 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for TFAP2B |
 Gene summary |
| Basic gene information | Gene symbol | TFAP2B |
| Gene name | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | |
| Synonyms | AP-2B|AP2-B | |
| Cytomap | UCSC genome browser: 6p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003221.3, | |
| Description | AP2-betaactivating enhancer binding protein 2 betaactivating enhancer-binding protein 2-betatranscription factor AP-2-beta | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 601601 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000008196 | ||
| HPRD : 03360 | ||
| Vega : OTTHUMG00000014836 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TFAP2B | |
| BioGPS: 7021 | ||
| Pathway | NCI Pathway Interaction Database: TFAP2B | |
| KEGG: TFAP2B | ||
| REACTOME: TFAP2B | ||
| Pathway Commons: TFAP2B | ||
| Context | iHOP: TFAP2B | |
| ligand binding site mutation search in PubMed: TFAP2B | ||
| UCL Cancer Institute: TFAP2B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastKidneyEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCAKIRC,KIRP,KICHUVM | |
| Reference showing the relevant tissue of TFAP2B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 7559606 | GO:0006355 | regulation of transcription, DNA-templated | 12169688 | GO:0008284 | positive regulation of cell proliferation | 17525748 | GO:0008285 | negative regulation of cell proliferation | 20607706 | GO:0043066 | negative regulation of apoptotic process | 17525748 | GO:0043525 | positive regulation of neuron apoptotic process | 20607706 | GO:0045595 | regulation of cell differentiation | 20607706 | GO:0045892 | negative regulation of transcription, DNA-templated | 20607706 | GO:0045893 | positive regulation of transcription, DNA-templated | 11505339 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12169688 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 7559606 | GO:0006355 | regulation of transcription, DNA-templated | 12169688 | GO:0008284 | positive regulation of cell proliferation | 17525748 | GO:0008285 | negative regulation of cell proliferation | 20607706 | GO:0043066 | negative regulation of apoptotic process | 17525748 | GO:0043525 | positive regulation of neuron apoptotic process | 20607706 | GO:0045595 | regulation of cell differentiation | 20607706 | GO:0045892 | negative regulation of transcription, DNA-templated | 20607706 | GO:0045893 | positive regulation of transcription, DNA-templated | 11505339 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12169688 |
| Top |
| TissGeneExp for TFAP2B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -2.037921663 | 1.069089965 | -3.107011628 | 3.95E-09 | 5.39E-08 |
| KICH | -1.43769571 | 6.45045229 | -7.888148 | 3.60E-13 | 4.67E-12 |
| KIRC | -1.800303543 | 6.301458957 | -8.1017625 | 8.23E-58 | 3.07E-55 |
| KIRP | -1.67601396 | 6.53025479 | -8.20626875 | 9.02E-26 | 1.35E-23 |
| LUSC | -0.744011631 | -2.022552808 | 1.278541176 | 0.0039 | 0.0066486 |
| PRAD | -2.570265402 | -1.560373094 | -1.009892308 | 0.00186 | 0.005484553 |
| Top |
| TissGene-miRNA for TFAP2B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for TFAP2B |
| TissGeneSNV for TFAP2B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S244L | UCEC | 2 |
| p.R256W | DLBC | 1 |
| p.V233F | LUAD | 1 |
| p.D355Y | LGG | 1 |
| p.S143L | UCEC | 1 |
| p.A127S | LUAD | 1 |
| p.G115D | KIRP | 1 |
| p.S251A | BLCA | 1 |
| p.D136H | DLBC | 1 |
| p.E366* | STAD | 1 |
| p.P82L | SKCM | 1 |
| p.T411M | LGG | 1 |
| p.E339D | LUAD | 1 |
| p.S116L | UCEC | 1 |
| p.T368M | OV | 1 |
| p.S277L | UVM | 1 |
| p.E183D | STAD | 1 |
| p.T329M | UCEC | 1 |
| p.P87L | SKCM | 1 |
| p.S266Y | UCEC | 1 |
| p.D31N | COAD | 1 |
| p.G280E | STAD | 1 |
| p.G289E | STAD | 1 |
| p.T354K | LGG | 1 |
| p.E330D | LUAD | 1 |
| p.S53C | LUAD | 1 |
| p.F340L | LUAD | 1 |
| p.H97R | SKCM | 1 |
| p.Q111K | LUAD | 1 |
| p.S153L | READ | 1 |
| p.T437I | STAD | 1 |
| p.S319F | SKCM | 1 |
| p.P341L | SKCM | 1 |
| p.E18K | PAAD | 1 |
| p.M190T | STAD | 1 |
| p.A413T | UCEC | 1 |
| p.R294Q | SKCM | 1 |
| p.G227R | LIHC | 1 |
| p.T345K | LGG | 1 |
| p.N191K | STAD | 1 |
| p.I400M | HNSC | 1 |
| p.K354T | STAD | 1 |
| p.P85S | GBM | 1 |
| p.P202S | SKCM | 1 |
| p.A54T | COAD | 1 |
| p.S71L | BLCA | 1 |
| p.E18D | UCEC | 1 |
| p.G189D | THYM | 1 |
| p.E313K | COAD | 1 |
| p.R459K | OV | 1 |
| p.E237D | LUAD | 1 |
| p.G107E | UCEC | 1 |
| p.G388R | LUAD | 1 |
| p.G53S | LUAD | 1 |
| p.G198D | THCA | 1 |
| p.S62C | LUAD | 1 |
| p.S310F | SKCM | 1 |
| p.Q195H | BRCA | 1 |
| p.R111Q | UCEC | 1 |
| p.K245E | LIHC | 1 |
| p.H353Q | LUAD | 1 |
| p.N214D | COAD | 1 |
| p.P139T | HNSC | 1 |
| p.E328K | UCEC | 1 |
| p.Q254H | ESCA | 1 |
| p.V144I | LUSC | 1 |
| p.F331L | LUAD | 1 |
| p.P132L | SKCM | 1 |
| p.S61L | BLCA | 1 |
| p.V242F | LUAD | 1 |
| p.Y26S | LUAD | 1 |
| p.S38* | LUSC | 1 |
| p.G404D | UCEC | 1 |
| p.R256G | LUSC | 1 |
| p.A381V | PRAD | 1 |
| p.E183V | READ | 1 |
| p.L293F | ESCA | 1 |
| p.D73E | LUAD | 1 |
| p.L357M | UCEC | 1 |
| p.G379R | LUAD | 1 |
| p.P80Q | LUAD | 1 |
| p.R285Q | SKCM | 1 |
| p.R459G | BRCA | 1 |
| p.E228D | LUAD | 1 |
| p.P73L | SKCM | 1 |
| p.V233F | ESCA | 1 |
| p.R309H | SARC | 1 |
| p.Q427L | LUAD | 1 |
| p.T396M | UCEC | 1 |
| p.E338Q | HNSC | 1 |
| p.R353* | UCEC | 1 |
| p.P341S | SKCM | 1 |
| p.P268R | LUAD | 1 |
| p.Y88D | LGG | 1 |
| p.Q263H | ESCA | 1 |
| p.R351Q | HNSC | 1 |
| p.P130T | HNSC | 1 |
| p.A424V | COAD | 1 |
| p.S210F | BRCA | 1 |
| p.P76L | PRAD | 1 |
| p.F79V | LIHC | 1 |
| p.E347Q | HNSC | 1 |
| p.S286L | UVM | 1 |
| p.P211S | SKCM | 1 |
| p.M1I | LUAD | 1 |
| p.E366X | STAD | 1 |
| p.H97Y | SKCM | 1 |
| p.R126Q | STAD | 1 |
| Top |
| TissGeneCNV for TFAP2B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for TFAP2B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for TFAP2B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (tumor) | TFAP2B, SSBP4, VPS11, CITED2, GRB2, SUMO1, MYC, UBE2I, SYT4, YEATS4, KRT14, SOD2, LZTR1, CITED1, CITED4, PTGDS, HIST1H2AC, SLC19A1 (normal) |
 |  |
| Top |
| TissGeneProg for TFAP2B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for TFAP2B |
| TissGeneDrug for TFAP2B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for TFAP2B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0013274 | Patent ductus arteriosus | 8 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0028754 | Obesity | 8 | BeFree,GAD,GWASCAT |
| umls:C1868570 | CHAR SYNDROME | 7 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,GAD,LHGDN |
| umls:C0152021 | Congenital heart disease | 2 | BeFree |
| umls:C0233849 | Personality Traits | 2 | GAD |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | GAD |
| umls:C0005586 | Bipolar Disorder | 1 | GAD |
| umls:C0005910 | Body Weight | 1 | CTD_human |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0018566 | Congenital Hand Deformities | 1 | CTD_human |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0037317 | Sleep disturbances | 1 | BeFree |
| umls:C0086132 | Depressive Symptoms | 1 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0206655 | Alveolar rhabdomyosarcoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0265264 | Holt-Oram syndrome | 1 | BeFree |
| umls:C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD,GWASCAT |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0740404 | Limb defects | 1 | BeFree |
| umls:C0851578 | Sleep Disorders | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |