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| TissGeneSummary for THRSP |
 Gene summary |
| Basic gene information | Gene symbol | THRSP |
| Gene name | thyroid hormone responsive | |
| Synonyms | LPGP1|Lpgp|S14|SPOT14|THRP | |
| Cytomap | UCSC genome browser: 11q14.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003251.3, | |
| Description | SPOT14 homologlipogenic protein 1spot 14 proteinthyroid hormone responsive (SPOT14 homolog, rat)thyroid hormone responsive SPOT14thyroid hormone-inducible hepatic protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601926 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151365 | ||
| HPRD : 03566 | ||
| Vega : OTTHUMG00000166632 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_THRSP | |
| BioGPS: 7069 | ||
| Pathway | NCI Pathway Interaction Database: THRSP | |
| KEGG: THRSP | ||
| REACTOME: THRSP | ||
| Pathway Commons: THRSP | ||
| Context | iHOP: THRSP | |
| ligand binding site mutation search in PubMed: THRSP | ||
| UCL Cancer Institute: THRSP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverSoft tissueSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSARCSKCM | |
| Reference showing the relevant tissue of THRSP | ||
| Description by TissGene annotations | Cancer gene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for THRSP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -1.619589689 | 1.187688088 | -2.807277778 | 9.98E-18 | 6.37E-17 |
| THCA | 4.590242867 | 1.624151342 | 2.966091525 | 1.28E-20 | 5.83E-19 |
| KIRP | -1.133088648 | 1.806033227 | -2.939121875 | 1.11E-06 | 5.58E-06 |
| LIHC | 4.544759477 | 8.489795477 | -3.945036 | 4.03E-09 | 3.87E-08 |
| BRCA | 3.164321056 | 6.766283337 | -3.601962281 | 2.08E-25 | 2.12E-24 |
| HNSC | -2.176534941 | 0.401574361 | -2.578109302 | 2.46E-06 | 1.67E-05 |
| PRAD | -2.519052831 | -1.144068215 | -1.374984615 | 0.000183 | 0.000731021 |
| KICH | 4.349583477 | 1.234463477 | 3.11512 | 0.000149 | 0.000374881 |
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| TissGene-miRNA for THRSP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-let-7c-5p | MIMAT0000064 | 0.032 | -0.29 | 56 |
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| TissGeneMut for THRSP |
| TissGeneSNV for THRSP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Y20H | STAD | 1 |
| p.E52K | BLCA | 1 |
| p.L124P | BRCA | 1 |
| p.S35N | LGG | 1 |
| p.V40M | BLCA | 1 |
| p.R7G | LIHC | 1 |
| p.Q29R | LIHC | 1 |
| p.V24A | BLCA | 1 |
| p.E78K | SKCM | 1 |
| p.R77Q | DLBC | 1 |
| p.E97K | SKCM | 1 |
| p.A49V | STAD | 1 |
| p.E96K | SKCM | 1 |
| p.E99K | BLCA | 1 |
| p.R38W | ESCA | 1 |
| p.D71H | GBM | 1 |
| p.V84G | LIHC | 1 |
| p.E23K | COAD | 1 |
| p.R38W | LIHC | 1 |
| p.A49T | OV | 1 |
| p.R38W | LUSC | 1 |
| p.K10N | COAD | 1 |
| p.K83N | UCEC | 1 |
| p.T142M | COAD | 1 |
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| TissGeneCNV for THRSP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for THRSP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A1LS-01A | PAK1-THRSP | 5'UTR-3'UTR | chr11:77184596 | chr11:77778704 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A0FV-01A | THRSP-NDUFC2-KCTD14 | 3'UTR-3'UTR | chr11:77775387 | chr11:77728316 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A1-A0SM-01A | ACER3-THRSP | CDS-3UTR | Chr11:76572123 | Chr11:77778705 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0CL-01A | GAB2-THRSP | CDS-3UTR | Chr11:77991647 | Chr11:77778705 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FV-01A | THRSP-KCTD14 | 3UTR-CDS | Chr11:77775387 | Chr11:77728316 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1EN-01A | PC-THRSP | 5UTR-3UTR | Chr11:66719901 | Chr11:77778705 |
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| TissGeneNet for THRSP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for THRSP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for THRSP |
| TissGeneDrug for THRSP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for THRSP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 4 | BeFree |
| umls:C0028754 | Obesity | 3 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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