TissGeneSummary for TRAF2 |
Gene summary |
Basic gene information | Gene symbol | TRAF2 |
Gene name | TNF receptor-associated factor 2 | |
Synonyms | MGC:45012|TRAP|TRAP3 | |
Cytomap | UCSC genome browser: 9q34 | |
Type of gene | protein-coding | |
RefGenes | NM_021138.3, | |
Description | E3 ubiquitin-protein ligase TRAF2tumor necrosis factor type 2 receptor associated protein 3tumor necrosis factor type 2 receptor-associated protein 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601895 | |
HGNC : HGNC | ||
Ensembl : ENSG00000127191 | ||
HPRD : 03538 | ||
Vega : OTTHUMG00000020952 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRAF2 | |
BioGPS: 7186 | ||
Pathway | NCI Pathway Interaction Database: TRAF2 | |
KEGG: TRAF2 | ||
REACTOME: TRAF2 | ||
Pathway Commons: TRAF2 | ||
Context | iHOP: TRAF2 | |
ligand binding site mutation search in PubMed: TRAF2 | ||
UCL Cancer Institute: TRAF2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of TRAF2 | ||
Description by TissGene annotations | Protective TissGene in OS Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 11907583 | GO:0042981 | regulation of apoptotic process | 11907583 | GO:0043507 | positive regulation of JUN kinase activity | 11907583 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 11279055 | GO:0051865 | protein autoubiquitination | 20577214 | GO:0070534 | protein K63-linked ubiquitination | 15258597 | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 11907583 | GO:0042981 | regulation of apoptotic process | 11907583 | GO:0043507 | positive regulation of JUN kinase activity | 11907583 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 11279055 | GO:0051865 | protein autoubiquitination | 20577214 | GO:0070534 | protein K63-linked ubiquitination | 15258597 |
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TissGeneExp for TRAF2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 0.037770242 | -1.125389133 | 1.163159375 | 1.01E-11 | 2.21E-09 |
ESCA | -0.14059936 | -1.262044815 | 1.121445455 | 1.12E-05 | 0.000996352 |
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TissGene-miRNA for TRAF2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TRAF2 |
TissGeneSNV for TRAF2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D488N | STAD | 1 |
p.E280K | BLCA | 1 |
p.E180K | COAD | 1 |
p.A190S | LUAD | 1 |
p.S408F | SKCM | 1 |
p.R445H | CESC | 1 |
p.E120X | COAD | 1 |
p.S460F | SKCM | 1 |
p.E153Q | BLCA | 1 |
p.L187V | PCPG | 1 |
p.T226K | THYM | 1 |
p.S430F | SKCM | 1 |
p.S89L | UCEC | 1 |
p.I249N | SKCM | 1 |
p.R372H | HNSC | 1 |
p.R424H | PRAD | 1 |
p.E205Q | BLCA | 1 |
p.S378F | SKCM | 1 |
p.A466T | UCEC | 1 |
p.R196L | KIRC | 1 |
p.R269T | BLCA | 1 |
p.L239V | PCPG | 1 |
p.S143F | PAAD | 1 |
p.R43M | PRAD | 1 |
p.L407M | UCEC | 1 |
p.M397I | SKCM | 1 |
p.V475I | ESCA | 1 |
p.E391Q | LUAD | 1 |
p.R43S | PRAD | 1 |
p.A70V | LUAD | 1 |
p.P511L | SKCM | 1 |
p.E305Q | LUAD | 1 |
p.R167W | PAAD | 1 |
p.P130S | SKCM | 1 |
p.P459L | SKCM | 1 |
p.R424H | HNSC | 1 |
p.E253Q | LUAD | 1 |
p.E398K | SKCM | 1 |
p.E288K | LUAD | 1 |
p.E75K | BLCA | 1 |
p.P526L | SKCM | 1 |
p.P374S | STAD | 1 |
p.V527I | PRAD | 1 |
p.R219W | PAAD | 1 |
p.Q509* | HNSC | 1 |
p.P182S | SKCM | 1 |
p.R424H | LGG | 1 |
p.V527I | ESCA | 1 |
p.L268F | OV | 1 |
p.E377Q | BLCA | 1 |
p.R202C | PRAD | 1 |
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TissGeneCNV for TRAF2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TRAF2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI031313 | TRAF2-DENND1C | chr9:139820247 | chr19:6475907 |
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TissGeneNet for TRAF2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TRAF2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TRAF2 |
TissGeneDrug for TRAF2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TRAF2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024530 | Malaria | 5 | BeFree |
umls:C0017636 | Glioblastoma | 3 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
umls:C0002395 | Alzheimer's Disease | 2 | GAD |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0019693 | HIV Infections | 2 | BeFree,GAD |
umls:C0021368 | Inflammation | 2 | GAD |
umls:C0023434 | Chronic Lymphocytic Leukemia | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
umls:C0024299 | Lymphoma | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0026764 | Multiple Myeloma | 2 | BeFree,GAD |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0151526 | Premature Birth | 2 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
umls:C0398689 | Hyper-IgM Immunodeficiency Syndrome, Type 1 | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0002871 | Anemia | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
umls:C0015929 | Fetal Diseases | 1 | GAD |
umls:C0016057 | Fibrosarcoma | 1 | BeFree |
umls:C0016169 | pathologic fistula | 1 | BeFree |
umls:C0016629 | Fowlpox | 1 | BeFree |
umls:C0017638 | Glioma | 1 | LHGDN |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0024535 | Malaria, Falciparum | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0025500 | Mesothelioma | 1 | BeFree |
umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029882 | Otitis Media | 1 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
umls:C0035344 | Retinopathy of Prematurity | 1 | GAD |
umls:C0037274 | Dermatologic disorders | 1 | GAD |
umls:C0039103 | Synovitis | 1 | BeFree |
umls:C0042900 | Vitiligo | 1 | BeFree |
umls:C0079731 | B-Cell Lymphomas | 1 | LHGDN |
umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0155094 | Corneal pannus | 1 | BeFree |
umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | BeFree |
umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
umls:C0265808 | Cyanotic congenital heart disease | 1 | BeFree |
umls:C0278883 | Metastatic melanoma | 1 | BeFree |
umls:C0333516 | Tumor necrosis | 1 | BeFree |
umls:C0376154 | Skin callus | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0393576 | Chorea Acanthocytosis Syndrome | 1 | BeFree |
umls:C0432487 | Post-transplant lymphoproliferative disorder | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0810032 | Pancreatic disorders (not diabetes) | 1 | BeFree |
umls:C0855095 | Small Lymphocytic Lymphoma | 1 | BeFree |
umls:C0872054 | latent infection | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1302547 | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 1 | BeFree |
umls:C1704216 | Basaloid carcinoma | 1 | BeFree |
umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
umls:C2827407 | Infectious Otitis Media | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
umls:C3495801 | Granulomatosis with polyangiitis | 1 | BeFree |
umls:C3714514 | Infection | 1 | GAD |