TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NXF2
check button Gene summary
Basic gene informationGene symbolNXF2
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NXF2
BioGPS: 728343
PathwayNCI Pathway Interaction Database: NXF2
KEGG: NXF2
REACTOME: NXF2
Pathway Commons: NXF2
ContextiHOP: NXF2
ligand binding site mutation search in PubMed: NXF2
UCL Cancer Institute: NXF2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of NXF2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for NXF2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-0.8268336420.242346358-1.069181.95E-089.90E-08
COAD0.294786666-0.9996441031.2944307690.01610.033404451
LUAD-0.177609090.953816772-1.1314258620.0002090.000500841


Top
TissGene-miRNA for NXF2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for NXF2
TissGeneSNV for NXF2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.T101MUCEC2
p.Q213HSTAD1
p.A424VUCEC1
p.T101MOV1
p.D428NSKCM1
p.P618LBLCA1
p.A621PLUAD1
p.E620*LUAD1
p.E614QUCEC1
p.R53HUCEC1
p.S626FHNSC1
p.A619TUCEC1
p.Q624KOV1
p.A433DLUAD1
p.R98HUCEC1
p.H92YCESC1
p.R87IUCEC1
p.P618LSKCM1


Top
TissGeneCNV for NXF2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for NXF2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


Top
TissGeneNet for NXF2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (tumor)NXF2, MAP1A, NUP214, MAP1B, HNRNPUL1, APEX1, NUP153, NUP62, NXT1, NXT2 (normal)
bullet pointbullet point


Top
TissGeneProg for NXF2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for NXF2
TissGeneDrug for NXF2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for NXF2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0036631Seminoma1BeFree
umls:C1847540Azoospermia, Nonobstructive1BeFree