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TissGeneSummary for C1R |
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Basic gene information | Gene symbol | C1R |
Gene name | complement component 1, r subcomponent | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001733.4, | |
Description | complement C1r subcomponent | |
Modification date | 20141207 | |
dbXrefs | MIM : 613785 | |
HGNC : HGNC | ||
Ensembl : ENSG00000159403 | ||
HPRD : 01954 | ||
Vega : OTTHUMG00000168149 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C1R | |
BioGPS: 715 | ||
Pathway | NCI Pathway Interaction Database: C1R | |
KEGG: C1R | ||
REACTOME: C1R | ||
Pathway Commons: C1R | ||
Context | iHOP: C1R | |
ligand binding site mutation search in PubMed: C1R | ||
UCL Cancer Institute: C1R | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverSoft tissue | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSARC | |
Reference showing the relevant tissue of C1R | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for C1R |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 2.83621375 | 4.79537975 | -1.959166 | 1.62E-16 | 6.79E-15 |
KICH | -4.18071025 | -0.65289425 | -3.527816 | 1.61E-12 | 1.83E-11 |
THCA | -1.861285234 | -0.35485642 | -1.506428814 | 3.91E-08 | 1.79E-07 |
BLCA | 0.056927434 | 1.707690592 | -1.650763158 | 8.86E-06 | 0.000175934 |
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TissGene-miRNA for C1R |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C1R |
TissGeneSNV for C1R |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q328H | ESCA | 1 |
p.L589F | LUAD | 1 |
p.G574E | SKCM | 1 |
p.R538L | HNSC | 1 |
p.N97S | SKCM | 1 |
p.P34L | SKCM | 1 |
p.D534N | SKCM | 1 |
p.G545E | SKCM | 1 |
p.G415C | UCEC | 1 |
p.G52R | SKCM | 1 |
p.M478I | THCA | 1 |
p.G507C | UCEC | 1 |
p.G178D | SKCM | 1 |
p.G605C | LUSC | 1 |
p.L452M | LGG | 1 |
p.E548K | SKCM | 1 |
p.Q408P | SKCM | 1 |
p.M478L | HNSC | 1 |
p.V708G | UCEC | 1 |
p.R13G | LIHC | 1 |
p.L535M | LGG | 1 |
p.C175Y | UCEC | 1 |
p.G26R | BLCA | 1 |
p.A438V | SKCM | 1 |
p.G268E | SKCM | 1 |
p.P454S | UCS | 1 |
p.T613A | LUAD | 1 |
p.E237A | BLCA | 1 |
p.L11M | UCEC | 1 |
p.I256S | UCEC | 1 |
p.D629Y | CESC | 1 |
p.R148W | SKCM | 1 |
p.P527L | SKCM | 1 |
p.G178S | SKCM | 1 |
p.E103K | SKCM | 1 |
p.P527S | SKCM | 1 |
p.F119C | UCEC | 1 |
p.D554N | SKCM | 1 |
p.R589C | LUSC | 1 |
p.E316K | SKCM | 1 |
p.F102L | UCEC | 1 |
p.D277N | LUSC | 1 |
p.S592C | SARC | 1 |
p.S147F | SKCM | 1 |
p.Y468* | UCEC | 1 |
p.L537F | LUAD | 1 |
p.G421S | SKCM | 1 |
p.G409R | UCEC | 1 |
p.G519R | KICH | 1 |
p.R486L | HNSC | 1 |
p.S108Y | UCEC | 1 |
p.P156S | SKCM | 1 |
p.E475K | LUAD | 1 |
p.E456K | SKCM | 1 |
p.T198M | ESCA | 1 |
p.Q339* | UCEC | 1 |
p.P253H | UCEC | 1 |
p.T277I | LUAD | 1 |
p.P21S | SKCM | 1 |
p.G27R | BLCA | 1 |
p.E331K | UCEC | 1 |
p.E458K | SKCM | 1 |
p.L25M | UCEC | 1 |
p.V605I | PAAD | 1 |
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TissGeneCNV for C1R |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C1R |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AU098919 | RYK-C1R | chr3:133926352 | chr12:7244194 | |
Chimerdb3.0 | ChiTaRs | NA | AW866363 | FBXW2-C1R | chr9:123548617 | chr12:7187582 | |
Chimerdb3.0 | ChiTaRs | NA | BE829955 | C1R-MYO9B | chr12:7188008 | chr19:17291776 |
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TissGeneNet for C1R |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C1R |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C1R |
TissGeneDrug for C1R |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C1R |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0014175 | Endometriosis | 1 | CTD_human |
umls:C0030524 | Paratuberculosis | 1 | CTD_human |
umls:C3150274 | COMPLEMENT COMPONENT C1r/C1s DEFICIENCY | 0 | CTD_human |