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| TissGeneSummary for SSX2 |
 Gene summary |
| Basic gene information | Gene symbol | SSX2 |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SSX2 | |
| BioGPS: 727837 | ||
| Pathway | NCI Pathway Interaction Database: SSX2 | |
| KEGG: SSX2 | ||
| REACTOME: SSX2 | ||
| Pathway Commons: SSX2 | ||
| Context | iHOP: SSX2 | |
| ligand binding site mutation search in PubMed: SSX2 | ||
| UCL Cancer Institute: SSX2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of SSX2 | Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer.Cancer Res. 2011 Nov 1;71(21):6785-95. doi: 10.1158/0008-5472.CAN-11-2127. (pmid:21880588) go to article | |
| Description by TissGene annotations | Cancer gene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SSX2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -0.130340758 | -2.326606758 | 2.196266 | 8.75E-06 | 3.75E-05 |
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| TissGene-miRNA for SSX2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SSX2 |
| TissGeneSNV for SSX2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
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| TissGeneCNV for SSX2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SSX2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AY138495 | SSX2-SS18 | chrX:52731674 | chr18:23610113 | |
| Chimerdb3.0 | ChiTaRs | NA | S79332 | SS18-SSX2 | chr18:23615074 | chrX:52726465 | |
| Chimerdb3.0 | ChiTaRs | NA | AB300357 | SS18-SSX2 | chr18:23670542 | chrX:52726465 | |
| Chimerdb3.0 | ChiTaRs | NA | X79200 | SS18-SSX2 | chr18:23612422 | chrX:52726158 | |
| Chimerdb3.0 | ChiTaRs | NA | AF230662 | SS18-SSX2 | chr18:23670542 | chrX:52727038 | |
| Chimerdb3.0 | ChiTaRs | NA | AY138491 | SS18-SSX2 | chr18:23612390 | chrX:52729539 | |
| Chimerdb3.0 | ChiTaRs | synovial sarcoma | AB012575 | SS18-SSX2 | chr18:23615074 | chrX:52729527 | |
| Chimerdb3.0 | FusionScan | SARC | TCGA-FX-A8OO-01A | SS18-SSX2 | In-Frame | chr18:23612362 | chrX:52789420 |
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| TissGeneNet for SSX2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
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| KICH (tumor) | KICH (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (tumor) | SSX2, SMARCA2, RNF2, SSX2IP, RAB3IP (normal) |
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| TissGeneProg for SSX2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SSX2 |
| TissGeneDrug for SSX2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SSX2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0039101 | synovial sarcoma | 128 | BeFree,CTD_human,LHGDN,ORPHANET |
| umls:C0153594 | Malignant neoplasm of testis | 21 | BeFree |
| umls:C1261473 | Sarcoma | 17 | BeFree |
| umls:C0025202 | melanoma | 10 | BeFree |
| umls:C0596263 | Carcinogenesis | 10 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 7 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree |
| umls:C0037579 | Soft Tissue Neoplasms | 4 | BeFree |
| umls:C0334507 | Synovial sarcoma, biphasic | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C1334801 | Monophasic Synovial Sarcoma | 3 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0751690 | Malignant Peripheral Nerve Sheath Tumor | 2 | BeFree |
| umls:C0855071 | Synovial sarcoma non-metastatic | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0026470 | Monoclonal Gammopathy of Undetermined Significance | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0205748 | Dysplastic Nevus | 1 | BeFree |
| umls:C0334471 | Round cell liposarcoma | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1275278 | Extraskeletal Myxoid Chondrosarcoma | 1 | BeFree |
| umls:C1334699 | Mesenchymal Cell Neoplasm | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree,LHGDN |
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