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| TissGeneSummary for C7 |
 Gene summary |
| Basic gene information | Gene symbol | C7 |
| Gene name | complement component 7 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 5p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000587.2, | |
| Description | complement component C7 | |
| Modification date | 20141221 | |
| dbXrefs | MIM : 217070 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000112936 | ||
| HPRD : 01957 | ||
| Vega : OTTHUMG00000150340 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C7 | |
| BioGPS: 730 | ||
| Pathway | NCI Pathway Interaction Database: C7 | |
| KEGG: C7 | ||
| REACTOME: C7 | ||
| Pathway Commons: C7 | ||
| Context | iHOP: C7 | |
| ligand binding site mutation search in PubMed: C7 | ||
| UCL Cancer Institute: C7 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvarySoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSARC | |
| Reference showing the relevant tissue of C7 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 1.697857269 | 5.394013269 | -3.696156 | 2.72E-13 | 6.23E-12 |
| BRCA | -0.535197117 | 2.678616041 | -3.213813158 | 7.85E-20 | 5.48E-19 |
| HNSC | -3.804475289 | 0.145380525 | -3.949855814 | 1.61E-11 | 3.94E-10 |
| LUSC | 0.72368472 | 5.406392563 | -4.682707843 | 4.83E-17 | 3.87E-16 |
| STAD | 0.419141644 | 3.656369769 | -3.237228125 | 1.64E-06 | 2.51E-05 |
| KICH | 1.815721269 | 5.968513269 | -4.152792 | 5.31E-07 | 2.10E-06 |
| BLCA | -2.293105889 | 4.258278321 | -6.551384211 | 2.79E-08 | 2.07E-06 |
| KIRC | 1.532404491 | 6.524326713 | -4.991922222 | 1.21E-25 | 1.51E-24 |
| COAD | -0.720250423 | 3.339368807 | -4.059619231 | 1.40E-09 | 1.51E-08 |
| THCA | -0.106410528 | 3.450206421 | -3.556616949 | 1.93E-11 | 1.41E-10 |
| LUAD | 2.593388303 | 4.971552096 | -2.378163793 | 1.58E-12 | 1.21E-11 |
| KIRP | 0.969988519 | 6.330166644 | -5.360178125 | 3.58E-15 | 1.00E-13 |
| ESCA | -0.579388186 | 3.608102723 | -4.187490909 | 0.000587 | 0.010120062 |
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| TissGene-miRNA for C7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C7 |
| TissGeneSNV for C7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G493E | SKCM | 4 |
| p.R402Q | SKCM | 4 |
| p.P590S | SKCM | 3 |
| p.E799K | SKCM | 3 |
| p.E546K | SKCM | 2 |
| p.G141E | SKCM | 2 |
| p.P80L | SKCM | 2 |
| p.E430K | SKCM | 2 |
| p.S658F | SKCM | 2 |
| p.G245E | SKCM | 2 |
| p.G380E | SKCM | 2 |
| p.E334* | UCEC | 2 |
| p.E334X | COAD | 2 |
| p.S281F | SKCM | 2 |
| p.C659S | LUAD | 2 |
| p.S229L | SKCM | 2 |
| p.W277* | SKCM | 2 |
| p.P414S | SKCM | 2 |
| p.H749Y | SKCM | 1 |
| p.S290N | PAAD | 1 |
| p.G602E | SKCM | 1 |
| p.R733K | SKCM | 1 |
| p.T366I | LUAD | 1 |
| p.D115Y | LUAD | 1 |
| p.G502V | THYM | 1 |
| p.H746N | LUSC | 1 |
| p.G515E | ACC | 1 |
| p.F671C | HNSC | 1 |
| p.S831Y | LUSC | 1 |
| p.P668S | SKCM | 1 |
| p.D394N | STAD | 1 |
| p.R533I | UCEC | 1 |
| p.S127A | BLCA | 1 |
| p.E706K | HNSC | 1 |
| p.R226K | ESCA | 1 |
| p.E720K | SKCM | 1 |
| p.E549K | SKCM | 1 |
| p.E69X | COAD | 1 |
| p.A405V | SKCM | 1 |
| p.S308L | SKCM | 1 |
| p.S768L | HNSC | 1 |
| p.S107F | BRCA | 1 |
| p.V632I | UCEC | 1 |
| p.R792Q | COAD | 1 |
| p.C702Y | OV | 1 |
| p.G380R | SKCM | 1 |
| p.W503L | SARC | 1 |
| p.S762I | SARC | 1 |
| p.D450N | SKCM | 1 |
| p.G515R | SKCM | 1 |
| p.N754Y | LUAD | 1 |
| p.E279K | SKCM | 1 |
| p.S93L | ESCA | 1 |
| p.P511S | SKCM | 1 |
| p.T539M | KIRC | 1 |
| p.E585A | OV | 1 |
| p.S803C | LIHC | 1 |
| p.Q150H | LUAD | 1 |
| p.D450Y | LUAD | 1 |
| p.G780E | SKCM | 1 |
| p.P267A | CESC | 1 |
| p.W679C | BRCA | 1 |
| p.G341V | LUAD | 1 |
| p.H643R | SKCM | 1 |
| p.R378I | LUSC | 1 |
| p.E138X | READ | 1 |
| p.R293Q | SARC | 1 |
| p.E312* | UCEC | 1 |
| p.R50W | BRCA | 1 |
| p.D195Y | UCEC | 1 |
| p.G59E | LUSC | 1 |
| p.D731Y | LGG | 1 |
| p.L147I | LUAD | 1 |
| p.E447D | UCEC | 1 |
| p.Q95X | DLBC | 1 |
| p.T598S | COAD | 1 |
| p.H343Y | LUAD | 1 |
| p.P575S | SKCM | 1 |
| p.A22V | COAD | 1 |
| p.N27D | LUAD | 1 |
| p.R233L | CHOL | 1 |
| p.C523F | ESCA | 1 |
| p.S534F | SKCM | 1 |
| p.S217L | LUAD | 1 |
| p.D106N | SKCM | 1 |
| p.R233H | UCEC | 1 |
| p.S228* | LUAD | 1 |
| p.E199K | SKCM | 1 |
| p.E333K | SKCM | 1 |
| p.T587P | COAD | 1 |
| p.Q843* | SKCM | 1 |
| p.V689I | UCEC | 1 |
| p.Q697H | LUAD | 1 |
| p.Q703* | SKCM | 1 |
| p.E357K | SKCM | 1 |
| p.S339F | SKCM | 1 |
| p.A484V | THYM | 1 |
| p.D172N | SKCM | 1 |
| p.G580* | UCEC | 1 |
| p.P644H | LUAD | 1 |
| p.L605H | LUAD | 1 |
| p.H746Y | HNSC | 1 |
| p.F196L | LIHC | 1 |
| p.Q697L | LUAD | 1 |
| p.G352V | THYM | 1 |
| p.L740V | THCA | 1 |
| p.E538K | BRCA | 1 |
| p.G84E | SKCM | 1 |
| p.Q95K | LUAD | 1 |
| p.R618P | LUAD | 1 |
| p.R792* | OV | 1 |
| p.P35S | SKCM | 1 |
| p.E569X | COAD | 1 |
| p.G827R | HNSC | 1 |
| p.D616N | CESC | 1 |
| p.P75S | UCEC | 1 |
| p.G373E | STAD | 1 |
| p.S542N | UCS | 1 |
| p.S389T | COAD | 1 |
| p.E569* | UCEC | 1 |
| p.V610M | UCEC | 1 |
| p.Q415R | LGG | 1 |
| p.D616E | LUAD | 1 |
| p.R736M | UCEC | 1 |
| p.R314G | LUAD | 1 |
| p.S237L | SKCM | 1 |
| p.R220W | SKCM | 1 |
| p.E116K | SKCM | 1 |
| p.I192T | SKCM | 1 |
| p.E82K | SKCM | 1 |
| p.F276L | UCEC | 1 |
| p.K244I | SKCM | 1 |
| p.A611G | LUAD | 1 |
| p.P562S | SKCM | 1 |
| p.V499F | UCEC | 1 |
| p.C773R | SKCM | 1 |
| p.D761E | LUAD | 1 |
| p.H243Y | SKCM | 1 |
| p.P459S | LUAD | 1 |
| p.S306C | ESCA | 1 |
| p.G580E | UCEC | 1 |
| p.E374K | SKCM | 1 |
| p.E469D | LUAD | 1 |
| p.S762N | SKCM | 1 |
| p.A359T | COAD | 1 |
| p.W277L | ESCA | 1 |
| p.A822T | PAAD | 1 |
| p.L633P | SKCM | 1 |
| p.A291D | KIRC | 1 |
| p.G65E | SKCM | 1 |
| p.Q703X | SKCM | 1 |
| p.G181E | SKCM | 1 |
| p.E819* | LUAD | 1 |
| p.D547H | BRCA | 1 |
| p.S664F | SKCM | 1 |
| p.S227Y | CESC | 1 |
| p.R687H | PAAD | 1 |
| p.K593N | LGG | 1 |
| p.A114D | LUAD | 1 |
| p.D500N | SKCM | 1 |
| p.R88H | LGG | 1 |
| p.V346F | LUAD | 1 |
| p.Y198S | SKCM | 1 |
| p.R220P | LUAD | 1 |
| p.S787I | LUSC | 1 |
| p.C473R | SKCM | 1 |
| p.G173E | SKCM | 1 |
| p.F262Y | BLCA | 1 |
| p.T211M | UCEC | 1 |
| p.G300R | SKCM | 1 |
| p.E785Q | BLCA | 1 |
| p.G78R | SKCM | 1 |
| p.G586S | SKCM | 1 |
| p.Q150K | LUAD | 1 |
| p.G532E | SKCM | 1 |
| p.P647A | BLCA | 1 |
| p.F589Y | SKCM | 1 |
| p.D616Y | COAD | 1 |
| p.E254K | PAAD | 1 |
| p.A405S | LUAD | 1 |
| p.L421P | STAD | 1 |
| p.C626X | UCS | 1 |
| p.L283F | LUAD | 1 |
| p.R712I | UCEC | 1 |
| p.G531R | LUSC | 1 |
| p.P479L | HNSC | 1 |
| p.P766T | HNSC | 1 |
| p.E538* | UCEC | 1 |
| p.L283F | SKCM | 1 |
| p.G607R | SKCM | 1 |
| p.T539M | LGG | 1 |
| p.L283V | SARC | 1 |
| p.S534C | LUSC | 1 |
| p.A822V | HNSC | 1 |
| p.P590L | SKCM | 1 |
| p.T467P | LUAD | 1 |
| p.L465F | THYM | 1 |
| p.T539M | STAD | 1 |
| p.P414H | STAD | 1 |
| p.A260T | UCEC | 1 |
| p.G387V | LUSC | 1 |
| p.E585K | SKCM | 1 |
| p.A729S | LUAD | 1 |
| p.W36* | SKCM | 1 |
| p.S281F | HNSC | 1 |
| p.K429N | LUAD | 1 |
| p.G41D | HNSC | 1 |
| p.R220L | LUSC | 1 |
| p.G398E | SKCM | 1 |
| p.P634S | STAD | 1 |
| p.Q627E | KIRP | 1 |
| p.G827R | SKCM | 1 |
| p.E74K | SKCM | 1 |
| p.V635L | SARC | 1 |
| p.V536I | KIRC | 1 |
| p.R760S | LUAD | 1 |
| p.Q249H | UCEC | 1 |
| p.P647L | SKCM | 1 |
| p.E549V | HNSC | 1 |
| p.P133H | HNSC | 1 |
| p.T158S | LUSC | 1 |
| p.A839G | LUAD | 1 |
| p.K678E | LUSC | 1 |
| p.Q29R | HNSC | 1 |
| p.R220Q | ESCA | 1 |
| p.C626* | UCS | 1 |
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| TissGeneCNV for C7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BP426067 | C7-DEFA6 | chr5:40936975 | chr8:6782216 | |
| Chimerdb3.0 | ChiTaRs | NA | AV705612 | DCPS-C7 | chr11:126208533 | chr5:40982513 |
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| TissGeneNet for C7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| COAD (tumor) | COAD (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| HNSC (tumor) | HNSC (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| KICH (tumor) | KICH (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| KIRC (tumor) | KIRC (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| KIRP (tumor) | KIRP (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| LIHC (tumor) | LIHC (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| LUAD (tumor) | LUAD (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| LUSC (tumor) | LUSC (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| PRAD (tumor) | PRAD (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| STAD (tumor) | STAD (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| THCA (tumor) | THCA (normal) |
| C7, PLG, C5, CLU (tumor) | C7, PLG, C5, CLU (normal) |
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| TissGeneProg for C7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C7 |
| TissGeneDrug for C7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1864694 | Complement Component 7 Deficiency | 5 | CLINVAR,CTD_human,GAD,UNIPROT |
| umls:C0242383 | Age related macular degeneration | 2 | GAD |
| umls:C1846064 | Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 2 | BeFree |
| umls:C0017665 | Membranous glomerulonephritis | 1 | RGD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0025303 | Meningococcal Infections | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | RGD |
| umls:C0036572 | Seizures | 1 | RGD |
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