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TissGeneSummary for TPMT |
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Basic gene information | Gene symbol | TPMT |
Gene name | thiopurine S-methyltransferase | |
Synonyms | - | |
Cytomap | UCSC genome browser: 6p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000367.3, | |
Description | S-adenosyl-L-methionine:thiopurine S-methyltransferase | |
Modification date | 20141222 | |
dbXrefs | MIM : 187680 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137364 | ||
HPRD : 01760 | ||
Vega : OTTHUMG00000014317 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TPMT | |
BioGPS: 7172 | ||
Pathway | NCI Pathway Interaction Database: TPMT | |
KEGG: TPMT | ||
REACTOME: TPMT | ||
Pathway Commons: TPMT | ||
Context | iHOP: TPMT | |
ligand binding site mutation search in PubMed: TPMT | ||
UCL Cancer Institute: TPMT | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTHCA | |
Reference showing the relevant tissue of TPMT | ||
Description by TissGene annotations | TissgsLTS Fused withTSGene Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for TPMT |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 1.200550542 | 2.704142542 | -1.503592 | 1.34E-11 | 1.25E-10 |
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TissGene-miRNA for TPMT |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TPMT |
TissGeneSNV for TPMT |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L138I | READ | 1 |
p.S129L | SKCM | 1 |
p.K176N | UCEC | 1 |
p.E98* | UCEC | 1 |
p.E114K | BLCA | 1 |
p.L138I | ESCA | 1 |
p.D54Y | LUAD | 1 |
p.Q30R | READ | 1 |
p.K119T | UCEC | 1 |
p.R226Q | LUAD | 1 |
p.G209S | SKCM | 1 |
p.S124F | SKCM | 1 |
p.E225Q | ESCA | 1 |
p.H227R | SARC | 1 |
p.E28Q | STAD | 1 |
p.R215C | COAD | 1 |
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TissGeneCNV for TPMT |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TPMT |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU608204 | TPMT-PHACTR2 | chr6:18130276 | chr6:144148681 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OW-01A | TPMT-BTBD9 | In-Frame | chr6:18149218 | chr6:38312869 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0CX-01A | KIF13A-TPMT | In-frame | Chr6:17987285 | Chr6:18134120 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12U-01A | RANBP9-TPMT | CDS-5UTR | Chr6:13711167 | Chr6:18149402 |
TCGAfusionPortal | PRADA | OV | TCGA-13-0714-01A | NF1-TPMT | CDS-5UTR | Chr17:29422387 | Chr6:18149402 |
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TissGeneNet for TPMT |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TPMT |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TPMT |
TissGeneDrug for TPMT |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01250 | Olsalazine | Inhibitor | Small molecule | Approved |
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TissGeneDisease for TPMT |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021390 | Inflammatory Bowel Diseases | 50 | BeFree,GAD,LHGDN |
umls:C0023449 | Acute lymphocytic leukemia | 44 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 39 | BeFree,GAD,LHGDN |
umls:C0023530 | Leukopenia | 34 | BeFree,CTD_human,GAD |
umls:C0854467 | Myelosuppression | 30 | BeFree |
umls:C0023418 | leukemia | 15 | BeFree,GAD |
umls:C0342801 | Thiopurine S methyltranferase deficiency | 14 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 13 | BeFree |
umls:C0010346 | Crohn Disease | 11 | BeFree,GAD |
umls:C0027947 | Neutropenia | 6 | BeFree,CTD_human,GAD |
umls:C0085669 | Acute leukemia | 6 | BeFree |
umls:C0004364 | Autoimmune Diseases | 5 | BeFree,GAD |
umls:C0009324 | Ulcerative Colitis | 5 | BeFree,GAD |
umls:C0023467 | Leukemia, Myelocytic, Acute | 5 | BeFree,GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 5 | BeFree |
umls:C0241910 | Hepatitis, Autoimmune | 4 | BeFree |
umls:C0948168 | Bone marrow toxicity | 4 | BeFree |
umls:C0023895 | Liver diseases | 3 | BeFree,GAD,LHGDN |
umls:C0035435 | Rheumatism | 3 | BeFree,GAD |
umls:C0242596 | Neoplasm, Residual | 3 | BeFree,LHGDN |
umls:C0001824 | Agranulocytosis | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
umls:C0013182 | Drug Allergy | 2 | GAD |
umls:C0013221 | Drug toxicity | 2 | GAD |
umls:C0018939 | Hematological Disease | 2 | GAD |
umls:C0027498 | Nausea and vomiting | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0037274 | Dermatologic disorders | 2 | BeFree,GAD |
umls:C0085183 | Neoplasms, Second Primary | 2 | GAD |
umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 2 | BeFree |
umls:C0206157 | Myopathies, Nemaline | 2 | GAD |
umls:C0746883 | Febrile Neutropenia | 2 | BeFree |
umls:C0003864 | Arthritis | 1 | GAD |
umls:C0005956 | Bone Marrow Diseases | 1 | GAD |
umls:C0006118 | Brain Neoplasms | 1 | BeFree,GAD |
umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
umls:C0012860 | DNA Damage | 1 | GAD |
umls:C0017181 | Gastrointestinal Hemorrhage | 1 | GAD |
umls:C0019156 | Hepatic Veno-Occlusive Disease | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | GAD |
umls:C0020507 | Hyperplasia | 1 | LHGDN |
umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
umls:C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | GAD |
umls:C0024314 | Lymphoproliferative Disorders | 1 | GAD |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree,LHGDN |
umls:C0030805 | Bullous pemphigoid | 1 | BeFree |
umls:C0033027 | Preleukemia | 1 | BeFree |
umls:C0037275 | Skin Diseases, Vesiculobullous | 1 | GAD |
umls:C0042721 | Viral hepatitis | 1 | BeFree |
umls:C0278704 | Malignant Childhood Neoplasm | 1 | BeFree |
umls:C0280745 | secondary myelodysplastic syndromes | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | BeFree,GAD |
umls:C0409974 | Lupus Erythematosus | 1 | GAD |
umls:C0568062 | Methotrexate poisoning | 1 | GAD |
umls:C0598766 | Leukemogenesis | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
umls:C0920028 | Leukaemia recurrent | 1 | BeFree |
umls:C0948441 | Venoocclusive disease | 1 | BeFree |
umls:C0949690 | Spondylarthritis | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | GAD |
umls:C1840451 | MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 1 | BeFree |
umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | GAD |
umls:C2697368 | Gastrointestinal irritation | 1 | BeFree |
umls:C2750088 | HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO | 1 | CTD_human,ORPHANET |
umls:C2919828 | Chronic ulcerative colitis | 1 | GAD |
umls:C3463824 | MYELODYSPLASTIC SYNDROME | 1 | BeFree |