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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for C5
check button Gene summary
Basic gene informationGene symbolC5
Gene namecomplement component 5
SynonymsC5D|C5a|C5b|CPAMD4|ECLZB
CytomapUCSC genome browser: 9q33-q34
Type of geneprotein-coding
RefGenesNM_001735.2,
DescriptionC3 and PZP-like alpha-2-macroglobulin domain-containing protein 4C5a anaphylatoxinanaphylatoxin C5a analogcomplement C5prepro-C5
Modification date20141221
dbXrefs MIM : 120900
HGNC : HGNC
Ensembl : ENSG00000106804
HPRD : 00405
Vega : OTTHUMG00000020579
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_C5
BioGPS: 727
PathwayNCI Pathway Interaction Database: C5
KEGG: C5
REACTOME: C5
Pathway Commons: C5
ContextiHOP: C5
ligand binding site mutation search in PubMed: C5
UCL Cancer Institute: C5
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of C5
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0010575positive regulation vascular endothelial growth factor production14566334
GO:0010760negative regulation of macrophage chemotaxis14566334
GO:0090197positive regulation of chemokine secretion14566334
GO:0010575positive regulation vascular endothelial growth factor production14566334
GO:0010760negative regulation of macrophage chemotaxis14566334
GO:0090197positive regulation of chemokine secretion14566334


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TissGeneExp for C5

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-1.5995431520.127037404-1.7265805562.01E-293.60E-28
KICH-2.858542819-0.069934819-2.7886085.09E-103.43E-09
LUAD0.1699669061.509535871-1.3395689666.74E-072.31E-06
LIHC5.5725851816.729377181-1.1567923.82E-061.82E-05
LUSC-0.6578603091.61913773-2.2769980391.60E-171.35E-16
BLCA-2.597450608-1.386197976-1.2112526320.007030.034260306
KIRP-1.0229691940.160824556-1.183793750.0001260.000418507


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TissGene-miRNA for C5

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for C5
TissGeneSNV for C5

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R1206CSKCM5
p.R1246CUCEC1
p.V734ILUAD1
p.Y312CSTAD1
p.F824YSKCM1
p.S169ASKCM1
p.E1339KCESC1
p.R1206CSTAD1
p.L571FSKCM1
p.E281KSKCM1
p.P60AHNSC1
p.A1530VBRCA1
p.R1476GSKCM1
p.A579PLUAD1
p.I1627VUCEC1
p.R956QREAD1
p.K818*LIHC1
p.R714XCOAD1
p.F1081CUCS1
p.E1414QBLCA1
p.I1169TSKCM1
p.G1351ECESC1
p.M1535VSTAD1
p.D1157NLGG1
p.A581TTHYM1
p.G1458ESKCM1
p.G69CLUAD1
p.M283TKIRC1
p.A215TTHYM1
p.S913LSKCM1
p.D377NCESC1
p.I231VLIHC1
p.D1263YUCEC1
p.R1226CSKCM1
p.G1282DESCA1
p.Y499CHNSC1
p.S147LCOAD1
p.F1174VUCEC1
p.R412CLGG1
p.E1339QBRCA1
p.S1196FSKCM1
p.S851YUCEC1
p.V802GSTAD1
p.V265ICOAD1
p.E1295KBLCA1
p.D1382NLGG1
p.P931SSKCM1
p.P166SSKCM1
p.T200MSTAD1
p.E1571KDLBC1
p.R835QSKCM1
p.N423SKICH1
p.D822YUCEC1
p.I1169VSKCM1
p.S860FUCEC1
p.E221KTGCT1
p.I1402TUCEC1
p.S1103FKIRC1
p.Y1399CUCEC1
p.L1309FBLCA1
p.S458TSTAD1
p.S1389CHNSC1
p.V588MSKCM1
p.R253SBRCA1
p.K189NUCEC1
p.T1383ILGG1
p.E730KDLBC1
p.A1211TSTAD1
p.R766QUCEC1
p.P1160SHNSC1
p.K818XLIHC1
p.T437ALIHC1
p.G981XCOAD1
p.S743CHNSC1
p.S1058PCOAD1
p.F1186VPCPG1
p.L126IUCEC1
p.S184YBLCA1
p.S598FSKCM1
p.S1117YUCEC1
p.R1478WSKCM1
p.P536SSKCM1
p.S1210LSKCM1
p.R956*PAAD1
p.L3PTHYM1
p.A812VCOAD1
p.P343LLIHC1
p.V1093ISKCM1
p.W1228XCOAD1
p.M853ILGG1
p.E958KSKCM1
p.I30TUCEC1
p.Y543CLUSC1
p.V833DSKCM1
p.Y501DUCEC1
p.L673IUCEC1
p.P360SLUAD1
p.E869KUCEC1
p.R1206CLGG1
p.L1175MBLCA1
p.D666GLIHC1
p.T1363PLAML1
p.E921GBRCA1
p.E1011KHNSC1
p.G1431EHNSC1
p.K280XLIHC1
p.R412LLUAD1
p.H753YSTAD1
p.L504VBLCA1
p.A1590TBLCA1
p.G1458EPRAD1
p.S832FSKCM1
p.E1109XESCA1
p.G1458XCOAD1
p.R1478WSTAD1
p.G1282SKIRP1
p.W1106*GBM1
p.S184CHNSC1
p.P529SSKCM1
p.P1468LSKCM1
p.P89RBLCA1
p.G1281VSARC1
p.T1166KUCEC1
p.Q785EOV1
p.Y582CPRAD1
p.Y222HSARC1
p.R1308CSTAD1
p.R1214TSKCM1
p.S1103YUCEC1
p.R539QUCEC1
p.G45XTHYM1
p.I1557FSARC1
p.L825MTHYM1
p.P1004HTGCT1
p.P186LSKCM1
p.I1152TSKCM1
p.S1564TREAD1


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TissGeneCNV for C5

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for C5

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanESCATCGA-LN-A49W-01AC5-PHF19Out-of-Framechr9:123789437chr9:123620564
TCGAfusionPortalPRADALUADTCGA-05-4427-01ACDC42BPA-C5Out-of-frameChr1:227504706Chr9:123780130
TCGAfusionPortalPRADAPRADTCGA-XQ-A8TA-01AC5-SEMA4DNAChr9:123837032Chr9:92070868
TCGAfusionPortalPRADAPRADTCGA-HC-7821-01AC5-DBC1Out-of-frameChr9:123794391Chr9:121930502


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TissGeneNet for C5

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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COAD (tumor)COAD (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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HNSC (tumor)HNSC (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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KICH (tumor)KICH (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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KIRC (tumor)KIRC (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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KIRP (tumor)KIRP (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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LIHC (tumor)LIHC (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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LUAD (tumor)LUAD (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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LUSC (tumor)LUSC (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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PRAD (tumor)PRAD (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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STAD (tumor)STAD (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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THCA (tumor)THCA (normal)
C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (tumor)C5, C8B, PITX3, C7, CPB2, C5AR1, C6, CPN1, C3, C2 (normal)
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TissGeneProg for C5

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for C5
TissGeneDrug for C5

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00028Immune Globulin HumanBinderBiotechApproved|Investigational
DB01257EculizumabAntibodyBiotechApproved|Investigational


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TissGeneDisease for C5

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0003873Rheumatoid Arthritis17BeFree,GAD,LHGDN
umls:C0004096Asthma6BeFree,GAD,RGD
umls:C0021368Inflammation6GAD,LHGDN
umls:C0243026Sepsis4BeFree,GAD,RGD
umls:C0003864Arthritis3BeFree,GAD
umls:C0022116Ischemia3BeFree
umls:C3495559Juvenile arthritis3GAD,LHGDN
umls:C0004364Autoimmune Diseases2GAD
umls:C0007786Brain Ischemia2GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2GAD
umls:C0014175Endometriosis2GAD,LHGDN
umls:C0017661IGA Glomerulonephritis2GAD,LHGDN
umls:C0024141Lupus Erythematosus, Systemic2GAD
umls:C0027055Myocardial Reperfusion Injury2RGD
umls:C0031154Peritonitis2CTD_human
umls:C0038454Cerebrovascular accident2GAD,LHGDN
umls:C0042769Virus Diseases2BeFree
umls:C0242383Age related macular degeneration2BeFree,GAD
umls:C0524910Hepatitis C, Chronic2BeFree,GAD
umls:C0993582Arthritis, Experimental2BeFree,RGD
umls:C0002171Alopecia Areata1GAD
umls:C0004153Atherosclerosis1GAD
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0007682CNS disorder1BeFree
umls:C0008149Chlamydia Infections1GAD
umls:C0009319Colitis1BeFree
umls:C0011065Cessation of life1LHGDN
umls:C0011854Diabetes Mellitus, Insulin-Dependent1GAD
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0014743Erythema Nodosum1GAD
umls:C0016059Fibrosis1LHGDN
umls:C0016412Folic Acid Deficiency1BeFree
umls:C0020523Immediate hypersensitivity1GAD
umls:C0020951Immune Complex Diseases1BeFree
umls:C0021051Immunologic Deficiency Syndromes1CTD_human
umls:C0021359Infertility1LHGDN
umls:C0023890Liver Cirrhosis1GAD
umls:C0024143Lupus Nephritis1GAD
umls:C0024305Lymphoma, Non-Hodgkin1GAD
umls:C0025294Meningococcal meningitis1BeFree
umls:C0025295Meningitis, Pneumococcal1BeFree
umls:C0025306Meningococcemia1BeFree
umls:C0027947Neutropenia1RGD
umls:C0035126Reperfusion Injury1RGD
umls:C0035222Respiratory Distress Syndrome, Adult1RGD
umls:C0035235Respiratory Syncytial Virus Infections1GAD
umls:C0036202Sarcoidosis1GAD
umls:C0036690Septicemia1BeFree
umls:C0040592Trachoma1GAD
umls:C0085129Bronchial Hyperreactivity1GAD
umls:C0151650Renal fibrosis1BeFree
umls:C0343713Gonococcal arthritis dermatitis syndrome1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0701807Acute anterior uveitis1BeFree
umls:C1260959Drusen1BeFree
umls:C1527311Brain Edema1RGD
umls:C1861172Venous Thromboembolism1GAD
umls:C1956346Coronary Artery Disease1GAD
umls:C2239176Liver carcinoma1BeFree
umls:C2717961Thrombotic Microangiopathies1BeFree
umls:C2745963Kashin-Beck Disease1BeFree
umls:C3662483Allergic sensitization1BeFree
umls:C0343047Complement component 5 deficiency0CLINVAR,CTD_human
umls:C3810402ECULIZUMAB, POOR RESPONSE TO0CLINVAR