TissGeneSummary for TFF1 |
Gene summary |
Basic gene information | Gene symbol | TFF1 |
Gene name | trefoil factor 1 | |
Synonyms | BCEI|D21S21|HP1.A|HPS2|pNR-2|pS2 | |
Cytomap | UCSC genome browser: 21q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_003225.2, | |
Description | breast cancer estrogen-inducible proteinbreast cancer estrogen-inducible sequencegastrointestinal trefoil protein pS2polypeptide P1.Aprotein pS2 | |
Modification date | 20141222 | |
dbXrefs | MIM : 113710 | |
HGNC : HGNC | ||
Ensembl : ENSG00000160182 | ||
HPRD : 00219 | ||
Vega : OTTHUMG00000086799 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TFF1 | |
BioGPS: 7031 | ||
Pathway | NCI Pathway Interaction Database: TFF1 | |
KEGG: TFF1 | ||
REACTOME: TFF1 | ||
Pathway Commons: TFF1 | ||
Context | iHOP: TFF1 | |
ligand binding site mutation search in PubMed: TFF1 | ||
UCL Cancer Institute: TFF1 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
Reference showing the relevant tissue of TFF1 | DNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers. J Korean Med Sci. 2010 Mar;25(3):405-17. doi: 10.3346/jkms.2010.25.3.405. Epub 2010 Feb 17. (pmid:20191040) go to article | |
Description by TissGene annotations | Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0032355 | response to estradiol | 15831516 | GO:0032355 | response to estradiol | 15831516 |
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TissGeneExp for TFF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.689288539 | -0.944978816 | -1.744309722 | 5.09E-10 | 1.71E-09 |
LUAD | 1.114915101 | -2.060391795 | 3.175306897 | 2.81E-08 | 1.19E-07 |
KICH | -2.810798761 | 0.184657239 | -2.995456 | 2.58E-07 | 1.08E-06 |
HNSC | -1.830813086 | 0.165726448 | -1.996539535 | 0.000747 | 0.002630282 |
BRCA | 5.686650643 | 3.928258537 | 1.758392105 | 0.000566 | 0.001141113 |
KIRP | -2.655148261 | -1.052167011 | -1.60298125 | 5.68E-05 | 0.000205728 |
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TissGene-miRNA for TFF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TFF1 |
TissGeneSNV for TFF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A26T | SKCM | 1 |
p.G55S | SKCM | 1 |
p.M17V | BLCA | 1 |
p.G21S | SKCM | 1 |
p.Q50* | SKCM | 1 |
p.S16F | SKCM | 1 |
p.V62I | SKCM | 1 |
p.R36C | SKCM | 1 |
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TissGeneCNV for TFF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TFF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BM786342 | TFF1-RALB | chr21:43786638 | chr2:121036327 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | ZNF295-TFF1 | 5'UTR-CDS | chr21:43430360 | chr21:43783516 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | ZNF295-TFF1 | 5'UTR-CDS | chr21:43423005 | chr21:43783516 |
TCGAfusionPortal | PRADA | LUAD | TCGA-97-7552-01A | TFF1-RABEP1 | NA | Chr21:43782391 | Chr17:5283828 |
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TissGeneNet for TFF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TFF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TFF1 |
TissGeneDrug for TFF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TFF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 58 | BeFree |
umls:C0678222 | Breast Carcinoma | 54 | BeFree |
umls:C0699791 | Stomach Carcinoma | 29 | BeFree,MGD |
umls:C0024623 | Malignant neoplasm of stomach | 26 | BeFree |
umls:C0596263 | Carcinogenesis | 18 | BeFree |
umls:C0038356 | Stomach Neoplasms | 10 | BeFree,LHGDN |
umls:C0079504 | Hermanski-Pudlak Syndrome | 7 | BeFree |
umls:C0001418 | Adenocarcinoma | 5 | BeFree,LHGDN |
umls:C0001430 | Adenoma | 5 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 5 | BeFree |
umls:C0242994 | Hantavirus Infections | 5 | BeFree |
umls:C0600139 | Prostate carcinoma | 5 | BeFree |
umls:C0038358 | Gastric ulcer | 4 | BeFree,RGD |
umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
umls:C1458155 | Mammary Neoplasms | 4 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0032927 | Precancerous Conditions | 3 | BeFree,LHGDN |
umls:C0206698 | Cholangiocarcinoma | 3 | BeFree,LHGDN |
umls:C0009324 | Ulcerative Colitis | 2 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | BeFree,LHGDN |
umls:C0010346 | Crohn Disease | 2 | BeFree |
umls:C0023530 | Leukopenia | 2 | BeFree |
umls:C0027947 | Neutropenia | 2 | BeFree |
umls:C0032584 | polyps | 2 | BeFree,LHGDN |
umls:C0035335 | Retinoblastoma | 2 | BeFree |
umls:C0078918 | Albinism, Oculocutaneous | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0206062 | Lung Diseases, Interstitial | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
umls:C0333983 | Hyperplastic Polyp | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C0001075 | Achlorhydria | 1 | RGD |
umls:C0001916 | Albinism | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0002622 | Amnesia | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007130 | Mucinous Adenocarcinoma | 1 | LHGDN |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0007570 | Celiac Disease | 1 | BeFree |
umls:C0007965 | Chediak-Higashi Syndrome | 1 | BeFree |
umls:C0009319 | Colitis | 1 | RGD |
umls:C0010633 | Cystadenoma | 1 | BeFree |
umls:C0017152 | Gastritis | 1 | BeFree |
umls:C0017178 | Gastrointestinal Diseases | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | LHGDN |
umls:C0022650 | Kidney Calculi | 1 | GAD |
umls:C0022658 | Kidney Diseases | 1 | GAD |
umls:C0024115 | Lung diseases | 1 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024291 | Lymphohistiocytosis, Hemophagocytic | 1 | BeFree |
umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
umls:C0027430 | Nasal Polyps | 1 | BeFree |
umls:C0030920 | Peptic Ulcer | 1 | BeFree |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
umls:C0038454 | Cerebrovascular accident | 1 | GAD |
umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
umls:C0079487 | Helicobacter Infections | 1 | BeFree |
umls:C0085695 | Chronic gastritis | 1 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
umls:C0149826 | Gastric adenoma | 1 | BeFree |
umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0221023 | Cyclic neutropenia | 1 | BeFree |
umls:C0236053 | Mucosal ulcer | 1 | BeFree |
umls:C0238033 | Carcinoma of Male Breast | 1 | BeFree |
umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
umls:C0242488 | Acute Lung Injury | 1 | CTD_human |
umls:C0267111 | Gastric dysplasia | 1 | BeFree |
umls:C0267952 | Fibrosis of pancreas | 1 | BeFree |
umls:C0276496 | Familial Alzheimer Disease (FAD) | 1 | BeFree |
umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0279680 | Transitional cell carcinoma of bladder | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0598935 | Tumor Initiation | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0751295 | Memory Loss | 1 | BeFree |
umls:C0751778 | Myoclonic Epilepsies, Progressive | 1 | BeFree |
umls:C0751785 | Unverricht-Lundborg Syndrome | 1 | BeFree |
umls:C0858252 | Breast adenocarcinoma | 1 | BeFree |
umls:C0878500 | Intraepithelial Neoplasia | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1297882 | Partial Trisomy | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
umls:C3669246 | Mammary adenocarcinoma | 1 | BeFree |