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| TissGeneSummary for TSHR |
 Gene summary |
| Basic gene information | Gene symbol | TSHR |
| Gene name | thyroid stimulating hormone receptor | |
| Synonyms | CHNG1|LGR3|hTSHR-I | |
| Cytomap | UCSC genome browser: 14q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000369.2, NM_001018036.2,NM_001142626.2, | |
| Description | seven transmembrane helix receptorthyrotropin receptorthyrotropin receptor-I, hTSHR-I | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603372 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000165409 | ||
| HPRD : 04537 | ||
| Vega : OTTHUMG00000171429 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TSHR | |
| BioGPS: 7253 | ||
| Pathway | NCI Pathway Interaction Database: TSHR | |
| KEGG: TSHR | ||
| REACTOME: TSHR | ||
| Pathway Commons: TSHR | ||
| Context | iHOP: TSHR | |
| ligand binding site mutation search in PubMed: TSHR | ||
| UCL Cancer Institute: TSHR | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTHCA | |
| Reference showing the relevant tissue of TSHR | Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma. Thyroid. 2017 Feb;27(2):236-252. doi: 10.1089/thy.2016.0285. Epub 2016 Dec 15. (pmid:27796151) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TSHR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -1.343759604 | -2.628404431 | 1.284644828 | 1.17E-07 | 4.52E-07 |
| BRCA | -1.450030808 | -0.125600106 | -1.324430702 | 5.84E-14 | 2.82E-13 |
| KIRC | -0.442791261 | -1.772053761 | 1.3292625 | 3.14E-12 | 1.29E-11 |
| COAD | -2.602697137 | -1.538562522 | -1.064134615 | 0.000311 | 0.001009483 |
| Top |
| TissGene-miRNA for TSHR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TSHR |
| TissGeneSNV for TSHR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E251K | SKCM | 3 |
| p.Y353C | STAD | 1 |
| p.R46H | COAD | 1 |
| p.F286Y | SKCM | 1 |
| p.A171T | UCEC | 1 |
| p.C699F | LUAD | 1 |
| p.L426R | THYM | 1 |
| p.Q686K | LUAD | 1 |
| p.N447K | LUSC | 1 |
| p.L184Q | LUSC | 1 |
| p.A4T | COAD | 1 |
| p.L263F | LGG | 1 |
| p.L6F | BLCA | 1 |
| p.G464E | SKCM | 1 |
| p.E107* | UCEC | 1 |
| p.T54M | STAD | 1 |
| p.G753D | SKCM | 1 |
| p.E506G | COAD | 1 |
| p.L267M | LUAD | 1 |
| p.V721A | SKCM | 1 |
| p.E303D | BLCA | 1 |
| p.L456M | STAD | 1 |
| p.Q359K | LUAD | 1 |
| p.V448I | LGG | 1 |
| p.R519C | BLCA | 1 |
| p.R609Q | STAD | 1 |
| p.A644S | HNSC | 1 |
| p.N187D | UCEC | 1 |
| p.E247K | BRCA | 1 |
| p.P162H | LUAD | 1 |
| p.Q686H | LUSC | 1 |
| p.L263P | STAD | 1 |
| p.A220E | LUAD | 1 |
| p.L241V | LUAD | 1 |
| p.L114* | LUAD | 1 |
| p.A581T | COAD | 1 |
| p.A579V | SKCM | 1 |
| p.N135K | LUSC | 1 |
| p.W488X | STAD | 1 |
| p.E30K | SKCM | 1 |
| p.D718N | SKCM | 1 |
| p.H351Y | LUAD | 1 |
| p.E575K | STAD | 1 |
| p.643_644YA>*S | HNSC | 1 |
| p.M164I | THYM | 1 |
| p.L629S | ESCA | 1 |
| p.Y98C | LUAD | 1 |
| p.E242K | SKCM | 1 |
| p.S659Y | LUAD | 1 |
| p.E242Q | LUAD | 1 |
| p.R531Q | KIRC | 1 |
| p.Y185* | LUAD | 1 |
| p.L19M | LGG | 1 |
| p.E233Q | BLCA | 1 |
| p.S245P | SKCM | 1 |
| p.N734S | UCS | 1 |
| p.P639Q | READ | 1 |
| p.G708V | LGG | 1 |
| p.S25L | SKCM | 1 |
| p.D617N | LUAD | 1 |
| p.R310H | COAD | 1 |
| p.D487N | PAAD | 1 |
| p.F221C | UCEC | 1 |
| p.R534L | GBM | 1 |
| p.E736K | SKCM | 1 |
| p.P556S | SKCM | 1 |
| p.A350T | HNSC | 1 |
| p.L131I | PAAD | 1 |
| p.E251K | STAD | 1 |
| p.S79F | SKCM | 1 |
| p.R46C | PRAD | 1 |
| p.M542I | SKCM | 1 |
| p.I622T | UCEC | 1 |
| p.P168S | LUAD | 1 |
| p.V448I | COAD | 1 |
| p.F141S | ESCA | 1 |
| p.P668T | COAD | 1 |
| p.A684V | LGG | 1 |
| p.Y643* | HNSC | 1 |
| p.E376V | SKCM | 1 |
| p.V656I | LUAD | 1 |
| p.D460N | BLCA | 1 |
| p.T346I | PAAD | 1 |
| p.T511M | STAD | 1 |
| p.D43N | SKCM | 1 |
| p.V656A | HNSC | 1 |
| p.M453T | THCA | 1 |
| p.S25L | UCS | 1 |
| p.L692I | ESCA | 1 |
| p.K258Q | STAD | 1 |
| p.K211T | COAD | 1 |
| p.E35K | BLCA | 1 |
| p.P675Q | LUAD | 1 |
| p.W520X | SKCM | 1 |
| p.Y82F | SKCM | 1 |
| p.G23V | ESCA | 1 |
| p.A350D | UCEC | 1 |
| p.R707W | UCEC | 1 |
| p.M760V | STAD | 1 |
| p.D617E | ESCA | 1 |
| p.R65K | UCEC | 1 |
| p.T214A | STAD | 1 |
| p.E247K | BLCA | 1 |
| p.S266F | COAD | 1 |
| p.F461L | BLCA | 1 |
| p.W520* | SKCM | 1 |
| p.A457D | BRCA | 1 |
| p.A673D | STAD | 1 |
| p.A684V | SKCM | 1 |
| p.W488* | STAD | 1 |
| p.A171G | DLBC | 1 |
| p.T490K | LUAD | 1 |
| p.D382Y | COAD | 1 |
| p.A380D | LUAD | 1 |
| p.R707Q | CESC | 1 |
| p.R312T | OV | 1 |
| p.K261M | BRCA | 1 |
| p.R310S | BRCA | 1 |
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| TissGeneCNV for TSHR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TSHR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for TSHR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, JAK2, GNAQ, RABAC1, CALR, HSPA5, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13, TSHB, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, JAK2, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAO1, GNAI1, GNA11, GNAI3, GNA13, LHCGR (normal) |
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| COAD (tumor) | COAD (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, JAK2, GNAQ, PIK3R1, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNA13, TSHB, LHCGR (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13 (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNAS, GNAO1, GNAI1, GNAI3, GNA13, LHCGR (normal) |
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| KICH (tumor) | KICH (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, CALR, CANX, GNAI2, CALCR, GNA12, GNAO1, GNAI1, GNA11, GNA13, TSHB, LHCGR (tumor) | TSHR, PPP1CA, UBC, FLNB, FN1, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13, LHCGR (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, GNAQ, RABAC1, PIK3R1, CALR, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNA13, TSHB, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FN1, STAT3, JAK2, GNAQ, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13, LHCGR (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNAS, GNAO1, GNAI1, TSHB, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FN1, STAT3, JAK2, PIK3R1, CALR, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, GNA13, TSHB, LHCGR (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, CALR, HSPA5, CANX, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3, TSHB (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNA11, GNAI3, GNA13, TSHB, LHCGR (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, GNAI2, GNA12, GNAS, GNAO1, GNAI1, GNAI3, GNA13, TSHB, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, GNAI2, GNAS, GNAO1, GNA11, GNAI3, GNA13, TSHB, LHCGR (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TSHR, UBC, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNAI3, GNA13, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAO1, GNAI1, GNAI3, TSHB, LHCGR (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TSHR, PPP1CA, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAO1, GNAI1, GNA11, GNAI3, GNA13, LHCGR (tumor) | TSHR, PPP1CA, UBC, JAK1, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNA11, GNA13, LHCGR (normal) |
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| STAD (tumor) | STAD (normal) |
| TSHR, PPP1CA, UBC, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNA12, GNAI1, GNA11, GNAI3, GNA13, TSHB, LHCGR (tumor) | TSHR, PPP1CA, JAK1, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA13, TSHB, LHCGR (normal) |
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| THCA (tumor) | THCA (normal) |
| TSHR, PPP1CA, UBC, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAO1, GNAI1, GNA11, GNAI3, GNA13 (tumor) | TSHR, PPP1CA, UBC, FLNB, FN1, STAT3, JAK2, GNAQ, RABAC1, PIK3R1, CALR, HSPA5, CANX, GNAI2, CALCR, GNA12, GNAS, GNAO1, GNAI1, GNA11, GNAI3 (normal) |
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| TissGeneProg for TSHR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TSHR |
| TissGeneDrug for TSHR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TSHR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0018213 | Graves Disease | 125 | BeFree,CTD_human,GAD,GWASCAT,LHGDN |
| umls:C0020550 | Hyperthyroidism | 57 | BeFree,CTD_human,LHGDN |
| umls:C0010308 | Congenital Hypothyroidism | 30 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0342200 | Endemic Cretinism | 30 | BeFree |
| umls:C0178468 | Autoimmune thyroid disease | 28 | BeFree,GAD |
| umls:C1836706 | Hyperthyroidism, Nonautoimmune | 28 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0549473 | Thyroid carcinoma | 26 | BeFree,GAD |
| umls:C0339143 | Thyroid associated opthalmopathies | 25 | BeFree,GAD |
| umls:C0040137 | Thyroid Nodule | 22 | BeFree,GAD |
| umls:C0040136 | Thyroid Neoplasm | 21 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0001430 | Adenoma | 19 | BeFree,CTD_human |
| umls:C0020676 | Hypothyroidism | 19 | BeFree,GAD,LHGDN |
| umls:C0007115 | Malignant neoplasm of thyroid | 17 | BeFree |
| umls:C3493776 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 1 | 14 | BeFree,CLINVAR,MGD,ORPHANET,UNIPROT |
| umls:C0018021 | Goiter | 13 | BeFree |
| umls:C0040128 | Thyroid Diseases | 13 | BeFree,GAD |
| umls:C0040156 | Thyrotoxicosis | 13 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0151468 | Thyroid Gland Follicular Adenoma | 12 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 10 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 10 | BeFree |
| umls:C1563716 | Thyroid Dysgenesis | 9 | BeFree,LHGDN |
| umls:C0302840 | Toxic thyroid adenoma | 8 | BeFree |
| umls:C1262098 | Congenital hyperthyroidism | 8 | BeFree |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 8 | BeFree |
| umls:C0015397 | Disorder of eye | 7 | BeFree,GAD,LHGDN |
| umls:C0700502 | Acquired hypothyroidism | 7 | BeFree |
| umls:C0027145 | Myxedema | 6 | BeFree |
| umls:C0029182 | orbit (eye disorders) | 6 | BeFree |
| umls:C0154143 | Toxic multinodular goiter | 6 | BeFree |
| umls:C0271790 | Subclinical hypothyroidism | 6 | BeFree |
| umls:C0342208 | Multinodular goiter | 6 | BeFree |
| umls:C2940786 | Thyroid Hormone Resistance Syndrome | 6 | BeFree |
| umls:C0028259 | Nodule | 5 | BeFree |
| umls:C0040021 | Thromboangiitis Obliterans | 5 | BeFree |
| umls:C0040147 | Thyroiditis | 5 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 5 | BeFree |
| umls:C0677607 | Hashimoto Disease | 5 | BeFree,GAD |
| umls:C0238462 | Medullary carcinoma of thyroid | 4 | BeFree |
| umls:C0869147 | Neonatal hyperthyroidism | 4 | BeFree |
| umls:C0002793 | Anaplasia | 3 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0032002 | Pituitary Diseases | 3 | BeFree |
| umls:C0151516 | Thyroid Hypoplasia | 3 | BeFree,ORPHANET |
| umls:C0151526 | Premature Birth | 3 | GAD |
| umls:C0238461 | Anaplastic thyroid carcinoma | 3 | BeFree |
| umls:C1112776 | Thyroid hyperplasia | 3 | BeFree |
| umls:C0013080 | Down Syndrome | 2 | BeFree |
| umls:C0018023 | Nodular Goiter | 2 | GAD,LHGDN |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0151514 | Atrophic condition of skin | 2 | BeFree |
| umls:C0205647 | Follicular adenoma | 2 | BeFree |
| umls:C0205696 | Anaplastic carcinoma | 2 | BeFree |
| umls:C0206693 | Medullary carcinoma | 2 | BeFree |
| umls:C0271791 | Severe hypothyroidism | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0749420 | Thyroid Agenesis | 2 | BeFree |
| umls:C0920350 | Autoimmune thyroiditis | 2 | BeFree,CTD_human,GAD |
| umls:C1998045 | Subclinical hyperthyroidism | 2 | BeFree |
| umls:C2940785 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 3 | 2 | BeFree |
| umls:C3714618 | Primary Hyperthyroidism | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0000809 | Abortion, Habitual | 1 | GAD |
| umls:C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
| umls:C0007867 | Cervix Diseases | 1 | BeFree |
| umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
| umls:C0014130 | Endocrine System Diseases | 1 | GAD |
| umls:C0015544 | Failure to Thrive | 1 | BeFree |
| umls:C0015929 | Fetal Diseases | 1 | GAD |
| umls:C0021361 | Female infertility | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
| umls:C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | GAD |
| umls:C0026267 | Mitral Valve Prolapse Syndrome | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | GAD |
| umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 1 | GAD |
| umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
| umls:C0033844 | Pseudotumor | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | GAD |
| umls:C0038013 | Ankylosing spondylitis | 1 | GAD |
| umls:C0038379 | Strabismus | 1 | BeFree |
| umls:C0040115 | Thymus Hyperplasia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0154094 | Carcinoma in situ of eye | 1 | GAD |
| umls:C0158983 | Neonatal thyrotoxicosis | 1 | BeFree |
| umls:C0205642 | Adenocarcinoma, Oxyphilic | 1 | BeFree |
| umls:C0271335 | Orbital congestion | 1 | BeFree |
| umls:C0342114 | Diffuse goiter | 1 | BeFree |
| umls:C0342127 | Toxic nodular goiter | 1 | BeFree |
| umls:C0410158 | Muscle damage | 1 | BeFree |
| umls:C0600086 | Toxic goiter | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0749424 | Thyroid Hurthle Cell Carcinoma | 1 | BeFree |
| umls:C0920420 | cancer recurrence | 1 | BeFree |
| umls:C1262091 | Lymphocytic infiltration | 1 | BeFree |
| umls:C1266050 | Poorly Differentiated Thyroid Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | GAD |
| umls:C1510502 | Oxyphilic Adenoma | 1 | BeFree |
| umls:C1863959 | Hyperthyroidism, Familial Gestational | 1 | CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C1955741 | Glucocorticoid deficiency | 1 | BeFree |
| umls:C2024965 | Caries of smooth surface of tooth | 1 | GWASCAT |
| umls:C3714514 | Infection | 1 | GAD |
| umls:C1863960 | Thyroid Adenoma, Hyperfunctioning | 0 | CLINVAR |
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