TissGeneSummary for RAD51AP2 |
Gene summary |
Basic gene information | Gene symbol | RAD51AP2 |
Gene name | RAD51 associated protein 2 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001099218.2, | |
Description | RAD51-associated protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000214842 | ||
Vega : OTTHUMG00000151761 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RAD51AP2 | |
BioGPS: 729475 | ||
Pathway | NCI Pathway Interaction Database: RAD51AP2 | |
KEGG: RAD51AP2 | ||
REACTOME: RAD51AP2 | ||
Pathway Commons: RAD51AP2 | ||
Context | iHOP: RAD51AP2 | |
ligand binding site mutation search in PubMed: RAD51AP2 | ||
UCL Cancer Institute: RAD51AP2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RAD51AP2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RAD51AP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.034095511 | -2.36905743 | 2.403152941 | 5.97E-21 | 8.15E-20 |
COAD | -0.358583298 | -1.709379451 | 1.350796154 | 5.61E-06 | 2.71E-05 |
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TissGene-miRNA for RAD51AP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RAD51AP2 |
TissGeneSNV for RAD51AP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D166N | SKCM | 2 |
p.E1060K | SKCM | 2 |
p.E1102* | UCEC | 2 |
p.E683G | DLBC | 1 |
p.R9Q | SKCM | 1 |
p.M711I | SKCM | 1 |
p.P1114L | SKCM | 1 |
p.E882K | SKCM | 1 |
p.N620H | UCEC | 1 |
p.H187R | MESO | 1 |
p.E1060G | PRAD | 1 |
p.K280N | UCEC | 1 |
p.R252T | LUAD | 1 |
p.D25N | SKCM | 1 |
p.D362N | SKCM | 1 |
p.E954* | LIHC | 1 |
p.S528N | PAAD | 1 |
p.K773N | UCEC | 1 |
p.P1068T | LUAD | 1 |
p.K365N | UCEC | 1 |
p.W430X | SKCM | 1 |
p.N431S | COAD | 1 |
p.V499I | LGG | 1 |
p.R405K | SKCM | 1 |
p.Q240H | LUAD | 1 |
p.S113I | LUSC | 1 |
p.Q761H | LUAD | 1 |
p.E39K | ESCA | 1 |
p.Q675* | LUAD | 1 |
p.N642Y | KIRC | 1 |
p.P1122L | OV | 1 |
p.V399I | PAAD | 1 |
p.P6S | ESCA | 1 |
p.G1116S | SKCM | 1 |
p.Q709H | LUAD | 1 |
p.P689L | SKCM | 1 |
p.K965N | CESC | 1 |
p.K391I | STAD | 1 |
p.G169R | SKCM | 1 |
p.R56C | PRAD | 1 |
p.E1012K | UCEC | 1 |
p.A319V | UCEC | 1 |
p.C538F | LUSC | 1 |
p.S669F | SKCM | 1 |
p.D698N | LUAD | 1 |
p.S392F | SKCM | 1 |
p.S355G | LUSC | 1 |
p.P263S | SKCM | 1 |
p.R128M | LGG | 1 |
p.P26T | LUAD | 1 |
p.Q997H | LUAD | 1 |
p.E189* | UCEC | 1 |
p.S671N | LUAD | 1 |
p.E91G | UCEC | 1 |
p.K773E | ESCA | 1 |
p.G1116D | SKCM | 1 |
p.R140K | SKCM | 1 |
p.D916N | SKCM | 1 |
p.T557S | LUAD | 1 |
p.P219T | ACC | 1 |
p.K539T | COAD | 1 |
p.G1109* | UCEC | 1 |
p.E954X | LIHC | 1 |
p.D1016Y | UCEC | 1 |
p.T677K | LUSC | 1 |
p.G735C | LUAD | 1 |
p.P1038S | SKCM | 1 |
p.H929N | UCEC | 1 |
p.R596I | UCEC | 1 |
p.R252G | SKCM | 1 |
p.K965E | BRCA | 1 |
p.K855N | LGG | 1 |
p.R223K | SKCM | 1 |
p.G546V | KIRC | 1 |
p.I167L | KIRP | 1 |
p.P689S | SKCM | 1 |
p.V850I | UCEC | 1 |
p.L987H | SARC | 1 |
p.I1035T | BLCA | 1 |
p.R1091I | READ | 1 |
p.E836K | SKCM | 1 |
p.R746Q | BLCA | 1 |
p.K188I | SKCM | 1 |
p.C37Y | STAD | 1 |
p.E1102X | READ | 1 |
p.P1114T | BLCA | 1 |
p.E784Q | BLCA | 1 |
p.R654K | UCEC | 1 |
p.T595P | SKCM | 1 |
p.R746Q | UCEC | 1 |
p.F323Y | SKCM | 1 |
p.K425N | SKCM | 1 |
p.C410Y | THCA | 1 |
p.K524E | BLCA | 1 |
p.I452M | BLCA | 1 |
p.E860* | LUAD | 1 |
p.S593Y | LUAD | 1 |
p.I513M | READ | 1 |
p.E277K | SKCM | 1 |
p.E606K | SKCM | 1 |
p.R302K | UCEC | 1 |
p.Y493C | COAD | 1 |
p.E986K | SKCM | 1 |
p.D526Y | UCEC | 1 |
p.W1050L | GBM | 1 |
p.K920N | BLCA | 1 |
p.N372S | SKCM | 1 |
p.A279T | STAD | 1 |
p.E200K | SKCM | 1 |
p.Q1045R | PCPG | 1 |
p.D696Y | LUAD | 1 |
p.D1016N | SKCM | 1 |
p.D313N | SKCM | 1 |
p.P714L | LUAD | 1 |
p.E59K | BLCA | 1 |
p.I452T | KIRC | 1 |
p.P332Q | LUAD | 1 |
p.Y617H | BLCA | 1 |
p.S95R | SKCM | 1 |
p.Q769E | LUAD | 1 |
p.N215D | LUAD | 1 |
p.G735D | UCEC | 1 |
p.T495N | UCEC | 1 |
p.V273I | LUSC | 1 |
p.N225H | UCEC | 1 |
p.S1043I | LUAD | 1 |
p.K525I | UCEC | 1 |
p.C708S | LUAD | 1 |
p.M1L | LUAD | 1 |
p.E1014K | BLCA | 1 |
p.S229L | SKCM | 1 |
p.S877L | SKCM | 1 |
p.P689S | UCEC | 1 |
p.R405I | READ | 1 |
p.P680L | UCEC | 1 |
p.M264I | SKCM | 1 |
p.K967T | UCEC | 1 |
p.E207K | SKCM | 1 |
p.A472T | LGG | 1 |
p.C942S | LGG | 1 |
p.P30Q | SKCM | 1 |
p.E1014X | READ | 1 |
p.D693N | SKCM | 1 |
p.S324F | SKCM | 1 |
p.Y297* | LUAD | 1 |
p.A214D | GBM | 1 |
p.W430* | SKCM | 1 |
p.G934C | LUAD | 1 |
p.K314E | LUAD | 1 |
p.E328Q | LUAD | 1 |
p.E24K | HNSC | 1 |
p.K560N | UCEC | 1 |
p.D961H | KIRC | 1 |
p.Q930E | LUAD | 1 |
p.G169E | BLCA | 1 |
p.V718M | PAAD | 1 |
p.E457K | CESC | 1 |
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TissGeneCNV for RAD51AP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RAD51AP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RAD51AP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RAD51AP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RAD51AP2 |
TissGeneDrug for RAD51AP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RAD51AP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |