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| TissGeneSummary for TPP2 |
 Gene summary |
| Basic gene information | Gene symbol | TPP2 |
| Gene name | tripeptidyl peptidase II | |
| Synonyms | TPP-2 | |
| Cytomap | UCSC genome browser: 13q32-q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003291.2, | |
| Description | TPP-IItripeptidyl aminopeptidasetripeptidyl-peptidase 2tripeptidyl-peptidase II | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 190470 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134900 | ||
| HPRD : 01834 | ||
| Vega : OTTHUMG00000017305 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TPP2 | |
| BioGPS: 7174 | ||
| Pathway | NCI Pathway Interaction Database: TPP2 | |
| KEGG: TPP2 | ||
| REACTOME: TPP2 | ||
| Pathway Commons: TPP2 | ||
| Context | iHOP: TPP2 | |
| ligand binding site mutation search in PubMed: TPP2 | ||
| UCL Cancer Institute: TPP2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of TPP2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TPP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for TPP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TPP2 |
| TissGeneSNV for TPP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R660* | UCEC | 5 |
| p.R889* | UCEC | 2 |
| p.P287S | SKCM | 2 |
| p.C197F | KIRP | 1 |
| p.T442A | UCEC | 1 |
| p.E483Q | LGG | 1 |
| p.M314I | LUAD | 1 |
| p.V549I | STAD | 1 |
| p.E493K | LUAD | 1 |
| p.S221F | BLCA | 1 |
| p.G615D | STAD | 1 |
| p.E281K | CESC | 1 |
| p.F1021L | COAD | 1 |
| p.T1011I | SKCM | 1 |
| p.E587* | LUAD | 1 |
| p.C1129S | SKCM | 1 |
| p.G1143R | BLCA | 1 |
| p.G162C | ESCA | 1 |
| p.T998S | SKCM | 1 |
| p.S328T | OV | 1 |
| p.E185Q | LUAD | 1 |
| p.D1155N | BLCA | 1 |
| p.H1147Y | HNSC | 1 |
| p.L712P | HNSC | 1 |
| p.M1207I | LGG | 1 |
| p.C1142S | SKCM | 1 |
| p.R798C | UCEC | 1 |
| p.F1034L | SKCM | 1 |
| p.E1036* | LUAD | 1 |
| p.L586F | LUAD | 1 |
| p.D871N | UCEC | 1 |
| p.V90G | STAD | 1 |
| p.S584N | KIRP | 1 |
| p.P140T | COAD | 1 |
| p.L292V | ESCA | 1 |
| p.S25Y | PAAD | 1 |
| p.V475F | BRCA | 1 |
| p.V258L | KIRC | 1 |
| p.C150F | LIHC | 1 |
| p.Q290* | HNSC | 1 |
| p.A426V | STAD | 1 |
| p.S976* | BLCA | 1 |
| p.L292I | BLCA | 1 |
| p.L690R | STAD | 1 |
| p.A419V | SKCM | 1 |
| p.V65I | COAD | 1 |
| p.S679L | SKCM | 1 |
| p.S516X | READ | 1 |
| p.P1257S | SKCM | 1 |
| p.D139G | UCEC | 1 |
| p.E88K | CESC | 1 |
| p.N771D | UCEC | 1 |
| p.H1201L | LIHC | 1 |
| p.A124T | ESCA | 1 |
| p.E281K | LUSC | 1 |
| p.N946T | BRCA | 1 |
| p.R865T | LGG | 1 |
| p.A426V | UCEC | 1 |
| p.Q503_splice | LUSC | 1 |
| p.N514K | LIHC | 1 |
| p.M1033I | BRCA | 1 |
| p.R889P | UCEC | 1 |
| p.R660X | READ | 1 |
| p.S711Y | UCEC | 1 |
| p.G457E | BLCA | 1 |
| p.K961E | SKCM | 1 |
| p.D861H | BLCA | 1 |
| p.E705Q | BLCA | 1 |
| p.M1098V | SKCM | 1 |
| p.E845G | ESCA | 1 |
| p.E1033V | SKCM | 1 |
| p.P799L | UCEC | 1 |
| p.H1188L | LIHC | 1 |
| p.C967F | LUAD | 1 |
| p.R660* | STAD | 1 |
| p.E20K | BLCA | 1 |
| p.V1121I | COAD | 1 |
| p.S1162Y | UCEC | 1 |
| p.D390N | CESC | 1 |
| p.G22V | THYM | 1 |
| p.G1156R | BLCA | 1 |
| p.H570R | BLCA | 1 |
| p.S245F | LUSC | 1 |
| p.M1111V | SKCM | 1 |
| p.K1209N | STAD | 1 |
| p.T369I | STAD | 1 |
| p.S359N | BRCA | 1 |
| p.G284E | BLCA | 1 |
| p.D1010Y | COAD | 1 |
| p.T1011S | SKCM | 1 |
| p.L398V | BLCA | 1 |
| p.E612K | BLCA | 1 |
| p.P943H | THYM | 1 |
| p.R133W | COAD | 1 |
| p.S411C | HNSC | 1 |
| p.Q761* | HNSC | 1 |
| p.S679L | STAD | 1 |
| p.M1241V | UCEC | 1 |
| p.D1142N | BLCA | 1 |
| p.E1169G | ESCA | 1 |
| p.N167S | LIHC | 1 |
| p.D1019H | BLCA | 1 |
| p.V986I | CESC | 1 |
| p.K933N | ESCA | 1 |
| p.P556Q | STAD | 1 |
| p.I318V | LUAD | 1 |
| p.L1058F | BLCA | 1 |
| p.S410P | COAD | 1 |
| p.G413E | LGG | 1 |
| p.K136N | UCEC | 1 |
| p.S163C | CESC | 1 |
| p.R660X | STAD | 1 |
| p.A1162T | SARC | 1 |
| p.D202N | LUAD | 1 |
| p.H201Y | HNSC | 1 |
| p.P1172L | SKCM | 1 |
| p.T676A | STAD | 1 |
| p.R598H | STAD | 1 |
| p.A489D | PAAD | 1 |
| p.F1021L | SKCM | 1 |
| p.W1215C | KIRP | 1 |
| p.N529S | ACC | 1 |
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| TissGeneCNV for TPP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TPP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF794140 | TPP2-TPP2 | chr13:103331395 | chr13:103331368 | |
| Chimerdb3.0 | ChiTaRs | NA | BF996738 | TPP2-MYO5B | chr13:103278434 | chr18:47519516 |
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| TissGeneNet for TPP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| COAD (tumor) | COAD (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| KICH (tumor) | KICH (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| STAD (tumor) | STAD (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| THCA (tumor) | THCA (normal) |
| TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (tumor) | TPP2, SIRT7, HNF4A, UBC, HLA-B, MCC (normal) |
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| TissGeneProg for TPP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TPP2 |
| TissGeneDrug for TPP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TPP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0022340 | Late-Infantile Neuronal Ceroid Lipfuscinosis | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0272126 | Evans syndrome | 1 | BeFree |
| umls:C0398686 | Primary immune deficiency disorder | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
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