0045893positive regulation of transcription, DNA-templated11505339
GO:0045944positive regulation of transcription from RNA polymerase II promoter12169688


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TissGeneExp for TFAP2B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC-2.0379216631.069089965-3.1070116283.95E-095.39E-08
KICH-1.437695716.45045229-7.8881483.60E-134.67E-12
KIRC-1.8003035436.301458957-8.10176258.23E-583.07E-55
KIRP-1.676013966.53025479-8.206268759.02E-261.35E-23
LUSC-0.744011631-2.0225528081.2785411760.00390.0066486
PRAD-2.570265402-1.560373094-1.0098923080.001860.005484553


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TissGene-miRNA for TFAP2B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TFAP2B
TissGeneSNV for TFAP2B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S244LUCEC2
p.R256WDLBC1
p.V233FLUAD1
p.D355YLGG1
p.S143LUCEC1
p.A127SLUAD1
p.G115DKIRP1
p.S251ABLCA1
p.D136HDLBC1
p.E366*STAD1
p.P82LSKCM1
p.T411MLGG1
p.E339DLUAD1
p.S116LUCEC1
p.T368MOV1
p.S277LUVM1
p.E183DSTAD1
p.T329MUCEC1
p.P87LSKCM1
p.S266YUCEC1
p.D31NCOAD1
p.G280ESTAD1
p.G289ESTAD1
p.T354KLGG1
p.E330DLUAD1
p.S53CLUAD1
p.F340LLUAD1
p.H97RSKCM1
p.Q111KLUAD1
p.S153LREAD1
p.T437ISTAD1
p.S319FSKCM1
p.P341LSKCM1
p.E18KPAAD1
p.M190TSTAD1
p.A413TUCEC1
p.R294QSKCM1
p.G227RLIHC1
p.T345KLGG1
p.N191KSTAD1
p.I400MHNSC1
p.K354TSTAD1
p.P85SGBM1
p.P202SSKCM1
p.A54TCOAD1
p.S71LBLCA1
p.E18DUCEC1
p.G189DTHYM1
p.E313KCOAD1
p.R459KOV1
p.E237DLUAD1
p.G107EUCEC1
p.G388RLUAD1
p.G53SLUAD1
p.G198DTHCA1
p.S62CLUAD1
p.S310FSKCM1
p.Q195HBRCA1
p.R111QUCEC1
p.K245ELIHC1
p.H353QLUAD1
p.N214DCOAD1
p.P139THNSC1
p.E328KUCEC1
p.Q254HESCA1
p.V144ILUSC1
p.F331LLUAD1
p.P132LSKCM1
p.S61LBLCA1
p.V242FLUAD1
p.Y26SLUAD1
p.S38*LUSC1
p.G404DUCEC1
p.R256GLUSC1
p.A381VPRAD1
p.E183VREAD1
p.L293FESCA1
p.D73ELUAD1
p.L357MUCEC1
p.G379RLUAD1
p.P80QLUAD1
p.R285QSKCM1
p.R459GBRCA1
p.E228DLUAD1
p.P73LSKCM1
p.V233FESCA1
p.R309HSARC1
p.Q427LLUAD1
p.T396MUCEC1
p.E338QHNSC1
p.R353*UCEC1
p.P341SSKCM1
p.P268RLUAD1
p.Y88DLGG1
p.Q263HESCA1
p.R351QHNSC1
p.P130THNSC1
p.A424VCOAD1
p.S210FBRCA1
p.P76LPRAD1
p.F79VLIHC1
p.E347QHNSC1
p.S286LUVM1
p.P211SSKCM1
p.M1ILUAD1
p.E366XSTAD1
p.H97YSKCM1
p.R126QSTAD1


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TissGeneCNV for TFAP2B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TFAP2B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for TFAP2B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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COAD (tumor)COAD (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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HNSC (tumor)HNSC (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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KICH (tumor)KICH (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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KIRC (tumor)KIRC (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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KIRP (tumor)KIRP (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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LIHC (tumor)LIHC (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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LUAD (tumor)LUAD (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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LUSC (tumor)LUSC (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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PRAD (tumor)PRAD (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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STAD (tumor)STAD (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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THCA (tumor)THCA (normal)
TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor)TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal)
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TissGeneProg for TFAP2B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TFAP2B
TissGeneDrug for TFAP2B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for TFAP2B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0013274Patent ductus arteriosus8BeFree,CTD_human,GAD,LHGDN
umls:C0028754Obesity8BeFree,GAD,GWASCAT
umls:C1868570CHAR SYNDROME7BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD,LHGDN
umls:C0152021Congenital heart disease2BeFree
umls:C0233849Personality Traits2GAD
umls:C0001418Adenocarcinoma1BeFree
umls:C0001973Alcoholic Intoxication, Chronic1BeFree
umls:C0003469Anxiety Disorders1GAD
umls:C0005586Bipolar Disorder1GAD
umls:C0005910Body Weight1CTD_human
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007134Renal Cell Carcinoma1LHGDN
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0011570Mental Depression1BeFree
umls:C0011581Depressive disorder1BeFree
umls:C0018566Congenital Hand Deformities1CTD_human
umls:C0021655Insulin Resistance1GAD
umls:C0024121Lung Neoplasms1LHGDN
umls:C0025202melanoma1BeFree
umls:C0035335Retinoblastoma1BeFree
umls:C0037317Sleep disturbances1BeFree
umls:C0086132Depressive Symptoms1BeFree
umls:C0151779Cutaneous Melanoma1BeFree
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0206655Alveolar rhabdomyosarcoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0265264Holt-Oram syndrome1BeFree
umls:C0376634Craniofacial Abnormalities1CTD_human
umls:C0524620Metabolic Syndrome X1GAD,GWASCAT
umls:C0596263Carcinogenesis1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0740404Limb defects1BeFree
umls:C0851578Sleep Disorders1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1520166Xenograft Model1BeFree