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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TNR
check button Gene summary
Basic gene informationGene symbolTNR
Gene nametenascin R
SynonymsTN-R
CytomapUCSC genome browser: 1q24
Type of geneprotein-coding
RefGenesNM_003285.2,
Descriptionjanusinrestrictintenascin-R
Modification date20141207
dbXrefs MIM : 601995
HGNC : HGNC
Ensembl : ENSG00000116147
HPRD : 03589
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TNR
BioGPS: 7143
PathwayNCI Pathway Interaction Database: TNR
KEGG: TNR
REACTOME: TNR
Pathway Commons: TNR
ContextiHOP: TNR
ligand binding site mutation search in PubMed: TNR
UCL Cancer Institute: TNR
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Brain
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGG
Reference showing the relevant tissue of TNR
Description by TissGene annotationsCancer gene
TissgsKTS
CNV lost TissGeneKTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for TNR

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC-1.0937439611.311456039-2.40525.51E-095.19E-08
KICH-1.582619961-0.509835961-1.0727841.25E-053.89E-05
LUSC-1.1552897651.866927882-3.0222176472.71E-151.75E-14
LUAD-0.7767403062.076364867-2.8531051721.09E-171.46E-16


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TissGene-miRNA for TNR

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TNR
TissGeneSNV for TNR

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E930KSKCM6
p.E6KSKCM4
p.E263KSKCM3
p.S441FSKCM3
p.E446KSKCM3
p.R899*SKCM2
p.R492LLUAD2
p.W346*SKCM2
p.R1007WUCEC2
p.L21FSKCM2
p.S149LSKCM2
p.E384KSKCM2
p.R1256CSKCM2
p.W346XSKCM2
p.R899XSKCM2
p.P555SSKCM2
p.E354KSKCM2
p.R234QCOAD2
p.E192KSKCM2
p.Q1113ELUAD1
p.Y287*LUAD1
p.W346CLUAD1
p.E1069KSKCM1
p.R683SBLCA1
p.L987RPAAD1
p.D4HACC1
p.G1313RPAAD1
p.A563VSKCM1
p.E446KSARC1
p.S176NESCA1
p.A952VSKCM1
p.Y256*LUAD1
p.G1186CLUAD1
p.P1334LSKCM1
p.V431MPRAD1
p.P956LSKCM1
p.K197NLUAD1
p.P267LLUAD1
p.T1032NLUAD1
p.G1350WLUAD1
p.S497WLUAD1
p.V561LLUAD1
p.E816QLUSC1
p.T408SLUAD1
p.A165SLUAD1
p.E284*LUAD1
p.S1259NSTAD1
p.G904*LUAD1
p.G546RSKCM1
p.D4NSKCM1
p.V288IHNSC1
p.T113SOV1
p.E232KSTAD1
p.D465NSKCM1
p.T608AKIRC1
p.S897APAAD1
p.R775HCOAD1
p.M832LLUAD1
p.S795ILUAD1
p.P746SLUAD1
p.A709DLUAD1
p.R372QLUAD1
p.G272VLUAD1
p.P361LKIRC1
p.E309KLUSC1
p.P205RLUAD1
p.Q674KSARC1
p.G193CLUSC1
p.G2VLUAD1
p.P374LLUAD1
p.S499NLIHC1
p.I342NLUAD1
p.D878NSKCM1
p.R803KSKCM1
p.E162KSKCM1
p.P74TLUAD1
p.M670ISKCM1
p.P418SSKCM1
p.R1217MSTAD1
p.E432VLUSC1
p.S448RACC1
p.I26MLUSC1
p.V936MLUAD1
p.E816KLUAD1
p.L1040_spliceLUSC1
p.A748TPAAD1
p.P555LSKCM1
p.R372WBLCA1
p.S783FSARC1
p.P495SSKCM1
p.P966SSKCM1
p.E455KSKCM1
p.D1104NSKCM1
p.G1174EHNSC1
p.D238NBLCA1
p.V1285AUCEC1
p.R1227CMESO1
p.G336SLUAD1
p.I1033NTHCA1
p.N581KLUSC1
p.D907HLUAD1
p.C230YLUSC1
p.P329TPAAD1
p.H950YUCEC1
p.G1158RSKCM1
p.L1347FSKCM1
p.S394NCOAD1
p.H1016QCOAD1
p.N843SSKCM1
p.S557GSTAD1
p.D812NSKCM1
p.P463RSKCM1
p.T430ASKCM1
p.R1130WLUAD1
p.S439LSKCM1
p.S226RUCEC1
p.W614XLIHC1
p.R234WLUAD1
p.Q1354HOV1
p.P437TLUAD1
p.R304*LUAD1
p.Q1272KLUAD1
p.R1007LLUSC1
p.S223NSTAD1
p.G217SSKCM1
p.R1341CSTAD1
p.S516LBLCA1
p.N12THNSC1
p.C230SLUAD1
p.H414YSTAD1
p.P642TLUAD1
p.R513CUCEC1
p.P173SLUAD1
p.E345VLUAD1
p.D514YLUSC1
p.R42GSTAD1
p.L244FSKCM1
p.A975TLUSC1
p.P62LLUAD1
p.A801GLUAD1
p.P566RKIRP1
p.P722SSKCM1
p.A563SLUAD1
p.E109QHNSC1
p.E263KLUAD1
p.E1247*HNSC1
p.V68LUCEC1
p.V845LLUAD1
p.K1083NLUAD1
p.Y54NHNSC1
p.D1114NBRCA1
p.P387QLUAD1
p.I860VPRAD1
p.G196RLUAD1
p.E489KSKCM1
p.R937WLUSC1
p.R760PLUSC1
p.R304QBLCA1
p.T502IHNSC1
p.E928KESCA1
p.S575TCOAD1
p.G477RKIRC1
p.V627LLUAD1
p.A363VBRCA1
p.V40LLUAD1
p.P1043SSKCM1
p.Y1260CLIHC1
p.P776LLUAD1
p.I1068TKIRC1
p.D595NBRCA1
p.V639LLUAD1
p.D823NSKCM1
p.P956HREAD1
p.G286CLUSC1
p.R937QCOAD1
p.D615NSKCM1
p.M1143ISKCM1
p.K877TCOAD1
p.E523VLUAD1
p.G1310ESKCM1
p.S1038FSKCM1
p.Q1221*BLCA1
p.R895*SKCM1
p.S560XTHYM1
p.A563PLUAD1
p.V669ITHYM1
p.M818KKIRC1
p.D865YLUAD1
p.E142KSKCM1
p.E995*LUAD1
p.R1274LOV1
p.Q370ELUAD1
p.R1274HESCA1
p.R1082HBLCA1
p.S942NSKCM1
p.R1007WOV1
p.R513SESCA1
p.P526SSKCM1
p.E544KSKCM1
p.R234WREAD1
p.P329LSARC1
p.D584YLUAD1
p.R605CSARC1
p.D1114GLIHC1
p.E142QBLCA1
p.T850ISTAD1
p.V215ELUAD1
p.M1021ILUAD1
p.T1106PESCA1
p.Q902KLUAD1
p.D153YCOAD1
p.P1153TACC1
p.R340SLIHC1
p.S44LHNSC1
p.A397PLUAD1
p.D1169NSKCM1
p.S1050NLGG1
p.V313FBLCA1
p.S883FSKCM1
p.A1049TCOAD1
p.R605HTHYM1
p.E259KSKCM1
p.R899*STAD1
p.F1244LUCEC1
p.E309KSARC1
p.S859FSKCM1
p.V903LLUAD1
p.L1148VLUSC1
p.A1297ELUSC1
p.M1230KLUAD1
p.D1213HLUAD1
p.Y359FPAAD1
p.Q509ELUAD1
p.K974MLUAD1
p.C190YHNSC1
p.T7KLUAD1
p.T257ILUAD1
p.S821FLUAD1
p.I841VHNSC1
p.L1255IPAAD1
p.E100KSKCM1
p.D532NSKCM1
p.Q562HSARC1
p.R569QSTAD1
p.E940DSKCM1
p.R1007WLUSC1
p.A1023VSTAD1
p.P867TLUAD1
p.S932RLUAD1
p.P887SSKCM1
p.A164DLUAD1
p.G663RSKCM1
p.L75FLUAD1
p.R333QUCEC1
p.S1050ILUAD1
p.R1353QSTAD1
p.E60KSKCM1
p.E386KSKCM1
p.T588SHNSC1
p.Q461PLUSC1
p.A327SESCA1
p.R760QCOAD1
p.G310ESKCM1
p.A128TUCEC1
p.S701PESCA1
p.P866SSKCM1
p.Y203CSTAD1
p.G633VLUAD1
p.P205SSKCM1
p.T1127RLUAD1
p.E571KSTAD1
p.G725ESKCM1
p.P255ALUAD1
p.E839XCOAD1
p.T719SLIHC1
p.V657ILGG1
p.D4HHNSC1
p.P658TLUAD1
p.R565QBRCA1
p.D958NSKCM1
p.D1282GLIHC1
p.N807KLUAD1
p.E46KSKCM1
p.R1256CESCA1
p.G444VLUSC1
p.V1287ELUSC1
p.V45LLUAD1
p.A124VSTAD1
p.T1147IDLBC1
p.E814KSKCM1
p.E201KSKCM1
p.H174YSKCM1
p.R578QSKCM1
p.R895XSKCM1
p.T353MACC1
p.R1095XSKCM1
p.G1262DSKCM1
p.A128SCOAD1
p.Q371KLUAD1
p.G420RSKCM1
p.S763NSKCM1
p.R899XSTAD1
p.A491TSTAD1
p.D1284GHNSC1
p.R140QBRCA1
p.R1256SLUAD1
p.E1314VACC1
p.G644DSKCM1
p.S787PBRCA1
p.R1305WCOAD1
p.A277TSTAD1
p.T648ISKCM1
p.E384DLUAD1
p.E745KSKCM1
p.T1024AHNSC1
p.L1108FUCEC1
p.S176CLUAD1
p.H178NLGG1
p.Q1221*LUAD1
p.P126LSKCM1
p.K1083_spliceLUSC1
p.N156KLUAD1
p.R601*UCEC1
p.K1254ESTAD1
p.T919SLUAD1
p.R569QSKCM1
p.V626GSARC1
p.V910LLUAD1
p.S231FSKCM1
p.F65LLUAD1
p.P205LSKCM1
p.R605HHNSC1
p.P1342LSKCM1
p.R551QSKCM1
p.D743ESTAD1
p.T425MCOAD1
p.E940KBLCA1
p.S1077FSKCM1
p.E571KBLCA1
p.P799RLIHC1
p.A397VLUAD1
p.V9ALIHC1
p.E930KSARC1
p.R1353WPAAD1
p.E284KSARC1
p.S200LLUAD1
p.T467MCOAD1
p.R528*LUAD1
p.A770VSKCM1
p.D465YLUAD1
p.E1247KCOAD1
p.S1259IKIRC1
p.S439*LUAD1
p.D170GTHYM1
p.E571KSKCM1
p.D802VLUAD1
p.T353MPAAD1
p.G1174WHNSC1
p.T721PLUAD1
p.E1067KSKCM1
p.D812HLUSC1
p.E930KPAAD1
p.W1093*SKCM1
p.H784YSKCM1
p.Q674KSTAD1
p.S200LUCEC1
p.R565WSTAD1
p.Q553PSKCM1
p.G1202WSKCM1
p.S1030TSTAD1
p.W377CHNSC1
p.G725WLUAD1
p.L1347HLUAD1
p.P329RLUAD1
p.D1229YLUSC1
p.G1001VLUAD1
p.W445*SKCM1
p.R1095*SKCM1
p.R1231WLGG1
p.C204FCOAD1
p.E96DLUSC1
p.K11NOV1
p.Q168KSTAD1
p.S1277TSKCM1
p.P74SSKCM1
p.P836QHNSC1
p.E428*UCEC1
p.E917KSKCM1
p.P647LSKCM1
p.F1125VLUAD1
p.A727VCOAD1
p.Y1260CUCEC1


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TissGeneCNV for TNR

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TNR

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAU89354CREBBP-TNRchr16:3778291chr1:175441100


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TissGeneNet for TNR

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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COAD (tumor)COAD (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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HNSC (tumor)HNSC (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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KICH (tumor)KICH (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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KIRC (tumor)KIRC (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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KIRP (tumor)KIRP (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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LIHC (tumor)LIHC (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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LUAD (tumor)LUAD (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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LUSC (tumor)LUSC (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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PRAD (tumor)PRAD (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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STAD (tumor)STAD (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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THCA (tumor)THCA (normal)
TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (tumor)TNR, NCAN, BCAN, CNTN1, NFASC, VCAN, ACAN, PTPRZ1, SIGLEC1 (normal)
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TissGeneProg for TNR

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TNR
TissGeneDrug for TNR

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for TNR

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0000768Congenital Abnormality1BeFree
umls:C0000786Spontaneous abortion1CTD_human
umls:C0002395Alzheimer's Disease1BeFree
umls:C0005586Bipolar Disorder1BeFree
umls:C0006142Malignant neoplasm of breast1GAD
umls:C0008495Chorioamnionitis1GAD
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0017636Glioblastoma1BeFree
umls:C0017639Gliosis1CTD_human
umls:C0017661IGA Glomerulonephritis1GAD
umls:C0022876Premature Obstetric Labor1GAD
umls:C0025149Medulloblastoma1BeFree
umls:C0028945oligodendroglioma1BeFree
umls:C0032914Pre-Eclampsia1GAD
umls:C0036341Schizophrenia1GAD
umls:C0040336Tobacco Use Disorder1GAD
umls:C0151526Premature Birth1GAD
umls:C0206716Ganglioglioma1BeFree
umls:C0334583Pilocytic Astrocytoma1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0751396Well Differentiated Oligodendroglioma1BeFree
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C3714756Intellectual Disability1BeFree