TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NKX2-1

Gene summary

Basic gene information	Gene symbol	NKX2-1
	Gene name	NK2 homeobox 1
	Synonyms	BCH\|BHC\|NK-2\|NKX2.1\|NKX2A\|T/EBP\|TEBP\|TITF1\|TTF-1\|TTF1
	Cytomap	UCSC genome browser: 14q13
	Type of gene	protein-coding
	RefGenes	NM_001079668.2, NM_003317.3,
	Description	NK-2 homolog Ahomeobox protein NK-2 homolog Ahomeobox protein Nkx-2.1thyroid nuclear factor 1thyroid transcription factor 1thyroid-specific enhancer-binding protein
	Modification date	20141207
dbXrefs	MIM : 600635
	HGNC : HGNC
	Ensembl : ENSG00000136352
	HPRD : 02798
	Vega : OTTHUMG00000140225
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NKX2-1
	BioGPS: 7080
Pathway	NCI Pathway Interaction Database: NKX2-1
	KEGG: NKX2-1
	REACTOME: NKX2-1
	Pathway Commons: NKX2-1
Context	iHOP: NKX2-1
	ligand binding site mutation search in PubMed: NKX2-1
	UCL Cancer Institute: NKX2-1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	LungThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LUAD,LUSCTHCA
Reference showing the relevant tissue of NKX2-1
Description by TissGene annotations	Cancer gene TissgsKTS CNV lost TissGeneKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0010628	positive regulation of gene expression	16960125
GO:0010719	negative regulation of epithelial to mesenchymal transition	19293183
GO:0030336	negative regulation of cell migration	19293183
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	19293183
GO:0045893	positive regulation of transcription, DNA-templated	14960358
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	16960125
GO:0010628	positive regulation of gene expression	16960125
GO:0010719	negative regulation of epithelial to mesenchymal transition	19293183
GO:0030336	negative regulation of cell migration	19293183
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	19293183
GO:0045893	positive regulation of transcription, DNA-templated	14960358
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	16960125

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TissGeneExp for NKX2-1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type

Mean(exp) in tumor

Mean(exp) in matched normal

Log2FC

P-val.

FDR

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TissGene-miRNA for NKX2-1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for NKX2-1

TissGeneSNV for NKX2-1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.S12L	BLCA	1
p.M1K	COAD	1
p.P131L	STAD	1
p.S187L	LGG	1
p.G134S	LUAD	1
p.G92V	KIRP	1
p.P190T	STAD	1
p.G33S	SKCM	1
p.M29I	SKCM	1
p.R29*	PRAD	1
p.G172R	LUSC	1
p.E190*	BLCA	1
p.R213H	PAAD	1
p.A188V	LGG	1
p.H199Y	SKCM	1
p.P160T	STAD	1
p.K163E	THCA	1
p.S169*	LGG	1
p.K25N	THCA	1
p.Y86C	LUAD	1
p.A39V	LUAD	1
p.G92C	LGG	1
p.A102E	LIHC	1
p.P22S	HNSC	1
p.G122V	KIRP	1
p.M31T	BLCA	1
p.L347P	COAD	1
p.T272S	LIHC	1
p.R243H	PAAD	1
p.R218C	COAD	1
p.A116T	STAD	1
p.A189T	STAD	1
p.L200M	STAD	1
p.S187L	COAD	1
p.A87T	CESC	1
p.L230M	STAD	1
p.A159T	STAD	1

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TissGeneCNV for NKX2-1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for NKX2-1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
TCGAfusionPortal	PRADA	LUAD	TCGA-L9-A444-01A	BAZ1A-NKX2-1	In-frame	Chr14:35331250	Chr14:36988575
TCGAfusionPortal	PRADA	LUSC	TCGA-39-5034-01A	NKX2-1-SLC25A21	Out-of-frame	Chr14:36988190	Chr14:37153085

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TissGeneNet for NKX2-1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
NKX2-1, NCK1, NCOA3, HIPK2, SP1, GRB2, RELA, SRC, RARA, NCOA1, FYN, NCOA2, RAB3GAP2, CALR, SP3, TDG, CCDC59, GATA6, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, SP1, GRB2, RELA, SRC, RARA, CREBBP, NCOA1, FYN, NCOA2, RAB3GAP2, CALR, SP3, TDG, WWTR1, PAX8, CCDC59, GATA6, SFTPB (normal)

COAD (tumor)	COAD (normal)
NKX2-1, NCOA3, HIPK2, SP1, GRB2, RELA, MAPK1, CREBBP, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, TDG, WWTR1, PAX8, CCDC59, GATA6, PTRF, SFTPB (tumor)	NKX2-1, HIPK2, SP1, RELA, SRC, MAPK1, RARA, CREBBP, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, CRK, TDG, WWTR1, PAX8, CCDC59, PTRF, TG, SFTPB (normal)

HNSC (tumor)	HNSC (normal)
NKX2-1, NCK1, NCOA3, SP1, GRB2, RELA, SRC, MAPK1, RARA, CREBBP, NCOA1, FYN, RAB3GAP2, ABL1, CALR, SP3, TDG, PAX8, GATA6, PTRF, SFTPB (tumor)	NKX2-1, SP1, GRB2, RELA, MAPK1, RARA, CREBBP, NCOA1, FYN, NCOA2, ABL1, CALR, SP3, TDG, WWTR1, PAX8, CCDC59, GATA6, PTRF, TG, SFTPB (normal)

KICH (tumor)	KICH (normal)
NKX2-1, NCK1, NCOA3, HIPK2, SP1, RELA, SRC, MAPK1, CREBBP, NCOA1, NCOA2, RAB3GAP2, ABL1, CALR, SP3, WWTR1, PAX8, CCDC59, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, HIPK2, SP1, GRB2, SRC, RARA, CREBBP, NCOA1, FYN, RAB3GAP2, ABL1, CRK, TDG, WWTR1, PAX8, CCDC59, GATA6, TG, SFTPB (normal)

KIRC (tumor)	KIRC (normal)
NKX2-1, HIPK2, SP1, GRB2, RELA, SRC, MAPK1, RARA, CREBBP, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, TDG, WWTR1, PAX8, CCDC59, GATA6, PTRF, SFTPB (tumor)	NKX2-1, NCK1, HIPK2, SRC, MAPK1, CREBBP, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, TDG, WWTR1, PAX8, CCDC59, GATA6, TG, SFTPB (normal)

KIRP (tumor)	KIRP (normal)
NKX2-1, NCK1, HIPK2, GRB2, RELA, MAPK1, RARA, CREBBP, FYN, NCOA2, RAB3GAP2, ABL1, CALR, CRK, WWTR1, PAX8, CCDC59, GATA6, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, HIPK2, SP1, RELA, RARA, CREBBP, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, TDG, WWTR1, CCDC59, GATA6, PTRF, TG, SFTPB (normal)

LIHC (tumor)	LIHC (normal)
NKX2-1, NCK1, HIPK2, SP1, GRB2, RELA, MAPK1, CREBBP, NCOA1, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, TDG, WWTR1, PAX8, CCDC59, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, HIPK2, SP1, MAPK1, RARA, CREBBP, NCOA1, FYN, RAB3GAP2, ABL1, CALR, SP3, TDG, WWTR1, PAX8, GATA6, PTRF, TG, SFTPB (normal)

LUAD (tumor)	LUAD (normal)
NKX2-1, NCK1, NCOA3, HIPK2, SP1, RELA, SRC, MAPK1, RARA, CREBBP, FYN, NCOA2, CALR, SP3, CRK, TDG, WWTR1, PAX8, CCDC59, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, HIPK2, SP1, GRB2, RELA, SRC, RARA, CREBBP, NCOA1, FYN, NCOA2, SP3, CRK, TDG, PAX8, CCDC59, GATA6, TG, SFTPB (normal)

LUSC (tumor)	LUSC (normal)
NKX2-1, NCK1, NCOA3, HIPK2, GRB2, RELA, SRC, RARA, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, TDG, WWTR1, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, HIPK2, SP1, GRB2, RELA, MAPK1, RARA, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, TDG, WWTR1, CCDC59, GATA6, PTRF, TG, SFTPB (normal)

PRAD (tumor)	PRAD (normal)
NKX2-1, HIPK2, GRB2, RELA, SRC, MAPK1, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, TDG, WWTR1, PAX8, GATA6, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, HIPK2, SP1, GRB2, RELA, SRC, MAPK1, CREBBP, NCOA1, ABL1, CALR, SP3, CRK, TDG, PAX8, CCDC59, GATA6, PTRF, TG, SFTPB (normal)

STAD (tumor)	STAD (normal)
NKX2-1, NCK1, GRB2, RELA, SRC, MAPK1, RARA, CREBBP, NCOA1, FYN, NCOA2, RAB3GAP2, ABL1, CALR, CRK, TDG, WWTR1, GATA6, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, HIPK2, SP1, GRB2, SRC, MAPK1, RARA, FYN, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, TDG, GATA6, PTRF, TG, SFTPB (normal)

THCA (tumor)	THCA (normal)
NKX2-1, NCOA3, HIPK2, GRB2, RELA, SRC, MAPK1, RARA, CREBBP, NCOA1, FYN, ABL1, CALR, SP3, CRK, TDG, WWTR1, PAX8, PTRF, TG, SFTPB (tumor)	NKX2-1, NCK1, NCOA3, SP1, GRB2, SRC, MAPK1, RARA, CREBBP, NCOA1, NCOA2, RAB3GAP2, ABL1, CALR, SP3, CRK, WWTR1, PAX8, CCDC59, GATA6, TG (normal)

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TissGeneProg for NKX2-1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for NKX2-1

TissGeneDrug for NKX2-1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for NKX2-1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0001418	Adenocarcinoma	69	BeFree,LHGDN
umls:C0152013	Adenocarcinoma of lung (disorder)	28	BeFree
umls:C0242379	Malignant neoplasm of lung	24	BeFree
umls:C0684249	Carcinoma of lung	21	BeFree
umls:C0393584	Benign Hereditary Chorea	20	BeFree,CLINVAR,ORPHANET,UNIPROT
umls:C0010308	Congenital Hypothyroidism	17	BeFree,GAD,LHGDN
umls:C0342200	Endemic Cretinism	17	BeFree
umls:C0549473	Thyroid carcinoma	15	BeFree,GAD
umls:C0007131	Non-Small Cell Lung Carcinoma	14	BeFree
umls:C0238463	Papillary thyroid carcinoma	14	BeFree,ORPHANET
umls:C0007137	Squamous cell carcinoma	13	BeFree
umls:C0024121	Lung Neoplasms	12	BeFree,LHGDN
umls:C0040136	Thyroid Neoplasm	10	BeFree,GAD,LHGDN
umls:C0020676	Hypothyroidism	8	BeFree,LHGDN
umls:C0596263	Carcinogenesis	8	BeFree
umls:C1563716	Thyroid Dysgenesis	8	BeFree
umls:C0024115	Lung diseases	7	BeFree,CTD_human
umls:C0027627	Neoplasm Metastasis	7	BeFree
umls:C0262584	Carcinoma, Small Cell	7	BeFree
umls:C0007133	Carcinoma, Papillary	6	BeFree,GAD
umls:C1145670	Respiratory Failure	6	BeFree
umls:C0007115	Malignant neoplasm of thyroid	5	BeFree
umls:C0032002	Pituitary Diseases	5	BeFree
umls:C0149925	Small cell carcinoma of lung	5	BeFree,LHGDN
umls:C1970269	Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress	5	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0007095	Carcinoid Tumor	4	BeFree
umls:C0008489	Chorea	4	BeFree,CTD_human,LHGDN
umls:C0678222	Breast Carcinoma	4	BeFree
umls:C1337013	Differentiated Thyroid Gland Carcinoma	4	BeFree
umls:C0001430	Adenoma	3	BeFree,LHGDN
umls:C0006142	Malignant neoplasm of breast	3	BeFree
umls:C0007130	Mucinous Adenocarcinoma	3	BeFree
umls:C0019284	Diaphragmatic Hernia	3	CTD_human,RGD
umls:C0019569	Hirschsprung Disease	3	BeFree,GAD,LHGDN
umls:C0032227	Pleural effusion disorder	3	BeFree
umls:C0178874	Tumor Progression	3	BeFree
umls:C0238461	Anaplastic thyroid carcinoma	3	BeFree
umls:C0852283	Respiratory Distress Syndrome	3	BeFree
umls:C1334455	Pulmonary Sclerosing Hemangioma	3	BeFree,LHGDN
umls:C0002793	Anaplasia	2	BeFree
umls:C0004096	Asthma	2	BeFree
umls:C0004134	Ataxia	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0032285	Pneumonia	2	BeFree
umls:C0035204	Respiration Disorders	2	BeFree
umls:C0035242	Respiratory Tract Diseases	2	BeFree
umls:C0085583	Choreoathetosis	2	BeFree
umls:C0205696	Anaplastic carcinoma	2	BeFree
umls:C0205698	Undifferentiated carcinoma	2	BeFree
umls:C0206704	Carcinoma, Large Cell	2	BeFree
umls:C0220650	Metastatic malignant neoplasm to brain	2	BeFree
umls:C0238462	Medullary carcinoma of thyroid	2	BeFree
umls:C0265783	Congenital hypoplasia of lung	2	BeFree
umls:C0342208	Multinodular goiter	2	BeFree
umls:C0699734	progressive chorea	2	BeFree
umls:C1265996	Large cell neuroendocrine carcinoma	2	BeFree
umls:C1709246	Non-Neoplastic Disorder	2	BeFree
umls:C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2	BeFree
umls:C0000768	Congenital Abnormality	1	BeFree
umls:C0007103	Malignant neoplasm of endometrium	1	BeFree
umls:C0007621	Neoplastic Cell Transformation	1	GAD
umls:C0009404	Colorectal Neoplasms	1	BeFree
umls:C0011265	Presenile dementia	1	BeFree
umls:C0013362	Dysarthria	1	BeFree
umls:C0013421	Dystonia	1	BeFree
umls:C0016522	Foramen Ovale, Patent	1	GAD
umls:C0017154	Gastritis, Atrophic	1	BeFree
umls:C0018021	Goiter	1	BeFree
umls:C0018023	Nodular Goiter	1	GAD
umls:C0018213	Graves Disease	1	BeFree
umls:C0019348	Herpes Simplex Infections	1	BeFree
umls:C0020179	Huntington Disease	1	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	1	BeFree
umls:C0025202	melanoma	1	BeFree
umls:C0025267	Multiple Endocrine Neoplasia Type 1	1	BeFree
umls:C0026650	Movement Disorders	1	BeFree
umls:C0026827	Muscle hypotonia	1	BeFree
umls:C0027066	Myoclonus	1	BeFree
umls:C0027708	Nephroblastoma	1	LHGDN
umls:C0028754	Obesity	1	GAD
umls:C0029925	Ovarian Carcinoma	1	BeFree
umls:C0032460	Polycystic Ovary Syndrome	1	GAD
umls:C0034012	Delayed Puberty	1	GAD
umls:C0034013	Precocious Puberty	1	GAD
umls:C0038454	Cerebrovascular accident	1	GAD
umls:C0079744	Diffuse Large B-Cell Lymphoma	1	BeFree
umls:C0080032	Pleural Effusion, Malignant	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085167	Granular cell tumor	1	BeFree
umls:C0085215	Ovarian Failure, Premature	1	GAD
umls:C0206062	Lung Diseases, Interstitial	1	BeFree
umls:C0206693	Medullary carcinoma	1	LHGDN
umls:C0206695	Carcinoma, Neuroendocrine	1	LHGDN
umls:C0235031	Neurologic Symptoms	1	BeFree
umls:C0265780	Congenital absence of lung	1	BeFree
umls:C0271829	Pendred's syndrome	1	BeFree
umls:C0334276	Adenocarcinoma in Situ	1	BeFree
umls:C0342196	Thyroid Dyshormonogenesis 5	1	BeFree
umls:C0342409	Hypophysitis	1	BeFree
umls:C0342419	Pituitary mass	1	BeFree
umls:C0345963	Benign neoplasm of lung	1	BeFree
umls:C0349476	Congenital goiter	1	BeFree
umls:C0393593	Dystonia Disorders	1	BeFree
umls:C0424605	Developmental delay (disorder)	1	BeFree
umls:C0456891	Primary pulmonary hypoplasia	1	BeFree
umls:C0476089	Endometrial Carcinoma	1	BeFree
umls:C0497327	Dementia	1	BeFree
umls:C0520947	Clumsiness - motor delay	1	BeFree
umls:C0521158	Recurrent tumor	1	BeFree
umls:C0521648	Neonatal respiratory failure	1	BeFree
umls:C0854988	Adenocarcinoma of lung, stage IV	1	BeFree
umls:C0919267	ovarian neoplasm	1	BeFree
umls:C1140680	Malignant neoplasm of ovary	1	BeFree
umls:C1266050	Poorly Differentiated Thyroid Carcinoma	1	BeFree
umls:C1333873	Granular cell tumor of neurohypophysis	1	BeFree
umls:C1569637	Adenocarcinoma, Endometrioid	1	BeFree
umls:C1834570	Myoclonic dystonia	1	BeFree
umls:C1868682	Paroxysmal kinesigenic choreoathetosis	1	BeFree
umls:C1883486	Uterine Corpus Cancer	1	BeFree
umls:C2986550	Pituicytoma	1	BeFree
umls:C3161105	Neuroendocrine cell hyperplasia of infancy	1	BeFree