TissGeneSummary for UGT2B4 |
Gene summary |
Basic gene information | Gene symbol | UGT2B4 |
Gene name | UDP glucuronosyltransferase 2 family, polypeptide B4 | |
Synonyms | HLUG25|UDPGT2B4|UDPGTH1|UDPGTh-1|UGT2B11 | |
Cytomap | UCSC genome browser: 4q13 | |
Type of gene | protein-coding | |
RefGenes | NM_001297615.1, NM_001297616.1,NM_021139.2, | |
Description | UDP-glucuronosyltransferase 2B4UDP-glucuronyltransferase, family 2, beta-4UDPGT 2B4hyodeoxycholic acidhyodeoxycholic acid-specific UDPGT | |
Modification date | 20141207 | |
dbXrefs | MIM : 600067 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156096 | ||
HPRD : 02507 | ||
Vega : OTTHUMG00000058891 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UGT2B4 | |
BioGPS: 7363 | ||
Pathway | NCI Pathway Interaction Database: UGT2B4 | |
KEGG: UGT2B4 | ||
REACTOME: UGT2B4 | ||
Pathway Commons: UGT2B4 | ||
Context | iHOP: UGT2B4 | |
ligand binding site mutation search in PubMed: UGT2B4 | ||
UCL Cancer Institute: UGT2B4 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of UGT2B4 | Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines. J Pharmacol Exp Ther. 2016 Oct;359(1):182-93. doi: 10.1124/jpet.116.235044. Epub 2016 Jul 29. (pmid:27474751) go to article | |
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006711 | estrogen catabolic process | 8333863 | GO:0006805 | xenobiotic metabolic process | 8333863 | GO:0008152 | metabolic process | 8333863 | GO:0052695 | cellular glucuronidation | 20056724 | GO:0006711 | estrogen catabolic process | 8333863 | GO:0006805 | xenobiotic metabolic process | 8333863 | GO:0008152 | metabolic process | 8333863 | GO:0052695 | cellular glucuronidation | 20056724 |
Top |
TissGeneExp for UGT2B4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 2.136350435 | -1.061795718 | 3.198146154 | 5.45E-10 | 9.47E-09 |
LUAD | -0.9387554 | 0.614135979 | -1.552891379 | 1.24E-06 | 4.11E-06 |
LUSC | -2.151541269 | 0.799668535 | -2.951209804 | 2.41E-20 | 2.97E-19 |
BRCA | -1.584665624 | -0.486627905 | -1.098037719 | 0.000142 | 0.000309244 |
Top |
TissGene-miRNA for UGT2B4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for UGT2B4 |
TissGeneSNV for UGT2B4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D263N | SKCM | 3 |
p.R259* | SKCM | 3 |
p.S110L | SKCM | 2 |
p.G522E | SKCM | 2 |
p.F18I | CESC | 2 |
p.E45K | SKCM | 2 |
p.E181K | SKCM | 2 |
p.L218F | SKCM | 2 |
p.M292I | SKCM | 1 |
p.E319X | COAD | 1 |
p.G279R | LUAD | 1 |
p.M250I | LUAD | 1 |
p.D398E | UCEC | 1 |
p.K439Q | SARC | 1 |
p.S326L | HNSC | 1 |
p.G387E | SKCM | 1 |
p.W463C | HNSC | 1 |
p.E440X | UCS | 1 |
p.L336M | UCEC | 1 |
p.K430N | UCEC | 1 |
p.G387R | SKCM | 1 |
p.R173C | SKCM | 1 |
p.D482N | COAD | 1 |
p.V432I | COAD | 1 |
p.R259Q | SKCM | 1 |
p.G278* | LUAD | 1 |
p.I90M | HNSC | 1 |
p.H268Q | HNSC | 1 |
p.M205I | COAD | 1 |
p.V274I | LUAD | 1 |
p.W262* | BLCA | 1 |
p.I433M | COAD | 1 |
p.N434S | LUAD | 1 |
p.S308F | SKCM | 1 |
p.M37I | SKCM | 1 |
p.A57T | PRAD | 1 |
p.D44N | SKCM | 1 |
p.S68N | SKCM | 1 |
p.Q141H | LUAD | 1 |
p.C511S | COAD | 1 |
p.W262* | SKCM | 1 |
p.K212E | HNSC | 1 |
p.E200K | LUAD | 1 |
p.S326L | LUAD | 1 |
p.M3I | SKCM | 1 |
p.E440* | UCS | 1 |
p.P78S | SKCM | 1 |
p.G348* | UCEC | 1 |
p.E45K | LUAD | 1 |
p.P155S | SKCM | 1 |
p.G472E | SKCM | 1 |
p.K40N | BRCA | 1 |
p.W5* | SKCM | 1 |
p.T6I | SKCM | 1 |
p.S311L | STAD | 1 |
p.T368N | ESCA | 1 |
p.G522V | OV | 1 |
p.E32* | CESC | 1 |
p.R469H | STAD | 1 |
p.P101S | SKCM | 1 |
p.T521A | LUAD | 1 |
p.D401H | HNSC | 1 |
p.P30S | LGG | 1 |
p.W97* | LUAD | 1 |
p.M443I | SKCM | 1 |
p.N350T | LGG | 1 |
p.D492N | SKCM | 1 |
p.K523Q | SKCM | 1 |
p.K40N | UCEC | 1 |
p.D482Y | UCEC | 1 |
p.G177D | LUAD | 1 |
p.P195S | PAAD | 1 |
p.P456L | LUAD | 1 |
p.V519A | LUSC | 1 |
p.I39M | SKCM | 1 |
p.K474E | LUAD | 1 |
p.S143* | LUAD | 1 |
p.D345V | HNSC | 1 |
p.W36C | LUAD | 1 |
p.S317* | HNSC | 1 |
p.M198I | STAD | 1 |
p.K286E | SKCM | 1 |
p.G375R | MESO | 1 |
p.R520I | LUAD | 1 |
p.A377D | GBM | 1 |
p.I226L | READ | 1 |
p.A412V | GBM | 1 |
p.R369I | LUAD | 1 |
p.W262X | SKCM | 1 |
p.M406I | SKCM | 1 |
p.F207L | LUAD | 1 |
p.I90F | LUAD | 1 |
p.R527I | UCEC | 1 |
p.R469S | THYM | 1 |
p.Y108C | SKCM | 1 |
p.D361N | SKCM | 1 |
p.K523R | STAD | 1 |
p.Y236F | LUAD | 1 |
p.Y261F | LGG | 1 |
p.H183N | LUSC | 1 |
p.R469C | LGG | 1 |
p.M229I | SKCM | 1 |
p.L27M | LUSC | 1 |
p.R469H | GBM | 1 |
p.G525E | SKCM | 1 |
p.G310R | SKCM | 1 |
p.M443I | BRCA | 1 |
p.P190H | UCEC | 1 |
p.D65N | SKCM | 1 |
p.E465* | BRCA | 1 |
p.E294Q | BLCA | 1 |
p.P30H | COAD | 1 |
p.M3L | LUAD | 1 |
p.E87X | SKCM | 1 |
p.T6I | GBM | 1 |
p.G24R | SKCM | 1 |
p.M214I | SKCM | 1 |
p.L429M | LUSC | 1 |
p.F462L | LUAD | 1 |
p.G376E | SKCM | 1 |
p.H418N | HNSC | 1 |
p.P456S | SKCM | 1 |
p.R49I | READ | 1 |
p.D44N | LUAD | 1 |
p.E294V | LGG | 1 |
p.R469H | COAD | 1 |
p.R144K | SKCM | 1 |
p.G310E | LGG | 1 |
p.P436S | SKCM | 1 |
p.L497M | LUAD | 1 |
p.H489Y | SKCM | 1 |
p.L362P | HNSC | 1 |
p.L100P | HNSC | 1 |
p.G472R | SKCM | 1 |
p.E301K | BLCA | 1 |
p.E87* | SKCM | 1 |
p.E294K | COAD | 1 |
p.R259* | GBM | 1 |
p.E440D | UCEC | 1 |
p.R520G | LUSC | 1 |
p.S311L | HNSC | 1 |
p.K182N | LUSC | 1 |
p.S298R | LUSC | 1 |
p.G341E | SKCM | 1 |
p.S422I | UCEC | 1 |
p.M37I | BLCA | 1 |
p.D424N | SKCM | 1 |
p.R259X | SKCM | 1 |
p.E162K | LUSC | 1 |
Top |
TissGeneCNV for UGT2B4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for UGT2B4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI114505 | EIF2AK3-UGT2B4 | chr2:88922517 | chr4:70345883 |
Top |
TissGeneNet for UGT2B4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for UGT2B4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for UGT2B4 |
TissGeneDrug for UGT2B4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for UGT2B4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree,GAD |
umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0013291 | Duodenal Neoplasms | 1 | GAD |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0028754 | Obesity | 1 | GAD |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | GAD |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | GAD |
umls:C0034012 | Delayed Puberty | 1 | GAD |
umls:C0034013 | Precocious Puberty | 1 | GAD |
umls:C0085215 | Ovarian Failure, Premature | 1 | GAD |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1268717 | Mammographic breast density | 1 | GAD |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3887873 | Hearing Loss | 1 | GAD |