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| TissGeneSummary for C9 |
 Gene summary |
| Basic gene information | Gene symbol | C9 |
| Gene name | complement component 9 | |
| Synonyms | ARMD15|C9D | |
| Cytomap | UCSC genome browser: 5p14-p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001737.3, | |
| Description | complement component C9 | |
| Modification date | 20141221 | |
| dbXrefs | MIM : 120940 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113600 | ||
| HPRD : 00408 | ||
| Vega : OTTHUMG00000094767 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C9 | |
| BioGPS: 735 | ||
| Pathway | NCI Pathway Interaction Database: C9 | |
| KEGG: C9 | ||
| REACTOME: C9 | ||
| Pathway Commons: C9 | ||
| Context | iHOP: C9 | |
| ligand binding site mutation search in PubMed: C9 | ||
| UCL Cancer Institute: C9 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of C9 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.034558894 | 3.284380769 | -2.249821875 | 1.26E-08 | 9.54E-08 |
| LIHC | 8.331264144 | 14.36924014 | -6.037976 | 1.64E-12 | 3.09E-11 |
| KIRC | 1.676759589 | 3.423704033 | -1.746944444 | 3.60E-12 | 1.46E-11 |
| KICH | 4.369962144 | 3.364002144 | 1.00596 | 0.029 | 0.047380282 |
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| TissGene-miRNA for C9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C9 |
| TissGeneSNV for C9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R63C | SKCM | 3 |
| p.E558K | SKCM | 3 |
| p.D312N | SKCM | 2 |
| p.E218K | SKCM | 2 |
| p.G179E | SKCM | 2 |
| p.E278K | SKCM | 2 |
| p.R311C | SKCM | 2 |
| p.R309I | UCEC | 2 |
| p.R116X | THYM | 2 |
| p.D312N | HNSC | 2 |
| p.P90S | STAD | 1 |
| p.W48X | SKCM | 1 |
| p.L295M | THYM | 1 |
| p.E149K | SKCM | 1 |
| p.M522I | SKCM | 1 |
| p.P167L | SKCM | 1 |
| p.R154* | ACC | 1 |
| p.W48* | SKCM | 1 |
| p.P171S | SKCM | 1 |
| p.G549_splice | GBM | 1 |
| p.Y177C | HNSC | 1 |
| p.L479V | HNSC | 1 |
| p.M522I | UCEC | 1 |
| p.K225I | LUAD | 1 |
| p.K472Q | UCEC | 1 |
| p.N463D | UCEC | 1 |
| p.D132E | PAAD | 1 |
| p.S201F | HNSC | 1 |
| p.Y192H | THYM | 1 |
| p.C510Y | UCEC | 1 |
| p.E218K | UCEC | 1 |
| p.K290Q | SKCM | 1 |
| p.G516E | SKCM | 1 |
| p.D133G | STAD | 1 |
| p.G75E | SKCM | 1 |
| p.D80N | SKCM | 1 |
| p.S66R | LUAD | 1 |
| p.Y286C | COAD | 1 |
| p.V449M | HNSC | 1 |
| p.R311H | STAD | 1 |
| p.Y286* | UCEC | 1 |
| p.P245H | LUSC | 1 |
| p.A81D | LUAD | 1 |
| p.D312N | BLCA | 1 |
| p.K407N | LUAD | 1 |
| p.D363Y | LUAD | 1 |
| p.R86Q | SKCM | 1 |
| p.R86L | LUAD | 1 |
| p.V406I | HNSC | 1 |
| p.I394M | BLCA | 1 |
| p.G179R | SKCM | 1 |
| p.D124N | HNSC | 1 |
| p.N120H | UCEC | 1 |
| p.G187E | SKCM | 1 |
| p.E291K | SKCM | 1 |
| p.Q60H | STAD | 1 |
| p.G179X | SKCM | 1 |
| p.G179* | SKCM | 1 |
| p.S129L | SKCM | 1 |
| p.E218K | COAD | 1 |
| p.R139C | STAD | 1 |
| p.E410Q | HNSC | 1 |
| p.G164E | SKCM | 1 |
| p.S240Y | UCEC | 1 |
| p.K298E | UCEC | 1 |
| p.T433S | LUAD | 1 |
| p.C142X | ESCA | 1 |
| p.G110S | BLCA | 1 |
| p.N123D | UCEC | 1 |
| p.R154* | LUAD | 1 |
| p.S418G | LIHC | 1 |
| p.R118Q | UCEC | 1 |
| p.C125X | ESCA | 1 |
| p.F62Y | STAD | 1 |
| p.C510F | OV | 1 |
| p.R154* | UCEC | 1 |
| p.I394F | ACC | 1 |
| p.T448N | LUSC | 1 |
| p.N198K | LUAD | 1 |
| p.A153T | THYM | 1 |
| p.D55N | UCEC | 1 |
| p.F176S | STAD | 1 |
| p.G397V | ACC | 1 |
| p.E278K | SARC | 1 |
| p.E219Q | GBM | 1 |
| p.Y356H | LUAD | 1 |
| p.M61I | SKCM | 1 |
| p.G411S | LIHC | 1 |
| p.V456I | LUAD | 1 |
| p.I11M | HNSC | 1 |
| p.R271W | SKCM | 1 |
| p.S461F | SKCM | 1 |
| p.D124N | LUAD | 1 |
| p.S348I | BLCA | 1 |
| p.D322N | SKCM | 1 |
| p.G397V | COAD | 1 |
| p.D42H | SARC | 1 |
| p.I203M | PRAD | 1 |
| p.E215K | SKCM | 1 |
| p.G371V | KIRC | 1 |
| p.R154Q | HNSC | 1 |
| p.N103D | SARC | 1 |
| p.C530R | COAD | 1 |
| p.Q72H | UCEC | 1 |
| p.S470G | BLCA | 1 |
| p.E257K | SKCM | 1 |
| p.T328I | SKCM | 1 |
| p.L295V | BLCA | 1 |
| p.F176L | PAAD | 1 |
| p.R86Q | LIHC | 1 |
| p.N234H | UCEC | 1 |
| p.D132N | SKCM | 1 |
| p.R369W | HNSC | 1 |
| p.I67V | LUAD | 1 |
| p.Y23H | KIRP | 1 |
| p.R118W | UCS | 1 |
| p.R154Q | SKCM | 1 |
| p.F438V | UCEC | 1 |
| p.E535Q | BLCA | 1 |
| p.F555Y | SKCM | 1 |
| p.P475S | SKCM | 1 |
| p.S35I | LUAD | 1 |
| p.L494F | LUAD | 1 |
| p.C142R | LUAD | 1 |
| p.Y436N | LUSC | 1 |
| p.Q53L | HNSC | 1 |
| p.D186N | LUAD | 1 |
| p.L19I | HNSC | 1 |
| p.V199L | LUAD | 1 |
| p.N234K | UCEC | 1 |
| p.P245T | LUAD | 1 |
| p.G179R | LUAD | 1 |
| p.R508G | STAD | 1 |
| p.A413S | BLCA | 1 |
| p.V297L | LUAD | 1 |
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| TissGeneCNV for C9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF990638 | C9-TEAD1 | chr5:39301401 | chr11:12961391 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A7HV-01A | NDRG1-C9 | Out-of-Frame | chr8:134292474 | chr5:39342298 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NE-01A | RICTOR-C9 | Out-of-Frame | chr5:39074212 | chr5:39342298 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A7-A26G-01A | LIFR-C9 | Out-of-frame | Chr5:38493708 | Chr5:39316131 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1R7-01A | FAM157A-C9 | Out-of-frame | Chr3:197894742 | Chr5:39316131 |
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| TissGeneNet for C9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| COAD (tumor) | COAD (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| KICH (tumor) | KICH (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| STAD (tumor) | STAD (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| THCA (tumor) | THCA (normal) |
| C9, C8A, CLU, CD59 (tumor) | C9, C8A, CLU, CD59 (normal) |
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| TissGeneProg for C9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C9 |
| TissGeneDrug for C9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C3151189 | C9 Deficiency | 4 | BeFree,CLINVAR,UNIPROT |
| umls:C0021051 | Immunologic Deficiency Syndromes | 2 | CTD_human |
| umls:C0242383 | Age related macular degeneration | 2 | CTD_human,GAD |
| umls:C2239176 | Liver carcinoma | 2 | BeFree,CTD_human |
| umls:C0011633 | Dermatomyositis | 1 | CTD_human |
| umls:C0014175 | Endometriosis | 1 | LHGDN |
| umls:C0015456 | Facial Dermatoses | 1 | CTD_human |
| umls:C0021359 | Infertility | 1 | LHGDN |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0025294 | Meningococcal meningitis | 1 | CTD_human |
| umls:C0027412 | Opioid-Related Disorders | 1 | CTD_human |
| umls:C0041834 | Erythema | 1 | CTD_human |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
| umls:C3810042 | MACULAR DEGENERATION, AGE-RELATED, 15 | 1 | CLINVAR,UNIPROT |
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