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| TissGeneSummary for C4BPA |
 Gene summary |
| Basic gene information | Gene symbol | C4BPA |
| Gene name | complement component 4 binding protein, alpha | |
| Synonyms | C4BP|PRP | |
| Cytomap | UCSC genome browser: 1q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000715.3, | |
| Description | C4b-binding protein alpha chainproline-rich protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 120830 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123838 | ||
| HPRD : 00403 | ||
| Vega : OTTHUMG00000036173 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C4BPA | |
| BioGPS: 722 | ||
| Pathway | NCI Pathway Interaction Database: C4BPA | |
| KEGG: C4BPA | ||
| REACTOME: C4BPA | ||
| Pathway Commons: C4BPA | ||
| Context | iHOP: C4BPA | |
| ligand binding site mutation search in PubMed: C4BPA | ||
| UCL Cancer Institute: C4BPA | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of C4BPA | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045732 | positive regulation of protein catabolic process | 22333221 | GO:0045959 | negative regulation of complement activation, classical pathway | 22333221 | GO:0045732 | positive regulation of protein catabolic process | 22333221 | GO:0045959 | negative regulation of complement activation, classical pathway | 22333221 |
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| TissGeneExp for C4BPA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 5.780042985 | 8.689679192 | -2.909636207 | 1.43E-09 | 7.42E-09 |
| BRCA | -2.28660647 | 1.338841775 | -3.625448246 | 6.15E-25 | 6.08E-24 |
| LUSC | 2.138338421 | 8.472528618 | -6.334190196 | 1.39E-16 | 1.06E-15 |
| ESCA | 1.296889224 | -2.991292595 | 4.288181818 | 0.004 | 0.034728615 |
| KIRP | -1.009494299 | -3.042500549 | 2.03300625 | 0.000796 | 0.002259028 |
| STAD | -0.249528674 | -2.756622424 | 2.50709375 | 0.00033 | 0.002157471 |
| LIHC | 9.874979951 | 11.47871195 | -1.603732 | 0.000134 | 0.00044889 |
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| TissGene-miRNA for C4BPA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C4BPA |
| TissGeneSNV for C4BPA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E448* | UCEC | 2 |
| p.R418L | LUAD | 1 |
| p.P356L | SKCM | 1 |
| p.G373D | SKCM | 1 |
| p.S208* | CESC | 1 |
| p.H246Q | BLCA | 1 |
| p.D284G | KIRC | 1 |
| p.T592S | LIHC | 1 |
| p.K456T | STAD | 1 |
| p.E125K | LIHC | 1 |
| p.D393N | SKCM | 1 |
| p.P314S | LUSC | 1 |
| p.S442L | ESCA | 1 |
| p.D63N | LGG | 1 |
| p.D243A | KIRC | 1 |
| p.A433V | COAD | 1 |
| p.E101K | HNSC | 1 |
| p.W227* | SKCM | 1 |
| p.A308T | SKCM | 1 |
| p.R418Q | BLCA | 1 |
| p.G196S | LGG | 1 |
| p.D158Y | READ | 1 |
| p.C267F | LUAD | 1 |
| p.P61L | READ | 1 |
| p.S98Y | LUAD | 1 |
| p.P533Q | COAD | 1 |
| p.R240H | COAD | 1 |
| p.Q479* | BLCA | 1 |
| p.S442* | UCEC | 1 |
| p.D63N | SKCM | 1 |
| p.T151A | PRAD | 1 |
| p.Q92H | STAD | 1 |
| p.G359E | SKCM | 1 |
| p.C364F | ESCA | 1 |
| p.M62I | SKCM | 1 |
| p.L273I | UCEC | 1 |
| p.V278L | SARC | 1 |
| p.P314S | SKCM | 1 |
| p.R331C | KIRC | 1 |
| p.P291L | SKCM | 1 |
| p.G527R | BLCA | 1 |
| p.Y391C | CESC | 1 |
| p.R485W | BRCA | 1 |
| p.G516D | THCA | 1 |
| p.Q268* | STAD | 1 |
| p.E118Q | BRCA | 1 |
| p.T317A | HNSC | 1 |
| p.P61L | BLCA | 1 |
| p.P289S | SKCM | 1 |
| p.S198C | BLCA | 1 |
| p.R153C | LGG | 1 |
| p.P229T | LGG | 1 |
| p.K14N | BLCA | 1 |
| p.A482V | UCEC | 1 |
| p.E125D | READ | 1 |
| p.R382H | SKCM | 1 |
| p.P205S | SKCM | 1 |
| p.G188S | COAD | 1 |
| p.R379K | SKCM | 1 |
| p.G188D | SKCM | 1 |
| p.W227X | SKCM | 1 |
| p.R120H | LGG | 1 |
| p.W102R | SKCM | 1 |
| p.R315W | SARC | 1 |
| p.E235K | SKCM | 1 |
| p.E137* | UCEC | 1 |
| p.P520S | HNSC | 1 |
| p.R70C | HNSC | 1 |
| p.E488Q | UCEC | 1 |
| p.L550P | STAD | 1 |
| p.P417L | LGG | 1 |
| p.E137X | ESCA | 1 |
| p.Q268X | STAD | 1 |
| p.K174* | LUAD | 1 |
| p.E503K | PRAD | 1 |
| p.P417L | LUSC | 1 |
| p.S396L | SKCM | 1 |
| p.S591C | SKCM | 1 |
| p.W287* | SKCM | 1 |
| p.P54S | SKCM | 1 |
| p.S245L | SKCM | 1 |
| p.G392E | SKCM | 1 |
| p.F144L | UCS | 1 |
| p.P7L | HNSC | 1 |
| p.T344M | READ | 1 |
| p.R120H | BRCA | 1 |
| p.E582K | SKCM | 1 |
| p.Q463* | LUAD | 1 |
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| TissGeneCNV for C4BPA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C4BPA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A0J2-01A | CCDC109B-C4BPA | Out-of-frame | Chr4:110481592 | Chr1:207317163 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-86-7953-01A | CD55-C4BPA | In-frame | Chr1:207500182 | Chr1:207300058 |
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| TissGeneNet for C4BPA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| COAD (tumor) | COAD (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| KICH (tumor) | KICH (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| STAD (tumor) | STAD (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| THCA (tumor) | THCA (normal) |
| C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (tumor) | C4BPA, GIT2, APCS, PITX3, SMARCD1, BMPR2, LRP1, PROS1, FXYD6, GTF2I, LBP, FOXJ2 (normal) |
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| TissGeneProg for C4BPA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C4BPA |
| TissGeneDrug for C4BPA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C4BPA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0162534 | Prion Diseases | 19 | BeFree |
| umls:C0022336 | Creutzfeldt-Jakob disease | 5 | BeFree |
| umls:C0017495 | Gerstmann-Straussler-Scheinker Disease | 4 | BeFree |
| umls:C0011334 | Dental caries | 3 | BeFree |
| umls:C0008479 | Chondrosarcoma | 2 | BeFree |
| umls:C0085584 | Encephalopathies | 2 | BeFree |
| umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
| umls:C0333519 | Caries (morphologic abnormality) | 2 | BeFree |
| umls:C0376329 | New Variant Creutzfeldt-Jakob Disease | 2 | BeFree |
| umls:C1857941 | Brooke-Spiegler syndrome | 2 | BeFree |
| umls:C2931788 | Atypical Hemolytic Uremic Syndrome | 2 | BeFree,GAD |
| umls:C0004610 | Bacteremia | 1 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0012546 | Diphtheria | 1 | BeFree |
| umls:C0019061 | Hemolytic-Uremic Syndrome | 1 | GAD,LHGDN |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0022660 | Kidney Failure, Acute | 1 | GAD |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0039614 | Tetanus | 1 | BeFree |
| umls:C0043194 | Wiskott-Aldrich Syndrome | 1 | BeFree |
| umls:C0085669 | Acute leukemia | 1 | BeFree |
| umls:C0206042 | Fatal Familial Insomnia | 1 | BeFree |
| umls:C0262404 | Cerebellar degeneration | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0311370 | Lupus anticoagulant disorder | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0751254 | Creutzfeldt-Jakob Disease, Familial | 1 | BeFree |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 1 | BeFree |
| umls:C1852467 | Creutzfeldt-Jakob Disease, Sporadic | 1 | BeFree |
| umls:C1860787 | DOWN SYNDROME CRITICAL REGION | 1 | BeFree |
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