TissGeneSummary for C4BPB |
Gene summary |
Basic gene information | Gene symbol | C4BPB |
Gene name | complement component 4 binding protein, beta | |
Synonyms | C4BP | |
Cytomap | UCSC genome browser: 1q32 | |
Type of gene | protein-coding | |
RefGenes | NM_000716.3, NM_001017364.1,NM_001017365.1,NM_001017366.1,NM_001017367.1, | |
Description | C4b-binding protein beta chain | |
Modification date | 20141207 | |
dbXrefs | MIM : 120831 | |
HGNC : HGNC | ||
Ensembl : ENSG00000123843 | ||
HPRD : 00404 | ||
Vega : OTTHUMG00000036035 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C4BPB | |
BioGPS: 725 | ||
Pathway | NCI Pathway Interaction Database: C4BPB | |
KEGG: C4BPB | ||
REACTOME: C4BPB | ||
Pathway Commons: C4BPB | ||
Context | iHOP: C4BPB | |
ligand binding site mutation search in PubMed: C4BPB | ||
UCL Cancer Institute: C4BPB | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLIHC | |
Reference showing the relevant tissue of C4BPB | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0045732 | positive regulation of protein catabolic process | 22333221 | GO:0045959 | negative regulation of complement activation, classical pathway | 22333221 | GO:0045732 | positive regulation of protein catabolic process | 22333221 | GO:0045959 | negative regulation of complement activation, classical pathway | 22333221 |
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TissGeneExp for C4BPB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 2.761453965 | -1.416850035 | 4.178304 | 9.08E-10 | 5.78E-09 |
BRCA | -0.98376793 | 0.18189786 | -1.165665789 | 1.89E-07 | 5.53E-07 |
LUSC | -1.687284545 | 1.404813494 | -3.092098039 | 4.93E-19 | 5.12E-18 |
BLCA | -2.355620561 | -1.028841614 | -1.326778947 | 0.00789 | 0.03717661 |
STAD | 3.280908715 | 1.01246184 | 2.268446875 | 0.0013 | 0.006511581 |
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TissGene-miRNA for C4BPB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C4BPB |
TissGeneSNV for C4BPB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D70Y | ESCA | 2 |
p.S162I | OV | 1 |
p.E220D | UCEC | 1 |
p.N221Y | BLCA | 1 |
p.E176D | BLCA | 1 |
p.K37N | SKCM | 1 |
p.I103M | HNSC | 1 |
p.Q210* | SKCM | 1 |
p.K102N | UCEC | 1 |
p.I112N | LGG | 1 |
p.E151K | SKCM | 1 |
p.C165R | STAD | 1 |
p.L251* | BRCA | 1 |
p.K102N | SKCM | 1 |
p.T60I | LAML | 1 |
p.S119R | BRCA | 1 |
p.G35W | GBM | 1 |
p.Q182R | MESO | 1 |
p.R14* | UCEC | 1 |
p.D70N | SKCM | 1 |
p.E25G | UCEC | 1 |
p.E220D | STAD | 1 |
p.Q228K | KIRP | 1 |
p.R14Q | SKCM | 1 |
p.T74I | KIRC | 1 |
p.I186T | MESO | 1 |
p.F91L | HNSC | 1 |
p.Q177K | KIRP | 1 |
p.P130H | SKCM | 1 |
p.A65T | UCEC | 1 |
p.E201Q | SARC | 1 |
p.C23F | THYM | 1 |
p.E196K | SKCM | 1 |
p.G173V | BLCA | 1 |
p.R77S | LUAD | 1 |
p.Q136H | ESCA | 1 |
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TissGeneCNV for C4BPB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C4BPB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C4BPB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C4BPB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C4BPB |
TissGeneDrug for C4BPB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C4BPB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
umls:C0004610 | Bacteremia | 1 | BeFree |
umls:C0004943 | Behcet Syndrome | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0242666 | Protein S Deficiency | 1 | BeFree |
umls:C0311370 | Lupus anticoagulant disorder | 1 | BeFree |