TissGeneSummary for TTK |
Gene summary |
Basic gene information | Gene symbol | TTK |
Gene name | TTK protein kinase | |
Synonyms | CT96|ESK|MPH1|MPS1|MPS1L1|PYT | |
Cytomap | UCSC genome browser: 6q14.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001166691.1, NM_003318.4, | |
Description | cancer/testis antigen 96dual specificity protein kinase TTKmonopolar spindle 1 kinasemonopolar spindle 1-like 1phosphotyrosine picked threonine kinasephosphotyrosine picked threonine-protein kinase | |
Modification date | 20141222 | |
dbXrefs | MIM : 604092 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112742 | ||
HPRD : 04973 | ||
Vega : OTTHUMG00000015088 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTK | |
BioGPS: 7272 | ||
Pathway | NCI Pathway Interaction Database: TTK | |
KEGG: TTK | ||
REACTOME: TTK | ||
Pathway Commons: TTK | ||
Context | iHOP: TTK | |
ligand binding site mutation search in PubMed: TTK | ||
UCL Cancer Institute: TTK | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TTK | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TTK |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 0.31415731 | -2.593197953 | 2.907355263 | 2.26E-42 | 8.22E-41 |
STAD | 0.723204404 | -2.011948721 | 2.735153125 | 3.47E-06 | 4.76E-05 |
KIRP | -2.502867471 | -4.940604971 | 2.4377375 | 4.29E-10 | 4.29E-09 |
BLCA | 1.176137135 | -2.79023655 | 3.966373684 | 1.26E-06 | 3.87E-05 |
HNSC | 1.260155494 | -0.32872125 | 1.588876744 | 3.20E-08 | 3.41E-07 |
LIHC | -1.602450971 | -5.440624971 | 3.838174 | 4.56E-21 | 3.07E-19 |
KICH | -2.261132971 | -4.540988971 | 2.279856 | 6.20E-08 | 2.95E-07 |
LUAD | -0.347968764 | -3.782258419 | 3.434289655 | 5.68E-26 | 2.77E-24 |
PRAD | -1.529787663 | -3.061599202 | 1.531811538 | 2.12E-08 | 2.38E-07 |
KIRC | -2.247845249 | -4.34133136 | 2.093486111 | 2.10E-23 | 2.18E-22 |
LUSC | 1.425408755 | -3.625908892 | 5.051317647 | 9.15E-41 | 2.06E-37 |
COAD | 1.152137337 | -0.14283574 | 1.294973077 | 1.28E-09 | 1.40E-08 |
ESCA | 1.233940484 | -1.282077698 | 2.516018182 | 0.00195 | 0.022583918 |
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TissGene-miRNA for TTK |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TTK |
TissGeneSNV for TTK |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R854G | STAD | 4 |
p.R854G | UCEC | 3 |
p.R854G | THYM | 1 |
p.D566G | LUSC | 1 |
p.L574F | LUAD | 1 |
p.T12R | LUSC | 1 |
p.N505H | UCS | 1 |
p.N326H | LUAD | 1 |
p.D697N | TGCT | 1 |
p.M297I | BLCA | 1 |
p.E373Q | BLCA | 1 |
p.E571K | UCEC | 1 |
p.G666R | GBM | 1 |
p.I572K | DLBC | 1 |
p.E570K | READ | 1 |
p.L654V | BLCA | 1 |
p.L819M | THYM | 1 |
p.E570K | SKCM | 1 |
p.P620S | SKCM | 1 |
p.E124* | UCEC | 1 |
p.C604F | LUAD | 1 |
p.P621S | STAD | 1 |
p.K576* | LUAD | 1 |
p.T676A | BRCA | 1 |
p.T46A | LUAD | 1 |
p.L723V | COAD | 1 |
p.Q683R | LIHC | 1 |
p.R414Q | SKCM | 1 |
p.R854K | ESCA | 1 |
p.M179I | STAD | 1 |
p.G813C | LUAD | 1 |
p.C603F | LUAD | 1 |
p.A143T | DLBC | 1 |
p.M726I | ESCA | 1 |
p.R307* | STAD | 1 |
p.S345N | STAD | 1 |
p.S214* | OV | 1 |
p.D696N | TGCT | 1 |
p.R854K | THYM | 1 |
p.R586* | LGG | 1 |
p.S449Y | UCEC | 1 |
p.L816R | STAD | 1 |
p.T675K | KIRC | 1 |
p.R307X | STAD | 1 |
p.S155* | PAAD | 1 |
p.D758N | KICH | 1 |
p.D620N | UCEC | 1 |
p.P756S | SKCM | 1 |
p.L825W | LUAD | 1 |
p.D590A | KIRC | 1 |
p.L575F | LUAD | 1 |
p.S218* | BLCA | 1 |
p.G658V | LUAD | 1 |
p.N326H | PAAD | 1 |
p.D762H | CESC | 1 |
p.R307Q | UCEC | 1 |
p.G803A | COAD | 1 |
p.Y553F | HNSC | 1 |
p.G666E | BRCA | 1 |
p.R90C | STAD | 1 |
p.S617F | SKCM | 1 |
p.I643L | LUAD | 1 |
p.Q507_splice | LUSC | 1 |
p.K140N | READ | 1 |
p.T637R | OV | 1 |
p.V601I | UCEC | 1 |
p.I741M | UCEC | 1 |
p.T360K | LUAD | 1 |
p.W628L | LUSC | 1 |
p.A572V | COAD | 1 |
p.K546N | UCEC | 1 |
p.I642L | LUAD | 1 |
p.I253M | LIHC | 1 |
p.G534E | GBM | 1 |
p.R256Q | ESCA | 1 |
p.L723S | READ | 1 |
p.L574W | LUAD | 1 |
p.F540L | UCEC | 1 |
p.E323* | BLCA | 1 |
p.P468L | SKCM | 1 |
p.Q105H | UCS | 1 |
p.S404* | THCA | 1 |
p.S823F | SKCM | 1 |
p.D763H | CESC | 1 |
p.N504H | UCS | 1 |
p.S677R | UCEC | 1 |
p.L327I | STAD | 1 |
p.S155T | STAD | 1 |
p.D757N | KICH | 1 |
p.Q386R | UCEC | 1 |
p.R136T | HNSC | 1 |
p.T288I | SKCM | 1 |
p.S581G | READ | 1 |
p.I396F | STAD | 1 |
p.D22Y | UCEC | 1 |
p.M179I | LGG | 1 |
p.E570K | HNSC | 1 |
p.P620Q | ESCA | 1 |
p.V791L | ESCA | 1 |
p.R623C | COAD | 1 |
p.R623H | COAD | 1 |
p.N18D | THCA | 1 |
p.M727I | ESCA | 1 |
p.P621Q | ESCA | 1 |
p.V811I | SKCM | 1 |
p.K201N | ESCA | 1 |
p.G657V | LUAD | 1 |
p.P822S | LUSC | 1 |
p.Q503H | READ | 1 |
p.K743T | UCEC | 1 |
p.R414Q | UCEC | 1 |
p.L653V | BLCA | 1 |
p.P487S | SARC | 1 |
p.K140N | ESCA | 1 |
p.N186Y | PAAD | 1 |
p.S510C | BLCA | 1 |
p.P62L | LUAD | 1 |
p.R854G | ESCA | 1 |
p.G803A | LUAD | 1 |
p.S329F | SKCM | 1 |
p.P380A | COAD | 1 |
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TissGeneCNV for TTK |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TTK |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A23Y-01A | TTK-TMEM63B | In-Frame | chr6:80721265 | chr6:44119582 |
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TissGeneNet for TTK |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TTK |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TTK |
TissGeneDrug for TTK |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TTK |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree,GAD |
umls:C0596263 | Carcinogenesis | 7 | BeFree |
umls:C0086795 | Pfaundler-Hurler Syndrome | 6 | BeFree |
umls:C0023786 | Mucopolysaccharidosis I | 5 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
umls:C0026703 | Mucopolysaccharidoses | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0025202 | melanoma | 3 | BeFree,LHGDN |
umls:C0018609 | Hartnup Disease | 2 | BeFree |
umls:C0026708 | Mucopolysaccharidosis V | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0085078 | Lysosomal Storage Diseases | 2 | BeFree |
umls:C0086431 | Hurler-Scheie Syndrome | 2 | BeFree |
umls:C0086647 | Mucopolysaccharidosis Type IIIA | 2 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C2713321 | alpha-L-Iduronidase Deficiency | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0006111 | Brain Diseases | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0015625 | Fanconi Anemia | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0024299 | Lymphoma | 1 | LHGDN |
umls:C0025517 | Metabolic Diseases | 1 | BeFree |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
umls:C0079748 | Precursor cell lymphoblastic lymphoma | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0238461 | Anaplastic thyroid carcinoma | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0346153 | Breast Cancer, Familial | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0410528 | Skeletal dysplasia | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1332225 | Aggressive Non-Hodgkin Lymphoma | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | GAD |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |
umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |