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| TissGeneSummary for C4A |
 Gene summary |
| Basic gene information | Gene symbol | C4A |
| Gene name | complement component 4A (Rodgers blood group) | |
| Synonyms | C4|C4A2|C4A3|C4A4|C4A6|C4AD|C4S|CO4|CPAMD2|RG | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001252204.1, NM_007293.2, | |
| Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2C4A anaphylatoxinRodgers form of C4acidic C4acidic complement C4complement C4-A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 120810 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000244731 | ||
| HPRD : 00401 | ||
| Vega : OTTHUMG00000031186 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C4A | |
| BioGPS: 720 | ||
| Pathway | NCI Pathway Interaction Database: C4A | |
| KEGG: C4A | ||
| REACTOME: C4A | ||
| Pathway Commons: C4A | ||
| Context | iHOP: C4A | |
| ligand binding site mutation search in PubMed: C4A | ||
| UCL Cancer Institute: C4A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of C4A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C4A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.956696907 | 1.357138387 | -2.313835294 | 4.85E-14 | 2.61E-13 |
| PRAD | 1.061692874 | -0.486426356 | 1.548119231 | 2.51E-07 | 2.08E-06 |
| KIRC | 3.429067554 | 0.563459221 | 2.865608333 | 3.72E-15 | 1.88E-14 |
| BRCA | 2.394536633 | 1.250006808 | 1.144529825 | 7.52E-06 | 1.88E-05 |
| KICH | -2.966960279 | -0.898532279 | -2.068428 | 0.00331 | 0.006490427 |
| KIRP | 2.626865471 | 1.005652971 | 1.6212125 | 0.00143 | 0.003771835 |
| BLCA | -1.793201964 | 0.468066457 | -2.261268421 | 0.000408 | 0.003437091 |
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| TissGene-miRNA for C4A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C4A |
| TissGeneSNV for C4A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R1060W | SKCM | 2 |
| p.D1073G | LUAD | 2 |
| p.G1115D | STAD | 1 |
| p.P1122L | DLBC | 1 |
| p.G1372V | BRCA | 1 |
| p.Q848H | BRCA | 1 |
| p.L1120R | DLBC | 1 |
| p.P1122L | SKCM | 1 |
| p.G1189D | THCA | 1 |
| p.L1202M | LUAD | 1 |
| p.D1125H | BLCA | 1 |
| p.A905T | SKCM | 1 |
| p.R916* | HNSC | 1 |
| p.S1116P | SKCM | 1 |
| p.S1171F | SKCM | 1 |
| p.V914A | OV | 1 |
| p.R895Q | SKCM | 1 |
| p.F1178L | PAAD | 1 |
| p.R1055Q | LGG | 1 |
| p.W1077R | STAD | 1 |
| p.R1291H | STAD | 1 |
| p.H1191L | HNSC | 1 |
| p.R1072Q | STAD | 1 |
| p.F919V | SKCM | 1 |
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| TissGeneCNV for C4A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C4A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C4A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| COAD (tumor) | COAD (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| KICH (tumor) | KICH (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| STAD (tumor) | STAD (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| THCA (tumor) | THCA (normal) |
| C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (tumor) | C4A, APC, SP1, TAF9, SP3, APOA2, NFIC, MASP2, KLF3, C3AR1, CR1, C1S, CST3 (normal) |
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| TissGeneProg for C4A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C4A |
| TissGeneDrug for C4A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C4A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024141 | Lupus Erythematosus, Systemic | 26 | BeFree,CTD_human,GAD,LHGDN,MGD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 7 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 6 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 6 | BeFree,GAD,LHGDN |
| umls:C0033626 | Protein Deficiency | 5 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 5 | BeFree,GAD |
| umls:C0001627 | Congenital adrenal hyperplasia | 4 | BeFree,GAD |
| umls:C0004352 | Autistic Disorder | 4 | BeFree |
| umls:C2936858 | Congenital adrenal hyperplasia due to 21 hydroxylase deficiency | 4 | BeFree |
| umls:C3280642 | Complement Component 4a Deficiency | 4 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 3 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 3 | BeFree |
| umls:C0038644 | Sudden infant death syndrome | 3 | BeFree |
| umls:C0155765 | Disease of capillaries | 3 | BeFree |
| umls:C0852654 | 21-hydroxylase deficiency | 3 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 2 | BeFree |
| umls:C0011265 | Presenile dementia | 2 | BeFree |
| umls:C0017658 | Glomerulonephritis | 2 | BeFree |
| umls:C0018213 | Graves Disease | 2 | BeFree,GAD |
| umls:C0024131 | Lupus Vulgaris | 2 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 2 | BeFree |
| umls:C0033860 | Psoriasis | 2 | BeFree,LHGDN |
| umls:C0039263 | Takayasu Arteritis | 2 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0162538 | Immunoglobulin A deficiency (disorder) | 2 | BeFree |
| umls:C0497327 | Dementia | 2 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 2 | BeFree |
| umls:C3280641 | COMPLEMENT COMPONENT 4B DEFICIENCY | 2 | BeFree |
| umls:C3495559 | Juvenile arthritis | 2 | BeFree,LHGDN |
| umls:C0004096 | Asthma | 1 | LHGDN |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | CTD_human |
| umls:C0021053 | Immune System Diseases | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0023890 | Liver Cirrhosis | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | LHGDN |
| umls:C0024140 | Lupus Erythematosus, Subacute Cutaneous | 1 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0029118 | Opportunistic Infections | 1 | GAD |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0034152 | Henoch-Schoenlein Purpura | 1 | GAD |
| umls:C0037116 | Silicosis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0042900 | Vitiligo | 1 | BeFree |
| umls:C0085437 | Meningitis, Bacterial | 1 | GAD |
| umls:C0086445 | Idiopathic Membranous Glomerulonephritis | 1 | BeFree |
| umls:C0241910 | Hepatitis, Autoimmune | 1 | BeFree |
| umls:C0266929 | Chronic Periodontitis | 1 | LHGDN |
| umls:C0342464 | Salt-losing congenital adrenal hyperplasia | 1 | BeFree |
| umls:C0343084 | Capillary Leak Syndrome | 1 | LHGDN |
| umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
| umls:C1258104 | Diffuse Scleroderma | 1 | GAD |
| umls:C1527336 | Sjogren's Syndrome | 1 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2609247 | Adrenal incidentaloma | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
| umls:C0004943 | Behcet Syndrome | 0 | ORPHANET |
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