 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for TGM3 |
 Gene summary |
| Basic gene information | Gene symbol | TGM3 |
| Gene name | transglutaminase 3 | |
| Synonyms | TGE | |
| Cytomap | UCSC genome browser: 20q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003245.3, | |
| Description | E polypeptide, protein-glutamine-gamma-glutamyltransferaseTG(E)TGase ETGase-3protein-glutamine gamma-glutamyltransferase Etransglutaminase Etransglutaminase-3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600238 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125780 | ||
| HPRD : 02584 | ||
| Vega : OTTHUMG00000031690 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TGM3 | |
| BioGPS: 7053 | ||
| Pathway | NCI Pathway Interaction Database: TGM3 | |
| KEGG: TGM3 | ||
| REACTOME: TGM3 | ||
| Pathway Commons: TGM3 | ||
| Context | iHOP: TGM3 | |
| ligand binding site mutation search in PubMed: TGM3 | ||
| UCL Cancer Institute: TGM3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
| Reference showing the relevant tissue of TGM3 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0018149 | peptide cross-linking | 12679341 | GO:0043163 | cell envelope organization | 24643 | GO:0051262 | protein tetramerization | 5038456 | GO:0018149 | peptide cross-linking | 12679341 | GO:0043163 | cell envelope organization | 24643 | GO:0051262 | protein tetramerization | 5038456 |
| Top |
| TissGeneExp for TGM3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 2.586105295 | -1.357688705 | 3.943794 | 3.72E-10 | 4.39E-09 |
| HNSC | 4.370105062 | 9.864788783 | -5.494683721 | 2.76E-08 | 2.97E-07 |
| PRAD | 3.603977602 | 0.593871833 | 3.010105769 | 2.86E-13 | 1.78E-11 |
| LUSC | 1.054135295 | -0.406366666 | 1.460501961 | 0.00896 | 0.014381981 |
| LUAD | -1.844518154 | -0.613226774 | -1.231291379 | 0.000574 | 0.001300487 |
| Top |
| TissGene-miRNA for TGM3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for TGM3 |
| TissGeneSNV for TGM3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E693K | SKCM | 2 |
| p.D206N | BLCA | 1 |
| p.T464R | OV | 1 |
| p.V586E | COAD | 1 |
| p.G528C | STAD | 1 |
| p.R450K | SKCM | 1 |
| p.S286F | SKCM | 1 |
| p.S249N | COAD | 1 |
| p.Q451X | STAD | 1 |
| p.V327I | STAD | 1 |
| p.S424G | UCEC | 1 |
| p.I163L | DLBC | 1 |
| p.T13K | LUAD | 1 |
| p.E182* | SKCM | 1 |
| p.D674H | HNSC | 1 |
| p.T13K | THCA | 1 |
| p.G243S | ESCA | 1 |
| p.R571Q | SKCM | 1 |
| p.R201L | LUAD | 1 |
| p.I524V | KIRC | 1 |
| p.V428L | STAD | 1 |
| p.G317R | SKCM | 1 |
| p.G49S | SKCM | 1 |
| p.A370T | COAD | 1 |
| p.W176* | SKCM | 1 |
| p.R110W | LIHC | 1 |
| p.Q157R | SARC | 1 |
| p.G288E | SKCM | 1 |
| p.E587K | CESC | 1 |
| p.S238N | STAD | 1 |
| p.R665W | SARC | 1 |
| p.A150T | BLCA | 1 |
| p.R269Q | COAD | 1 |
| p.S187N | SARC | 1 |
| p.V578A | LIHC | 1 |
| p.L190F | SKCM | 1 |
| p.I570M | HNSC | 1 |
| p.L233F | STAD | 1 |
| p.Y63C | BLCA | 1 |
| p.T13K | PRAD | 1 |
| p.E52K | SKCM | 1 |
| p.R397S | LUSC | 1 |
| p.A14T | SKCM | 1 |
| p.P64S | SKCM | 1 |
| p.R397C | BLCA | 1 |
| p.Q451* | STAD | 1 |
| p.R152T | LIHC | 1 |
| p.K565R | STAD | 1 |
| p.E182X | SKCM | 1 |
| p.V607L | LUAD | 1 |
| p.A521T | ESCA | 1 |
| p.G317E | SKCM | 1 |
| p.D314N | SKCM | 1 |
| p.E154K | STAD | 1 |
| p.T282I | BLCA | 1 |
| p.V414E | HNSC | 1 |
| p.P647S | SKCM | 1 |
| p.R658C | SKCM | 1 |
| p.M146I | SKCM | 1 |
| p.L460F | GBM | 1 |
| p.R665W | SKCM | 1 |
| p.A682S | LIHC | 1 |
| p.A692T | UCEC | 1 |
| p.M472V | KIRC | 1 |
| p.S80N | LUSC | 1 |
| p.D674N | LGG | 1 |
| p.P552L | SKCM | 1 |
| p.R285W | STAD | 1 |
| p.S263F | CESC | 1 |
| p.R195K | SKCM | 1 |
| p.G640S | LIHC | 1 |
| p.N10D | STAD | 1 |
| p.W410* | LUSC | 1 |
| p.A427V | HNSC | 1 |
| p.A432S | THYM | 1 |
| p.R376* | SKCM | 1 |
| p.E653D | LUAD | 1 |
| p.D627N | SKCM | 1 |
| p.R376Q | SKCM | 1 |
| p.P319T | GBM | 1 |
| p.A150V | BRCA | 1 |
| p.E392K | SKCM | 1 |
| p.P681T | STAD | 1 |
| p.Q180X | COAD | 1 |
| p.L193* | LUAD | 1 |
| p.R53I | READ | 1 |
| p.D580N | BLCA | 1 |
| p.P681S | SKCM | 1 |
| p.L128R | ESCA | 1 |
| p.T295N | BRCA | 1 |
| p.V646M | COAD | 1 |
| p.G654R | COAD | 1 |
| p.T70R | LUAD | 1 |
| p.R110W | STAD | 1 |
| p.G368S | SKCM | 1 |
| p.P103L | SKCM | 1 |
| p.P247S | SKCM | 1 |
| p.G378C | SARC | 1 |
| p.R608Q | OV | 1 |
| p.A468T | HNSC | 1 |
| p.S676F | HNSC | 1 |
| p.D589V | BLCA | 1 |
| p.K679T | LUAD | 1 |
| p.R658C | COAD | 1 |
| p.R200H | UCEC | 1 |
| p.R269* | MESO | 1 |
| p.P64L | SKCM | 1 |
| p.V87A | UCEC | 1 |
| p.G368D | SKCM | 1 |
| p.V327I | GBM | 1 |
| p.A19V | STAD | 1 |
| p.V436I | UCEC | 1 |
| p.R376X | COAD | 1 |
| p.D645_splice | GBM | 1 |
| p.K24N | THYM | 1 |
| p.E477G | DLBC | 1 |
| p.T469M | BLCA | 1 |
| p.S413F | SKCM | 1 |
| p.G634R | SKCM | 1 |
| Top |
| TissGeneCNV for TGM3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for TGM3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE715869 | VPS72-TGM3 | chr1:151149451 | chr20:2321161 | |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CN-4733-01A | EPB41L1-TGM3 | 5UTR-CDS | Chr20:34680735 | Chr20:2290303 |
| Top |
| TissGeneNet for TGM3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (tumor) | TGM3, SIRT7, SP1, ETS2, KIAA0101, UCHL5, ATG12, PRKAB1, CALML5, USP53 (normal) |
 |  |
| Top |
| TissGeneProg for TGM3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for TGM3 |
| TissGeneDrug for TGM3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for TGM3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011608 | Dermatitis Herpetiformis | 3 | BeFree,LHGDN |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 2 | GWASCAT |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
| umls:C0033860 | Psoriasis | 2 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0020179 | Huntington Disease | 1 | LHGDN |
| umls:C0023531 | Leukoplakia | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree,LHGDN |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |