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| TissGeneSummary for C5 |
 Gene summary |
| Basic gene information | Gene symbol | C5 |
| Gene name | complement component 5 | |
| Synonyms | C5D|C5a|C5b|CPAMD4|ECLZB | |
| Cytomap | UCSC genome browser: 9q33-q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001735.2, | |
| Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4C5a anaphylatoxinanaphylatoxin C5a analogcomplement C5prepro-C5 | |
| Modification date | 20141221 | |
| dbXrefs | MIM : 120900 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106804 | ||
| HPRD : 00405 | ||
| Vega : OTTHUMG00000020579 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C5 | |
| BioGPS: 727 | ||
| Pathway | NCI Pathway Interaction Database: C5 | |
| KEGG: C5 | ||
| REACTOME: C5 | ||
| Pathway Commons: C5 | ||
| Context | iHOP: C5 | |
| ligand binding site mutation search in PubMed: C5 | ||
| UCL Cancer Institute: C5 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of C5 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0010575 | positive regulation vascular endothelial growth factor production | 14566334 | GO:0010760 | negative regulation of macrophage chemotaxis | 14566334 | GO:0090197 | positive regulation of chemokine secretion | 14566334 | GO:0010575 | positive regulation vascular endothelial growth factor production | 14566334 | GO:0010760 | negative regulation of macrophage chemotaxis | 14566334 | GO:0090197 | positive regulation of chemokine secretion | 14566334 |
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| TissGeneExp for C5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -1.599543152 | 0.127037404 | -1.726580556 | 2.01E-29 | 3.60E-28 |
| KICH | -2.858542819 | -0.069934819 | -2.788608 | 5.09E-10 | 3.43E-09 |
| LUAD | 0.169966906 | 1.509535871 | -1.339568966 | 6.74E-07 | 2.31E-06 |
| LIHC | 5.572585181 | 6.729377181 | -1.156792 | 3.82E-06 | 1.82E-05 |
| LUSC | -0.657860309 | 1.61913773 | -2.276998039 | 1.60E-17 | 1.35E-16 |
| BLCA | -2.597450608 | -1.386197976 | -1.211252632 | 0.00703 | 0.034260306 |
| KIRP | -1.022969194 | 0.160824556 | -1.18379375 | 0.000126 | 0.000418507 |
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| TissGene-miRNA for C5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C5 |
| TissGeneSNV for C5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R1206C | SKCM | 5 |
| p.R1246C | UCEC | 1 |
| p.V734I | LUAD | 1 |
| p.Y312C | STAD | 1 |
| p.F824Y | SKCM | 1 |
| p.S169A | SKCM | 1 |
| p.E1339K | CESC | 1 |
| p.R1206C | STAD | 1 |
| p.L571F | SKCM | 1 |
| p.E281K | SKCM | 1 |
| p.P60A | HNSC | 1 |
| p.A1530V | BRCA | 1 |
| p.R1476G | SKCM | 1 |
| p.A579P | LUAD | 1 |
| p.I1627V | UCEC | 1 |
| p.R956Q | READ | 1 |
| p.K818* | LIHC | 1 |
| p.R714X | COAD | 1 |
| p.F1081C | UCS | 1 |
| p.E1414Q | BLCA | 1 |
| p.I1169T | SKCM | 1 |
| p.G1351E | CESC | 1 |
| p.M1535V | STAD | 1 |
| p.D1157N | LGG | 1 |
| p.A581T | THYM | 1 |
| p.G1458E | SKCM | 1 |
| p.G69C | LUAD | 1 |
| p.M283T | KIRC | 1 |
| p.A215T | THYM | 1 |
| p.S913L | SKCM | 1 |
| p.D377N | CESC | 1 |
| p.I231V | LIHC | 1 |
| p.D1263Y | UCEC | 1 |
| p.R1226C | SKCM | 1 |
| p.G1282D | ESCA | 1 |
| p.Y499C | HNSC | 1 |
| p.S147L | COAD | 1 |
| p.F1174V | UCEC | 1 |
| p.R412C | LGG | 1 |
| p.E1339Q | BRCA | 1 |
| p.S1196F | SKCM | 1 |
| p.S851Y | UCEC | 1 |
| p.V802G | STAD | 1 |
| p.V265I | COAD | 1 |
| p.E1295K | BLCA | 1 |
| p.D1382N | LGG | 1 |
| p.P931S | SKCM | 1 |
| p.P166S | SKCM | 1 |
| p.T200M | STAD | 1 |
| p.E1571K | DLBC | 1 |
| p.R835Q | SKCM | 1 |
| p.N423S | KICH | 1 |
| p.D822Y | UCEC | 1 |
| p.I1169V | SKCM | 1 |
| p.S860F | UCEC | 1 |
| p.E221K | TGCT | 1 |
| p.I1402T | UCEC | 1 |
| p.S1103F | KIRC | 1 |
| p.Y1399C | UCEC | 1 |
| p.L1309F | BLCA | 1 |
| p.S458T | STAD | 1 |
| p.S1389C | HNSC | 1 |
| p.V588M | SKCM | 1 |
| p.R253S | BRCA | 1 |
| p.K189N | UCEC | 1 |
| p.T1383I | LGG | 1 |
| p.E730K | DLBC | 1 |
| p.A1211T | STAD | 1 |
| p.R766Q | UCEC | 1 |
| p.P1160S | HNSC | 1 |
| p.K818X | LIHC | 1 |
| p.T437A | LIHC | 1 |
| p.G981X | COAD | 1 |
| p.S743C | HNSC | 1 |
| p.S1058P | COAD | 1 |
| p.F1186V | PCPG | 1 |
| p.L126I | UCEC | 1 |
| p.S184Y | BLCA | 1 |
| p.S598F | SKCM | 1 |
| p.S1117Y | UCEC | 1 |
| p.R1478W | SKCM | 1 |
| p.P536S | SKCM | 1 |
| p.S1210L | SKCM | 1 |
| p.R956* | PAAD | 1 |
| p.L3P | THYM | 1 |
| p.A812V | COAD | 1 |
| p.P343L | LIHC | 1 |
| p.V1093I | SKCM | 1 |
| p.W1228X | COAD | 1 |
| p.M853I | LGG | 1 |
| p.E958K | SKCM | 1 |
| p.I30T | UCEC | 1 |
| p.Y543C | LUSC | 1 |
| p.V833D | SKCM | 1 |
| p.Y501D | UCEC | 1 |
| p.L673I | UCEC | 1 |
| p.P360S | LUAD | 1 |
| p.E869K | UCEC | 1 |
| p.R1206C | LGG | 1 |
| p.L1175M | BLCA | 1 |
| p.D666G | LIHC | 1 |
| p.T1363P | LAML | 1 |
| p.E921G | BRCA | 1 |
| p.E1011K | HNSC | 1 |
| p.G1431E | HNSC | 1 |
| p.K280X | LIHC | 1 |
| p.R412L | LUAD | 1 |
| p.H753Y | STAD | 1 |
| p.L504V | BLCA | 1 |
| p.A1590T | BLCA | 1 |
| p.G1458E | PRAD | 1 |
| p.S832F | SKCM | 1 |
| p.E1109X | ESCA | 1 |
| p.G1458X | COAD | 1 |
| p.R1478W | STAD | 1 |
| p.G1282S | KIRP | 1 |
| p.W1106* | GBM | 1 |
| p.S184C | HNSC | 1 |
| p.P529S | SKCM | 1 |
| p.P1468L | SKCM | 1 |
| p.P89R | BLCA | 1 |
| p.G1281V | SARC | 1 |
| p.T1166K | UCEC | 1 |
| p.Q785E | OV | 1 |
| p.Y582C | PRAD | 1 |
| p.Y222H | SARC | 1 |
| p.R1308C | STAD | 1 |
| p.R1214T | SKCM | 1 |
| p.S1103Y | UCEC | 1 |
| p.R539Q | UCEC | 1 |
| p.G45X | THYM | 1 |
| p.I1557F | SARC | 1 |
| p.L825M | THYM | 1 |
| p.P1004H | TGCT | 1 |
| p.P186L | SKCM | 1 |
| p.I1152T | SKCM | 1 |
| p.S1564T | READ | 1 |
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| TissGeneCNV for C5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49W-01A | C5-PHF19 | Out-of-Frame | chr9:123789437 | chr9:123620564 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4427-01A | CDC42BPA-C5 | Out-of-frame | Chr1:227504706 | Chr9:123780130 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-XQ-A8TA-01A | C5-SEMA4D | NA | Chr9:123837032 | Chr9:92070868 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-HC-7821-01A | C5-DBC1 | Out-of-frame | Chr9:123794391 | Chr9:121930502 |
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| TissGeneNet for C5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| COAD (tumor) | COAD (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| KICH (tumor) | KICH (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| STAD (tumor) | STAD (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| THCA (tumor) | THCA (normal) |
| C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor) | C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal) |
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| TissGeneProg for C5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C5 |
| TissGeneDrug for C5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00028 | Immune Globulin Human | Binder | Biotech | Approved|Investigational |
| DB01257 | Eculizumab | Antibody | Biotech | Approved|Investigational |
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| TissGeneDisease for C5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003873 | Rheumatoid Arthritis | 17 | BeFree,GAD,LHGDN |
| umls:C0004096 | Asthma | 6 | BeFree,GAD,RGD |
| umls:C0021368 | Inflammation | 6 | GAD,LHGDN |
| umls:C0243026 | Sepsis | 4 | BeFree,GAD,RGD |
| umls:C0003864 | Arthritis | 3 | BeFree,GAD |
| umls:C0022116 | Ischemia | 3 | BeFree |
| umls:C3495559 | Juvenile arthritis | 3 | GAD,LHGDN |
| umls:C0004364 | Autoimmune Diseases | 2 | GAD |
| umls:C0007786 | Brain Ischemia | 2 | GAD,LHGDN |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
| umls:C0014175 | Endometriosis | 2 | GAD,LHGDN |
| umls:C0017661 | IGA Glomerulonephritis | 2 | GAD,LHGDN |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | GAD |
| umls:C0027055 | Myocardial Reperfusion Injury | 2 | RGD |
| umls:C0031154 | Peritonitis | 2 | CTD_human |
| umls:C0038454 | Cerebrovascular accident | 2 | GAD,LHGDN |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
| umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree,GAD |
| umls:C0993582 | Arthritis, Experimental | 2 | BeFree,RGD |
| umls:C0002171 | Alopecia Areata | 1 | GAD |
| umls:C0004153 | Atherosclerosis | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007682 | CNS disorder | 1 | BeFree |
| umls:C0008149 | Chlamydia Infections | 1 | GAD |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0011065 | Cessation of life | 1 | LHGDN |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
| umls:C0014743 | Erythema Nodosum | 1 | GAD |
| umls:C0016059 | Fibrosis | 1 | LHGDN |
| umls:C0016412 | Folic Acid Deficiency | 1 | BeFree |
| umls:C0020523 | Immediate hypersensitivity | 1 | GAD |
| umls:C0020951 | Immune Complex Diseases | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | CTD_human |
| umls:C0021359 | Infertility | 1 | LHGDN |
| umls:C0023890 | Liver Cirrhosis | 1 | GAD |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0025294 | Meningococcal meningitis | 1 | BeFree |
| umls:C0025295 | Meningitis, Pneumococcal | 1 | BeFree |
| umls:C0025306 | Meningococcemia | 1 | BeFree |
| umls:C0027947 | Neutropenia | 1 | RGD |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | RGD |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036202 | Sarcoidosis | 1 | GAD |
| umls:C0036690 | Septicemia | 1 | BeFree |
| umls:C0040592 | Trachoma | 1 | GAD |
| umls:C0085129 | Bronchial Hyperreactivity | 1 | GAD |
| umls:C0151650 | Renal fibrosis | 1 | BeFree |
| umls:C0343713 | Gonococcal arthritis dermatitis syndrome | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0701807 | Acute anterior uveitis | 1 | BeFree |
| umls:C1260959 | Drusen | 1 | BeFree |
| umls:C1527311 | Brain Edema | 1 | RGD |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2717961 | Thrombotic Microangiopathies | 1 | BeFree |
| umls:C2745963 | Kashin-Beck Disease | 1 | BeFree |
| umls:C3662483 | Allergic sensitization | 1 | BeFree |
| umls:C0343047 | Complement component 5 deficiency | 0 | CLINVAR,CTD_human |
| umls:C3810402 | ECULIZUMAB, POOR RESPONSE TO | 0 | CLINVAR |
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