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| TissGeneSummary for TPO |
 Gene summary |
| Basic gene information | Gene symbol | TPO |
| Gene name | thyroid peroxidase | |
| Synonyms | MSA|TDH2A|TPX | |
| Cytomap | UCSC genome browser: 2p25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000547.5, NM_001206744.1,NM_001206745.1,NM_175719.3,NM_175721.3, NM_175722.3,NM_175720.1, | |
| Description | thyroid microsomal antigenthyroperoxidase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 606765 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115705 | ||
| HPRD : 06000 | ||
| Vega : OTTHUMG00000090271 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TPO | |
| BioGPS: 7173 | ||
| Pathway | NCI Pathway Interaction Database: TPO | |
| KEGG: TPO | ||
| REACTOME: TPO | ||
| Pathway Commons: TPO | ||
| Context | iHOP: TPO | |
| ligand binding site mutation search in PubMed: TPO | ||
| UCL Cancer Institute: TPO | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of TPO | ||
| Description by TissGene annotations | Cancer gene Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0035162 | embryonic hemopoiesis | 21149635 | GO:0035162 | embryonic hemopoiesis | 21149635 |
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| TissGeneExp for TPO |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -0.721833314 | 1.55921284 | -2.281046154 | 8.75E-08 | 6.20E-07 |
| LUSC | -1.057799226 | -2.285707069 | 1.227907843 | 2.13E-05 | 4.71E-05 |
| BRCA | -0.260908617 | 3.06667033 | -3.327578947 | 1.49E-51 | 1.40E-49 |
| THCA | 8.622370598 | 13.40394517 | -4.781574576 | 7.55E-16 | 1.16E-14 |
| BLCA | -1.790477038 | 0.461638751 | -2.252115789 | 0.000262 | 0.002427867 |
| STAD | -0.21619365 | 1.5526876 | -1.76888125 | 0.00019 | 0.001331184 |
| PRAD | -0.066081391 | -1.211402544 | 1.145321154 | 0.000263 | 0.000995579 |
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| TissGene-miRNA for TPO |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TPO |
| TissGeneSNV for TPO |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S398T | THCA | 4 |
| p.S398T | SKCM | 4 |
| p.E830K | SKCM | 4 |
| p.A373S | COAD | 2 |
| p.S398T | COAD | 2 |
| p.P601H | LIHC | 2 |
| p.D452N | SKCM | 2 |
| p.S885L | SKCM | 2 |
| p.A373S | PCPG | 2 |
| p.E45K | SKCM | 2 |
| p.P715S | SKCM | 2 |
| p.S398T | STAD | 2 |
| p.P140S | SKCM | 2 |
| p.G786E | SKCM | 2 |
| p.A910T | STAD | 2 |
| p.R887Q | UCEC | 1 |
| p.A303V | GBM | 1 |
| p.R887Q | SKCM | 1 |
| p.G835R | SKCM | 1 |
| p.A326V | HNSC | 1 |
| p.G234R | SKCM | 1 |
| p.Y181H | LUAD | 1 |
| p.K150T | UCEC | 1 |
| p.E886K | LUAD | 1 |
| p.R175Q | HNSC | 1 |
| p.P512H | LUAD | 1 |
| p.G297S | PRAD | 1 |
| p.D117_splice | LUSC | 1 |
| p.G760R | BRCA | 1 |
| p.Q682H | READ | 1 |
| p.D505N | KIRP | 1 |
| p.P645S | SKCM | 1 |
| p.V329M | COAD | 1 |
| p.A295T | PAAD | 1 |
| p.A148V | CESC | 1 |
| p.P135S | SKCM | 1 |
| p.T328I | SKCM | 1 |
| p.E276K | SKCM | 1 |
| p.A168T | BLCA | 1 |
| p.L831* | SKCM | 1 |
| p.E218D | LUAD | 1 |
| p.R206L | ESCA | 1 |
| p.A826T | COAD | 1 |
| p.E757K | BLCA | 1 |
| p.E121K | SKCM | 1 |
| p.S851F | SKCM | 1 |
| p.S851F | BLCA | 1 |
| p.A326S | LIHC | 1 |
| p.N698T | STAD | 1 |
| p.W732* | BLCA | 1 |
| p.A373S | READ | 1 |
| p.M556V | UCEC | 1 |
| p.P918R | BRCA | 1 |
| p.S867L | ACC | 1 |
| p.R25T | BLCA | 1 |
| p.I87N | THYM | 1 |
| p.G66E | SKCM | 1 |
| p.Y453S | UCEC | 1 |
| p.A489T | LUSC | 1 |
| p.D745H | COAD | 1 |
| p.F485L | UCEC | 1 |
| p.S41I | DLBC | 1 |
| p.G743V | STAD | 1 |
| p.S309Y | HNSC | 1 |
| p.A53T | READ | 1 |
| p.A640V | SKCM | 1 |
| p.E558K | HNSC | 1 |
| p.P193L | SKCM | 1 |
| p.L844I | LUAD | 1 |
| p.L686P | LUSC | 1 |
| p.P193S | SKCM | 1 |
| p.V42I | CESC | 1 |
| p.S398T | PCPG | 1 |
| p.T702I | LGG | 1 |
| p.G306A | LIHC | 1 |
| p.F323L | LUAD | 1 |
| p.W428R | BLCA | 1 |
| p.D834N | SKCM | 1 |
| p.S811C | BLCA | 1 |
| p.S914L | SKCM | 1 |
| p.T572N | LUAD | 1 |
| p.G864V | LIHC | 1 |
| p.A607V | SKCM | 1 |
| p.M137T | LUAD | 1 |
| p.N569H | UCEC | 1 |
| p.A576V | STAD | 1 |
| p.D325E | LIHC | 1 |
| p.A810T | STAD | 1 |
| p.R602C | SKCM | 1 |
| p.A3V | READ | 1 |
| p.E218K | SKCM | 1 |
| p.R175* | UCS | 1 |
| p.S867L | SKCM | 1 |
| p.Q916K | COAD | 1 |
| p.R769W | COAD | 1 |
| p.A242T | LUAD | 1 |
| p.A5V | BLCA | 1 |
| p.A118V | UCEC | 1 |
| p.A3V | DLBC | 1 |
| p.A100V | UCEC | 1 |
| p.S398T | READ | 1 |
| p.G532E | SKCM | 1 |
| p.S75Y | COAD | 1 |
| p.D752N | SKCM | 1 |
| p.M58I | ESCA | 1 |
| p.D834N | OV | 1 |
| p.V205F | HNSC | 1 |
| p.C756Y | CESC | 1 |
| p.R684C | LIHC | 1 |
| p.A576E | LGG | 1 |
| p.F643L | STAD | 1 |
| p.A282T | SKCM | 1 |
| p.A53T | BRCA | 1 |
| p.G468S | SKCM | 1 |
| p.G255R | SKCM | 1 |
| p.T57M | STAD | 1 |
| p.T57M | COAD | 1 |
| p.E734K | SKCM | 1 |
| p.A242T | STAD | 1 |
| p.P892S | LUSC | 1 |
| p.R225H | LGG | 1 |
| p.R152K | SKCM | 1 |
| p.R165T | BLCA | 1 |
| p.S747N | BLCA | 1 |
| p.L529V | LUSC | 1 |
| p.L686M | LIHC | 1 |
| p.D513N | LUSC | 1 |
| p.D788N | SKCM | 1 |
| p.D258H | HNSC | 1 |
| p.A462T | SKCM | 1 |
| p.A640P | LUAD | 1 |
| p.P313Q | LUAD | 1 |
| p.T116M | BLCA | 1 |
| p.T171M | GBM | 1 |
| p.T449S | STAD | 1 |
| p.Q187K | HNSC | 1 |
| p.G493S | STAD | 1 |
| p.A242T | HNSC | 1 |
| p.A614T | STAD | 1 |
| p.V42I | PRAD | 1 |
| p.M58I | PAAD | 1 |
| p.R777W | COAD | 1 |
| p.G534D | STAD | 1 |
| p.D162E | LAML | 1 |
| p.Y136H | DLBC | 1 |
| p.A242T | COAD | 1 |
| p.T817N | LUAD | 1 |
| p.E778K | SKCM | 1 |
| p.Q214E | SKCM | 1 |
| p.R175X | UCS | 1 |
| p.D222N | SKCM | 1 |
| p.R842H | BRCA | 1 |
| p.L230R | ESCA | 1 |
| p.S8F | SKCM | 1 |
| p.T57M | PAAD | 1 |
| p.D258Y | LUAD | 1 |
| p.A56T | UCEC | 1 |
| p.D633N | STAD | 1 |
| p.S926F | SKCM | 1 |
| p.A282V | UCEC | 1 |
| p.G650E | SKCM | 1 |
| p.W31L | LUAD | 1 |
| p.D238N | GBM | 1 |
| p.R602H | PAAD | 1 |
| p.M58I | LUAD | 1 |
| p.M13I | BLCA | 1 |
| p.C886F | LUAD | 1 |
| p.S610C | LUAD | 1 |
| p.E778Q | STAD | 1 |
| p.R846W | UCEC | 1 |
| p.F709L | ESCA | 1 |
| p.A607T | UCEC | 1 |
| p.P204L | COAD | 1 |
| p.F195L | UCEC | 1 |
| p.P70T | STAD | 1 |
| p.Q779* | ESCA | 1 |
| p.V902I | BLCA | 1 |
| p.D827V | STAD | 1 |
| p.L119S | HNSC | 1 |
| p.E687* | LUAD | 1 |
| p.P268S | SKCM | 1 |
| p.D117N | SKCM | 1 |
| p.D452N | SARC | 1 |
| p.W233* | LIHC | 1 |
| p.R665Q | PAAD | 1 |
| p.S24L | LGG | 1 |
| p.I632M | LUAD | 1 |
| p.A812V | STAD | 1 |
| p.E95K | SKCM | 1 |
| p.E799K | OV | 1 |
| p.P153L | SKCM | 1 |
| p.P512S | LIHC | 1 |
| p.K621E | LUSC | 1 |
| p.G493C | LUAD | 1 |
| p.G587E | SKCM | 1 |
| p.R38C | SKCM | 1 |
| p.R165I | CESC | 1 |
| p.N159D | LIHC | 1 |
| p.A5T | COAD | 1 |
| p.Y55H | STAD | 1 |
| p.Q775* | SKCM | 1 |
| p.Q550H | LUAD | 1 |
| p.A812E | LUAD | 1 |
| p.M706I | KIRC | 1 |
| p.D258N | HNSC | 1 |
| p.D585E | OV | 1 |
| p.S112P | LIHC | 1 |
| p.G184S | LUAD | 1 |
| p.W849R | SKCM | 1 |
| p.R648G | CESC | 1 |
| p.S97P | UCEC | 1 |
| p.T171M | READ | 1 |
| p.D840_splice | UCEC | 1 |
| p.D608N | SKCM | 1 |
| p.L933H | BRCA | 1 |
| p.G306R | SKCM | 1 |
| p.T848N | LUSC | 1 |
| p.P737S | SKCM | 1 |
| p.P21L | SKCM | 1 |
| p.P791S | STAD | 1 |
| p.R161I | LIHC | 1 |
| p.G459E | SKCM | 1 |
| p.S853L | COAD | 1 |
| p.T699A | LUAD | 1 |
| p.G254R | DLBC | 1 |
| p.T891P | SKCM | 1 |
| p.G751E | SKCM | 1 |
| p.Y55* | LUAD | 1 |
| p.P178S | SKCM | 1 |
| p.K627R | HNSC | 1 |
| p.R206L | BLCA | 1 |
| p.V484M | STAD | 1 |
| p.L691M | SKCM | 1 |
| p.S227Y | LUAD | 1 |
| p.G786R | SKCM | 1 |
| p.V212F | LIHC | 1 |
| p.Q187K | PRAD | 1 |
| p.L543F | CESC | 1 |
| p.R189* | PAAD | 1 |
| p.V902L | UVM | 1 |
| p.S723N | ESCA | 1 |
| p.R684C | PRAD | 1 |
| p.D740N | COAD | 1 |
| p.V467M | GBM | 1 |
| p.S120L | SKCM | 1 |
| p.R895K | LUSC | 1 |
| p.V902I | COAD | 1 |
| p.A168T | STAD | 1 |
| p.P737T | UCEC | 1 |
| p.L831X | SKCM | 1 |
| p.D840Y | UCEC | 1 |
| p.G468D | LUAD | 1 |
| p.D802E | LUSC | 1 |
| p.L340R | LUAD | 1 |
| p.E673K | SKCM | 1 |
| p.A148E | KIRC | 1 |
| p.G712S | LGG | 1 |
| p.A826T | SKCM | 1 |
| p.E773X | ESCA | 1 |
| p.P651S | THCA | 1 |
| p.G85R | HNSC | 1 |
| p.A863T | BRCA | 1 |
| p.G786* | UCEC | 1 |
| p.E92K | LIHC | 1 |
| p.C286S | BLCA | 1 |
| p.S97X | THYM | 1 |
| p.L11V | OV | 1 |
| p.L458Q | SKCM | 1 |
| p.P892S | LUAD | 1 |
| p.W176C | SARC | 1 |
| p.R602C | PAAD | 1 |
| p.A295S | ESCA | 1 |
| p.D802E | READ | 1 |
| p.G712D | PRAD | 1 |
| p.T449I | LIHC | 1 |
| p.Q682* | STAD | 1 |
| p.P526Q | LUAD | 1 |
| p.D474E | BLCA | 1 |
| p.L656V | READ | 1 |
| p.E36D | COAD | 1 |
| p.R908W | COAD | 1 |
| p.W233X | LIHC | 1 |
| p.S853L | SKCM | 1 |
| p.Q682X | STAD | 1 |
| p.A826V | STAD | 1 |
| p.A3T | PCPG | 1 |
| p.L30F | SKCM | 1 |
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| TissGeneCNV for TPO |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TPO |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI004881 | TPO-RAB11FIP3 | chr2:1546295 | chr16:546060 | |
| Chimerdb3.0 | ChiTaRs | NA | BG990924 | TPO-TPO | chr2:1497812 | chr2:1488388 | |
| TCGAfusionPortal | PRADA | THCA | TCGA-H2-A2K9-01A | CNPY3-TPO | CDS-5UTR | Chr6:42902336 | Chr2:1417252 |
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| TissGeneNet for TPO |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| COAD (tumor) | COAD (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| KICH (tumor) | KICH (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| STAD (tumor) | STAD (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| THCA (tumor) | THCA (normal) |
| TPO, TXNDC11, DUOX1 (tumor) | TPO, TXNDC11, DUOX1 (normal) |
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| TissGeneProg for TPO |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TPO |
| TissGeneDrug for TPO |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TPO |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010308 | Congenital Hypothyroidism | 41 | BeFree,CTD_human,LHGDN |
| umls:C0342200 | Endemic Cretinism | 36 | BeFree |
| umls:C0178468 | Autoimmune thyroid disease | 28 | BeFree |
| umls:C0020676 | Hypothyroidism | 19 | BeFree,GAD,LHGDN |
| umls:C0549473 | Thyroid carcinoma | 19 | BeFree |
| umls:C0040128 | Thyroid Diseases | 17 | BeFree,LHGDN |
| umls:C0018021 | Goiter | 15 | BeFree,CTD_human,LHGDN |
| umls:C1291299 | Deficiency of iodide peroxidase (disorder) | 15 | CLINVAR,CTD_human,MGD,UNIPROT |
| umls:C0018213 | Graves Disease | 13 | BeFree |
| umls:C0040147 | Thyroiditis | 13 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 11 | BeFree |
| umls:C0393571 | Multiple System Atrophy | 9 | BeFree |
| umls:C0677607 | Hashimoto Disease | 9 | BeFree,LHGDN |
| umls:C1321809 | HYPOTHYROIDISM, GOITROUS | 9 | BeFree |
| umls:C0037019 | Shy-Drager Syndrome | 8 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 7 | BeFree,LHGDN |
| umls:C0020550 | Hyperthyroidism | 6 | BeFree |
| umls:C0920350 | Autoimmune thyroiditis | 6 | BeFree |
| umls:C0349476 | Congenital goiter | 5 | BeFree |
| umls:C0004134 | Ataxia | 4 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 4 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 4 | BeFree |
| umls:C0836924 | Thrombocytosis | 4 | BeFree,LHGDN |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 4 | BeFree |
| umls:C0001430 | Adenoma | 3 | BeFree,LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0271829 | Pendred's syndrome | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 2 | BeFree,LHGDN |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0030567 | Parkinson Disease | 2 | BeFree |
| umls:C0040137 | Thyroid Nodule | 2 | BeFree |
| umls:C0205696 | Anaplastic carcinoma | 2 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 2 | BeFree |
| umls:C0271790 | Subclinical hypothyroidism | 2 | BeFree |
| umls:C0339143 | Thyroid associated opthalmopathies | 2 | BeFree |
| umls:C0342158 | Hypothyroidism, Autoimmune | 2 | BeFree |
| umls:C0342208 | Multinodular goiter | 2 | BeFree |
| umls:C0555198 | Malignant Glioma | 2 | BeFree |
| umls:C0752347 | Lewy Body Disease | 2 | BeFree |
| umls:C0001403 | Addison Disease | 1 | BeFree |
| umls:C0001621 | Adrenal Gland Diseases | 1 | BeFree |
| umls:C0001815 | Primary Myelofibrosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | GAD |
| umls:C0005129 | Bernard-Soulier Syndrome | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007570 | Celiac Disease | 1 | BeFree |
| umls:C0007758 | Cerebellar Ataxia | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0014130 | Endocrine System Diseases | 1 | BeFree |
| umls:C0015625 | Fanconi Anemia | 1 | BeFree |
| umls:C0017154 | Gastritis, Atrophic | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | GAD |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0026987 | Myelofibrosis | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0027145 | Myxedema | 1 | BeFree |
| umls:C0029182 | orbit (eye disorders) | 1 | BeFree |
| umls:C0029464 | Osteosclerosis | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0035920 | Rubella | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0040034 | Thrombocytopenia | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0040822 | Tremor | 1 | BeFree |
| umls:C0156841 | Thyroid dysfunction, postpartum | 1 | BeFree |
| umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
| umls:C0205647 | Follicular adenoma | 1 | BeFree |
| umls:C0205698 | Undifferentiated carcinoma | 1 | BeFree |
| umls:C0205734 | Diabetes, Autoimmune | 1 | BeFree |
| umls:C0206693 | Medullary carcinoma | 1 | BeFree |
| umls:C0221777 | Nontoxic goiter | 1 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0239981 | Hypoalbuminemia | 1 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
| umls:C0271795 | Transient hypothyroidism | 1 | BeFree |
| umls:C0271815 | Postpartum Thyroiditis | 1 | BeFree |
| umls:C0271816 | Focal thyroiditis | 1 | BeFree |
| umls:C0271826 | Iodide transport defect | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0311361 | Adenomatous goiter | 1 | BeFree |
| umls:C0342122 | Toxic diffuse goiter | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
| umls:C0410000 | Overlap syndrome | 1 | BeFree |
| umls:C0474808 | Follicular neoplasm | 1 | BeFree |
| umls:C0524528 | Pervasive Development Disorder | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree |
| umls:C0543874 | Apraxia, oculomotor, Cogan type | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0749470 | Thyroid cold nodule | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C0949664 | Tauopathies | 1 | BeFree |
| umls:C1175175 | Severe Acute Respiratory Syndrome | 1 | LHGDN |
| umls:C1262091 | Lymphocytic infiltration | 1 | BeFree |
| umls:C1290884 | Inflammatory disorder | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1563716 | Thyroid Dysgenesis | 1 | GAD |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1709457 | Papillary Thyroid Microcarcinoma | 1 | BeFree |
| umls:C1848805 | Thyroid Dyshormonogenesis 1 | 1 | BeFree |
| umls:C1855794 | Bamforth syndrome | 1 | BeFree |
| umls:C1861185 | THROMBOCYTOPENIA 2 (disorder) | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |
| umls:C3489733 | Oculomotor apraxia | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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