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| TissGeneSummary for SFTPA1 |
 Gene summary |
| Basic gene information | Gene symbol | SFTPA1 |
| Gene name | surfactant protein A2 | |
| Synonyms | COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-A|SPA2|SPAII | |
| Cytomap | UCSC genome browser: 10q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001098668.2, | |
| Description | 35 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5pulmonary surfactant-associated protein A2surfactant, pulmonary-associated protein A2A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 178642 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185303 | ||
| Vega : OTTHUMG00000018566 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SFTPA1 | |
| BioGPS: 729238 | ||
| Pathway | NCI Pathway Interaction Database: SFTPA1 | |
| KEGG: SFTPA1 | ||
| REACTOME: SFTPA1 | ||
| Pathway Commons: SFTPA1 | ||
| Context | iHOP: SFTPA1 | |
| ligand binding site mutation search in PubMed: SFTPA1 | ||
| UCL Cancer Institute: SFTPA1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of SFTPA1 | ||
| Description by TissGene annotations | Cancer gene TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SFTPA1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 6.862303792 | 14.75447634 | -7.892172549 | 9.41E-18 | 8.34E-17 |
| THCA | 0.667484051 | -2.020582051 | 2.688066102 | 9.44E-07 | 3.55E-06 |
| LUAD | 9.759305617 | 14.81888838 | -5.059582759 | 1.40E-15 | 1.51E-14 |
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| TissGene-miRNA for SFTPA1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SFTPA1 |
| TissGeneSNV for SFTPA1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E105K | LUAD | 1 |
| p.A217T | COAD | 1 |
| p.R137K | LUSC | 1 |
| p.T11S | LUAD | 1 |
| p.P56S | SKCM | 1 |
| p.E90K | SKCM | 1 |
| p.G77V | LUAD | 1 |
| p.A217S | LGG | 1 |
| p.P112T | ESCA | 1 |
| p.I131V | HNSC | 1 |
| p.Q120R | HNSC | 1 |
| p.T162S | DLBC | 1 |
| p.G74R | SKCM | 1 |
| p.G135E | SKCM | 1 |
| p.A33S | STAD | 1 |
| p.G95S | SKCM | 1 |
| p.P97T | ESCA | 1 |
| p.R242Q | UCEC | 1 |
| p.D245N | DLBC | 1 |
| p.R214C | STAD | 1 |
| p.A10V | PAAD | 1 |
| p.R161S | LUAD | 1 |
| p.N225S | LUSC | 1 |
| p.R199C | UCEC | 1 |
| p.R214P | ESCA | 1 |
| p.Q132E | CESC | 1 |
| p.L140V | LUSC | 1 |
| p.G203E | SKCM | 1 |
| p.H112N | UCEC | 1 |
| p.G52R | LUAD | 1 |
| p.G61S | UCEC | 1 |
| p.R199C | STAD | 1 |
| p.A18S | STAD | 1 |
| p.P193S | SKCM | 1 |
| p.R199P | ESCA | 1 |
| p.C41F | LUSC | 1 |
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| TissGeneCNV for SFTPA1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SFTPA1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SFTPA1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| COAD (tumor) | COAD (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| KICH (tumor) | KICH (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| STAD (tumor) | STAD (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| THCA (tumor) | THCA (normal) |
| SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (tumor) | SFTPA1, SFTPD, LY96, DSP, SFTPA2, TLR2, TLR4, MPO, C1QA, DMBT1, MYO18A (normal) |
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| TissGeneProg for SFTPA1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SFTPA1 |
| TissGeneDrug for SFTPA1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SFTPA1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0035220 | Respiratory Distress Syndrome, Newborn | 22 | BeFree,GAD,RGD |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 20 | BeFree |
| umls:C0024115 | Lung diseases | 6 | BeFree,GAD,RGD |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 6 | BeFree |
| umls:C0001418 | Adenocarcinoma | 5 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 5 | BeFree |
| umls:C0004096 | Asthma | 4 | BeFree,RGD |
| umls:C0006287 | Bronchopulmonary Dysplasia | 4 | BeFree |
| umls:C0023522 | Leukodystrophy, Metachromatic | 4 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 4 | BeFree,GAD |
| umls:C0006012 | Borderline Personality Disorder | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 3 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 3 | BeFree,GAD,LHGDN |
| umls:C0041296 | Tuberculosis | 3 | BeFree,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0266999 | Vesicular Stomatitis | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0876973 | Infectious disease of lung | 3 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 3 | BeFree,CTD_human,ORPHANET |
| umls:C0004031 | Aspergillosis, Allergic Bronchopulmonary | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0017205 | Gaucher Disease | 2 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 2 | BeFree |
| umls:C0149516 | Chronic sinusitis | 2 | BeFree |
| umls:C0242706 | Hyperoxia | 2 | RGD |
| umls:C2350344 | Chronic Lung Injury | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0003123 | Anorexia | 1 | BeFree |
| umls:C0004626 | Pneumonia, Bacterial | 1 | RGD |
| umls:C0005699 | Blast Phase | 1 | BeFree |
| umls:C0006272 | Bronchiolitis Obliterans | 1 | LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0010043 | Corneal Ulcer | 1 | BeFree |
| umls:C0016057 | Fibrosarcoma | 1 | BeFree |
| umls:C0019357 | Keratitis, Herpetic | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0023474 | Leukemia, Myeloid, Chronic-Phase | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0025295 | Meningitis, Pneumococcal | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | RGD |
| umls:C0032227 | Pleural effusion disorder | 1 | BeFree |
| umls:C0033027 | Preleukemia | 1 | BeFree |
| umls:C0034050 | Pulmonary Alveolar Proteinosis | 1 | BeFree |
| umls:C0038644 | Sudden infant death syndrome | 1 | GAD |
| umls:C0042029 | Urinary tract infection | 1 | GAD |
| umls:C0085293 | Hepatitis E | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0152021 | Congenital heart disease | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206062 | Lung Diseases, Interstitial | 1 | BeFree |
| umls:C0235833 | Congenital diaphragmatic hernia | 1 | BeFree |
| umls:C0264936 | Secondary pulmonary hypertension | 1 | BeFree |
| umls:C0278493 | Breast cancer recurrent | 1 | BeFree |
| umls:C0280217 | stage, non-small cell lung cancer | 1 | BeFree |
| umls:C0340100 | High altitude pulmonary edema | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0600260 | Lung Diseases, Obstructive | 1 | BeFree |
| umls:C0694549 | Community acquired pneumonia | 1 | BeFree |
| umls:C1274233 | T-lymphocyte immunodeficiency | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C2931829 | RDS - infants | 1 | BeFree |
| umls:C3463824 | MYELODYSPLASTIC SYNDROME | 1 | BeFree |
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