TissGeneSummary for TNR |
Gene summary |
Basic gene information | Gene symbol | TNR |
Gene name | tenascin R | |
Synonyms | TN-R | |
Cytomap | UCSC genome browser: 1q24 | |
Type of gene | protein-coding | |
RefGenes | NM_003285.2, | |
Description | janusinrestrictintenascin-R | |
Modification date | 20141207 | |
dbXrefs | MIM : 601995 | |
HGNC : HGNC | ||
Ensembl : ENSG00000116147 | ||
HPRD : 03589 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TNR | |
BioGPS: 7143 | ||
Pathway | NCI Pathway Interaction Database: TNR | |
KEGG: TNR | ||
REACTOME: TNR | ||
Pathway Commons: TNR | ||
Context | iHOP: TNR | |
ligand binding site mutation search in PubMed: TNR | ||
UCL Cancer Institute: TNR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of TNR | ||
Description by TissGene annotations | Cancer gene TissgsKTS CNV lost TissGeneKTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TNR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.093743961 | 1.311456039 | -2.4052 | 5.51E-09 | 5.19E-08 |
KICH | -1.582619961 | -0.509835961 | -1.072784 | 1.25E-05 | 3.89E-05 |
LUSC | -1.155289765 | 1.866927882 | -3.022217647 | 2.71E-15 | 1.75E-14 |
LUAD | -0.776740306 | 2.076364867 | -2.853105172 | 1.09E-17 | 1.46E-16 |
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TissGene-miRNA for TNR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TNR |
TissGeneSNV for TNR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E930K | SKCM | 6 |
p.E6K | SKCM | 4 |
p.E263K | SKCM | 3 |
p.S441F | SKCM | 3 |
p.E446K | SKCM | 3 |
p.R899* | SKCM | 2 |
p.R492L | LUAD | 2 |
p.W346* | SKCM | 2 |
p.R1007W | UCEC | 2 |
p.L21F | SKCM | 2 |
p.S149L | SKCM | 2 |
p.E384K | SKCM | 2 |
p.R1256C | SKCM | 2 |
p.W346X | SKCM | 2 |
p.R899X | SKCM | 2 |
p.P555S | SKCM | 2 |
p.E354K | SKCM | 2 |
p.R234Q | COAD | 2 |
p.E192K | SKCM | 2 |
p.Q1113E | LUAD | 1 |
p.Y287* | LUAD | 1 |
p.W346C | LUAD | 1 |
p.E1069K | SKCM | 1 |
p.R683S | BLCA | 1 |
p.L987R | PAAD | 1 |
p.D4H | ACC | 1 |
p.G1313R | PAAD | 1 |
p.A563V | SKCM | 1 |
p.E446K | SARC | 1 |
p.S176N | ESCA | 1 |
p.A952V | SKCM | 1 |
p.Y256* | LUAD | 1 |
p.G1186C | LUAD | 1 |
p.P1334L | SKCM | 1 |
p.V431M | PRAD | 1 |
p.P956L | SKCM | 1 |
p.K197N | LUAD | 1 |
p.P267L | LUAD | 1 |
p.T1032N | LUAD | 1 |
p.G1350W | LUAD | 1 |
p.S497W | LUAD | 1 |
p.V561L | LUAD | 1 |
p.E816Q | LUSC | 1 |
p.T408S | LUAD | 1 |
p.A165S | LUAD | 1 |
p.E284* | LUAD | 1 |
p.S1259N | STAD | 1 |
p.G904* | LUAD | 1 |
p.G546R | SKCM | 1 |
p.D4N | SKCM | 1 |
p.V288I | HNSC | 1 |
p.T113S | OV | 1 |
p.E232K | STAD | 1 |
p.D465N | SKCM | 1 |
p.T608A | KIRC | 1 |
p.S897A | PAAD | 1 |
p.R775H | COAD | 1 |
p.M832L | LUAD | 1 |
p.S795I | LUAD | 1 |
p.P746S | LUAD | 1 |
p.A709D | LUAD | 1 |
p.R372Q | LUAD | 1 |
p.G272V | LUAD | 1 |
p.P361L | KIRC | 1 |
p.E309K | LUSC | 1 |
p.P205R | LUAD | 1 |
p.Q674K | SARC | 1 |
p.G193C | LUSC | 1 |
p.G2V | LUAD | 1 |
p.P374L | LUAD | 1 |
p.S499N | LIHC | 1 |
p.I342N | LUAD | 1 |
p.D878N | SKCM | 1 |
p.R803K | SKCM | 1 |
p.E162K | SKCM | 1 |
p.P74T | LUAD | 1 |
p.M670I | SKCM | 1 |
p.P418S | SKCM | 1 |
p.R1217M | STAD | 1 |
p.E432V | LUSC | 1 |
p.S448R | ACC | 1 |
p.I26M | LUSC | 1 |
p.V936M | LUAD | 1 |
p.E816K | LUAD | 1 |
p.L1040_splice | LUSC | 1 |
p.A748T | PAAD | 1 |
p.P555L | SKCM | 1 |
p.R372W | BLCA | 1 |
p.S783F | SARC | 1 |
p.P495S | SKCM | 1 |
p.P966S | SKCM | 1 |
p.E455K | SKCM | 1 |
p.D1104N | SKCM | 1 |
p.G1174E | HNSC | 1 |
p.D238N | BLCA | 1 |
p.V1285A | UCEC | 1 |
p.R1227C | MESO | 1 |
p.G336S | LUAD | 1 |
p.I1033N | THCA | 1 |
p.N581K | LUSC | 1 |
p.D907H | LUAD | 1 |
p.C230Y | LUSC | 1 |
p.P329T | PAAD | 1 |
p.H950Y | UCEC | 1 |
p.G1158R | SKCM | 1 |
p.L1347F | SKCM | 1 |
p.S394N | COAD | 1 |
p.H1016Q | COAD | 1 |
p.N843S | SKCM | 1 |
p.S557G | STAD | 1 |
p.D812N | SKCM | 1 |
p.P463R | SKCM | 1 |
p.T430A | SKCM | 1 |
p.R1130W | LUAD | 1 |
p.S439L | SKCM | 1 |
p.S226R | UCEC | 1 |
p.W614X | LIHC | 1 |
p.R234W | LUAD | 1 |
p.Q1354H | OV | 1 |
p.P437T | LUAD | 1 |
p.R304* | LUAD | 1 |
p.Q1272K | LUAD | 1 |
p.R1007L | LUSC | 1 |
p.S223N | STAD | 1 |
p.G217S | SKCM | 1 |
p.R1341C | STAD | 1 |
p.S516L | BLCA | 1 |
p.N12T | HNSC | 1 |
p.C230S | LUAD | 1 |
p.H414Y | STAD | 1 |
p.P642T | LUAD | 1 |
p.R513C | UCEC | 1 |
p.P173S | LUAD | 1 |
p.E345V | LUAD | 1 |
p.D514Y | LUSC | 1 |
p.R42G | STAD | 1 |
p.L244F | SKCM | 1 |
p.A975T | LUSC | 1 |
p.P62L | LUAD | 1 |
p.A801G | LUAD | 1 |
p.P566R | KIRP | 1 |
p.P722S | SKCM | 1 |
p.A563S | LUAD | 1 |
p.E109Q | HNSC | 1 |
p.E263K | LUAD | 1 |
p.E1247* | HNSC | 1 |
p.V68L | UCEC | 1 |
p.V845L | LUAD | 1 |
p.K1083N | LUAD | 1 |
p.Y54N | HNSC | 1 |
p.D1114N | BRCA | 1 |
p.P387Q | LUAD | 1 |
p.I860V | PRAD | 1 |
p.G196R | LUAD | 1 |
p.E489K | SKCM | 1 |
p.R937W | LUSC | 1 |
p.R760P | LUSC | 1 |
p.R304Q | BLCA | 1 |
p.T502I | HNSC | 1 |
p.E928K | ESCA | 1 |
p.S575T | COAD | 1 |
p.G477R | KIRC | 1 |
p.V627L | LUAD | 1 |
p.A363V | BRCA | 1 |
p.V40L | LUAD | 1 |
p.P1043S | SKCM | 1 |
p.Y1260C | LIHC | 1 |
p.P776L | LUAD | 1 |
p.I1068T | KIRC | 1 |
p.D595N | BRCA | 1 |
p.V639L | LUAD | 1 |
p.D823N | SKCM | 1 |
p.P956H | READ | 1 |
p.G286C | LUSC | 1 |
p.R937Q | COAD | 1 |
p.D615N | SKCM | 1 |
p.M1143I | SKCM | 1 |
p.K877T | COAD | 1 |
p.E523V | LUAD | 1 |
p.G1310E | SKCM | 1 |
p.S1038F | SKCM | 1 |
p.Q1221* | BLCA | 1 |
p.R895* | SKCM | 1 |
p.S560X | THYM | 1 |
p.A563P | LUAD | 1 |
p.V669I | THYM | 1 |
p.M818K | KIRC | 1 |
p.D865Y | LUAD | 1 |
p.E142K | SKCM | 1 |
p.E995* | LUAD | 1 |
p.R1274L | OV | 1 |
p.Q370E | LUAD | 1 |
p.R1274H | ESCA | 1 |
p.R1082H | BLCA | 1 |
p.S942N | SKCM | 1 |
p.R1007W | OV | 1 |
p.R513S | ESCA | 1 |
p.P526S | SKCM | 1 |
p.E544K | SKCM | 1 |
p.R234W | READ | 1 |
p.P329L | SARC | 1 |
p.D584Y | LUAD | 1 |
p.R605C | SARC | 1 |
p.D1114G | LIHC | 1 |
p.E142Q | BLCA | 1 |
p.T850I | STAD | 1 |
p.V215E | LUAD | 1 |
p.M1021I | LUAD | 1 |
p.T1106P | ESCA | 1 |
p.Q902K | LUAD | 1 |
p.D153Y | COAD | 1 |
p.P1153T | ACC | 1 |
p.R340S | LIHC | 1 |
p.S44L | HNSC | 1 |
p.A397P | LUAD | 1 |
p.D1169N | SKCM | 1 |
p.S1050N | LGG | 1 |
p.V313F | BLCA | 1 |
p.S883F | SKCM | 1 |
p.A1049T | COAD | 1 |
p.R605H | THYM | 1 |
p.E259K | SKCM | 1 |
p.R899* | STAD | 1 |
p.F1244L | UCEC | 1 |
p.E309K | SARC | 1 |
p.S859F | SKCM | 1 |
p.V903L | LUAD | 1 |
p.L1148V | LUSC | 1 |
p.A1297E | LUSC | 1 |
p.M1230K | LUAD | 1 |
p.D1213H | LUAD | 1 |
p.Y359F | PAAD | 1 |
p.Q509E | LUAD | 1 |
p.K974M | LUAD | 1 |
p.C190Y | HNSC | 1 |
p.T7K | LUAD | 1 |
p.T257I | LUAD | 1 |
p.S821F | LUAD | 1 |
p.I841V | HNSC | 1 |
p.L1255I | PAAD | 1 |
p.E100K | SKCM | 1 |
p.D532N | SKCM | 1 |
p.Q562H | SARC | 1 |
p.R569Q | STAD | 1 |
p.E940D | SKCM | 1 |
p.R1007W | LUSC | 1 |
p.A1023V | STAD | 1 |
p.P867T | LUAD | 1 |
p.S932R | LUAD | 1 |
p.P887S | SKCM | 1 |
p.A164D | LUAD | 1 |
p.G663R | SKCM | 1 |
p.L75F | LUAD | 1 |
p.R333Q | UCEC | 1 |
p.S1050I | LUAD | 1 |
p.R1353Q | STAD | 1 |
p.E60K | SKCM | 1 |
p.E386K | SKCM | 1 |
p.T588S | HNSC | 1 |
p.Q461P | LUSC | 1 |
p.A327S | ESCA | 1 |
p.R760Q | COAD | 1 |
p.G310E | SKCM | 1 |
p.A128T | UCEC | 1 |
p.S701P | ESCA | 1 |
p.P866S | SKCM | 1 |
p.Y203C | STAD | 1 |
p.G633V | LUAD | 1 |
p.P205S | SKCM | 1 |
p.T1127R | LUAD | 1 |
p.E571K | STAD | 1 |
p.G725E | SKCM | 1 |
p.P255A | LUAD | 1 |
p.E839X | COAD | 1 |
p.T719S | LIHC | 1 |
p.V657I | LGG | 1 |
p.D4H | HNSC | 1 |
p.P658T | LUAD | 1 |
p.R565Q | BRCA | 1 |
p.D958N | SKCM | 1 |
p.D1282G | LIHC | 1 |
p.N807K | LUAD | 1 |
p.E46K | SKCM | 1 |
p.R1256C | ESCA | 1 |
p.G444V | LUSC | 1 |
p.V1287E | LUSC | 1 |
p.V45L | LUAD | 1 |
p.A124V | STAD | 1 |
p.T1147I | DLBC | 1 |
p.E814K | SKCM | 1 |
p.E201K | SKCM | 1 |
p.H174Y | SKCM | 1 |
p.R578Q | SKCM | 1 |
p.R895X | SKCM | 1 |
p.T353M | ACC | 1 |
p.R1095X | SKCM | 1 |
p.G1262D | SKCM | 1 |
p.A128S | COAD | 1 |
p.Q371K | LUAD | 1 |
p.G420R | SKCM | 1 |
p.S763N | SKCM | 1 |
p.R899X | STAD | 1 |
p.A491T | STAD | 1 |
p.D1284G | HNSC | 1 |
p.R140Q | BRCA | 1 |
p.R1256S | LUAD | 1 |
p.E1314V | ACC | 1 |
p.G644D | SKCM | 1 |
p.S787P | BRCA | 1 |
p.R1305W | COAD | 1 |
p.A277T | STAD | 1 |
p.T648I | SKCM | 1 |
p.E384D | LUAD | 1 |
p.E745K | SKCM | 1 |
p.T1024A | HNSC | 1 |
p.L1108F | UCEC | 1 |
p.S176C | LUAD | 1 |
p.H178N | LGG | 1 |
p.Q1221* | LUAD | 1 |
p.P126L | SKCM | 1 |
p.K1083_splice | LUSC | 1 |
p.N156K | LUAD | 1 |
p.R601* | UCEC | 1 |
p.K1254E | STAD | 1 |
p.T919S | LUAD | 1 |
p.R569Q | SKCM | 1 |
p.V626G | SARC | 1 |
p.V910L | LUAD | 1 |
p.S231F | SKCM | 1 |
p.F65L | LUAD | 1 |
p.P205L | SKCM | 1 |
p.R605H | HNSC | 1 |
p.P1342L | SKCM | 1 |
p.R551Q | SKCM | 1 |
p.D743E | STAD | 1 |
p.T425M | COAD | 1 |
p.E940K | BLCA | 1 |
p.S1077F | SKCM | 1 |
p.E571K | BLCA | 1 |
p.P799R | LIHC | 1 |
p.A397V | LUAD | 1 |
p.V9A | LIHC | 1 |
p.E930K | SARC | 1 |
p.R1353W | PAAD | 1 |
p.E284K | SARC | 1 |
p.S200L | LUAD | 1 |
p.T467M | COAD | 1 |
p.R528* | LUAD | 1 |
p.A770V | SKCM | 1 |
p.D465Y | LUAD | 1 |
p.E1247K | COAD | 1 |
p.S1259I | KIRC | 1 |
p.S439* | LUAD | 1 |
p.D170G | THYM | 1 |
p.E571K | SKCM | 1 |
p.D802V | LUAD | 1 |
p.T353M | PAAD | 1 |
p.G1174W | HNSC | 1 |
p.T721P | LUAD | 1 |
p.E1067K | SKCM | 1 |
p.D812H | LUSC | 1 |
p.E930K | PAAD | 1 |
p.W1093* | SKCM | 1 |
p.H784Y | SKCM | 1 |
p.Q674K | STAD | 1 |
p.S200L | UCEC | 1 |
p.R565W | STAD | 1 |
p.Q553P | SKCM | 1 |
p.G1202W | SKCM | 1 |
p.S1030T | STAD | 1 |
p.W377C | HNSC | 1 |
p.G725W | LUAD | 1 |
p.L1347H | LUAD | 1 |
p.P329R | LUAD | 1 |
p.D1229Y | LUSC | 1 |
p.G1001V | LUAD | 1 |
p.W445* | SKCM | 1 |
p.R1095* | SKCM | 1 |
p.R1231W | LGG | 1 |
p.C204F | COAD | 1 |
p.E96D | LUSC | 1 |
p.K11N | OV | 1 |
p.Q168K | STAD | 1 |
p.S1277T | SKCM | 1 |
p.P74S | SKCM | 1 |
p.P836Q | HNSC | 1 |
p.E428* | UCEC | 1 |
p.E917K | SKCM | 1 |
p.P647L | SKCM | 1 |
p.F1125V | LUAD | 1 |
p.A727V | COAD | 1 |
p.Y1260C | UCEC | 1 |
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TissGeneCNV for TNR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TNR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | U89354 | CREBBP-TNR | chr16:3778291 | chr1:175441100 |
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TissGeneNet for TNR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TNR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TNR |
TissGeneDrug for TNR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TNR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0000768 | Congenital Abnormality | 1 | BeFree |
umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
umls:C0008495 | Chorioamnionitis | 1 | GAD |
umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017639 | Gliosis | 1 | CTD_human |
umls:C0017661 | IGA Glomerulonephritis | 1 | GAD |
umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0028945 | oligodendroglioma | 1 | BeFree |
umls:C0032914 | Pre-Eclampsia | 1 | GAD |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0151526 | Premature Birth | 1 | GAD |
umls:C0206716 | Ganglioglioma | 1 | BeFree |
umls:C0334583 | Pilocytic Astrocytoma | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |
umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
umls:C3714756 | Intellectual Disability | 1 | BeFree |