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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SCGB1A1
check button Gene summary
Basic gene informationGene symbolSCGB1A1
Gene namesecretoglobin, family 1A, member 1 (uteroglobin)
SynonymsCC10|CC16|CCPBP|CCSP|UGB|UP-1|UP1
CytomapUCSC genome browser: 11q12.3
Type of geneprotein-coding
RefGenesNM_003357.4,
Descriptionblastokininclara cell phospholipid-binding proteinclara cells 10 kDa secretory proteinurinary protein 1urine protein 1uteroglobin
Modification date20141222
dbXrefs MIM : 192020
HGNC : HGNC
Ensembl : ENSG00000149021
HPRD : 01884
Vega : OTTHUMG00000167526
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SCGB1A1
BioGPS: 7356
PathwayNCI Pathway Interaction Database: SCGB1A1
KEGG: SCGB1A1
REACTOME: SCGB1A1
Pathway Commons: SCGB1A1
ContextiHOP: SCGB1A1
ligand binding site mutation search in PubMed: SCGB1A1
UCL Cancer Institute: SCGB1A1
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LungProstate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSCPRAD
Reference showing the relevant tissue of SCGB1A1Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Khavinson VKh, Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkova NS, Ashapkin VV, Polyakova VO, Basharina VS, Bernadotte A. Lung. 2014 Oct;192(5):781-91. doi: 10.1007/s00408-014-9620-7. Epub 2014 Jul 12 (pmid:25015171)
go to article
Description by TissGene annotationsProtective TissGene in OS
Cancer gene
Significant down-regulated DEG
TissgsKTS
CNV lost TissGeneKTS
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SCGB1A1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC3.3377191889.92059958-6.5828803926.40E-164.50E-15
LUAD4.73309592910.46148041-5.7283844832.77E-132.30E-12
HNSC-0.8628243591.80729192-2.6701162790.0001080.00047929
PRAD2.8325349885.23854268-2.4060076927.05E-050.000306778


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TissGene-miRNA for SCGB1A1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SCGB1A1
TissGeneSNV for SCGB1A1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.I78NSKCM1
p.I23TPRAD1
p.E75*UCEC1
p.I43NSKCM1
p.A25DLUAD1
p.A10VPRAD1
p.M36VSTAD1
p.I77TLIHC1
p.E22KSARC1
p.P16HLGG1
p.L35ILUAD1
p.L80FUCEC1


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TissGeneCNV for SCGB1A1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SCGB1A1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABU676932SCGB1A1-RAB27Achr11:62190667chr15:55496120
Chimerdb3.0FusionScanSARCTCGA-DX-A1KY-01AFAM220A-SCGB1A15'UTR-CDSchr7:6388203chr11:62189692


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TissGeneNet for SCGB1A1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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COAD (tumor)COAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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HNSC (tumor)HNSC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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KICH (tumor)KICH (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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KIRC (tumor)KIRC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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KIRP (tumor)KIRP (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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LIHC (tumor)LIHC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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LUAD (tumor)LUAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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LUSC (tumor)LUSC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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PRAD (tumor)PRAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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STAD (tumor)STAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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THCA (tumor)THCA (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)
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TissGeneProg for SCGB1A1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SCGB1A1
TissGeneDrug for SCGB1A1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SCGB1A1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0004096Asthma32BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0017661IGA Glomerulonephritis12BeFree,GAD,LHGDN
umls:C0021368Inflammation7CTD_human,GAD,LHGDN
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0027430Nasal Polyps5BeFree,LHGDN
umls:C0035455Rhinitis5BeFree,LHGDN
umls:C0242379Malignant neoplasm of lung5BeFree
umls:C0684249Carcinoma of lung5BeFree
umls:C0010278Craniosynostosis4BeFree
umls:C0022658Kidney Diseases4BeFree
umls:C0024115Lung diseases4BeFree,CTD_human,LHGDN
umls:C0085129Bronchial Hyperreactivity4BeFree,GAD,LHGDN
umls:C0149516Chronic sinusitis4BeFree
umls:C0155877Allergic asthma4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C0699949airway disease4BeFree
umls:C2607914Allergic rhinitis (disorder)4BeFree
umls:C3539909Allergic disposition4BeFree
umls:C0001418Adenocarcinoma3BeFree
umls:C0035222Respiratory Distress Syndrome, Adult3BeFree,GAD
umls:C0035235Respiratory Syncytial Virus Infections3BeFree,GAD
umls:C0036202Sarcoidosis3BeFree,GAD,LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0268731Renal glomerular disease3BeFree
umls:C0339510Vitelliform Macular Dystrophy3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0006012Borderline Personality Disorder2BeFree
umls:C0006274Bronchiolitis, Viral2GAD
umls:C0006287Bronchopulmonary Dysplasia2BeFree
umls:C0009782Connective Tissue Diseases2BeFree,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2GAD
umls:C0017658Glomerulonephritis2BeFree
umls:C0020517Hypersensitivity2GAD
umls:C0020523Immediate hypersensitivity2GAD
umls:C0020538Hypertensive disease2BeFree
umls:C0024121Lung Neoplasms2BeFree,LHGDN
umls:C0027697Nephritis2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0032285Pneumonia2BeFree
umls:C0035220Respiratory Distress Syndrome, Newborn2BeFree
umls:C0036341Schizophrenia2BeFree
umls:C0043144Wheezing2BeFree
umls:C0151526Premature Birth2GAD
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C0001430Adenoma1BeFree
umls:C0003873Rheumatoid Arthritis1GAD
umls:C0007786Brain Ischemia1GAD
umls:C0008149Chlamydia Infections1GAD
umls:C0014170Endometrial Neoplasms1LHGDN
umls:C0014173Endometrial Hyperplasia1LHGDN
umls:C0014599Epithelial hyperplasia1BeFree
umls:C0014743Erythema Nodosum1GAD
umls:C0015929Fetal Diseases1GAD
umls:C0018621Hay fever1BeFree
umls:C0021053Immune System Diseases1BeFree
umls:C0022661Kidney Failure, Chronic1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree,GWASCAT
umls:C0024141Lupus Erythematosus, Systemic1BeFree,GAD
umls:C0025048Meconium Aspiration Syndrome1LHGDN
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0027404Narcolepsy1GAD
umls:C0029882Otitis Media1RGD
umls:C0032584polyps1BeFree
umls:C0032964Pregnancy Complications, Hematologic1GAD
umls:C0032987Ectopic Pregnancy1BeFree
umls:C0032994Pregnancy, Tubal1BeFree
umls:C0033771Prurigo1BeFree
umls:C0034069Pulmonary Fibrosis1RGD
umls:C0034152Henoch-Schoenlein Purpura1BeFree,GAD
umls:C0035204Respiration Disorders1CTD_human
umls:C0036130Salpingitis1BeFree
umls:C0037116Silicosis1LHGDN
umls:C0037274Dermatologic disorders1GAD
umls:C0038218Status Asthmaticus1BeFree
umls:C0038436Post-Traumatic Stress Disorder1BeFree
umls:C0038454Cerebrovascular accident1GAD
umls:C0040592Trachoma1GAD
umls:C0153633Malignant neoplasm of brain1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0242172Pelvic Inflammatory Disease1BeFree
umls:C0242488Acute Lung Injury1RGD
umls:C0282612Prostatic Intraepithelial Neoplasias1BeFree
umls:C0333186Restenosis1GAD
umls:C0339805Cat allergy (disorder)1BeFree
umls:C0477474Dermatitis and eczema1GAD
umls:C0582415Acute asthma1BeFree
umls:C0750979Primary malignant neoplasm of brain1BeFree
umls:C1153706Endometrial adenocarcinoma1BeFree
umls:C1861172Venous Thromboembolism1GAD
umls:C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1BeFree
umls:C1956346Coronary Artery Disease1GAD
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2609414Acute kidney injury1RGD
umls:C3714514Infection1GAD