TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TTR

Gene summary

Basic gene information	Gene symbol	TTR
	Gene name	transthyretin
	Synonyms	CTS\|CTS1\|HEL111\|HsT2651\|PALB\|TBPA
	Cytomap	UCSC genome browser: 18q12.1
	Type of gene	protein-coding
	RefGenes	NM_000371.3,
	Description	ATTRcarpal tunnel syndrome 1epididymis luminal protein 111prealbumin, amyloidosis type Ithyroxine-binding prealbumin
	Modification date	20141222
dbXrefs	MIM : 176300
	HGNC : HGNC
	Ensembl : ENSG00000118271
	HPRD : 01447
	Vega : OTTHUMG00000131984
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TTR
	BioGPS: 7276
Pathway	NCI Pathway Interaction Database: TTR
	KEGG: TTR
	REACTOME: TTR
	Pathway Commons: TTR
Context	iHOP: TTR
	ligand binding site mutation search in PubMed: TTR
	UCL Cancer Institute: TTR
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	LiverPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHCPAAD
Reference showing the relevant tissue of TTR	Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 2011 Jun 6;339(1-2):144-50. doi: 10.1016/j.mce.2011.04.008. Epub 2011 Apr 22. (pmid:21539888) go to articleLiver transplantation and transthyretin amyloidosis. Muscle Nerve. 2013 Feb;47(2):157-62. doi: 10.1002/mus.23521. Epub 2012 Nov 21 (pmid:23169427) go to article
Description by TissGene annotations	Cancer gene Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for TTR

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LIHC	10.45183768	13.27613168	-2.824294	6.91E-09	6.34E-08
COAD	-2.021310477	0.532289523	-2.5536	6.83E-07	3.98E-06
KIRC	-2.902403212	0.933882899	-3.836286111	1.15E-34	2.93E-33
KIRP	-3.073083073	0.961420052	-4.034503125	7.11E-14	1.44E-12
KICH	3.346783677	0.884603677	2.46218	0.00112	0.002403583

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TissGene-miRNA for TTR

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for TTR

TissGeneSNV for TTR

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.L32R	CHOL	1
p.R123C	COAD	1
p.A129T	STAD	1
p.R5C	SKCM	1
p.D94H	ESCA	1
p.L9V	CESC	1
p.Y136D	KIRP	1
p.R41Q	UCEC	1
p.T80I	LUSC	1
p.Y136C	KIRP	1
p.E19D	STAD	1
p.S135F	LUSC	1
p.E92*	LUAD	1
p.G13E	BLCA	1
p.E62D	STAD	1
p.M33I	LGG	1
p.E109D	READ	1
p.T139K	SKCM	1
p.T69A	UCEC	1
p.T79S	LUAD	1
p.S18F	COAD	1

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TissGeneCNV for TTR

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for TTR

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	CD102904	RERE-TTR		chr1:8564230	chr18:29172939
Chimerdb3.0	ChiTaRs	NA	AW955743	SURF6-TTR		chr9:136198612	chr18:29178568
Chimerdb3.0	ChiTaRs	NA	CB999552	IARS-TTR		chr9:95055977	chr18:29171840
Chimerdb3.0	ChiTaRs	NA	CA773572	INS-IGF2-TTR		chr11:2182120	chr18:29171854
Chimerdb3.0	ChiTaRs	NA	AI133630	TTR-TPT1		chr18:29178789	chr13:45912799
Chimerdb3.0	ChiTaRs	NA	BE466906	TTR-KPNB1		chr18:29178784	chr17:45755446
Chimerdb3.0	FusionScan	CESC	TCGA-EK-A3GM-01A	DSG2-TTR	In-Frame	chr18:29078259	chr18:29172858
Chimerdb3.0	FusionScan	PRAD	TCGA-ZG-A9N3-01A	DSG2-TTR	In-Frame	chr18:29078259	chr18:29172858

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TissGeneNet for TTR

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
TTR, SETDB1, IKBKAP, APP, PIK3R1, FEZ1, NGFR, IL7R, RAI1, A2M, KIAA1377, PHYHIP, DDR1, PRKCI, VIM, TAF5L, FOXP3, LRP2, ST3GAL3, CTNND2, INPP5K (tumor)	TTR, TAF1C, GOLGA2, APP, PITX3, ALB, GET4, C14orf1, APOA1, KIAA1377, SUMO3, AGER, OTUB1, PHYHIP, ST13, PRKCI, MARK3, SP110, CTNND2, RBP4, ASNA1 (normal)

COAD (tumor)	COAD (normal)
TTR, CHD3, ACTB, PIK3R1, NGFR, GET4, RAI1, A2M, EEF1A1, HSPG2, TUBA1A, SUMO3, OTUB1, PHYHIP, PRKCI, QARS, INPP5K, SDF4, RBP4, MT3, ASNA1 (tumor)	TTR, CHD3, SETDB1, ZBED1, IKBKAP, APP, PIK3R1, ALB, NGFR, A2M, HSPG2, APOA1, OTUB1, ST13, TF, ATF4, CLU, ST3GAL3, CTNND2, RBP4, ASNA1 (normal)

HNSC (tumor)	HNSC (normal)
TTR, APP, ACTB, ALB, FEZ1, IL7R, RAI1, A2M, APOA1, SUMO3, PHYHIP, ST13, MARK3, TAF5L, ATF4, LRP2, SP110, CTNND2, INPP5K, RBP4, MT3 (tumor)	TTR, ALB, FEZ1, IL7R, RAI1, EEF1A1, HSPG2, TUBA1A, APOA1, AGER, DDR1, PRKCI, MARK3, TF, HNRNPH3, PIK3R5, CLU, CTNND2, SDF4, RBP4, ASNA1 (normal)

KICH (tumor)	KICH (normal)
TTR, TAF1C, CHD3, SETDB1, IKBKAP, APP, ALB, A2M, EEF1A1, HSPG2, APOA1, KIAA1377, OTUB1, PHYHIP, ST13, HNRNPH3, LRP2, CLU, CTNND2, ASNA1, CPNE6 (tumor)	TTR, TAF1C, IKBKAP, PIK3R1, PITX3, NGFR, C14orf1, RAI1, EEF1A1, TUBA1A, AGER, ST13, DDR1, PRKCI, TAF5L, ATF4, HNRNPH3, PIK3R5, INPP5K, SDF4, ASNA1 (normal)

KIRC (tumor)	KIRC (normal)
TTR, CHD3, APP, ACTB, PITX3, ALB, EEF1A1, HSPG2, APOA1, SUMO3, PHYHIP, ST13, PRKCI, HNRNPH3, LRP2, CLU, SP110, ST3GAL3, RBP4, ASNA1, CPNE6 (tumor)	TTR, SETDB1, ZBED1, PIK3R1, ALB, GET4, C14orf1, IL7R, A2M, HSPG2, APOA1, KIAA1377, OTUB1, TF, VIM, HNRNPH3, LRP2, PIK3R5, SP110, QARS, ASNA1 (normal)

KIRP (tumor)	KIRP (normal)
TTR, CHD3, APP, PITX3, ALB, NGFR, HSPG2, APOA1, KIAA1377, PHYHIP, ST13, DDR1, PRKCI, HNRNPH3, LRP2, CLU, SP110, ST3GAL3, CTNND2, MT3, CPNE6 (tumor)	TTR, CHD3, SETDB1, IKBKAP, PIK3R1, PITX3, ALB, NGFR, TUBA1A, APOA1, PHYHIP, ST13, TF, VIM, ATF4, HNRNPH3, LRP2, CTNND2, INPP5K, RBP4, MT3 (normal)

LIHC (tumor)	LIHC (normal)
TTR, CHD3, IKBKAP, ALB, GET4, C14orf1, IL7R, HSPG2, TUBA1A, APOA1, KIAA1377, ST13, PRKCI, TF, VIM, PIK3R5, CLU, SP110, ST3GAL3, SDF4, RBP4 (tumor)	TTR, CHD3, GOLGA2, PIK3R1, PITX3, ALB, C14orf1, RAI1, TUBA1A, APOA1, KIAA1377, DDR1, PRKCI, TF, VIM, HNRNPH3, CLU, ST3GAL3, CTNND2, RBP4, CPNE6 (normal)

LUAD (tumor)	LUAD (normal)
TTR, TAF1C, APP, PITX3, IL7R, TUBA1A, KIAA1377, SUMO3, OTUB1, PHYHIP, ST13, PRKCI, MARK3, TF, VIM, FOXP3, PIK3R5, CLU, ST3GAL3, INPP5K, MT3 (tumor)	TTR, TAF1C, ZBED1, APP, ACTB, ALB, GET4, APOA1, KIAA1377, SUMO3, OTUB1, DDR1, TF, VIM, TAF5L, ATF4, CLU, CTNND2, SDF4, RBP4, CPNE6 (normal)

LUSC (tumor)	LUSC (normal)
TTR, SETDB1, PIK3R1, PITX3, ALB, A2M, TUBA1A, KIAA1377, AGER, ST13, PRKCI, MARK3, TF, VIM, FOXP3, PIK3R5, CLU, SP110, CTNND2, SDF4, CPNE6 (tumor)	TTR, CHD3, GOLGA2, APP, ALB, RAI1, HSPG2, TUBA1A, APOA1, KIAA1377, OTUB1, DDR1, PRKCI, TF, TAF5L, LRP2, CLU, CTNND2, SDF4, RBP4, ASNA1 (normal)

PRAD (tumor)	PRAD (normal)
TTR, GOLGA2, APP, ALB, FEZ1, C14orf1, RAI1, HSPG2, APOA1, SUMO3, ST13, PRKCI, MARK3, TF, CLU, SP110, CTNND2, INPP5K, RBP4, MT3, CPNE6 (tumor)	TTR, TAF1C, SETDB1, GOLGA2, IKBKAP, APP, PIK3R1, ALB, GET4, C14orf1, IL7R, RAI1, APOA1, OTUB1, DDR1, TAF5L, ATF4, INPP5K, SDF4, RBP4, ASNA1 (normal)

STAD (tumor)	STAD (normal)
TTR, CHD3, GOLGA2, ZBED1, IKBKAP, ALB, NGFR, IL7R, RAI1, APOA1, KIAA1377, SUMO3, PHYHIP, MARK3, TF, PIK3R5, SP110, CTNND2, SDF4, RBP4, ASNA1 (tumor)	TTR, SETDB1, GOLGA2, ACTB, ALB, FEZ1, GET4, C14orf1, RAI1, A2M, EEF1A1, APOA1, KIAA1377, AGER, TF, LRP2, CLU, SP110, CTNND2, RBP4, ASNA1 (normal)

THCA (tumor)	THCA (normal)
TTR, TAF1C, CHD3, GOLGA2, PIK3R1, PITX3, FEZ1, NGFR, C14orf1, RAI1, EEF1A1, HSPG2, APOA1, KIAA1377, SUMO3, AGER, PHYHIP, DDR1, SP110, SDF4, RBP4 (tumor)	TTR, TAF1C, GOLGA2, IKBKAP, ALB, GET4, C14orf1, RAI1, APOA1, KIAA1377, OTUB1, PRKCI, TF, VIM, TAF5L, HNRNPH3, ST3GAL3, CTNND2, INPP5K, SDF4, CPNE6 (normal)

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TissGeneProg for TTR

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for TTR

TissGeneDrug for TTR

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for TTR

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0002726	Amyloidosis	257	BeFree,CTD_human,GAD,LHGDN
umls:C0152025	Polyneuropathy	173	BeFree,LHGDN
umls:C0206245	Amyloid Neuropathies, Familial	160	BeFree,CTD_human,GAD,LHGDN
umls:C0032580	Adenomatous Polyposis Coli	110	BeFree
umls:C0268407	Senile cardiac amyloidosis	81	BeFree,GAD
umls:C2751492	AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED	67	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C2936349	Plaque, Amyloid	66	BeFree
umls:C0878544	Cardiomyopathies	43	BeFree
umls:C0342623	Senile systemic amyloidosis	41	BeFree
umls:C0268380	Systemic amyloidosis	38	BeFree
umls:C0281479	Primary Systemic Amyloidosis	38	BeFree
umls:C0740340	Amyloidosis, Familial	34	BeFree,CTD_human
umls:C0206247	Amyloid Neuropathies	32	BeFree,GAD
umls:C0206246	Amyloidosis, Hereditary	25	BeFree
umls:C0442874	Neuropathy	22	BeFree
umls:C0031117	Peripheral Neuropathy	17	BeFree
umls:C0007286	Carpal Tunnel Syndrome	16	BeFree,CTD_human,LHGDN,UNIPROT
umls:C0268384	Familial Amyloid Neuropathy, Portuguese Type	16	BeFree
umls:C0342613	Danish type familial amyloid cardiomyopathy	12	BeFree
umls:C0524851	Neurodegenerative Disorders	11	BeFree
umls:C0018802	Congestive heart failure	10	BeFree
umls:C0259749	Autonomic neuropathy	10	BeFree
umls:C0002395	Alzheimer's Disease	9	BeFree,GAD,LHGDN
umls:C0020551	Hyperthyroxinemia	9	BeFree
umls:C2239176	Liver carcinoma	8	BeFree
umls:C0018801	Heart failure	7	BeFree
umls:C0027819	Neuroblastoma	7	BeFree
umls:C0700095	Central neuroblastoma	7	BeFree
umls:C0221014	Reactive systemic amyloidosis	6	BeFree
umls:C0271682	Mixed sensory-motor polyneuropathy	6	BeFree
umls:C0007196	Restrictive cardiomyopathy	5	BeFree
umls:C1842937	AURAL ATRESIA, CONGENITAL	5	BeFree
umls:C0024121	Lung Neoplasms	4	CTD_human,LHGDN
umls:C0085220	Cerebral Amyloid Angiopathy	4	BeFree
umls:C0333463	Senile Plaques	4	BeFree
umls:C0339562	Amyloid of vitreous	4	BeFree
umls:C0002871	Anemia	3	BeFree
umls:C0007134	Renal Cell Carcinoma	3	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	3	BeFree
umls:C0014474	Ependymoma	3	BeFree
umls:C0017638	Glioma	3	BeFree
umls:C0018799	Heart Diseases	3	BeFree,GAD
umls:C0022658	Kidney Diseases	3	BeFree
umls:C0023903	Liver neoplasms	3	BeFree
umls:C0027765	nervous system disorder	3	BeFree
umls:C0268381	Primary amyloidosis	3	BeFree
umls:C0268406	Age-related amyloidosis	3	BeFree
umls:C0271683	Polyneuropathy, Motor	3	BeFree
umls:C0598589	Inherited neuropathies	3	BeFree
umls:C0002736	Amyotrophic Lateral Sclerosis	2	BeFree
umls:C0003850	Arteriosclerosis	2	BeFree
umls:C0011265	Presenile dementia	2	BeFree
umls:C0013080	Down Syndrome	2	BeFree
umls:C0017601	Glaucoma	2	BeFree,LHGDN
umls:C0021400	Influenza	2	BeFree
umls:C0022661	Kidney Failure, Chronic	2	BeFree
umls:C0027627	Neoplasm Metastasis	2	BeFree,LHGDN
umls:C0042373	Vascular Diseases	2	BeFree
umls:C0162429	Malnutrition	2	BeFree
umls:C0235025	Peripheral motor neuropathy	2	BeFree
umls:C0338656	Impaired cognition	2	BeFree
umls:C0497327	Dementia	2	BeFree
umls:C0555278	Cerebral metastasis	2	BeFree
umls:C0677932	Progressive Neoplastic Disease	2	BeFree
umls:C0679407	Gastrointestinal dysfunction	2	BeFree
umls:C0686377	CNS metastases	2	BeFree
umls:C0751448	Polyneuropathy, Familial	2	BeFree
umls:C1559271	Non-Malignant Ascites Adverse Event	2	BeFree
umls:C1719315	Hereditary cardiac amyloidosis	2	BeFree
umls:C2316810	Chronic kidney disease stage 5	2	BeFree
umls:C2931784	Amyloid angiopathy	2	BeFree
umls:C2939462	Immunoglobulin deposition disease	2	BeFree
umls:C3539781	Progressive cGVHD	2	BeFree
umls:C0004153	Atherosclerosis	1	BeFree
umls:C0005956	Bone Marrow Diseases	1	BeFree
umls:C0006142	Malignant neoplasm of breast	1	BeFree
umls:C0007095	Carcinoid Tumor	1	BeFree
umls:C0007133	Carcinoma, Papillary	1	BeFree
umls:C0007194	Hypertrophic Cardiomyopathy	1	BeFree
umls:C0007682	CNS disorder	1	BeFree
umls:C0007786	Brain Ischemia	1	RGD
umls:C0007789	Cerebral Palsy	1	BeFree
umls:C0008350	Cholelithiasis	1	BeFree
umls:C0008925	Cleft Palate	1	GAD
umls:C0009319	Colitis	1	BeFree
umls:C0009421	Comatose	1	BeFree
umls:C0010266	Cranial nerve diseases	1	BeFree
umls:C0011570	Mental Depression	1	BeFree
umls:C0011581	Depressive disorder	1	BeFree
umls:C0011609	Drug Eruptions	1	CTD_human
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	1	BeFree
umls:C0013404	Dyspnea	1	BeFree
umls:C0015397	Disorder of eye	1	BeFree
umls:C0016085	Filariasis	1	BeFree
umls:C0018790	Cardiac Arrest	1	BeFree
umls:C0019158	Hepatitis	1	BeFree
umls:C0019159	Hepatitis A	1	BeFree
umls:C0020538	Hypertensive disease	1	LHGDN
umls:C0020676	Hypothyroidism	1	GAD
umls:C0022116	Ischemia	1	BeFree
umls:C0022806	Kwashiorkor	1	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	1	BeFree
umls:C0024408	Machado-Joseph Disease	1	BeFree
umls:C0025149	Medulloblastoma	1	BeFree
umls:C0025286	Meningioma	1	BeFree
umls:C0025362	Mental Retardation	1	BeFree
umls:C0026470	Monoclonal Gammopathy of Undetermined Significance	1	BeFree
umls:C0027796	Neuralgia	1	BeFree
umls:C0027809	Neurilemmoma	1	BeFree
umls:C0029408	Degenerative polyarthritis	1	BeFree
umls:C0030353	Papilledema	1	BeFree
umls:C0030354	Papilloma	1	BeFree
umls:C0030421	Paraganglioma	1	BeFree
umls:C0031511	Pheochromocytoma	1	BeFree
umls:C0033075	Presbyopia	1	BeFree
umls:C0036341	Schizophrenia	1	BeFree,GAD
umls:C0036572	Seizures	1	BeFree
umls:C0037019	Shy-Drager Syndrome	1	BeFree
umls:C0037061	Siderosis	1	BeFree
umls:C0037928	Spinal Cord Diseases	1	BeFree
umls:C0038525	Subarachnoid Hemorrhage	1	BeFree
umls:C0040156	Thyrotoxicosis	1	BeFree
umls:C0085400	Neurofibrillary degeneration (morphologic abnormality)	1	BeFree
umls:C0149721	Left Ventricular Hypertrophy	1	BeFree
umls:C0149893	Secondary glaucoma	1	BeFree
umls:C0152096	Complete trisomy 18 syndrome	1	BeFree
umls:C0155552	Hearing Loss, Mixed Conductive-Sensorineural	1	BeFree
umls:C0155765	Disease of capillaries	1	BeFree
umls:C0205770	Choroid Plexus Papilloma	1	BeFree
umls:C0206624	Hepatoblastoma	1	BeFree
umls:C0206698	Cholangiocarcinoma	1	LHGDN
umls:C0234366	Ataxic	1	BeFree
umls:C0238190	Inclusion Body Myositis (disorder)	1	BeFree
umls:C0239233	Early satiety	1	BeFree
umls:C0242363	Islet Cell Tumor	1	BeFree
umls:C0267839	Hepatic amyloidosis	1	BeFree
umls:C0268382	Amyloid nephropathy	1	BeFree
umls:C0268392	Localized amyloidosis	1	BeFree
umls:C0268397	Amyloidosis, Primary Cutaneous	1	BeFree
umls:C0268579	Propionic acidemia	1	BeFree
umls:C0270921	Axonal neuropathy	1	BeFree
umls:C0272247	Biclonal gammopathy	1	BeFree
umls:C0278996	Cancer of Head and Neck	1	BeFree
umls:C0281361	Adenocarcinoma of pancreas	1	BeFree
umls:C0334299	Carcinoid tumor no ICD-O subtype	1	BeFree
umls:C0338484	Familial Hemiplegic Migraine	1	BeFree
umls:C0342199	Iodine deficiency syndrome	1	BeFree
umls:C0342276	Maturity onset diabetes mellitus in young	1	BeFree
umls:C0342618	Amyloid myopathy	1	BeFree
umls:C0393571	Multiple System Atrophy	1	BeFree
umls:C0474853	Plasma cell tumor, malignant	1	BeFree
umls:C0547030	Visual disturbance	1	BeFree
umls:C0555198	Malignant Glioma	1	BeFree
umls:C0559758	Multisystem disorder	1	BeFree
umls:C0595936	Aqueous Humor Disorders	1	BeFree
umls:C0596452	disabling disease	1	BeFree
umls:C0678222	Breast Carcinoma	1	BeFree
umls:C0730345	Microalbuminuria	1	BeFree
umls:C0741933	cardiac symptom	1	BeFree
umls:C0751409	Upper Extremity Paresis	1	BeFree
umls:C0751498	Sigmoid Cancer	1	BeFree
umls:C0751658	Ulnar Nerve Entrapment Syndrome	1	BeFree
umls:C0751713	Inclusion Body Myopathy, Sporadic	1	BeFree
umls:C0751870	Heredodegenerative Disorders, Nervous System	1	BeFree
umls:C0860207	Drug-Induced Liver Injury	1	CTD_human
umls:C0936273	Familial Amyloid Polyneuropathy, Type IV	1	BeFree
umls:C0947622	Cholecystolithiasis	1	BeFree
umls:C1112256	Peripheral sensorimotor neuropathy	1	GAD
umls:C1136084	Plasma cell dyscrasia	1	BeFree
umls:C1136085	Monoclonal Gammapathies	1	BeFree
umls:C1270972	Mild cognitive disorder	1	BeFree
umls:C1285162	Degenerative disorder	1	BeFree
umls:C1328479	Pancreatic Endocrine Carcinoma	1	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	1	BeFree
umls:C1861735	Dementia, familial Danish	1	BeFree
umls:C2718001	Protein Misfolding Disorders	1	BeFree
umls:C2750824	Dystransthyretinemic Euthyroidal Hyperthyroxinemia	1	CLINVAR,CTD_human,UNIPROT
umls:C3536715	AA amyloidosis	1	BeFree
umls:C3665346	Unspecified visual loss	1	BeFree
umls:C3151470	AMYLOIDOSIS, LEPTOMENINGEAL, TRANSTHYRETIN-RELATED	0	CLINVAR
umls:C3151471	AMYLOID CARDIOMYOPATHY, TRANSTHYRETIN-RELATED	0	CLINVAR