TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SCGB1A1

Gene summary

Basic gene information	Gene symbol	SCGB1A1
	Gene name	secretoglobin, family 1A, member 1 (uteroglobin)
	Synonyms	CC10\|CC16\|CCPBP\|CCSP\|UGB\|UP-1\|UP1
	Cytomap	UCSC genome browser: 11q12.3
	Type of gene	protein-coding
	RefGenes	NM_003357.4,
	Description	blastokininclara cell phospholipid-binding proteinclara cells 10 kDa secretory proteinurinary protein 1urine protein 1uteroglobin
	Modification date	20141222
dbXrefs	MIM : 192020
	HGNC : HGNC
	Ensembl : ENSG00000149021
	HPRD : 01884
	Vega : OTTHUMG00000167526
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SCGB1A1
	BioGPS: 7356
Pathway	NCI Pathway Interaction Database: SCGB1A1
	KEGG: SCGB1A1
	REACTOME: SCGB1A1
	Pathway Commons: SCGB1A1
Context	iHOP: SCGB1A1
	ligand binding site mutation search in PubMed: SCGB1A1
	UCL Cancer Institute: SCGB1A1
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	LungProstate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LUAD,LUSCPRAD
Reference showing the relevant tissue of SCGB1A1	Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Khavinson VKh, Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkova NS, Ashapkin VV, Polyakova VO, Basharina VS, Bernadotte A. Lung. 2014 Oct;192(5):781-91. doi: 10.1007/s00408-014-9620-7. Epub 2014 Jul 12 (pmid:25015171) go to article
Description by TissGene annotations	Protective TissGene in OS Cancer gene Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS Fused withOncogene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for SCGB1A1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LUSC	3.337719188	9.92059958	-6.582880392	6.40E-16	4.50E-15
LUAD	4.733095929	10.46148041	-5.728384483	2.77E-13	2.30E-12
HNSC	-0.862824359	1.80729192	-2.670116279	0.000108	0.00047929
PRAD	2.832534988	5.23854268	-2.406007692	7.05E-05	0.000306778

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TissGene-miRNA for SCGB1A1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for SCGB1A1

TissGeneSNV for SCGB1A1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.I78N	SKCM	1
p.I23T	PRAD	1
p.E75*	UCEC	1
p.I43N	SKCM	1
p.A25D	LUAD	1
p.A10V	PRAD	1
p.M36V	STAD	1
p.I77T	LIHC	1
p.E22K	SARC	1
p.P16H	LGG	1
p.L35I	LUAD	1
p.L80F	UCEC	1

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TissGeneCNV for SCGB1A1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for SCGB1A1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BU676932	SCGB1A1-RAB27A		chr11:62190667	chr15:55496120
Chimerdb3.0	FusionScan	SARC	TCGA-DX-A1KY-01A	FAM220A-SCGB1A1	5'UTR-CDS	chr7:6388203	chr11:62189692

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TissGeneNet for SCGB1A1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

COAD (tumor)	COAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

HNSC (tumor)	HNSC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

KICH (tumor)	KICH (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

KIRC (tumor)	KIRC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

KIRP (tumor)	KIRP (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

LIHC (tumor)	LIHC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

LUAD (tumor)	LUAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

LUSC (tumor)	LUSC (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

PRAD (tumor)	PRAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

STAD (tumor)	STAD (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

THCA (tumor)	THCA (normal)
SCGB1A1, FN1, LRP2, LMBR1L, CUBN (tumor)	SCGB1A1, FN1, LRP2, LMBR1L, CUBN (normal)

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TissGeneProg for SCGB1A1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for SCGB1A1

TissGeneDrug for SCGB1A1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for SCGB1A1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0004096	Asthma	32	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0017661	IGA Glomerulonephritis	12	BeFree,GAD,LHGDN
umls:C0021368	Inflammation	7	CTD_human,GAD,LHGDN
umls:C0006142	Malignant neoplasm of breast	5	BeFree
umls:C0027430	Nasal Polyps	5	BeFree,LHGDN
umls:C0035455	Rhinitis	5	BeFree,LHGDN
umls:C0242379	Malignant neoplasm of lung	5	BeFree
umls:C0684249	Carcinoma of lung	5	BeFree
umls:C0010278	Craniosynostosis	4	BeFree
umls:C0022658	Kidney Diseases	4	BeFree
umls:C0024115	Lung diseases	4	BeFree,CTD_human,LHGDN
umls:C0085129	Bronchial Hyperreactivity	4	BeFree,GAD,LHGDN
umls:C0149516	Chronic sinusitis	4	BeFree
umls:C0155877	Allergic asthma	4	BeFree
umls:C0678222	Breast Carcinoma	4	BeFree
umls:C0699949	airway disease	4	BeFree
umls:C2607914	Allergic rhinitis (disorder)	4	BeFree
umls:C3539909	Allergic disposition	4	BeFree
umls:C0001418	Adenocarcinoma	3	BeFree
umls:C0035222	Respiratory Distress Syndrome, Adult	3	BeFree,GAD
umls:C0035235	Respiratory Syncytial Virus Infections	3	BeFree,GAD
umls:C0036202	Sarcoidosis	3	BeFree,GAD,LHGDN
umls:C0152013	Adenocarcinoma of lung (disorder)	3	BeFree
umls:C0178874	Tumor Progression	3	BeFree
umls:C0268731	Renal glomerular disease	3	BeFree
umls:C0339510	Vitelliform Macular Dystrophy	3	BeFree
umls:C0596263	Carcinogenesis	3	BeFree
umls:C0006012	Borderline Personality Disorder	2	BeFree
umls:C0006274	Bronchiolitis, Viral	2	GAD
umls:C0006287	Bronchopulmonary Dysplasia	2	BeFree
umls:C0009782	Connective Tissue Diseases	2	BeFree,GAD
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	2	GAD
umls:C0017658	Glomerulonephritis	2	BeFree
umls:C0020517	Hypersensitivity	2	GAD
umls:C0020523	Immediate hypersensitivity	2	GAD
umls:C0020538	Hypertensive disease	2	BeFree
umls:C0024121	Lung Neoplasms	2	BeFree,LHGDN
umls:C0027697	Nephritis	2	BeFree
umls:C0029925	Ovarian Carcinoma	2	BeFree
umls:C0032285	Pneumonia	2	BeFree
umls:C0035220	Respiratory Distress Syndrome, Newborn	2	BeFree
umls:C0036341	Schizophrenia	2	BeFree
umls:C0043144	Wheezing	2	BeFree
umls:C0151526	Premature Birth	2	GAD
umls:C0376358	Malignant neoplasm of prostate	2	BeFree
umls:C0600139	Prostate carcinoma	2	BeFree
umls:C1140680	Malignant neoplasm of ovary	2	BeFree
umls:C0001430	Adenoma	1	BeFree
umls:C0003873	Rheumatoid Arthritis	1	GAD
umls:C0007786	Brain Ischemia	1	GAD
umls:C0008149	Chlamydia Infections	1	GAD
umls:C0014170	Endometrial Neoplasms	1	LHGDN
umls:C0014173	Endometrial Hyperplasia	1	LHGDN
umls:C0014599	Epithelial hyperplasia	1	BeFree
umls:C0014743	Erythema Nodosum	1	GAD
umls:C0015929	Fetal Diseases	1	GAD
umls:C0018621	Hay fever	1	BeFree
umls:C0021053	Immune System Diseases	1	BeFree
umls:C0022661	Kidney Failure, Chronic	1	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	1	BeFree,GWASCAT
umls:C0024141	Lupus Erythematosus, Systemic	1	BeFree,GAD
umls:C0025048	Meconium Aspiration Syndrome	1	LHGDN
umls:C0026857	Musculoskeletal Diseases	1	GAD
umls:C0027404	Narcolepsy	1	GAD
umls:C0029882	Otitis Media	1	RGD
umls:C0032584	polyps	1	BeFree
umls:C0032964	Pregnancy Complications, Hematologic	1	GAD
umls:C0032987	Ectopic Pregnancy	1	BeFree
umls:C0032994	Pregnancy, Tubal	1	BeFree
umls:C0033771	Prurigo	1	BeFree
umls:C0034069	Pulmonary Fibrosis	1	RGD
umls:C0034152	Henoch-Schoenlein Purpura	1	BeFree,GAD
umls:C0035204	Respiration Disorders	1	CTD_human
umls:C0036130	Salpingitis	1	BeFree
umls:C0037116	Silicosis	1	LHGDN
umls:C0037274	Dermatologic disorders	1	GAD
umls:C0038218	Status Asthmaticus	1	BeFree
umls:C0038436	Post-Traumatic Stress Disorder	1	BeFree
umls:C0038454	Cerebrovascular accident	1	GAD
umls:C0040592	Trachoma	1	GAD
umls:C0153633	Malignant neoplasm of brain	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0206698	Cholangiocarcinoma	1	BeFree
umls:C0242172	Pelvic Inflammatory Disease	1	BeFree
umls:C0242488	Acute Lung Injury	1	RGD
umls:C0282612	Prostatic Intraepithelial Neoplasias	1	BeFree
umls:C0333186	Restenosis	1	GAD
umls:C0339805	Cat allergy (disorder)	1	BeFree
umls:C0477474	Dermatitis and eczema	1	GAD
umls:C0582415	Acute asthma	1	BeFree
umls:C0750979	Primary malignant neoplasm of brain	1	BeFree
umls:C1153706	Endometrial adenocarcinoma	1	BeFree
umls:C1861172	Venous Thromboembolism	1	GAD
umls:C1866075	GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)	1	BeFree
umls:C1956346	Coronary Artery Disease	1	GAD
umls:C2316810	Chronic kidney disease stage 5	1	BeFree
umls:C2609414	Acute kidney injury	1	RGD
umls:C3714514	Infection	1	GAD