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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TRAF2
check button Gene summary
Basic gene informationGene symbolTRAF2
Gene nameTNF receptor-associated factor 2
SynonymsMGC:45012|TRAP|TRAP3
CytomapUCSC genome browser: 9q34
Type of geneprotein-coding
RefGenesNM_021138.3,
DescriptionE3 ubiquitin-protein ligase TRAF2tumor necrosis factor type 2 receptor associated protein 3tumor necrosis factor type 2 receptor-associated protein 3
Modification date20141207
dbXrefs MIM : 601895
HGNC : HGNC
Ensembl : ENSG00000127191
HPRD : 03538
Vega : OTTHUMG00000020952
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRAF2
BioGPS: 7186
PathwayNCI Pathway Interaction Database: TRAF2
KEGG: TRAF2
REACTOME: TRAF2
Pathway Commons: TRAF2
ContextiHOP: TRAF2
ligand binding site mutation search in PubMed: TRAF2
UCL Cancer Institute: TRAF2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)CervixTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)CESCTGCT
Reference showing the relevant tissue of TRAF2
Description by TissGene annotationsProtective TissGene in OS
Cancer gene
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0033209tumor necrosis factor-mediated signaling pathway11907583
GO:0042981regulation of apoptotic process11907583
GO:0043507positive regulation of JUN kinase activity11907583
GO:0051092positive regulation of NF-kappaB transcription factor activity11279055
GO:0051865protein autoubiquitination20577214
GO:0070534protein K63-linked ubiquitination15258597
GO:0033209tumor necrosis factor-mediated signaling pathway11907583
GO:0042981regulation of apoptotic process11907583
GO:0043507positive regulation of JUN kinase activity11907583
GO:0051092positive regulation of NF-kappaB transcription factor activity11279055
GO:0051865protein autoubiquitination20577214
GO:0070534protein K63-linked ubiquitination15258597


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TissGeneExp for TRAF2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
STAD0.037770242-1.1253891331.1631593751.01E-112.21E-09
ESCA-0.14059936-1.2620448151.1214454551.12E-050.000996352


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TissGene-miRNA for TRAF2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TRAF2
TissGeneSNV for TRAF2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D488NSTAD1
p.E280KBLCA1
p.E180KCOAD1
p.A190SLUAD1
p.S408FSKCM1
p.R445HCESC1
p.E120XCOAD1
p.S460FSKCM1
p.E153QBLCA1
p.L187VPCPG1
p.T226KTHYM1
p.S430FSKCM1
p.S89LUCEC1
p.I249NSKCM1
p.R372HHNSC1
p.R424HPRAD1
p.E205QBLCA1
p.S378FSKCM1
p.A466TUCEC1
p.R196LKIRC1
p.R269TBLCA1
p.L239VPCPG1
p.S143FPAAD1
p.R43MPRAD1
p.L407MUCEC1
p.M397ISKCM1
p.V475IESCA1
p.E391QLUAD1
p.R43SPRAD1
p.A70VLUAD1
p.P511LSKCM1
p.E305QLUAD1
p.R167WPAAD1
p.P130SSKCM1
p.P459LSKCM1
p.R424HHNSC1
p.E253QLUAD1
p.E398KSKCM1
p.E288KLUAD1
p.E75KBLCA1
p.P526LSKCM1
p.P374SSTAD1
p.V527IPRAD1
p.R219WPAAD1
p.Q509*HNSC1
p.P182SSKCM1
p.R424HLGG1
p.V527IESCA1
p.L268FOV1
p.E377QBLCA1
p.R202CPRAD1


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TissGeneCNV for TRAF2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TRAF2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABI031313TRAF2-DENND1Cchr9:139820247chr19:6475907


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TissGeneNet for TRAF2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TRAF2, FADD, RUVBL2, DVL2, TRIP6, TNFRSF14, ZNF205, RUVBL1, TRAIP, TAB1, UBXN11, TCEA2, EPS15, RGS14, BAHD1, TNFRSF18, SPHK1, ZNF646, FBF1, BANP, CCDC130 (tumor)TRAF2, RUVBL2, IKBKG, CDK9, PIN1, TNFRSF14, GSK3B, MAP3K11, STUB1, EP300, ZNF205, TRADD, TNFRSF4, PKN1, PFKL, THAP7, AFF4, TNFRSF25, LZTS2, MAP4K3, CCDC130 (normal)
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COAD (tumor)COAD (normal)
TRAF2, IKBKE, MAP3K5, CRY1, CDK9, MAP3K11, SPATA2, SMURF1, BAG2, DAB2IP, HIVEP3, CAV1, TRAF3, TRADD, RHEB, AASDHPPT, ZMYND11, EDARADD, TNFRSF11A, ZNF646, MAP4K3 (tumor)TRAF2, IKBKG, CDK9, NRIP1, TNFRSF14, GSK3B, TANK, STUB1, ZNF205, RHEBL1, CDCA3, MAST2, TRADD, UBXN11, AASDHPPT, AFF4, TNFRSF25, IPO11, MAP4K3, FBF1, CHMP2B (normal)
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HNSC (tumor)HNSC (normal)
TRAF2, FADD, MAP3K7, IKBKG, TRIP6, CDK9, MAPK9, TNFRSF14, TRIM37, APPL1, LTBR, PIAS2, HSPA9, TRADD, RPS6KA3, ZBTB25, EPS15, NECAP2, MAP4K3, BANP, CCDC130 (tumor)TRAF2, GORASP2, MAP4K5, PIN1, TNFRSF14, MAP3K14, CALM1, ZNF205, ATXN1, RHEBL1, CLTC, TRAIP, UBXN11, ANKRD36BP1, RIBC2, ERN1, NECAP2, AFF4, MAP4K3, FATE1, ABLIM1 (normal)
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KICH (tumor)KICH (normal)
TRAF2, MAP3K5, DVL2, CDK9, UBE2N, MAP3K11, CHUK, SLC25A5, CYLD, ZNF205, ATXN1, TRAF3, CAD, SIAH2, RHEB, AIMP2, IFIT3, NGFRAP1, LZTS2, APIP, USP31 (tumor)TRAF2, CRY1, RUVBL2, MAP3K7, CDK9, MAP3K11, STUB1, ZNF205, CLTC, TAB2, ANKRD36BP1, CDC40, TCEA2, RAD23A, CFLAR, THAP7, AFF4, FAM120B, TAOK3, TRPT1, CCDC130 (normal)
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KIRC (tumor)KIRC (normal)
TRAF2, FADD, DVL2, CDK9, MAPK9, MAP3K11, ZNF205, CLTC, LTBR, TAB1, LNX1, TRADD, CALM3, TNFRSF13B, TNFRSF18, CFLAR, CD27, FAM120B, LZTS2, APIP, APEX2 (tumor)TRAF2, RUVBL2, IKBKG, CDK9, TRAF1, PIN1, TNFRSF14, MAP3K11, CHUK, ZNF205, APPL1, TAB1, UBXN11, ZMYND11, RAD23A, TNFRSF18, THAP7, AFF4, IPO11, LZTS2, CCDC130 (normal)
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KIRP (tumor)KIRP (normal)
TRAF2, DVL2, CDK9, CASP1, CALM1, TNF, CHUK, SLC25A5, TUBB, TNFRSF1B, ZNF205, PIAS2, CAD, HSPA9, CD40, USP2, TNFRSF18, TRAF3IP2, LZTS2, TNFSF14, DLGAP5 (tumor)TRAF2, TRAF6, MAP3K7, CDK9, GSK3B, MAP3K11, ZNF205, APPL1, CLTC, LTBR, PIAS2, MTOR, UBXN11, ZMYND11, RAD23A, ERN1, THAP7, AFF4, FAM120B, CHMP2B, CCDC130 (normal)
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LIHC (tumor)LIHC (normal)
TRAF2, TRIP6, TRIM31, NUDT18, TNFRSF14, PARK2, APPL1, EEF1A2, SALL1, TAB2, TRADD, TNFRSF4, TCEA2, ZMYND11, TNFRSF18, PEG3, SOX9, SPHK1, GSTP1, TAB3, CCDC130 (tumor)TRAF2, IKBKE, TRAF6, CDK9, TRIM31, NRIP1, ZNF205, RHEBL1, CDCA3, UBE2Z, NAP1L1, TRAIP, UBXN11, TNFRSF4, RPL23, RIBC2, ERN1, TNFRSF18, SPHK1, MYLK2, DLGAP5 (normal)
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LUAD (tumor)LUAD (normal)
TRAF2, TRIP6, TRAF1, FBXO28, MAPK9, TBK1, MAP3K11, CHUK, ZNF205, UBQLN4, PIAS2, TAB1, LNX1, TRADD, TNFRSF4, PKN1, RGS14, LZTS2, MAP4K3, BANP, CHMP2B (tumor)TRAF2, CDK9, MAP3K11, SMURF2, ZNF205, TNIK, ATXN1, FXR2, LTBR, IFNAR1, SPRY2, CDC40, TNFRSF4, GOLGA3, EPS15, KIAA0408, TNFRSF25, IPO11, LZTS2, BANP, CCDC130 (normal)
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LUSC (tumor)LUSC (normal)
TRAF2, RUVBL2, IKBKG, TRIP6, CDK9, PIN1, MAP3K14, MAP3K11, ZNF205, FXR2, TRADD, CDC40, AASDHPPT, EPS15, PKN1, PFKL, BAHD1, TNFRSF18, ZNF646, LZTS2, FBF1 (tumor)TRAF2, IKBKE, BIRC3, CDK9, TRAF1, ZBTB43, TNFRSF14, MAP3K14, CALM1, MAP3K11, TNFAIP3, ZNF205, DAB2IP, AASDHPPT, TNFRSF4, GOLGA3, IL15RA, TNFRSF25, IPO11, MAP4K3, CCDC130 (normal)
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PRAD (tumor)PRAD (normal)
TRAF2, RUVBL2, MAP3K7, TNFRSF14, HSPA1B, MAP3K11, CASP8AP2, ZNF205, APPL1, LTBR, RB1CC1, ANKRD36BP1, RPL23, DIABLO, ERN1, TNFRSF18, PEG3, CFLAR, QARS, IPO11, CCDC130 (tumor)TRAF2, RUVBL2, CDK9, MAP3K11, CHUK, STUB1, EP300, ZNF205, PIAS2, UBXN11, ANKRD36BP1, HTRA2, TCEA2, ZMYND11, EPS15, RAD23A, USP53, TNFRSF18, THAP7, AFF4, CCDC130 (normal)
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STAD (tumor)STAD (normal)
TRAF2, IKBKE, CALM1, RIPK3, TRPC4AP, PARK2, CAV1, TRAIP, TRADD, RHEB, ZMYND11, RGS14, EDARADD, PFKL, TNFRSF18, NECAP2, QARS, TRAF3IP2, GCKR, DLGAP5, APEX2 (tumor)TRAF2, IKBKE, MAP4K5, CDK9, CALM1, TANK, MAP3K11, SPATA2, ZNF205, RHEBL1, CDCA3, CAV1, LTBR, TRAIP, RPS6KA3, ZMYND11, EPS15, PEG3, KIAA0408, AFF4, MAP4K3 (normal)
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THCA (tumor)THCA (normal)
TRAF2, FADD, RUVBL2, MAP3K7, MAP4K5, ZBTB43, FBXO28, NUDT18, BIRC2, SMURF2, EP300, RB1CC1, PIAS2, RGS14, THAP7, QARS, AFF4, APEX2, TAB3, WDR65, ABLIM1 (tumor)TRAF2, RUVBL2, MAP3K7, MAP4K5, FBXO28, NUDT18, GSK3B, ZNF205, TNIK, CLTC, RB1CC1, UBXN11, ANKRD36BP1, RPS6KA3, TCEA2, USP53, THAP7, AFF4, TAB3, TRPT1, CCDC130 (normal)
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TissGeneProg for TRAF2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TRAF2
TissGeneDrug for TRAF2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for TRAF2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0024530Malaria5BeFree
umls:C0017636Glioblastoma3BeFree
umls:C0023467Leukemia, Myelocytic, Acute3BeFree
umls:C0235974Pancreatic carcinoma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0002395Alzheimer's Disease2GAD
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0019693HIV Infections2BeFree,GAD
umls:C0021368Inflammation2GAD
umls:C0023434Chronic Lymphocytic Leukemia2BeFree
umls:C0024141Lupus Erythematosus, Systemic2BeFree
umls:C0024299Lymphoma2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0026764Multiple Myeloma2BeFree,GAD
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0151526Premature Birth2GAD
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0398689Hyper-IgM Immunodeficiency Syndrome, Type 12BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0002871Anemia1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0009782Connective Tissue Diseases1GAD
umls:C0015929Fetal Diseases1GAD
umls:C0016057Fibrosarcoma1BeFree
umls:C0016169pathologic fistula1BeFree
umls:C0016629Fowlpox1BeFree
umls:C0017638Glioma1LHGDN
umls:C0024305Lymphoma, Non-Hodgkin1GAD
umls:C0024535Malaria, Falciparum1BeFree
umls:C0025202melanoma1BeFree
umls:C0025500Mesothelioma1BeFree
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0029882Otitis Media1BeFree
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0032964Pregnancy Complications, Hematologic1GAD
umls:C0035344Retinopathy of Prematurity1GAD
umls:C0037274Dermatologic disorders1GAD
umls:C0039103Synovitis1BeFree
umls:C0042900Vitiligo1BeFree
umls:C0079731B-Cell Lymphomas1LHGDN
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085400Neurofibrillary degeneration (morphologic abnormality)1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0155094Corneal pannus1BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma1BeFree
umls:C0242647Mucosa-Associated Lymphoid Tissue Lymphoma1BeFree
umls:C0265808Cyanotic congenital heart disease1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0333516Tumor necrosis1BeFree
umls:C0376154Skin callus1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0393576Chorea Acanthocytosis Syndrome1BeFree
umls:C0432487Post-transplant lymphoproliferative disorder1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0810032Pancreatic disorders (not diabetes)1BeFree
umls:C0855095Small Lymphocytic Lymphoma1BeFree
umls:C0872054latent infection1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C1302547Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma1BeFree
umls:C1704216Basaloid carcinoma1BeFree
umls:C1847835VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C2827407Infectious Otitis Media1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C3495801Granulomatosis with polyangiitis1BeFree
umls:C3714514Infection1GAD