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TissGeneSummary for NR2F2 |
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Basic gene information | Gene symbol | NR2F2 |
Gene name | nuclear receptor subfamily 2, group F, member 2 | |
Synonyms | ARP1|CHTD4|COUPTFB|COUPTFII|NF-E3|NR2F1|SVP40|TFCOUP2 | |
Cytomap | UCSC genome browser: 15q26 | |
Type of gene | protein-coding | |
RefGenes | NM_001145155.1, NM_001145156.1,NM_001145157.1,NM_021005.3, | |
Description | ADP-ribosylation factor related protein 1COUP transcription factor 2COUP transcription factor IIapolipoprotein A-I regulatory protein 1apolipoprotein AI regulatory protein 1chicken ovalbumin upstream promoter transcription factor 2chicken ovalbumin | |
Modification date | 20141207 | |
dbXrefs | MIM : 107773 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185551 | ||
HPRD : 00139 | ||
Vega : OTTHUMG00000149848 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NR2F2 | |
BioGPS: 7026 | ||
Pathway | NCI Pathway Interaction Database: NR2F2 | |
KEGG: NR2F2 | ||
REACTOME: NR2F2 | ||
Pathway Commons: NR2F2 | ||
Context | iHOP: NR2F2 | |
ligand binding site mutation search in PubMed: NR2F2 | ||
UCL Cancer Institute: NR2F2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvarySoft tissue | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSARC | |
Reference showing the relevant tissue of NR2F2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 9343308 | GO:0030522 | intracellular receptor signaling pathway | 18798693 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 19210544 | GO:0045892 | negative regulation of transcription, DNA-templated | 19210544 | GO:0045893 | positive regulation of transcription, DNA-templated | 18798693 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 9343308 | GO:0030522 | intracellular receptor signaling pathway | 18798693 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 19210544 | GO:0045892 | negative regulation of transcription, DNA-templated | 19210544 | GO:0045893 | positive regulation of transcription, DNA-templated | 18798693 |
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TissGeneExp for NR2F2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.287046202 | 1.571685798 | -1.858732 | 8.27E-12 | 8.14E-11 |
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TissGene-miRNA for NR2F2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UVM | hsa-miR-365a-3p | MIMAT0000710 | 0.019 | -0.26 | 80 |
UVM | hsa-miR-365b-3p | MIMAT0022834 | 0.017 | -0.27 | 80 |
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TissGeneMut for NR2F2 |
TissGeneSNV for NR2F2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S101G | KIRP | 1 |
p.P234R | KIRP | 1 |
p.E225* | LUAD | 1 |
p.A257V | UCEC | 1 |
p.R218K | CESC | 1 |
p.R359K | STAD | 1 |
p.R108W | COAD | 1 |
p.I182L | UCEC | 1 |
p.A317V | STAD | 1 |
p.G208V | LIHC | 1 |
p.Y353H | SKCM | 1 |
p.R284W | ESCA | 1 |
p.Y181H | STAD | 1 |
p.Q150X | THYM | 1 |
p.A258V | LGG | 1 |
p.L337V | UCEC | 1 |
p.G208A | GBM | 1 |
p.R135S | LIHC | 1 |
p.Y133H | KIRP | 1 |
p.A412T | BLCA | 1 |
p.E78D | LGG | 1 |
p.K104N | HNSC | 1 |
p.P234S | SKCM | 1 |
p.Q414* | HNSC | 1 |
p.Q342* | BLCA | 1 |
p.G92C | HNSC | 1 |
p.E300K | BLCA | 1 |
p.A257G | LIHC | 1 |
p.G255D | COAD | 1 |
p.L220P | STAD | 1 |
p.S106R | THYM | 1 |
p.Q414* | CESC | 1 |
p.R105G | PRAD | 1 |
p.S329F | BLCA | 1 |
p.G327D | UCEC | 1 |
p.R293W | GBM | 1 |
p.A258V | UCEC | 1 |
p.Y220H | SKCM | 1 |
p.A272P | HNSC | 1 |
p.P101S | SKCM | 1 |
p.R109M | KIRP | 1 |
p.Q414* | LGG | 1 |
p.A273S | BLCA | 1 |
p.F103C | HNSC | 1 |
p.R109W | OV | 1 |
p.P171A | HNSC | 1 |
p.G36R | SKCM | 1 |
p.G169R | SKCM | 1 |
p.P368T | CESC | 1 |
p.P391H | KIRP | 1 |
p.V373I | UCEC | 1 |
p.R246H | LGG | 1 |
p.Q73H | PAAD | 1 |
p.R233C | COAD | 1 |
p.A271G | HNSC | 1 |
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TissGeneCNV for NR2F2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NR2F2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI214117 | NR2F2-MRTO4 | chr15:96880999 | chr1:19578335 | |
Chimerdb3.0 | ChiTaRs | NA | CK725089 | NR2F2-NR2F2 | chr15:96875159 | chr15:96875180 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-C8-A12P-01A | NR2F2-MSI2 | Out-of-Frame | chr15:96869581 | chr17:55607036 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12P-01A | NR2F2-MSI2 | Out-of-frame | Chr15:96869581 | Chr17:55607037 |
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TissGeneNet for NR2F2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NR2F2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NR2F2 |
TissGeneDrug for NR2F2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NR2F2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 10 | BeFree |
umls:C0678222 | Breast Carcinoma | 10 | BeFree |
umls:C0026764 | Multiple Myeloma | 5 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
umls:C0235833 | Congenital diaphragmatic hernia | 4 | BeFree,MGD |
umls:C0014175 | Endometriosis | 3 | BeFree,CTD_human |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0000768 | Congenital Abnormality | 2 | BeFree |
umls:C0018798 | Congenital Heart Defects | 2 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 2 | BeFree |
umls:C0035869 | Rotavirus Infections | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
umls:C0004153 | Atherosclerosis | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0021361 | Female infertility | 1 | CTD_human |
umls:C0023267 | Fibroid Tumor | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0027708 | Nephroblastoma | 1 | BeFree |
umls:C0029124 | Optic Atrophy | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0037769 | West Syndrome | 1 | BeFree |
umls:C0042133 | Uterine Fibroids | 1 | BeFree |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0220766 | Congenital hypoplasia of adrenal gland | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0752123 | Spinocerebellar Ataxia Type 5 | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C1720816 | Endometrial Diseases | 1 | BeFree |
umls:C1852093 | Maturity-Onset Diabetes of the Young, Type 1 | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | BeFree |
umls:C4014310 | CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 4 | 1 | UNIPROT |
umls:C0221215 | Common atrioventricular canal | 0 | ORPHANET |
umls:C0344735 | Partial atrioventricular canal | 0 | ORPHANET |
umls:C0344787 | Complete atrioventricular septal defect | 0 | ORPHANET |